M Feitelson

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint Genetic mechanisms of hepatocarcinogenesis
    Mark A Feitelson
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Oncogene 21:2593-604. 2002
  2. doi request reprint Hepatitis B virus X protein mutants exhibit distinct biological activities in hepatoma Huh7 cells
    Xiaohong Liu
    Department of Pathology, Changhai Hospital, Second Military Medical University, 174 Changhai Road, Shanghai 200433, PR China
    Biochem Biophys Res Commun 373:643-7. 2008
  3. pmc Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses
    Xiaohong Liu
    Department of Pathology, Changhai Hospital, Second Military Medical University, 174 Changhai Road, Shanghai 200433, People s Republic of China
    Carcinogenesis 29:1207-14. 2008
  4. ncbi request reprint The hepatitis B x antigen effector, URG7, blocks tumour necrosis factor alpha-mediated apoptosis by activation of phosphoinositol 3-kinase and beta-catenin
    Jingbo Pan
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    J Gen Virol 88:3275-85. 2007
  5. ncbi request reprint Hepatitis B x antigen up-regulates vascular endothelial growth factor receptor 3 in hepatocarcinogenesis
    Zhaorui Lian
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Hepatology 45:1390-9. 2007
  6. ncbi request reprint Chronic hepatitis C virus infection and the pathogenesis of hepatocellular carcinoma
    M Feitelson
    Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Arch Immunol Ther Exp (Warsz) 49:S65-74. 2001
  7. ncbi request reprint Early molecular and genetic determinants of primary liver malignancy
    Mark A Feitelson
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Surg Clin North Am 84:339-54. 2004
  8. ncbi request reprint Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin
    Zhaorui Lian
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hepatology 43:415-24. 2006
  9. ncbi request reprint Parallel epigenetic and genetic changes in the pathogenesis of hepatitis virus-associated hepatocellular carcinoma
    Mark A Feitelson
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Room 222 Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107, USA
    Cancer Lett 239:10-20. 2006
  10. ncbi request reprint Pharmacotherapy of chronic viral hepatitis and hepatocellular carcinoma
    Mark A Feitelson
    Temple University, Department of Biology, College of Science and Technology, Suite 409, BioLife Science Building, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Expert Opin Pharmacother 9:2233-45. 2008

Collaborators

  • Jie Liu
  • Li Li
  • P Arbuthnot
  • Hie Won L Hann
  • Zhaorui Lian
  • Jingbo Pan
  • Xiaohong Liu
  • Michael Kew
  • Hong Yang Wang
  • N Lale Satiroglu Tufan
  • Minghua Zhu
  • Xianxing Li
  • Marcy Clayton
  • Meng Chao Wu
  • Shunmin Zhang
  • Jing Lin
  • Hengjun Gao
  • Shuhui Zhang
  • Jessica A Chichester
  • Li Wang
  • Sarah Wallett
  • Mengchao Wu
  • Sarah Wallet
  • Catherine E Calkins
  • Daiming Fan
  • Marcy M Clayton

Detail Information

Publications22

  1. ncbi request reprint Genetic mechanisms of hepatocarcinogenesis
    Mark A Feitelson
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Oncogene 21:2593-604. 2002
    ..An understanding of the molecular pathogenesis of HCC may provide new markers for tumor staging, for assessment of the relative risk of tumor formation, and open new opportunities for therapeutic intervention...
  2. doi request reprint Hepatitis B virus X protein mutants exhibit distinct biological activities in hepatoma Huh7 cells
    Xiaohong Liu
    Department of Pathology, Changhai Hospital, Second Military Medical University, 174 Changhai Road, Shanghai 200433, PR China
    Biochem Biophys Res Commun 373:643-7. 2008
    ..In conclusions, HBx variants showed different effects and functions on cell proliferation and invasion by regulation of the cell cycle progression and its associated proteins expression...
  3. pmc Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses
    Xiaohong Liu
    Department of Pathology, Changhai Hospital, Second Military Medical University, 174 Changhai Road, Shanghai 200433, People s Republic of China
    Carcinogenesis 29:1207-14. 2008
    ..The hepatitis B virus x gene (HBx) is a promiscuous transactivator implicated in the development of hepatocellular carcinoma (HCC). The present study was designed to investigate the molecular events regulated by HBx...
  4. ncbi request reprint The hepatitis B x antigen effector, URG7, blocks tumour necrosis factor alpha-mediated apoptosis by activation of phosphoinositol 3-kinase and beta-catenin
    Jingbo Pan
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    J Gen Virol 88:3275-85. 2007
    ..This suggests that URG7 helps to protect virus-infected hepatocytes during chronic hepatitis B virus infection...
  5. ncbi request reprint Hepatitis B x antigen up-regulates vascular endothelial growth factor receptor 3 in hepatocarcinogenesis
    Zhaorui Lian
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Hepatology 45:1390-9. 2007
    ..In conclusion, HBxAg may short circuit VEGFR-3(S) signaling in liver cancer. Blocking VEGFR-3(S) signaling may be effective in preventing tumor development and/or prolonging survival in tumor bearing patients...
  6. ncbi request reprint Chronic hepatitis C virus infection and the pathogenesis of hepatocellular carcinoma
    M Feitelson
    Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Arch Immunol Ther Exp (Warsz) 49:S65-74. 2001
    ....
  7. ncbi request reprint Early molecular and genetic determinants of primary liver malignancy
    Mark A Feitelson
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Surg Clin North Am 84:339-54. 2004
    ..Together, these approaches will go far in reducing the very high morbidity and mortality associated with HCC...
  8. ncbi request reprint Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin
    Zhaorui Lian
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hepatology 43:415-24. 2006
    ..These observations also suggest that URG11 may be a regulatory element in the beta-catenin signaling pathway and may be a target for chemoprevention of HCC...
  9. ncbi request reprint Parallel epigenetic and genetic changes in the pathogenesis of hepatitis virus-associated hepatocellular carcinoma
    Mark A Feitelson
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Room 222 Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107, USA
    Cancer Lett 239:10-20. 2006
    ..From the perspective of the virus, this promotes chronic infection, while from the perspective of the host, this promotes tumorigenesis...
  10. ncbi request reprint Pharmacotherapy of chronic viral hepatitis and hepatocellular carcinoma
    Mark A Feitelson
    Temple University, Department of Biology, College of Science and Technology, Suite 409, BioLife Science Building, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Expert Opin Pharmacother 9:2233-45. 2008
    ..However, they are too expensive, not well tolerated, and result in the development of resistance when given as mono or salvage therapies. In addition, most of these drugs target only the virus polymerase...
  11. ncbi request reprint Preneoplastic markers of hepatitis B virus-associated hepatocellular carcinoma
    Hie Won L Hann
    Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    Cancer Res 64:7329-35. 2004
    ..Hence, these antibodies may serve as preneoplastic markers for HCC in HBV carriers with chronic liver disease, and may be identified by a simple blood test...
  12. ncbi request reprint Human S15a expression is upregulated by hepatitis B virus X protein
    Zhaorui Lian
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6749, USA
    Mol Carcinog 40:34-46. 2004
    ..Hence, HBxAg upregulated the expression of S15a, the latter of which participates in the development of HCC, perhaps by altering the integrity of translation...
  13. pmc Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival
    N Lale Satiroglu Tufan
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107 6799, USA
    Neoplasia 4:355-68. 2002
    ..Hence, URG4 may be a natural effector of HBxAg that contributes importantly to multistep hepatocarcinogenesis...
  14. pmc Upregulated expression of a unique gene by hepatitis B x antigen promotes hepatocellular growth and tumorigenesis
    Zhaorui Lian
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Neoplasia 5:229-44. 2003
    ..01), and yielded larger tumors (P < 0.02) in SCID mice injected subcutaneously with HepG2 cells. These data suggest that URG11 is a natural effector of HB x Ag that may promote the development of hepatocellular carcinoma...
  15. ncbi request reprint Hepatitis B virus transgenic severe combined immunodeficient mouse model of acute and chronic liver disease
    Mark A Feitelson
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Methods Mol Med 96:269-87. 2004
  16. ncbi request reprint Development of a novel mouse model to evaluate drug candidates against hepatitis B virus
    Mark A Feitelson
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Antivir Chem Chemother 18:213-23. 2007
    ..This system will be useful for preclinical assessment of small amounts of single or multiple compounds against HBV in vivo...
  17. ncbi request reprint A translational worldwide perspective for liver cancer - First International Meeting
    Mark A Feitelson
    Department of Biology, College of Science and Technology, Temple University, 1900 N 12 Street, Philadelphia, PA 19122, USA
    IDrugs 10:630-2. 2007
  18. ncbi request reprint Hepatitis B virus X antigen promotes transforming growth factor-beta1 (TGF-beta1) activity by up-regulation of TGF-beta1 and down-regulation of alpha2-macroglobulin
    Jingbo Pan
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Room 222 Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107, USA
    J Gen Virol 85:275-82. 2004
    ..Since elevated TGF-beta1 promotes the development of many tumour types, these observations suggest that the HBxAg-mediated alteration in TGF-beta1 and alpha(2)-M production may contribute importantly to the pathogenesis of HCC...
  19. ncbi request reprint Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis
    Mark A Feitelson
    Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Cancer Lett 252:157-70. 2007
    ..If so, then selected integration events may alter pathways that are rate limiting in hepatocarcinogenesis, thereby providing targets with diagnostic/prognostic potential and for therapeutic intervention...
  20. pmc Transient inhibition of Th1-type cytokine production by CD4 T cells in hepatitis B core antigen immunized mice is mediated by regulatory T cells
    Jessica A Chichester
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Immunology 118:438-48. 2006
    ..This delay by regulatory T cells of Th1-type cytokine production could contribute to viral persistence in chronic HBV infection by interfering with the critical role IFN-gamma plays in protection against viral infections...
  21. ncbi request reprint HEP DART 2005 -- frontiers in drug development for viral hepatitis
    Mark A Feitelson
    Thomas Jefferson University, Department of Pathology, Anatomy and Cell Biology, Room 222 Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107, USA
    IDrugs 9:165-7. 2006
  22. ncbi request reprint c-myc overexpression in hepatocarcinogenesis
    Mark A Feitelson
    Hum Pathol 35:1299-302. 2004