Barry J Goldstein

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
    B J Goldstein
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 275:4283-9. 2000
  2. ncbi Current views on the mechanism of action of thiazolidinedione insulin sensitizers
    B J Goldstein
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Diabetes Technol Ther 1:267-75. 1999
  3. ncbi Differentiating members of the thiazolidinedione class: a focus on efficacy
    Barry J Goldstein
    Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Diabetes Metab Res Rev 18:S16-22. 2002
  4. ncbi Protein-tyrosine phosphatases: emerging targets for therapeutic intervention in type 2 diabetes and related states of insulin resistance
    Barry J Goldstein
    Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    J Clin Endocrinol Metab 87:2474-80. 2002
  5. ncbi Insulin resistance as the core defect in type 2 diabetes mellitus
    Barry J Goldstein
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolic Disease, Jefferson Medical College, Jefferson Alumni Hall Suite 349, 1020 Locust Street, Philadelphia, PA 19107, USA
    Am J Cardiol 90:3G-10G. 2002
  6. ncbi Are the metabolic effects of rosiglitazone influenced by baseline glycaemic control?
    Barry J Goldstein
    Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
    Curr Med Res Opin 19:192-9. 2003
  7. ncbi Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance
    B J Goldstein
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, 19107 6799, USA
    Curr Drug Targets Immune Endocr Metabol Disord 1:265-75. 2001
  8. pmc Hyperglycemia potentiates H(2)O(2) production in adipocytes and enhances insulin signal transduction: potential role for oxidative inhibition of thiol-sensitive protein-tyrosine phosphatases
    Xiangdong Wu
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Antioxid Redox Signal 7:526-37. 2005
  9. ncbi Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling
    Xiangdong Wu
    Dept of Medicine, Jefferson Medical College, Suite 320 Curtis Bldg, 1015 Walnut St, Philadelphia, PA 19107, USA
    Am J Physiol Endocrinol Metab 293:E1836-44. 2007
  10. pmc Adiponectin regulates albuminuria and podocyte function in mice
    Kumar Sharma
    Translational Research in Kidney Disease, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0711, La Jolla, California 92093 0711, USA
    J Clin Invest 118:1645-56. 2008

Detail Information

Publications50

  1. ncbi Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
    B J Goldstein
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 275:4283-9. 2000
    ....
  2. ncbi Current views on the mechanism of action of thiazolidinedione insulin sensitizers
    B J Goldstein
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Diabetes Technol Ther 1:267-75. 1999
    ..A detailed understanding of the action of thiazolidinediones will provide new insights into the pathogenesis of insulin resistance, diabetes and some of the causes of increased cardiovascular mortality in these conditions...
  3. ncbi Differentiating members of the thiazolidinedione class: a focus on efficacy
    Barry J Goldstein
    Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Diabetes Metab Res Rev 18:S16-22. 2002
    ..It is not sufficient to assume that 'all glitazones are the same' because the studies have not yet been done to support this statement. This article will review what is known about the relative efficacy of the TZDs...
  4. ncbi Protein-tyrosine phosphatases: emerging targets for therapeutic intervention in type 2 diabetes and related states of insulin resistance
    Barry J Goldstein
    Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    J Clin Endocrinol Metab 87:2474-80. 2002
  5. ncbi Insulin resistance as the core defect in type 2 diabetes mellitus
    Barry J Goldstein
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolic Disease, Jefferson Medical College, Jefferson Alumni Hall Suite 349, 1020 Locust Street, Philadelphia, PA 19107, USA
    Am J Cardiol 90:3G-10G. 2002
    ..Increasing evidence supports the early use of thiazolidinediones for preventing, delaying, or treating diabetes by improving insulin sensitivity and beta-cell insulin secretion...
  6. ncbi Are the metabolic effects of rosiglitazone influenced by baseline glycaemic control?
    Barry J Goldstein
    Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
    Curr Med Res Opin 19:192-9. 2003
    ....
  7. ncbi Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance
    B J Goldstein
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, 19107 6799, USA
    Curr Drug Targets Immune Endocr Metabol Disord 1:265-75. 2001
    ..Overall, these studies have paved the way for the commercial development of PTP1B inhibitors that may serve as a novel type of "insulin sensitizer" in the management of type 2 diabetes and the cardiovascular / metabolic syndrome...
  8. pmc Hyperglycemia potentiates H(2)O(2) production in adipocytes and enhances insulin signal transduction: potential role for oxidative inhibition of thiol-sensitive protein-tyrosine phosphatases
    Xiangdong Wu
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Antioxid Redox Signal 7:526-37. 2005
    ....
  9. ncbi Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling
    Xiangdong Wu
    Dept of Medicine, Jefferson Medical College, Suite 320 Curtis Bldg, 1015 Walnut St, Philadelphia, PA 19107, USA
    Am J Physiol Endocrinol Metab 293:E1836-44. 2007
    ..These findings support an important role for adiponectin in anti-inflammatory signaling in the endothelium and also imply that multiple pathways are involved in the cellular effects of adiponectin...
  10. pmc Adiponectin regulates albuminuria and podocyte function in mice
    Kumar Sharma
    Translational Research in Kidney Disease, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0711, La Jolla, California 92093 0711, USA
    J Clin Invest 118:1645-56. 2008
    ..These results suggest that adiponectin is a key regulator of albuminuria, likely acting through the AMPK pathway to modulate oxidant stress in podocytes...
  11. pmc The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction
    Kalyankar Mahadev
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6799, USA
    Mol Cell Biol 24:1844-54. 2004
    ....
  12. ncbi Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway
    Raogo Ouedraogo
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Diabetes 55:1840-6. 2006
    ..Thus, adiponectin suppresses excess ROS production under high-glucose conditions via a cAMP/PKA-dependent pathway, an effect that has implications for vascular protection in diabetes...
  13. doi Adiponectin protects against angiotensin II or tumor necrosis factor alpha-induced endothelial cell monolayer hyperpermeability: role of cAMP/PKA signaling
    Shi Qiong Xu
    Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Arterioscler Thromb Vasc Biol 28:899-905. 2008
    ..Angiotensin II (Ang II) and tumor necrosis factor (TNF)-alpha levels increase endothelial permeability, and we hypothesized that adiponectin suppressed these responses in a cAMP-dependent manner...
  14. doi Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells
    Kalyankar Mahadev
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Suite 320, Curtis Building, 1015 Walnut Street, Philadelphia, PA 19107, USA
    Cardiovasc Res 78:376-84. 2008
    ..We investigated whether adiponectin suppresses VEGF-induced migration and related signal transduction responses in human coronary artery endothelial cells (HCAECs)...
  15. ncbi Reductions in biomarkers of cardiovascular risk in type 2 diabetes with rosiglitazone added to metformin compared with dose escalation of metformin: an EMPIRE trial sub-study
    Barry J Goldstein
    Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA
    Curr Med Res Opin 22:1715-23. 2006
    ..To compare the effects of rosiglitazone added to metformin with dose escalation of metformin on cardiovascular risk biomarkers in type 2 diabetes mellitus...
  16. pmc Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo
    Raogo Ouedraogo
    Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6799, USA
    J Clin Invest 117:1718-26. 2007
    ..Overall, we provide evidence that loss of adiponectin induces a primary state of endothelial dysfunction with increased leukocyte-endothelium adhesiveness...
  17. ncbi Integration of multiple downstream signals determines the net effect of insulin on MAP kinase vs. PI 3'-kinase activation: potential role of insulin-stimulated H(2)O(2)
    Kalyankar Mahadev
    Department of Medicine, Jefferson Medical College of Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107 6799, USA
    Cell Signal 16:323-31. 2004
    ....
  18. pmc Role of insulin-induced reactive oxygen species in the insulin signaling pathway
    Barry J Goldstein
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Antioxid Redox Signal 7:1021-31. 2005
    ..These recent studies have provided insight into Nox4 as a novel molecular link between insulin-stimulated reactive oxygen species and mechanisms involved in their modulation of insulin signal transduction...
  19. pmc AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin
    Yajing Wang
    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Circulation 119:835-44. 2009
    ..Deficiency of both AMP-activated protein kinase (AMPK) and adiponectin occurs in diabetes, but whether AMPK is cardioprotective or a central mediator of adiponectin cardioprotection in vivo remains unknown...
  20. ncbi Protein-tyrosine phosphatase activity in human adipocytes is strongly correlated with insulin-stimulated glucose uptake and is a target of insulin-induced oxidative inhibition
    Xiangdong Wu
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Metabolism 52:705-12. 2003
    ..The insulin-stimulated oxidative inhibition of PTPases may also have an important permissive role in the transmission of the insulin signal to glucose transport in human adipocytes...
  21. ncbi Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL
    Hiroyuki Motoshima
    Dorrance Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biochem Biophys Res Commun 315:264-71. 2004
    ..These data indicate that gAd inhibits oxLDL-induced cell proliferation and suppresses cellular superoxide generation, possibly through an NAD(P)H oxidase-linked mechanism...
  22. ncbi Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes
    Xiangdong Wu
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Diabetes 52:1355-63. 2003
    ....
  23. ncbi Dual PPAR alpha/gamma agonists: promises and pitfalls in type 2 diabetes
    Intekhab Ahmed
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Ther 14:49-62. 2007
    ....
  24. pmc Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets
    Barry J Goldstein
    Dorrance Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Diabetes 54:311-21. 2005
    ....
  25. ncbi Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes
    Barry J Goldstein
    Division of Endocrinology, Diabetes, and Metabolic Diseases, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Diabetes Care 30:1979-87. 2007
    ..To assess the efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes and inadequate glycemic control on diet and exercise...
  26. ncbi Multicenter, randomized, double-masked, parallel-group assessment of simultaneous glipizide/metformin as second-line pharmacologic treatment for patients with type 2 diabetes mellitus that is inadequately controlled by a sulfonylurea
    Barry J Goldstein
    Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Ther 25:890-903. 2003
    ..The synergistic effects of combining glipizide with metformin on glucose control may be realized by treating the primary effects of type 2 DM, impaired insulin secretion, and insulin resistance...
  27. pmc First versus repeat treatment with a lifestyle intervention program: attendance and weight loss outcomes
    E M Venditti
    Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Int J Obes (Lond) 32:1537-44. 2008
    ..This study compares the effects of the lifestyle program between participants who had previous exposure and those who had not...
  28. ncbi Cardiovascular risk in the spectrum of type 2 diabetes mellitus
    Intekhab Ahmed
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Jefferson Alumni Hall, Suite 349, 1020 Locust Street, Philadelphia, PA 19107 6799, USA
    Mt Sinai J Med 73:759-68. 2006
    ..In this brief review, we will cover several key concepts in the pathophysiology of type 2 diabetes that confer increased cardiovascular risk and influence the choice of oral therapies for this widespread disorder...
  29. pmc Menopause and risk of diabetes in the Diabetes Prevention Program
    Catherine Kim
    Department of Medicine, University of Michigan, Ann Arbor, MI, USA
    Menopause 18:857-68. 2011
    ..The study objectives were to examine the association between menopause status and diabetes risk among women with glucose intolerance and to determine if menopause status modifies response to diabetes prevention interventions...
  30. ncbi Adiponectin: A novel adipokine linking adipocytes and vascular function
    Barry J Goldstein
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Endocrinol Metab 89:2563-8. 2004
    ..Adiponectin is now a recognized component of a novel signaling network among adipocytes, insulin-sensitive tissues, and vascular function that has important consequences for cardiovascular risk...
  31. ncbi Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone
    Hiroyuki Motoshima
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Endocrinol Metab 87:5662-7. 2002
    ....
  32. pmc Reactive oxygen species production via NADPH oxidase mediates TGF-beta-induced cytoskeletal alterations in endothelial cells
    Taishan Hu
    The Dorrance Hamilton Research Laboratories, Thomas Jefferson Univ, Philadelphia, PA 19107, USA
    Am J Physiol Renal Physiol 289:F816-25. 2005
    ..In conclusion, our studies show for the first time that TGF-beta-induced ROS production in human endothelial cells is via Nox4 and that TGF-beta alteration of cytoskeleton in HUVEC is mediated via a Nox4-dependent pathway...
  33. ncbi Insulin resistance: from benign to type 2 diabetes mellitus
    Barry J Goldstein
    Dorrance Hamilton Research Laboratories, Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Rev Cardiovasc Med 4:S3-10. 2003
    ....
  34. ncbi Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress
    Ling Tao
    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Circulation 115:1408-16. 2007
    ..The present study was designed to determine the mechanism by which adiponectin exerts its protective effects against myocardial ischemia/reperfusion...
  35. ncbi Effect of tesaglitazar, a dual PPAR alpha/gamma agonist, on glucose and lipid abnormalities in patients with type 2 diabetes: a 12-week dose-ranging trial
    Barry J Goldstein
    Department of Medicine, Jefferson Medical College of Thomas Jefferson University, 349 Jefferson Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107, USA
    Curr Med Res Opin 22:2575-90. 2006
    ..The Glucose and Lipid Assessment in Diabetes (GLAD) trial examined the dose-response relationship of the dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist tesaglitazar in type 2 diabetic patients...
  36. ncbi Insulin resistance, diabetes and cardiovascular risk: approaches to treatment
    Daniel E Rosenberg
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Diabetes Obes Metab 7:642-53. 2005
    ..As macrovascular disease is the major cause of morbidity and mortality, an early, aggressive, multi-factorial approach to treatment of the metabolic syndrome and diabetes is vital to prevent adverse cardiac outcomes...
  37. ncbi Clinical translation of "a diabetes outcome progression trial": ADOPT appropriate combination oral therapies in type 2 diabetes
    Barry J Goldstein
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Suite 349, 1020 Locust Street, Philadelphia, Pennsylvania 19107 6799, USA
    J Clin Endocrinol Metab 92:1226-8. 2007
  38. doi Coronary artery disease screening in patients with diabetes
    Vincent Savarese
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College, 6th Floor, 211 South 9th Street, Philadelphia, PA 19107, USA
    Endocrine 33:225-9. 2008
    ..However, based on the current evidence we presently do not recommend screening for CAD in this population...
  39. ncbi Adipokines and vascular disease in diabetes
    Barry J Goldstein
    Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College of Thomas Jefferson University, Suite 349, 1020 Locust Street, Philadelphia, PA 19107, USA
    Curr Diab Rep 7:25-33. 2007
    ..This highly active area of investigation has identified novel hormonal mechanisms by which the adipose tissue mass can influence vascular function with important consequences for cardiovascular risk...
  40. pmc Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study
    Richard R Rubin
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 33:2549-51. 2010
    ..To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS)...
  41. ncbi Mindfulness-based stress reduction is associated with improved glycemic control in type 2 diabetes mellitus: a pilot study
    Steven Rosenzweig
    Department of Emergency Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
    Altern Ther Health Med 13:36-8. 2007
    ..Psychological distress is linked with impaired glycemic control among diabetics...
  42. ncbi Human epicardial adipose tissue is a source of inflammatory mediators
    Tomasz Mazurek
    Department of Surgery, Thomas Jefferson University, Suite 623, 1025 Walnut St, Philadelphia, PA 19107, USA
    Circulation 108:2460-6. 2003
    ..In this study, we sought to compare expression of inflammatory mediators in epicardial and subcutaneous adipose stores in patients with critical CAD...
  43. pmc Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  44. ncbi Pathogenesis of type 2 diabetes
    Michael Stumvoll
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Endocr Res 32:19-37. 2007
  45. ncbi Possible vascular-protective effects of antidiabetic agents such as the thiazolidinediones (TZDs)
    Barry J Goldstein
    Clin Ther 24:1358-60; author reply 1360-2. 2002
  46. ncbi Effect of tesaglitazar, a dual PPARalpha/gamma agonist, on glucose and lipid abnormalities in patients with type 2 diabetes: a 12-week dose-ranging trial
    Barry J Goldstein
    Curr Med Res Opin 22:2575-90. 2006
    ..0 mg and 3.0 mg doses limits conclusions about the efficacy of these doses. The 0.5 mg and 1.0 mg tesaglitazar doses were identified for further investigation...
  47. ncbi Type 2 diabetes: principles of pathogenesis and therapy
    Michael Stumvoll
    Third Medical Department, University of Leipzig, Leipzig, Germany
    Lancet 365:1333-46. 2005
    ..Management includes not only diet and exercise, but also combinations of anti-hyperglycaemic drug treatment with lipid-lowering, antihypertensive, and anti platelet therapy...
  48. pmc Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells
    Yoshimasa Nakamura
    Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Circ Res 102:1182-91. 2008
    ..Induction of PTP1B by hindlimb ischemia may represent an important counterregulatory mechanism that blunts overactivation of VEGFR2 during angiogenesis in vivo...
  49. doi Type 2 diabetes: pathogenesis and treatment
    Michael Stumvoll
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Lancet 371:2153-6. 2008
  50. ncbi Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity
    Rong Li
    Department of Physiology, The Fourth Military Medical University, Xian, China
    Am J Physiol Endocrinol Metab 293:E1703-8. 2007
    ....