Jan B Hoek

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint Ethanol, oxidative stress, and cytokine-induced liver cell injury
    Jan B Hoek
    Alcohol Research Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, JAH Room 269, 1020 Locust Street, Philadelphia, PA 19107, USA
    Alcohol 27:63-8. 2002
  2. pmc Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains
    Nikolay M Borisov
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
    Biosystems 83:152-66. 2006
  3. pmc Systems-level interactions between insulin-EGF networks amplify mitogenic signaling
    Nikolay Borisov
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Syst Biol 5:256. 2009
  4. doi request reprint Rapid temporal changes in the expression of a set of neuromodulatory genes during alcohol withdrawal in the dorsal vagal complex: molecular evidence of homeostatic disturbance
    Kate Freeman
    Department of Pathology, Anatomy and Cell Biology, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University Philadelphia, Philadelphia, PA 19107, USA
    Alcohol Clin Exp Res 36:1688-700. 2012
  5. pmc Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops
    Anatoly Kiyatkin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:19925-38. 2006
  6. pmc Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells
    Edita Aksamitiene
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, Pennsylvania 19107, USA
    Cell Signal 23:1794-805. 2011
  7. ncbi request reprint Cell signaling. Mitochondrial longevity pathways
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Science 315:607-9. 2007
  8. ncbi request reprint Hexokinase II: the integration of energy metabolism and control of apoptosis
    John G Pastorino
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Med Chem 10:1535-51. 2003
  9. ncbi request reprint TNF-alpha-induced cell death in ethanol-exposed cells depends on p38 MAPK signaling but is independent of Bid and caspase-8
    John G Pastorino
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 285:G503-16. 2003
  10. pmc PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells
    Edita Aksamitiene
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
    Cell Signal 22:1369-78. 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Ethanol, oxidative stress, and cytokine-induced liver cell injury
    Jan B Hoek
    Alcohol Research Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, JAH Room 269, 1020 Locust Street, Philadelphia, PA 19107, USA
    Alcohol 27:63-8. 2002
    ....
  2. pmc Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains
    Nikolay M Borisov
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
    Biosystems 83:152-66. 2006
    ..Thus, our results greatly facilitate quantitative analysis and computational modeling of multi-protein signaling networks...
  3. pmc Systems-level interactions between insulin-EGF networks amplify mitogenic signaling
    Nikolay Borisov
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Syst Biol 5:256. 2009
    ..Our results show the feasibility of using computational models to identify key target combinations and predict complex cellular responses to a mixture of external cues...
  4. doi request reprint Rapid temporal changes in the expression of a set of neuromodulatory genes during alcohol withdrawal in the dorsal vagal complex: molecular evidence of homeostatic disturbance
    Kate Freeman
    Department of Pathology, Anatomy and Cell Biology, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University Philadelphia, Philadelphia, PA 19107, USA
    Alcohol Clin Exp Res 36:1688-700. 2012
    ..Further, it is unexplored in the dorsal vagal complex (DVC), a brainstem autonomic regulatory structure...
  5. pmc Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops
    Anatoly Kiyatkin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:19925-38. 2006
    ..By amplifying positive interactions between survival and mitogenic pathways, GAB1 plays the critical role in cell proliferation and tumorigenesis...
  6. pmc Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells
    Edita Aksamitiene
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, Pennsylvania 19107, USA
    Cell Signal 23:1794-805. 2011
    ..By interconnecting diverse signaling pathways PLR may enhance proliferation, survival, migration and invasiveness of breast cancer cells...
  7. ncbi request reprint Cell signaling. Mitochondrial longevity pathways
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Science 315:607-9. 2007
  8. ncbi request reprint Hexokinase II: the integration of energy metabolism and control of apoptosis
    John G Pastorino
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Med Chem 10:1535-51. 2003
    ..Mitochondrial binding of hexokinase II may constitute an attractive target for therapeutic intervention to suppress tumor growth...
  9. ncbi request reprint TNF-alpha-induced cell death in ethanol-exposed cells depends on p38 MAPK signaling but is independent of Bid and caspase-8
    John G Pastorino
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 285:G503-16. 2003
    ....
  10. pmc PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells
    Edita Aksamitiene
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
    Cell Signal 22:1369-78. 2010
    ..We discuss candidate proteins that can be involved in this activation circuitry and suggest that PDZ-Binding Kinase/T-LAK Cell-Originated Protein Kinase (PBK/TOPK) may play a role in mediating MEK-independent ERK activation...
  11. pmc Chronic ethanol feeding enhances miR-21 induction during liver regeneration while inhibiting proliferation in rats
    Rachael P Dippold
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Gastrointest Liver Physiol 303:G733-43. 2012
    ..Our analysis of potential targets of miR-21 suggests that miR-21 affects a broad range of target processes and may have a widespread regulatory role under conditions of suppressed liver regeneration in ethanol-treated animals...
  12. pmc Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades
    Nick I Markevich
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Locust St, Philadelphia, PA 19107, USA
    Mol Syst Biol 2:61. 2006
    ..The finding of phosphorylation waves traveling with constant amplitude and high velocity may solve a long-standing enigma of survival signaling in developing neurons...
  13. ncbi request reprint Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity
    John G Pastorino
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 65:10545-54. 2005
    ..Such findings indicate that interference with the binding of HXK II to mitochondria may be a practicable modality by which to potentiate the efficacy of conventional chemotherapeutic agents...
  14. doi request reprint Coordinated dynamic gene expression changes in the central nucleus of the amygdala during alcohol withdrawal
    Kate Freeman
    Department of Pathology, Anatomy and Cell Biology, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Alcohol Clin Exp Res 37:E88-100. 2013
    ..While alcohol-induced neurochemical changes play a role in dependence and drinking behavior, little is known about the CeA's dynamic changes during withdrawal, a period of emotional and physiologic disturbance...
  15. ncbi request reprint Cellular signaling mechanisms in alcohol-induced liver damage
    Jan B Hoek
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Semin Liver Dis 24:257-72. 2004
    ..We also discuss the complications and challenges of extrapolating these findings to the conditions in vivo and what we can learn from these studies regarding the nature of the liver defects associated with chronic alcohol consumption...
  16. ncbi request reprint Elevated PTEN levels account for the increased sensitivity of ethanol-exposed cells to tumor necrosis factor-induced cytotoxicity
    Nataly Shulga
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:9416-24. 2005
    ....
  17. pmc Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
    Nick I Markevich
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
    J Cell Biol 164:353-9. 2004
    ..Hence, bistability induced by multisite covalent modification may be a widespread mechanism of the control of protein activity...
  18. pmc Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexity
    Nikolay M Borisov
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Biophys J 89:951-66. 2005
    ..Our domain-oriented approach drastically reduces the number of states, processes, and kinetic parameters to be considered for quantification of complex signaling networks that propagate distinct physiological responses...
  19. pmc Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat
    Egle Juskeviciute
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    BMC Genomics 9:527. 2008
    ....
  20. ncbi request reprint RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death
    Gyongyi Szabo
    Thomas Jefferson University JBH, GH, Department of Pathology, Anatomy and Cell Biology, Philadelphia, PA 19107 6799, USA
    Alcohol Clin Exp Res 29:1749-52. 2005
    ....
  21. ncbi request reprint Inhibition of insulin-like growth factor I receptor tyrosine kinase by ethanol
    Raphael Rubin
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, 226 Alumni Hall, Philadelphia, PA 19107, USA
    Biochem Pharmacol 68:2009-17. 2004
    ..The data are consistent with a model wherein ethanol prevents the initial phase of IRK and IGF-IRK activation, by inhibiting the engagement of the kinase activation loop...
  22. pmc A Ca2+-induced mitochondrial permeability transition causes complete release of rat liver endonuclease G activity from its exclusive location within the mitochondrial intermembrane space. Identification of a novel endo-exonuclease activity residing within
    Adrian M Davies
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Nucleic Acids Res 31:1364-73. 2003
    ....
  23. pmc Chronic ethanol feeding alters miRNA expression dynamics during liver regeneration
    Rachael P Dippold
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Alcohol Clin Exp Res 37:E59-69. 2013
    ..Adaptation to chronic ethanol (EtOH) treatment of rats results in a changed functional state of the liver and greatly inhibits its regenerative ability, which may contribute to the progression of alcoholic liver disease...
  24. pmc Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats
    Sudipto Das
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Pflugers Arch 464:101-9. 2012
    ..Collectively, these results indicate that mitochondria in normal hepatocytes show relatively slow dynamics, which is very sensitive to suppression by ethanol exposure...
  25. pmc Untangling the wires: a strategy to trace functional interactions in signaling and gene networks
    Boris N Kholodenko
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 99:12841-6. 2002
    ..The method is tested and illustrated by using computer-generated responses of a modeled mitogen-activated protein kinase cascade and gene network...
  26. pmc Alcohol and mitochondria: a dysfunctional relationship
    Jan B Hoek
    Alcohol Research Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 122:2049-63. 2002
    ....
  27. pmc Multistrip Western blotting to increase quantitative data output
    Edita Aksamitiene
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Electrophoresis 28:3163-73. 2007
    ..Compared to the traditional methods, this approach provides a more economical, reproducible, and effective procedure, facilitating the generation of large amounts of high-quality quantifiable data...
  28. pmc Adenine nucleotide changes in the remnant liver: An early signal for regeneration after partial hepatectomy
    Sara Crumm
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Hepatology 48:898-908. 2008
    ..Pretreatment with the purinergic receptor antagonist suramin also partly suppressed early regenerative signals and c-fos expression, but without preventing TAN loss...
  29. pmc Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei
    Kate Freeman
    Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, 19107, USA
    J Neuroinflammation 9:97. 2012
    ....
  30. ncbi request reprint Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Alcohol Clin Exp Res 29:693-701. 2005
    ..This article discusses potential mechanisms of the effect of alcohol on mitochondrial membrane permeabilization and visualization of mitochondria-dependent apoptosis in cardiac muscle...
  31. pmc Acetate causes alcohol hangover headache in rats
    Christina R Maxwell
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e15963. 2010
    ..Despite a lack of mechanistic studies, there are a number of theories positing congeners, dehydration, or the ethanol metabolite acetaldehyde as causes of hangover headache...
  32. ncbi request reprint Temperature dependence of the epidermal growth factor receptor signaling network can be accounted for by a kinetic model
    Gisela Moehren
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA
    Biochemistry 41:306-20. 2002
    ..A combination of high-resolution experimental monitoring and molecular level kinetic modeling made it possible to quantitatively account for the temperature dependence of the integrative signaling responses...
  33. ncbi request reprint Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
    John G Pastorino
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Jefferson Alumni Hall Rm 269, Philadelphia, PA 19107, USA
    J Biol Chem 277:7610-8. 2002
    ..Similar results were found in intact cells, in which the detachment of mitochondrial bound HXK II or its overexpression potentiated and inhibited, respectively, Bax-induced mitochondrial dysfunction and cell death...
  34. ncbi request reprint Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes
    Hazem Hallak
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA, USA
    Hepatology 36:1509-18. 2002
    ..The findings also show a role for IGFBP-3 in the inhibition of IGF-I signaling in hepatocytes...
  35. ncbi request reprint Modular response analysis of cellular regulatory networks
    Frank J Bruggeman
    Department of Molecular Cell Physiology, BioCentrum Amsterdam, De Boelelaan 1087, The Netherlands
    J Theor Biol 218:507-20. 2002
    ..The approach is illustrated by two examples: (i) mitogenic signalling through the mitogen-activated protein kinase cascade in the epidermal growth factor receptor network and (ii) regulation of ammonium assimilation in Escherichia coli...
  36. pmc Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses
    Marc R Birtwistle
    Department of Chemical Engineering, University of Delaware, Newark, DE, USA
    Mol Syst Biol 3:144. 2007
    ..Sensitivity analysis leads to the hypothesis that ERK activation is robust to parameter perturbation at high ligand doses, while Akt activation is not...
  37. ncbi request reprint Mechanisms of alcohol-induced tissue injury
    Patricia E Molina
    Department of Physiology LSUHSC, 1901 Perdido Street, New Orleans, LA 70112, USA
    Alcohol Clin Exp Res 27:563-75. 2003
  38. ncbi request reprint Tyr-317 phosphorylation increases Shc structural rigidity and reduces coupling of domain motions remote from the phosphorylation site as revealed by molecular dynamics simulations
    Atsushi Suenaga
    Bioinformatics Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Biol Chem 279:4657-62. 2004
    ....
  39. ncbi request reprint Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol
    Raj Lakshman
    Lipid Research Laboratory, VA Medical Center, and the Department of Biochemistry, Molecular Biology, and Medicine, George Washington University, Washington, DC 20422, USA
    Alcohol Clin Exp Res 29:1726-34. 2005
    ..Donohue...