Research Topics
Genomes and Genes | Jan B HoekSummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Publications
Ethanol, oxidative stress, and cytokine-induced liver cell injuryJan B Hoek
Alcohol Research Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, JAH Room 269, 1020 Locust Street, Philadelphia, PA 19107, USA
Alcohol 27:63-8. 2002....
Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domainsNikolay M Borisov
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
Biosystems 83:152-66. 2006..Thus, our results greatly facilitate quantitative analysis and computational modeling of multi-protein signaling networks...- Systems-level interactions between insulin-EGF networks amplify mitogenic signalingNikolay Borisov
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Mol Syst Biol 5:256. 2009..Our results show the feasibility of using computational models to identify key target combinations and predict complex cellular responses to a mixture of external cues... - Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loopsAnatoly Kiyatkin
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 281:19925-38. 2006..By amplifying positive interactions between survival and mitogenic pathways, GAB1 plays the critical role in cell proliferation and tumorigenesis... - Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cellsEdita Aksamitiene
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, Pennsylvania 19107, USA
Cell Signal 23:1794-805. 2011..By interconnecting diverse signaling pathways PLR may enhance proliferation, survival, migration and invasiveness of breast cancer cells... - Cell signaling. Mitochondrial longevity pathwaysGyorgy Hajnoczky
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Science 315:607-9. 2007 - Hexokinase II: the integration of energy metabolism and control of apoptosisJohn G Pastorino
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Curr Med Chem 10:1535-51. 2003..Mitochondrial binding of hexokinase II may constitute an attractive target for therapeutic intervention to suppress tumor growth... - TNF-alpha-induced cell death in ethanol-exposed cells depends on p38 MAPK signaling but is independent of Bid and caspase-8John G Pastorino
Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Am J Physiol Gastrointest Liver Physiol 285:G503-16. 2003.... - PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cellsEdita Aksamitiene
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
Cell Signal 22:1369-78. 2010..We discuss candidate proteins that can be involved in this activation circuitry and suggest that PDZ-Binding Kinase/T-LAK Cell-Originated Protein Kinase (PBK/TOPK) may play a role in mediating MEK-independent ERK activation... - Chronic ethanol feeding enhances miR-21 induction during liver regeneration while inhibiting proliferation in ratsRachael P Dippold
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Am J Physiol Gastrointest Liver Physiol 303:G733-43. 2012..Our analysis of potential targets of miR-21 suggests that miR-21 affects a broad range of target processes and may have a widespread regulatory role under conditions of suppressed liver regeneration in ethanol-treated animals... - Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascadesNick I Markevich
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Locust St, Philadelphia, PA 19107, USA
Mol Syst Biol 2:61. 2006..The finding of phosphorylation waves traveling with constant amplitude and high velocity may solve a long-standing enigma of survival signaling in developing neurons... - Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicityJohn G Pastorino
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 65:10545-54. 2005..Such findings indicate that interference with the binding of HXK II to mitochondria may be a practicable modality by which to potentiate the efficacy of conventional chemotherapeutic agents... 
Coordinated dynamic gene expression changes in the central nucleus of the amygdala during alcohol withdrawalKate Freeman
Department of Pathology, Anatomy and Cell Biology, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Alcohol Clin Exp Res 37:E88-100. 2013..While alcohol-induced neurochemical changes play a role in dependence and drinking behavior, little is known about the CeA's dynamic changes during withdrawal, a period of emotional and physiologic disturbance...- Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexityNikolay M Borisov
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Biophys J 89:951-66. 2005..Our domain-oriented approach drastically reduces the number of states, processes, and kinetic parameters to be considered for quantification of complex signaling networks that propagate distinct physiological responses... - Elevated PTEN levels account for the increased sensitivity of ethanol-exposed cells to tumor necrosis factor-induced cytotoxicityNataly Shulga
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 280:9416-24. 2005.... - Cellular signaling mechanisms in alcohol-induced liver damageJan B Hoek
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Semin Liver Dis 24:257-72. 2004..We also discuss the complications and challenges of extrapolating these findings to the conditions in vivo and what we can learn from these studies regarding the nature of the liver defects associated with chronic alcohol consumption... - Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascadesNick I Markevich
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
J Cell Biol 164:353-9. 2004..Hence, bistability induced by multisite covalent modification may be a widespread mechanism of the control of protein activity... - Rapid temporal changes in the expression of a set of neuromodulatory genes during alcohol withdrawal in the dorsal vagal complex: molecular evidence of homeostatic disturbanceKate Freeman
Department of Pathology, Anatomy and Cell Biology, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University Philadelphia, Philadelphia, PA 19107, USA
Alcohol Clin Exp Res 36:1688-700. 2012..Further, it is unexplored in the dorsal vagal complex (DVC), a brainstem autonomic regulatory structure... - Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the ratEgle Juskeviciute
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
BMC Genomics 9:527. 2008.... - RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and deathGyongyi Szabo
Thomas Jefferson University (JBH, GH, Department of Pathology, Anatomy and Cell Biology, Philadelphia, PA 19107-6799, USA
Alcohol Clin Exp Res 29:1749-52. 2005.... - A Ca2+-induced mitochondrial permeability transition causes complete release of rat liver endonuclease G activity from its exclusive location within the mitochondrial intermembrane space. Identification of a novel endo-exonuclease activity residing withinAdrian M Davies
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Nucleic Acids Res 31:1364-73. 2003.... - Inhibition of insulin-like growth factor I receptor tyrosine kinase by ethanolRaphael Rubin
Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, 226 Alumni Hall, Philadelphia, PA 19107, USA
Biochem Pharmacol 68:2009-17. 2004..The data are consistent with a model wherein ethanol prevents the initial phase of IRK and IGF-IRK activation, by inhibiting the engagement of the kinase activation loop... - Chronic Ethanol Feeding Alters miRNA Expression Dynamics During Liver RegenerationRachael P Dippold
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania
Alcohol Clin Exp Res 37:E59-69. 2013..Adaptation to chronic ethanol (EtOH) treatment of rats results in a changed functional state of the liver and greatly inhibits its regenerative ability, which may contribute to the progression of alcoholic liver disease... - Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed ratsSudipto Das
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Pflugers Arch 464:101-9. 2012..Collectively, these results indicate that mitochondria in normal hepatocytes show relatively slow dynamics, which is very sensitive to suppression by ethanol exposure... - Adenine nucleotide changes in the remnant liver: An early signal for regeneration after partial hepatectomySara Crumm
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
Hepatology 48:898-908. 2008..CONCLUSION: The rapid loss of adenine nucleotides after PHx generates early stress signals that contribute to the onset of liver regeneration... - Alcohol and mitochondria: a dysfunctional relationshipJan B Hoek
Alcohol Research Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Gastroenterology 122:2049-63. 2002.... - Multistrip Western blotting to increase quantitative data outputEdita Aksamitiene
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Electrophoresis 28:3163-73. 2007..Compared to the traditional methods, this approach provides a more economical, reproducible, and effective procedure, facilitating the generation of large amounts of high-quality quantifiable data... - Untangling the wires: a strategy to trace functional interactions in signaling and gene networksBoris N Kholodenko
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 99:12841-6. 2002..The method is tested and illustrated by using computer-generated responses of a modeled mitogen-activated protein kinase cascade and gene network... - Acetate causes alcohol hangover headache in ratsChristina R Maxwell
Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
PLoS ONE 5:e15963. 2010..Despite a lack of mechanistic studies, there are a number of theories positing congeners, dehydration, or the ethanol metabolite acetaldehyde as causes of hangover headache... - Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualizationGyorgy Hajnoczky
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Alcohol Clin Exp Res 29:693-701. 2005..This article discusses potential mechanisms of the effect of alcohol on mitochondrial membrane permeabilization and visualization of mitochondria-dependent apoptosis in cardiac muscle... - Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nucleiKate Freeman
Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, 19107, USA
J Neuroinflammation 9:97. 2012.... - Temperature dependence of the epidermal growth factor receptor signaling network can be accounted for by a kinetic modelGisela Moehren
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA
Biochemistry 41:306-20. 2002..A combination of high-resolution experimental monitoring and molecular level kinetic modeling made it possible to quantitatively account for the temperature dependence of the integrative signaling responses... - Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosisJohn G Pastorino
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Jefferson Alumni Hall Rm 269, Philadelphia, PA 19107, USA
J Biol Chem 277:7610-8. 2002..Similar results were found in intact cells, in which the detachment of mitochondrial bound HXK II or its overexpression potentiated and inhibited, respectively, Bax-induced mitochondrial dysfunction and cell death... - Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytesHazem Hallak
Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA, USA
Hepatology 36:1509-18. 2002..The findings also show a role for IGFBP-3 in the inhibition of IGF-I signaling in hepatocytes... - Modular response analysis of cellular regulatory networksFrank J Bruggeman
Department of Molecular Cell Physiology, BioCentrum Amsterdam, De Boelelaan 1087, The Netherlands
J Theor Biol 218:507-20. 2002..The approach is illustrated by two examples: (i) mitogenic signalling through the mitogen-activated protein kinase cascade in the epidermal growth factor receptor network and (ii) regulation of ammonium assimilation in Escherichia coli... - Ligand-dependent responses of the ErbB signaling network: experimental and modeling analysesMarc R Birtwistle
Department of Chemical Engineering, University of Delaware, Newark, DE, USA
Mol Syst Biol 3:144. 2007..Sensitivity analysis leads to the hypothesis that ERK activation is robust to parameter perturbation at high ligand doses, while Akt activation is not... - Mechanisms of alcohol-induced tissue injuryPatricia E Molina
Department of Physiology LSUHSC, 1901 Perdido Street, New Orleans, LA 70112, USA
Alcohol Clin Exp Res 27:563-75. 2003 - Tyr-317 phosphorylation increases Shc structural rigidity and reduces coupling of domain motions remote from the phosphorylation site as revealed by molecular dynamics simulationsAtsushi Suenaga
Bioinformatics Group, RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
J Biol Chem 279:4657-62. 2004.... - Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanolRaj Lakshman
Lipid Research Laboratory, VA Medical Center, and the Department of Biochemistry, Molecular Biology, and Medicine, George Washington University, Washington, DC 20422, USA
Alcohol Clin Exp Res 29:1726-34. 2005..Donohue...