Research Topics
Genomes and Genes
| R FishelSummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Detail Information
Publications
Differential cellular expression of the human MSH2 repair enzyme in small and large intestineT M Wilson
Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, IN 46202, USA
Cancer Res 55:5146-50. 1995..These results confirm the hypothesis that hMSH2 is expressed in highly proliferative cells of the gut, and mutations in this gene could, therefore, be expected to expedite the progression of adenoma to carcinoma in this tissue...- The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancerR Fishel
Department of Microbiology and Molecular Genetics Markey Center for Molecular Genetics University of Vermont Medical School Burlington 05405
Cell 75:1027-38. 1993..These data and reports indicating that S. cerevisiae msh2 mutations cause an instability of dinucleotide repeats like those associated with HNPCC suggest that hMSH2 is the HNPCC gene... - The GTP hydrolysis defect of the Saccharomyces cerevisiae mutant G-protein Gpa1(G50V)L Kallal
Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Yeast 16:387-400. 2000..These biochemical results can explain many of the known gpa1(G50V) yeast cell phenotypes... - MutS homologs in mammalian cellsR Fishel
DNA Repair and Molecular Carcinogenesis Program, Kimmel Cancer Institute and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Curr Opin Genet Dev 7:105-13. 1997..The redundant functions of MSH3 and MSH6 explain the greater prevalence of hmsh2 mutations in HNPCC families... - The interaction of DNA mismatch repair proteins with human exonuclease IC Schmutte
Genetics and Molecular Biology Program, Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 276:33011-8. 2001..In addition, hExoI forms an immunoprecipitable complex with hMLH1/hPMS2 in vivo. The study of interaction regions suggests a biochemical mechanism of the involvement of hExoI as a downstream effector in MMR and/or DNA recombination... - A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2Y Murakumo
Genetics and Molecular Biology Program, Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 275:4391-7. 2000..While overexpression of hREV7 does not lead to cell cycle arrest, we entertain the possibility that it may act as an adapter between DNA repair and the spindle assembly checkpoint... - hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesisT Bocker
Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University and Medical College, Philadelphia, Pennsylvania 19107, USA
Cancer Res 59:816-22. 1999..hMSH5 interacts specifically with hMSH4, confirming the generality of functional heterodimeric interactions in the eukaryotic MutS homologue, which also includes hMSH2-hMSH3 and hMSH2-hMSH6... 
Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancerS Guerrette
Genetics and Molecular Biology Program, Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Mol Cell Biol 18:6616-23. 1998..These data support the notion that these HNPCC-associated mutations may affect some other function of the heterodimeric complexes than simply the static interaction of hMSH2 with hMSH3 or hMSH2 with hMSH6...- Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1Q Wang
Department of Pathology and Laboratory Medicine, The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, PA 19104, USA
Oncogene 20:4640-9. 2001..The functional interaction between BRCA1 and hMSH2 may provide a partial explanation for the background of gynecological and colorectal cancer in both HNPCC and BRCA1 kindreds, respectively... - BCR/ABL regulates mammalian RecA homologs, resulting in drug resistanceA Slupianek
Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Mol Cell 8:795-806. 2001..Induction of the mammalian RecA homologs establishes a unique mechanism for DNA damage resistance in mammalian cells transformed by an oncogenic tyrosine kinase... - The interaction of the human MutL homologues in hereditary nonpolyposis colon cancerS Guerrette
Genetics and Molecular Biology Program, Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 274:6336-41. 1999.... - Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 loss of heterozygosity (LOH)C Schmutte
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 59:4564-9. 1999..No indication of hypermethylation was found. These results suggest that hRad51 is not a tumor suppressor because it is either an essential gene, redundant gene and/or independent of the BRCA1/BRCA2 tumor suppressor pathway(s)... - Refined chromosomal localization of the mismatch repair and hereditary nonpolyposis colorectal cancer genes hMSH2 and hMSH6C Schmutte
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 58:5023-6. 1998..These results clarify the position of the chromosome 2 hereditary nonpolyposis colorectal cancer locus, which was originally reported to be associated with an adjacent region (chromosome 2p14-16)... - Female embryonic lethality in Msh2-Trp53 nullizygous mice is strain dependentA Cranston
Genetics and Molecular Biology Program, Kimmel Cancer Center BLSB933, Thomas Jefferson University, 233 South 10th Street, Philadelphia, Pennsylvania 19107, USA
Mamm Genome 10:1020-2. 1999 - The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switchS Gradia
Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cell 91:995-1005. 1997..These results suggest a new model for the function of MutS proteins during mismatch repair in which the switch determines the timing of downstream events... - Human exonuclease I interacts with the mismatch repair protein hMSH2C Schmutte
Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 58:4537-42. 1998..hExoI was found to interact strongly with the human MMR protein hMSH2, suggesting its involvement in the MMR process and/or DNA recombination... - hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6S Acharya
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 93:13629-34. 1996..These results help to explain the distribution of mutations in different mismatch-repair genes seen in hereditary nonpolyposis colon cancer... 
Severe attenuation of the B cell immune response in Msh2-deficient miceK A Vora
Department of Microbiology and Immunology and The Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
J Exp Med 189:471-82. 1999..Interpretation of the impact of an MMR deficiency on the mechanism of V gene somatic hypermutation could be easily confounded by these perturbations...- Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: a region of high loss of heterozygosity in gastric cancerC Schmutte
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 57:3010-5. 1997..At present, we have found no evidence that TDG is central to the development of gastric cancer, limiting the importance of TDG in T:G mismatch repair and subsequent carcinogenesis... - Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumorsD Rasio
Kimmel Cancer Institute and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 57:2378-83. 1997..We have examined the hRAD54 gene in several breast tumors and breast tumor cell lines and, although the gene region appears to be deleted in several tumors, at present we have found no coding sequence mutations... - Genomic instability: first step to carcinogenesisC Schmutte
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Anticancer Res 19:4665-96. 1999..Therefore, genomic instability including genetic and/or epigenetic alterations may be the first step in carcinogenesis. Knowledge of these biochemical mechanisms are likely to lead to more effective cancer diagnosis and therapy... - Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activationA Saleh
Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 274:17941-5. 1999.... - Female embryonic lethality in mice nullizygous for both Msh2 and p53A Cranston
Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Nat Genet 17:114-8. 1997..Synergism in tumorigenesis and independent segregation of the MSI phenotype suggest that Msh2 and p53 are not genetically epistatic... - Microsatellite instability analysis: a multicenter study for reliability and quality controlT Bocker
Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 57:4739-43. 1997..The number of marker loci analyzed as well as the number of unstable marker loci found should always be identified. These criteria should result in reports of MSI that are more comparable between studies... - Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7Y Murakumo
Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
J Biol Chem 276:35644-51. 2001..These findings suggest the possibility that hREV7 might play an important role in regulating the enzymatic activities of hREV1 and hREV3 for mutagenesis in response to DNA damage... - Purified human MSH2 protein binds to DNA containing mismatched nucleotidesR Fishel
Department of Microbiology and Molecular Genetics, Markey Center for Molecular Genetics, University of Vermont School of Medicine, Burlington 05405
Cancer Res 54:5539-42. 1994..Here we demonstrate that purified hMSH2 binds specifically to mismatched nucleotides, providing a target for the excision repair processes characteristic of postreplication mismatch repair... - Binding of mismatched microsatellite DNA sequences by the human MSH2 proteinR Fishel
Department of Microbiology and Molecular Genetics, Markey Center for Molecular Genetics, University of Vermont School of Medicine, Burlington 05405
Science 266:1403-5. 1994..These results support a direct role for hMSH2 in mutation avoidance and microsatellite stability in human cells... - The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancerR Fishel
Cell 77:167. 1994 - Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorinJ Roche
University of Colorado Health Sciences and Cancer Centers, Denver 80262, USA
Oncogene 12:1289-97. 1996..This appears to represent one of the first demonstrations of homozygous deletions affecting 3p in direct lung tumors... - The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 inductionL M Fried
Department of Radiation Oncology, Stanford University School of Medicine, CA 94305, USA
Proc Natl Acad Sci U S A 93:13825-30. 1996..We conclude that the DNA damage response involving p53 and RPA is not associated with the defect in DNA repair in SCID cells and that the physiological substrate(s) for DNA-PK essential for DNA repair has not yet been identified... - Cell cycle regulation of the human DNA mismatch repair genes hMSH2, hMLH1, and hPMS2M Meyers
Department of Human Oncology, University of Wisconsin, Madison 53792, USA
Cancer Res 57:206-8. 1997..Our data indicate that, at least in normal cells, the machinery responsible for the detection and repair of mismatched DNA bases is present throughout the cell cycle... - Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair proteinQ H Phung
Laboratory of Molecular Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
J Exp Med 187:1745-51. 1998..The results suggest that the hypermutation pathway frequently mutates G.C pairs, and a MSH2-dependent pathway preferentially corrects mismatches at G and C... - The role of mismatch repair in small-cell lung cancer cellsL T Hansen
Institute of Molecular Pathology, University of Copenhagen, DK 2100 Copenhagen, Denmark
Eur J Cancer 39:1456-67. 2003..We conclude that MMR deficiency is largely not associated with the pathogenesis of SCLC...