Michael Holinstat

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis
    Michael Holinstat
    Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA
    Arterioscler Thromb Vasc Biol 31:435-42. 2011
  2. doi request reprint 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity
    J Yeung
    Michael Holinstat, Department of Medicine, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, 1020 Locust Street, Suite 394, Jefferson Alumni Hall, Philadelphia, PA, USA, Tel 1 215 955 6121, Fax 1 215 955 9170, E mail
    Thromb Haemost 110:569-81. 2013
  3. pmc Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation
    Jennifer Yeung
    Department of Medicine, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Pharmacol 81:420-30. 2012
  4. pmc Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
    Leonard C Edelstein
    The Cardeza Foundation for Hematologic Research and Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Nat Med 19:1609-16. 2013
  5. doi request reprint Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation
    Michael Holinstat
    Department of Medicine, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA, USA
    J Thromb Thrombolysis 35:209-22. 2013
  6. pmc 12-lipoxygenase: a potential target for novel anti-platelet therapeutics
    Jennifer Yeung
    Department of Medicine, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA, USA
    Cardiovasc Hematol Agents Med Chem 9:154-64. 2011
  7. pmc Newer agents in antiplatelet therapy: a review
    Jennifer Yeung
    Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Blood Med 3:33-42. 2012

Collaborators

  • Olivier Boutaud
  • Paul F Bray
  • Jing Fei Dong
  • Anton Simeonov
  • Jennifer Yeung
  • J Yeung
  • Leonard C Edelstein
  • Narla Mohandas
  • T R Holman
  • Srikanth Nagalla
  • Raúl Teruel Montoya
  • Edward S Chen
  • Xianguo Kong
  • Angela Bergeron
  • G Rai
  • J Vesci
  • M Stolla
  • Chad Shaw
  • D J Maloney
  • P L Apopa
  • David E Cohen
  • A Jadhav
  • P Fernandez-Perez
  • Lukas M Simon
  • Theodore R Holman
  • Ajit Jadhav
  • Victor Kenyon
  • Ganesha Rai
  • Joanne Vesci
  • David J Maloney
  • Patrick L Apopa

Detail Information

Publications7

  1. pmc Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis
    Michael Holinstat
    Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA
    Arterioscler Thromb Vasc Biol 31:435-42. 2011
    ..We evaluated signaling via the human platelet thrombin receptors, protease-activated receptor (PAR) 1 and PAR4, to the activation of cPLA(2α), which provides a substrate for the biosynthesis of TxA(2) and 12-HETE...
  2. doi request reprint 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity
    J Yeung
    Michael Holinstat, Department of Medicine, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, 1020 Locust Street, Suite 394, Jefferson Alumni Hall, Philadelphia, PA, USA, Tel 1 215 955 6121, Fax 1 215 955 9170, E mail
    Thromb Haemost 110:569-81. 2013
    ..Furthermore, the data presented here provide a basis for potentially targeting 12-LOX as a means to attenuate unwanted platelet activation and clot formation. ..
  3. pmc Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation
    Jennifer Yeung
    Department of Medicine, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Pharmacol 81:420-30. 2012
    ..These studies support an essential role for PKC downstream of 12-LOX activation in human platelets and suggest 12-LOX as a possible target for antiplatelet therapy...
  4. pmc Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
    Leonard C Edelstein
    The Cardeza Foundation for Hematologic Research and Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Nat Med 19:1609-16. 2013
    ....
  5. doi request reprint Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation
    Michael Holinstat
    Department of Medicine, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA, USA
    J Thromb Thrombolysis 35:209-22. 2013
    ..Hence, our data are the first to show that exposure to bivalirudin increased P-selectin expression with certain conditions demonstrating that bivalirudin can increase inherent platelet activity...
  6. pmc 12-lipoxygenase: a potential target for novel anti-platelet therapeutics
    Jennifer Yeung
    Department of Medicine, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA, USA
    Cardiovasc Hematol Agents Med Chem 9:154-64. 2011
    ....
  7. pmc Newer agents in antiplatelet therapy: a review
    Jennifer Yeung
    Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    J Blood Med 3:33-42. 2012
    ....