Gyorgy Hajnoczky

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit
    Muqing Yi
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Biol 167:661-72. 2004
  2. pmc Structural and functional features and significance of the physical linkage between ER and mitochondria
    György Csordás
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Biol 174:915-21. 2006
  3. pmc Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts
    Hua Zhang
    Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    BMC Neurosci 9:38. 2008
  4. ncbi request reprint Cell signaling. Mitochondrial longevity pathways
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Science 315:607-9. 2007
  5. ncbi request reprint Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Alcohol Clin Exp Res 29:693-701. 2005
  6. pmc Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Calcium 40:553-60. 2006
  7. pmc Calcium signalling: fishing out molecules of mitochondrial calcium transport
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Biol 20:R888-91. 2010
  8. ncbi request reprint Ca2+-dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC)
    Gyorgy Bathori
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:17347-58. 2006
  9. pmc Uncoupling of ER-mitochondrial calcium communication by transforming growth factor-beta
    Pal Pacher
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Renal Physiol 295:F1303-12. 2008
  10. ncbi request reprint Control of calcium signal propagation to the mitochondria by inositol 1,4,5-trisphosphate-binding proteins
    Xuena Lin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:12820-32. 2005

Research Grants

  1. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2000
  2. Mitochondrial Dynamics in Alcohol-induced Tissue Injury
    Gyorgy Hajnoczky; Fiscal Year: 2011
  3. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2001
  4. MECHANISMS OF PULSATILE CALCIUM SIGNALING
    Gyorgy Hajnoczky; Fiscal Year: 2001
  5. MECHANISMS OF PULSATILE CALCIUM SIGNALING
    Gyorgy Hajnoczky; Fiscal Year: 2009
  6. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2009
  7. Mitochondrial Dynamics in Alcohol-induced Tissue Injury
    Gyorgy Hajnoczky; Fiscal Year: 2009
  8. MECHANISMS OF PULSATILE CALCIUM SIGNALING
    Gyorgy Hajnoczky; Fiscal Year: 2010
  9. Mitochondrial Dynamics in Alcohol-induced Tissue Injury
    Gyorgy Hajnoczky; Fiscal Year: 2009
  10. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2010

Collaborators

Detail Information

Publications44

  1. pmc Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit
    Muqing Yi
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Biol 167:661-72. 2004
    ..Diminished mitochondrial motility in the region of the [Ca2+]c rise promotes recruitment of mitochondria to enhance local Ca2+ buffering and energy supply. This mechanism may provide a novel homeostatic circuit in calcium signaling...
  2. pmc Structural and functional features and significance of the physical linkage between ER and mitochondria
    György Csordás
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Biol 174:915-21. 2006
    ..These results reveal an unexpected dependence of cell function and survival on the maintenance of proper spacing between the ER and mitochondria...
  3. pmc Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts
    Hua Zhang
    Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    BMC Neurosci 9:38. 2008
    ..Therefore, in addition to elucidating the mechanisms responsible for polyQ-mediated pathology, it is also important to understand the normal function of Htt protein for both basic biology and for HD...
  4. ncbi request reprint Cell signaling. Mitochondrial longevity pathways
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Science 315:607-9. 2007
  5. ncbi request reprint Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Alcohol Clin Exp Res 29:693-701. 2005
    ..This article discusses potential mechanisms of the effect of alcohol on mitochondrial membrane permeabilization and visualization of mitochondria-dependent apoptosis in cardiac muscle...
  6. pmc Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Calcium 40:553-60. 2006
    ..We also present a systematic evaluation of the effect of ruthenium red and Ru360, two inhibitors of mitochondrial Ca(2+) uptake on cytosolic [Ca(2+)] and [Ca(2+)](m) in intact cultured cells...
  7. pmc Calcium signalling: fishing out molecules of mitochondrial calcium transport
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Biol 20:R888-91. 2010
    ..Now, RNAi studies link three proteins - MICU1, NCLX and LETM1 - to the previously unknown molecular mechanism of mitochondrial calcium transport...
  8. ncbi request reprint Ca2+-dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC)
    Gyorgy Bathori
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:17347-58. 2006
    ..Thus, the VDAC gating is dependent on the physiological concentrations of cations, allowing the OMM to control the passage of ions and some small molecules. The OMM barrier is likely to decrease during the calcium signal...
  9. pmc Uncoupling of ER-mitochondrial calcium communication by transforming growth factor-beta
    Pal Pacher
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Renal Physiol 295:F1303-12. 2008
    ..The impaired ER-mitochondrial coupling may contribute to the vascular pathophysiology associated with TGF-beta production...
  10. ncbi request reprint Control of calcium signal propagation to the mitochondria by inositol 1,4,5-trisphosphate-binding proteins
    Xuena Lin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:12820-32. 2005
    ....
  11. pmc Bid-induced mitochondrial membrane permeabilization waves propagated by local reactive oxygen species (ROS) signaling
    Cecilia Garcia-Perez
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 109:4497-502. 2012
    ..Thus, Bid engages a ROS-dependent, local intermitochondrial potentiation mechanism that amplifies the apoptotic signal as a wave...
  12. doi request reprint Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle
    Cecilia Garcia-Perez
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 283:32771-80. 2008
    ..The transferred Ca(2+) stimulates dehydrogenase activity and affects mitochondrial membrane permeabilization, indicating the broad significance of the physical coupling in mitochondrial function...
  13. pmc Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death
    Soumya Sinha Roy
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell 33:377-88. 2009
    ..Thus, phospho-regulatory mechanisms converge on Bad to switch between the survival and apoptotic functions of mitochondrial calcium signaling by activating a mechanism whereby a BH3-only protein bypasses Bax/Bak and engages the PTP...
  14. pmc Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface
    György Csordás
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell 39:121-32. 2010
    ..These studies provide direct evidence for the existence of high-Ca(2+) microdomains between the ER and mitochondria and suggest an optimal gap width for efficient Ca(2+) transfer...
  15. pmc MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter
    György Csordás
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Metab 17:976-87. 2013
    ..Collectively, the data indicate that MICU1 senses the [Ca(2+)]c to establish the uniporter's threshold and gain, thereby allowing mitochondria to properly decode different inputs...
  16. pmc tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane
    György Csordás
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    EMBO J 21:2198-206. 2002
    ..Facilitation of Ca(2+) delivery to the mitochondria by tcBid may also support recruitment of mitochondria to the cell death machinery...
  17. pmc Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points
    Cecilia Garcia-Perez
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Physiol Heart Circ Physiol 301:H1907-15. 2011
    ..Close coupling of the SR, OMM, and IMM is likely to provide a favorable spatial arrangement for local ryanodine receptor-mitochondrial Ca(2+) signaling...
  18. ncbi request reprint Plasticity of mitochondrial calcium signaling
    György Csordás
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Biol Chem 278:42273-82. 2003
    ..This plasticity may allow cooperation among sequential IP3 receptor-mediated [Ca2+] transients in the control of calcium signal propagation to the mitochondria...
  19. pmc Switch from ER-mitochondrial to SR-mitochondrial calcium coupling during muscle differentiation
    Muqing Yi
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Calcium 52:355-65. 2012
    ..Thus, RyR expression alone is sufficient to induce the steps essential for their alignment with mitochondrial Ca2+ uptake sites, whereas the mitochondrial proliferation and reshaping utilize either downstream or alternative pathways...
  20. pmc Calcium, mitochondria and apoptosis studied by fluorescence measurements
    Soumya Sinha Roy
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Suite 253 JAH, Philadelphia, PA 19107, USA
    Methods 46:213-23. 2008
    ..We outline here fluorometric and fluorescence imaging protocols that we set up for the study of calcium in the context of apoptosis...
  21. ncbi request reprint Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells
    Kumar Sharma
    Dorrance Hamilton Research Laboratories, Division of Nephrology, Department of Medicine, Thomas Jefferson University, Suite 353, Jeff Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107, USA
    Am J Physiol Renal Physiol 285:F1258-70. 2003
    ..We conclude that TGF-beta plays an important role in the vascular dysfunction of early diabetes by inhibiting calcium transients in vascular smooth muscle cells...
  22. pmc Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species
    Száva Bánsághi
    From the MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    J Biol Chem 289:8170-81. 2014
    ..Thus, ROS seem to specifically sensitize IP3Rs through a thiol group(s) within the IP3R, which is probably inaccessible in the chicken IP3R3. ..
  23. pmc SR/ER-mitochondrial local communication: calcium and ROS
    György Csordás
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biochim Biophys Acta 1787:1352-62. 2009
    ..We describe here possible mechanisms of the mutual interaction between local Ca(2+) and ROS signaling in the control of SR/ER-mitochondrial function...
  24. ncbi request reprint Calcium signaling and apoptosis
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biochem Biophys Res Commun 304:445-54. 2003
    ..In this paper, the recent progress of research on the mechanisms mediating the apoptosis-regulating effects of Ca(2+) and the interactions of Bcl-2 family proteins with the Ca(2+) storage organelles are discussed...
  25. ncbi request reprint Mitochondria and endoplasmic reticulum: the lethal interorganelle cross-talk
    Ludivine Walter
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Bioenerg Biomembr 37:191-206. 2005
    ..The apoptotic means of the mitochondria and ER will eventually come together to control the dismantling of the cell by the caspases and other enzymes...
  26. ncbi request reprint Calcium signalling and mitochondrial motility
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Novartis Found Symp 287:105-17; discussion 117-21. 2007
    ....
  27. pmc Ca2+ marks: miniature calcium signals in single mitochondria driven by ryanodine receptors
    Pal Pacher
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 99:2380-5. 2002
    ....
  28. pmc Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase
    Masao Saotome
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 105:20728-33. 2008
    ..Thus, Miro proteins serve as a [Ca(2+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria...
  29. pmc Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics
    Xingguo Liu
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    EMBO J 28:3074-89. 2009
    ..Transient fusions were also necessary and sufficient to support mitochondrial metabolism. Thus, Opa1 expression and cytoskeletal anchorage govern a novel form of fusion that has a distinct function in mitochondrial maintenance...
  30. pmc Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling
    Veronica Eisner
    MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107
    J Cell Biol 205:179-95. 2014
    ..Thus, fusion dynamically connects skeletal muscle mitochondria and its prolonged loss jeopardizes bioenergetics and excitation-contraction coupling, providing a potential pathomechanism contributing to myopathies. ..
  31. pmc Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca²⁺ and reactive oxygen species signaling
    Veronica Eisner
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Sci 126:2965-78. 2013
    ..In particular, we discuss the recent demonstration of SR/ER-mitochondria tethers that are formed by multiple proteins, and local Ca(2+) transfer between SR/ER and mitochondria. ..
  32. pmc Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology
    György Csordás
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell Endocrinol 353:109-13. 2012
    ..This paper provides an update on the pharmacological aspects of the molecular mechanisms of the inner mitochondrial membrane Ca(2+) transport...
  33. ncbi request reprint Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion
    David Weaver
    MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell 54:870-8. 2014
    ..Thus, OMM protein distribution depends on mitochondrial fusion and is a locus of apoptotic dysfunction in conditions of fusion deficiency...
  34. pmc MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
    Karthik Mallilankaraman
    Department of Biochemistry, Temple University, Philadelphia, Pennsylvania 19140, USA
    Nat Cell Biol 14:1336-43. 2012
    ..Thus, MCUR1 is a critical component of a mitochondrial uniporter channel complex required for mitochondrial Ca(2+) uptake and maintenance of normal cellular bioenergetics...
  35. ncbi request reprint RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death
    Gyongyi Szabo
    Thomas Jefferson University JBH, GH, Department of Pathology, Anatomy and Cell Biology, Philadelphia, PA 19107 6799, USA
    Alcohol Clin Exp Res 29:1749-52. 2005
    ..energy metabolism: the role of NO by Victor Darley-Usmar, 3) Ethanol and apoptosis in the heart by Gyorgy Hajnoczky, 4) Alcohol and mitochondrial biogenesis in development by Thomas Knudsen, and 5) Alcohol, mitochondrial ..
  36. ncbi request reprint Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins
    Shiva Kazerounian
    Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Pharmacol Exp Ther 314:1013-22. 2005
    ..They suggest that combining guanylyl cyclase C agonists and SOC inhibitors offers a novel paradigm for cGMP-directed therapy and prevention for colorectal tumors...
  37. pmc Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats
    Sudipto Das
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Pflugers Arch 464:101-9. 2012
    ..Collectively, these results indicate that mitochondria in normal hepatocytes show relatively slow dynamics, which is very sensitive to suppression by ethanol exposure...
  38. ncbi request reprint IP3 receptors in cell survival and apoptosis: Ca2+ release and beyond
    Suresh K Joseph
    Department of Pathology and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Apoptosis 12:951-68. 2007
    ..The role of IP(3)Rs in delivering Ca(2+) to the mitochondria is discussed from the perspective of the factors determining inter-organellar dynamics and the spatial proximity of mitochondria and ER membranes...
  39. pmc Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex
    Xingguo Liu
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Biochem Cell Biol 41:1972-6. 2009
    ..Evidence is emerging that calcium signaling through Miro-Milton is central to coordination of the local oxidative metabolism with the energy demands and protection against Ca(2+)-induced cell injury...
  40. ncbi request reprint TGF-beta-induced Ca(2+) influx involves the type III IP(3) receptor and regulates actin cytoskeleton
    Tracy A McGowan
    Dorrance Hamilton Laboratory, Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Renal Physiol 282:F910-20. 2002
    ..The alterations in the actin cytoskeleton by TGF-beta are dependent on TGF-beta-induced Ca(2+) influx. These studies identify a novel pathway by which TGF-beta regulates Ca(2+) influx and induces cytoskeletal alterations...
  41. pmc VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria
    Soumya Sinha Roy
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Suite 261 JAH, Philadelphia, Pennsylvania 19107, USA
    EMBO Rep 10:1341-7. 2009
    ..Thus, VDAC2 acts as a crucial component in mitochondrial apoptosis by allowing the mitochondrial recruitment of BAK, thereby controlling tBID-induced OMM permeabilization and cell death...
  42. pmc Fluorometric methods for detection of mitochondrial membrane permeabilization in apoptosis
    Soumya Sinha Roy
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Methods Mol Biol 559:173-90. 2009
    ....
  43. ncbi request reprint Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization
    Muniswamy Madesh
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:5651-9. 2002
    ..The tBid-induced loss of DeltaPsi(m) occurs after cytochrome c release and reflects impairment of oxidative metabolism...
  44. ncbi request reprint Visualization of binding and transcytosis of botulinum toxin by human intestinal epithelial cells
    Chowdhury R Ahsan
    Department of Medicine, Jefferson Medical College, Room 314 JAH, 1020 Locust Street, Philadelphia, PA 19107, USA
    J Pharmacol Exp Ther 315:1028-35. 2005
    ..Transcytosed toxin began to reach the contralateral surface within ca. 5 min, and transcytosis was essentially complete within 20 to 30 min...

Research Grants25

  1. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2000
    ..abstract_text> ..
  2. Mitochondrial Dynamics in Alcohol-induced Tissue Injury
    Gyorgy Hajnoczky; Fiscal Year: 2011
    ..Recent progress in the study of mitochondrial structure and function in live cells will enable us to establish the mechanisms and significance of mitochondrial dynamics in the alcoholic liver and cardiac muscle injury. ..
  3. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2001
    ..abstract_text> ..
  4. MECHANISMS OF PULSATILE CALCIUM SIGNALING
    Gyorgy Hajnoczky; Fiscal Year: 2001
    ..g., ATP production, feedback on cytosolic calcium signaling, initiation of apoptosis) but will also provide a key component in elucidating the mechanisms underlying mitochondrial diseases. ..
  5. MECHANISMS OF PULSATILE CALCIUM SIGNALING
    Gyorgy Hajnoczky; Fiscal Year: 2009
    ..abstract_text> ..
  6. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2009
    ....
  7. Mitochondrial Dynamics in Alcohol-induced Tissue Injury
    Gyorgy Hajnoczky; Fiscal Year: 2009
    ..Recent progress in the study of mitochondrial structure and function in live cells will enable us to establish the mechanisms and significance of mitochondrial dynamics in the alcoholic liver and cardiac muscle injury. ..
  8. MECHANISMS OF PULSATILE CALCIUM SIGNALING
    Gyorgy Hajnoczky; Fiscal Year: 2010
    ..abstract_text> ..
  9. Mitochondrial Dynamics in Alcohol-induced Tissue Injury
    Gyorgy Hajnoczky; Fiscal Year: 2009
    ..Recent progress in the study of mitochondrial structure and function in live cells will enable us to establish the mechanisms and significance of mitochondrial dynamics in the alcoholic liver and cardiac muscle injury. ..
  10. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2010
    ....
  11. Mitochondrial Dynamics in Alcohol-induced Tissue Injury
    Gyorgy Hajnoczky; Fiscal Year: 2010
    ..Recent progress in the study of mitochondrial structure and function in live cells will enable us to establish the mechanisms and significance of mitochondrial dynamics in the alcoholic liver and cardiac muscle injury. ..
  12. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2007
    ..abstract_text> ..
  13. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2002
    ..abstract_text> ..
  14. MECHANISMS OF PULSATILE CALCIUM SIGNALING
    Gyorgy Hajnoczky; Fiscal Year: 2002
    ..g., ATP production, feedback on cytosolic calcium signaling, initiation of apoptosis) but will also provide a key component in elucidating the mechanisms underlying mitochondrial diseases. ..
  15. MECHANISMS OF PULSATILE CALCIUM SIGNALING
    Gyorgy Hajnoczky; Fiscal Year: 2003
    ..g., ATP production, feedback on cytosolic calcium signaling, initiation of apoptosis) but will also provide a key component in elucidating the mechanisms underlying mitochondrial diseases. ..
  16. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2003
    ..abstract_text> ..
  17. MECHANISMS OF PULSATILE CALCIUM SIGNALING
    Gyorgy Hajnoczky; Fiscal Year: 2004
    ..g., ATP production, feedback on cytosolic calcium signaling, initiation of apoptosis) but will also provide a key component in elucidating the mechanisms underlying mitochondrial diseases. ..
  18. MITOCHONDRIAL CALCIUM SIGNALING IN CELL DEATH
    Gyorgy Hajnoczky; Fiscal Year: 2004
    ..abstract_text> ..
  19. Mitochondrial Calcium Signaling in Cell Death.
    Gyorgy Hajnoczky; Fiscal Year: 2005
    ..abstract_text> ..
  20. MECHANISMS OF PULSATILE CALCIUM SIGNALING
    Gyorgy Hajnoczky; Fiscal Year: 2005
    ..g., ATP production, feedback on cytosolic calcium signaling, initiation of apoptosis) but will also provide a key component in elucidating the mechanisms underlying mitochondrial diseases. ..
  21. Mitochondrial Calcium Signaling in Cell Death.
    Gyorgy Hajnoczky; Fiscal Year: 2006
    ..abstract_text> ..
  22. MECHANISMS OF PULSATILE CALCIUM SIGNALING
    Gyorgy Hajnoczky; Fiscal Year: 2007
    ....