PAOLO M FORTINA

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc The complex transcriptional landscape of the anucleate human platelet
    Paul F Bray
    Cardeza Foundation for Hematologic Research, Division of Hematology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    BMC Genomics 14:1. 2013
  2. pmc Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling
    Liraz Levi
    Department Marine Biology and Biotechnology, Israel Oceanographic and Limnological Research, Haifa, Israel
    BMC Genomics 10:141. 2009
  3. pmc Whole-exome sequencing of DNA from peripheral blood mononuclear cells (PBMC) and EBV-transformed lymphocytes from the same donor
    Eric R Londin
    Cancer Genomics Laboratory, Kimmel Cancer Center
    BMC Genomics 12:464. 2011
  4. ncbi request reprint Applications of nanoparticles to diagnostics and therapeutics in colorectal cancer
    Paolo Fortina
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA 19107, USA
    Trends Biotechnol 25:145-52. 2007
  5. ncbi request reprint Nanobiotechnology: the promise and reality of new approaches to molecular recognition
    Paolo Fortina
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Trends Biotechnol 23:168-73. 2005
  6. ncbi request reprint Opportunities for near-infrared thermal ablation of colorectal metastases by guanylyl cyclase C-targeted gold nanoshells
    Scott A Waldman
    Thomas Jefferson University, Jefferson Medical College, Department of Pharmacology and Experimental Therapeutics, Philadelphia, PA 19107, USA
    Future Oncol 2:705-16. 2006
  7. ncbi request reprint Gene expression profiling during the transition to failure in TNF-alpha over-expressing mice demonstrates the development of autoimmune myocarditis
    Zhonghua Tang
    Department of Medicine, Center for Translational Medicine, Thomas Jefferson University, Suite 813 College Building, 1025 Walnut Street, Philadelphia, PA 19107, USA
    J Mol Cell Cardiol 36:515-30. 2004
  8. doi request reprint NFκB activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis
    Francesco Del Galdo
    Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Ann Rheum Dis 69:2024-33. 2010
  9. pmc p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo
    Manran Liu
    Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 106:19035-9. 2009
  10. pmc Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts
    Ayanna S Augustus
    Dept of Cancer Biology, Thomas Jefferson Univ, 233 S 10th St, BLSB 933, Philadelphia, PA 19107, USA
    Am J Physiol Heart Circ Physiol 295:H657-66. 2008

Research Grants

Collaborators

  • L J Kricka
  • W J Koch
  • Scott Waldman
  • Piotr Grodzinski
  • Philippe G Frank
  • Agnieszka K Witkiewicz
  • Tuomas Mirtti
  • A M Feldman
  • S A Jimenez
  • Federica Sotgia
  • EVAN ABEL
  • Sally A Huber
  • Brian S McGowan
  • Makarand Risbud
  • Maurizio Ferrari
  • Javad Parvizi
  • Masahiro Iwamoto
  • Zhonghua Tang
  • Ian Krantz
  • Sankar Addya
  • Saul Surrey
  • Lei Gu
  • Terry Hyslop
  • Michael P Lisanti
  • Richard G Pestell
  • Ayanna S Augustus
  • Kathleen Delgrosso
  • Xing Jian Lou
  • Paul F Bray
  • Adam Ertel
  • Eric R Londin
  • Peter Wilding
  • Jacqueline Lutz
  • Bruno Dallapiccola
  • George Feldman
  • Lukas Bubendorf
  • Benjamin Leiby
  • Mansi Saraiya
  • Francesco Del Galdo
  • Marja T Nevalainen
  • Abhijit Dasgupta
  • Ayush Dagvadorj
  • Eric Rappaport
  • Liraz Levi
  • Stephanos Pavlides
  • Mathew C Casimiro
  • Chenguang Wang
  • Manran Liu
  • Ellen Gutman
  • Andre Bensadoun
  • Rosa Santacroce
  • Alessandro Ferraris
  • Jonathan Buchanan
  • Giuseppe Rengo
  • Steven E McKenzie
  • Jelena Stewart
  • Annalisa Schirinzi
  • Donald Swanson
  • Steve Huang
  • John M Maris
  • Radoje Drmanac
  • Snezana Drmanac
  • Shannon Cowie
  • Nicholas J Panaro
  • Tomoharu Kajiyama
  • David J Graves
  • Hung Ju Su
  • Gabriella Restagno
  • Maurizio Margaglione
  • Leonard C Edelstein
  • Srikanth Nagalla
  • Phillipe Loher
  • Huang Wen Chen
  • Joan Kupper
  • Eric Londin
  • Isidore Rigoutsos
  • Yi Jing
  • Margaret A Keller
  • Michael R D'Andrea
  • Ravi Kumar Ponnappan
  • Paraskevi Vogiatzi
  • Todd J Albert
  • Irving M Shapiro
  • David Azimi
  • Chelsea Dalsey
  • David Greg Anderson
  • Yan Zeng
  • Marcella Devoto
  • Maurizio Pacifici
  • Carlton Cooper

Detail Information

Publications27

  1. pmc The complex transcriptional landscape of the anucleate human platelet
    Paul F Bray
    Cardeza Foundation for Hematologic Research, Division of Hematology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    BMC Genomics 14:1. 2013
    ..The goal of this effort was to deep-sequence RNA from leukocyte-depleted platelets to capture the complex profile of all expressed transcripts...
  2. pmc Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling
    Liraz Levi
    Department Marine Biology and Biotechnology, Israel Oceanographic and Limnological Research, Haifa, Israel
    BMC Genomics 10:141. 2009
    ....
  3. pmc Whole-exome sequencing of DNA from peripheral blood mononuclear cells (PBMC) and EBV-transformed lymphocytes from the same donor
    Eric R Londin
    Cancer Genomics Laboratory, Kimmel Cancer Center
    BMC Genomics 12:464. 2011
    ....
  4. ncbi request reprint Applications of nanoparticles to diagnostics and therapeutics in colorectal cancer
    Paolo Fortina
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA 19107, USA
    Trends Biotechnol 25:145-52. 2007
    ..Although the scenarios outlined in this article are hypothetical, they might stimulate ideas about how other cancers could be attacked using nanotechnology...
  5. ncbi request reprint Nanobiotechnology: the promise and reality of new approaches to molecular recognition
    Paolo Fortina
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Trends Biotechnol 23:168-73. 2005
    ..We also speculate on further pathways in nanotechnology development and the emergence of order in this somewhat chaotic, yet promising, new field...
  6. ncbi request reprint Opportunities for near-infrared thermal ablation of colorectal metastases by guanylyl cyclase C-targeted gold nanoshells
    Scott A Waldman
    Thomas Jefferson University, Jefferson Medical College, Department of Pharmacology and Experimental Therapeutics, Philadelphia, PA 19107, USA
    Future Oncol 2:705-16. 2006
    ....
  7. ncbi request reprint Gene expression profiling during the transition to failure in TNF-alpha over-expressing mice demonstrates the development of autoimmune myocarditis
    Zhonghua Tang
    Department of Medicine, Center for Translational Medicine, Thomas Jefferson University, Suite 813 College Building, 1025 Walnut Street, Philadelphia, PA 19107, USA
    J Mol Cell Cardiol 36:515-30. 2004
    ..The autoimmune response occurs concomitantly with cardiac decompensation and may participate in triggering the transition to failure in TNF1.6 mice...
  8. doi request reprint NFκB activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis
    Francesco Del Galdo
    Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Ann Rheum Dis 69:2024-33. 2010
    ..To elucidate the mechanisms responsible for macrophage activation, the effects of the GdBCA Omniscan on normal human macrophage global gene expression, chemokine production and nuclear factor κB (NFκB) activation was examined...
  9. pmc p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo
    Manran Liu
    Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 106:19035-9. 2009
    ..Thus, the in vitro cell culture assays reflect the changes observed in vivo in transgenic mice. These findings establish a link between the loss of p21(CIP1) and the acquisition of breast cancer EMT and stem cell properties in vivo...
  10. pmc Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts
    Ayanna S Augustus
    Dept of Cancer Biology, Thomas Jefferson Univ, 233 S 10th St, BLSB 933, Philadelphia, PA 19107, USA
    Am J Physiol Heart Circ Physiol 295:H657-66. 2008
    ..Moreover, a loss of Cav3 mRNA altered the expression of several genes not previously linked to cardiac growth and function. Thus we have identified a number of new target genes associated with the pathogenesis of cardiac hypertrophy...
  11. ncbi request reprint Identification of APC gene mutations in colorectal cancer using universal microarray-based combinatorial sequencing-by-hybridization
    Shannon Cowie
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Hum Mutat 24:261-71. 2004
    ..6 kb from a PCR target, with 99.97% accuracy on a single HyChip trade mark slide. cSBH is a fast, cost-efficient method for first stage mutation screening in the APC or any other gene...
  12. pmc Genotyping on a thermal gradient DNA chip
    Tomoharu Kajiyama
    Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genome Res 13:467-75. 2003
    ..Unambiguous typing was achieved for clinically relevant loci within the factor VII and hemochromatosis genes...
  13. ncbi request reprint L-selenomethionine modulates high LET radiation-induced alterations of gene expression in cultured human thyroid cells
    Jelena Stewart
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6072, USA
    Oncol Rep 16:569-74. 2006
    ..This study provides a basis for furthering our knowledge about radiation-induced molecular and cellular changes that lead to cellular transformation and death...
  14. pmc The Otto Aufranc Award: Identification of a 4 Mb region on chromosome 17q21 linked to developmental dysplasia of the hip in one 18-member, multigeneration family
    George Feldman
    Thomas Jefferson University and the Rothman Institute of Orthopaedics, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 468:337-44. 2010
    ..Discovering the genetic basis of the disease would be an important step in understanding the etiology of this disabling condition...
  15. pmc Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth
    Lei Gu
    Department of Cancer Biology, Medical Oncology, Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Pathol 176:1959-72. 2010
    ..This work provides the first mechanistic comparison of the biological effects induced by transcription factors Stat5a/b versus Stat3 in prostate cancer...
  16. pmc Reversine enhances generation of progenitor-like cells by dedifferentiation of annulus fibrosus cells
    Mansi Saraiya
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    Tissue Eng Part A 16:1443-55. 2010
    ..This agent could be used to generate skeletal progenitor cells to orchestrate the repair of the intervertebral disc...
  17. doi request reprint Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo
    Lei Gu
    Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Endocr Relat Cancer 17:481-93. 2010
    ..Stat5 may provide a therapeutic target protein for disseminated prostate cancer...
  18. ncbi request reprint The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    Stephanos Pavlides
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 8:3984-4001. 2009
    ..Thus, an absence of stromal Cav-1 may be a biomarker for the "Reverse Warburg Effect," explaining its powerful predictive value...
  19. ncbi request reprint Microchips: an all-language literature survey including books and patents
    Larry J Kricka
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Clin Chem 48:1620-2. 2002
  20. ncbi request reprint Pyrosequencing for detection of mutations in the connexin 26 (GJB2) and mitochondrial 12S RNA (MTRNR1) genes associated with hereditary hearing loss
    Alessandro Ferraris
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Hum Mutat 20:312-20. 2002
    ....
  21. ncbi request reprint Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism
    Ayanna S Augustus
    Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cell Cycle 7:2509-18. 2008
    ..In summary, targeted loss of Cav1 produces a unique model of cardiac hypertrophy with normal substrate utilization and expression of genes involved in energy metabolism...
  22. ncbi request reprint Analysis of clinically relevant single-nucleotide polymorphisms by use of microelectronic array technology
    Rosa Santacroce
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Chem 48:2124-30. 2002
    ..Microelectronic DNA chip devices represent an emerging technology for genotyping. We developed methods for detection of single-nucleotide polymorphisms (SNPs) in clinically relevant genes...
  23. ncbi request reprint Combinatorial sequencing-by-hybridization: analysis of the NF1 gene
    Annalisa Schirinzi
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Genet Test 10:8-17. 2006
    ..In addition, cSBH analysis of the entire NF1 gene demonstrates reproducibility, efficiency and reduced time; therefore, representing an alternative to extensive DNA sequence characterization...
  24. pmc Region-specific detection of neuroblastoma loss of heterozygosity at multiple loci simultaneously using a SNP-based tag-array platform
    John M Maris
    Division of Oncology, The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genome Res 15:1168-76. 2005
    ....
  25. ncbi request reprint Increased amplification efficiency of microchip-based PCR by dynamic surface passivation
    Xing Jian Lou
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Biotechniques 36:248-52. 2004
    ..It can also be used in combination with static passivation (silicon oxide surface layer) to further improve PCR performance using silicon-glass PCR chips...
  26. ncbi request reprint Mutation detection using ligase chain reaction in passivated silicon-glass microchips and microchip capillary electrophoresis
    Xing Jian Lou
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biotechniques 37:392, 394, 396-8. 2004
    ..Ligated primers were detected and quantified simply and conveniently using microchip capillary electrophoresis...
  27. ncbi request reprint Kinetics of heterogeneous hybridization on indium tin oxide surfaces with and without an applied potential
    Hung Ju Su
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Philadelphia, 19104, USA
    Electrophoresis 23:1551-7. 2002
    ..This approach may have implications for enhancing array-based hybrid capture for mutation detection, copy number determination and/or gene expression profiling...

Research Grants1

  1. FOUR COLOR ARRAY BOUND SNP/MUTATION DETECTION IN CANCER
    Paolo Fortina; Fiscal Year: 2004
    ..In addition, it will help establish basic knowledge required to rapidly define the molecular basis of specific malignancies and eventually provide a foundation for rational molecular assessment of therapeutic. ..