P J Donovan

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint Germline exclusion of Cks1 in the mouse reveals a metaphase I role for Cks proteins in male and female meiosis
    Peter J Donovan
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennslvania 19107, USA
    Cell Cycle 2:275-6. 2003
  2. ncbi request reprint Turning germ cells into stem cells
    Peter J Donovan
    Kimmel Cancer Center, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Genet Dev 13:463-71. 2003
  3. ncbi request reprint The end of the beginning for pluripotent stem cells
    P J Donovan
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 414:92-7. 2001
  4. ncbi request reprint Germ cell biology--from generation to generation
    P J Donovan
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Dev Biol 45:523-31. 2001
  5. ncbi request reprint The germ cell--the mother of all stem cells
    P J Donovan
    Cell Biology of Development and Differentiation Group, ABL Basic Research Program, NCI FCRDC, Frederick MD, USA
    Int J Dev Biol 42:1043-50. 1998
  6. ncbi request reprint Lack of germline transmission of vector sequences following systemic administration of recombinant AAV-2 vector in males
    V R Arruda
    The Children's Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Ther 4:586-92. 2001
  7. ncbi request reprint Decorin, epiphycan, and lumican genes are closely linked on murine Chromosome 10 and are deleted in lethal steel mutants
    K G Danielson
    Department of Pathology, Anatomy and Cell Biology, Room 249 Jefferson Alumni Hall, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA
    Mamm Genome 10:201-3. 1999
  8. ncbi request reprint Cellular apoptosis susceptibility gene capts maps to mouse chromosome 2
    M De Miguel
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI FCRDC, PO Box B, Bldg 539, Frederick, Maryland 21702 1201, USA
    Mamm Genome 9:411-2. 1998
  9. ncbi request reprint The four cdc25 genes from the nematode Caenorhabditis elegans
    N R Ashcroft
    ABL Basic Research Program, Gene Regulation, Chromosome Biology Laboratory, PO Box B, Building 539, National Cancer Institute Frederick Cancer Research, Development Center, Frederick, MD 21702, USA
    Gene 214:59-66. 1998
  10. pmc A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators
    G Gopalan
    Cell Biology of Development and Differentiation Group, ABL Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201, USA
    J Cell Biol 138:643-56. 1997

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Germline exclusion of Cks1 in the mouse reveals a metaphase I role for Cks proteins in male and female meiosis
    Peter J Donovan
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennslvania 19107, USA
    Cell Cycle 2:275-6. 2003
  2. ncbi request reprint Turning germ cells into stem cells
    Peter J Donovan
    Kimmel Cancer Center, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Genet Dev 13:463-71. 2003
    ..Understanding the genetics of embryonal carcinoma cell formation and the growth factor signaling pathways controlling embryonic germ cell derivation could tell us much about the molecular controls on developmental potency in mammals...
  3. ncbi request reprint The end of the beginning for pluripotent stem cells
    P J Donovan
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 414:92-7. 2001
    ..As such they represent an incredible resource for the repair of diseased or damaged tissues in our bodies. These cells also promise to open a new window into the embryonic development of our species...
  4. ncbi request reprint Germ cell biology--from generation to generation
    P J Donovan
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Dev Biol 45:523-31. 2001
    ..This review will focus on these two key aspects of germ cell biology, developmental potency and meiosis...
  5. ncbi request reprint The germ cell--the mother of all stem cells
    P J Donovan
    Cell Biology of Development and Differentiation Group, ABL Basic Research Program, NCI FCRDC, Frederick MD, USA
    Int J Dev Biol 42:1043-50. 1998
    ....
  6. ncbi request reprint Lack of germline transmission of vector sequences following systemic administration of recombinant AAV-2 vector in males
    V R Arruda
    The Children's Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Ther 4:586-92. 2001
    ..We conclude that the risk of inadvertent germline transmission of vector sequences following IM or hepatic artery injection of AAV-2 vectors is extremely low...
  7. ncbi request reprint Decorin, epiphycan, and lumican genes are closely linked on murine Chromosome 10 and are deleted in lethal steel mutants
    K G Danielson
    Department of Pathology, Anatomy and Cell Biology, Room 249 Jefferson Alumni Hall, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA
    Mamm Genome 10:201-3. 1999
  8. ncbi request reprint Cellular apoptosis susceptibility gene capts maps to mouse chromosome 2
    M De Miguel
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI FCRDC, PO Box B, Bldg 539, Frederick, Maryland 21702 1201, USA
    Mamm Genome 9:411-2. 1998
  9. ncbi request reprint The four cdc25 genes from the nematode Caenorhabditis elegans
    N R Ashcroft
    ABL Basic Research Program, Gene Regulation, Chromosome Biology Laboratory, PO Box B, Building 539, National Cancer Institute Frederick Cancer Research, Development Center, Frederick, MD 21702, USA
    Gene 214:59-66. 1998
    ..These data demonstrate the value of genome database searching for identifying new members of known gene families, understanding genetic diversity, and for studying gene structure...
  10. pmc A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators
    G Gopalan
    Cell Biology of Development and Differentiation Group, ABL Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201, USA
    J Cell Biol 138:643-56. 1997
    ..We suggest that IAK1 is a new member of an emerging subfamily of the serine/threonine kinase superfamily. The members of this subfamily may be important regulators of chromosome segregation...
  11. pmc RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females
    Sergey Kuznetsov
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Cell Biol 176:581-92. 2007
    ..Based on the marked reduction in Holliday junction (HJ) resolution activity in Rad51c-null mouse embryonic fibroblasts, we propose that this late function may be associated with HJ resolution...
  12. ncbi request reprint Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis
    Charles H Spruck
    Department of Molecular Biology, MB 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 300:647-50. 2003
    ....
  13. ncbi request reprint Meeting summary: European Workshop on Stem Cells, European Centre for the Validation of Biomedical Testing Methods, Institute for Health and Consumer Protection, Joint Research Centre, Ispra, Italy, November 21-23, 2001
    Laura Gribaldo
    European Centre for the Validation of Biomedical Testing Methods, Institute for Health and Consumer Protection, Joint Research Centre, Ispra, Italy
    Exp Hematol 30:628-33. 2002
  14. ncbi request reprint Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation
    A Jeannine Lincoln
    National Cancer Institute FCRDC, Frederick, Maryland 21702, USA
    Nat Genet 30:446-9. 2002
    ..Cdc25b is therefore essential for meiotic resumption in female mice. Mice lacking Cdc25b provide the first genetic model for studying the mechanisms regulating prophase arrest in vertebrates...
  15. pmc Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer
    Maria P De Miguel
    Kimmel Cancer Center, Thomas Jefferson University, Bluemle Life Sciences Building, Room 706, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 99:10458-63. 2002
    ..Such technology for manipulating gene expression in PGCs will allow many of the molecular mechanisms regulating germ cell growth, behavior, and differentiation to be comprehensively analyzed...
  16. pmc Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development
    Andrea Vecchione
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 11:275-89. 2007
    ..Accordingly, Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice...
  17. ncbi request reprint Embryonic germ cells: when germ cells become stem cells
    Candace L Kerr
    Institute for Cell Engineering, Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Semin Reprod Med 24:304-13. 2006
    ..Transplantation studies have begun in a variety of models in hopes of defining their potential use to treat a wide variety of human conditions, including diabetes and urological and neurological disorders...
  18. ncbi request reprint Staining embryonic stem cells using monoclonal antibodies to stage-specific embryonic antigens
    Bruce A Fenderson
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Methods Mol Biol 325:207-24. 2006
    ....
  19. ncbi request reprint Neurotrophins mediate human embryonic stem cell survival
    April D Pyle
    Germ Cell and Stem Cell Group, Institute for Cell Engineering, Johns Hopkins University, School of Medicine, Broadway Research Building, Suite 759, 733 North Broadway, Baltimore, Maryland 21205, USA
    Nat Biotechnol 24:344-50. 2006
    ..Neurotrophins improve hES cell survival and may facilitate their manipulation and the development of high-throughput screens to identify factors responsible for hES cell differentiation...
  20. pmc Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases
    Angela M Ferguson
    Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Ave, St Louis, MO 63110, USA
    Mol Cell Biol 25:2853-60. 2005
    ..These findings indicate that Cdc25A, or possibly other phosphatases, is able to functionally compensate for the loss of Cdc25B and Cdc25C in mice...
  21. pmc Chipping away at 'stemness'
    April D Pyle
    Germ Cell and Stem Cell Group, Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Genome Biol 5:235. 2004
    ..Support remains elusive, however, for the concept of 'stemness'--a pattern of expression of genes that is common to all stem cells...
  22. ncbi request reprint Isolation and culture of embryonic germ cells
    Maria P De Miguel
    Department of Microbiology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Methods Enzymol 365:353-63. 2003
  23. ncbi request reprint Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival
    Aaron M Elliott
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Dev Biol 311:347-58. 2007
    ..Loss of CBP in PGCs leads to increased apoptosis and subsequent reduction in PGC numbers. These data indicate an essential role for CBP in maintaining normal germ cell development...