David L Thomas

Summary

Country: USA

Publications

  1. pmc Highly active anti-hepatitis C therapy: seven lessons from HIV
    David L Thomas
    Johns Hopkins School of Medicine, Baltimore, MD, USA
    Antivir Ther 17:1183-8. 2012
  2. pmc Provisional guidance on the use of hepatitis C virus protease inhibitors for treatment of hepatitis C in HIV-infected persons
    David L Thomas
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Clin Infect Dis 54:979-83. 2012
  3. ncbi request reprint Rapid fibrosis progression among HIV/hepatitis C virus-co-infected adults
    Mark S Sulkowski
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    AIDS 21:2209-16. 2007
  4. pmc Incidence and risk factors for steatosis progression in adults coinfected with HIV and hepatitis C virus
    Tinsay A Woreta
    The Johns Hopkins Hospital University School of Medicine, Baltimore, Maryland 21287, USA
    Gastroenterology 140:809-17. 2011
  5. ncbi request reprint Progression of liver fibrosis among injection drug users with chronic hepatitis C
    Lucy E Wilson
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21231 1002, USA
    Hepatology 43:788-95. 2006
  6. pmc Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution
    Ashwin Balagopal
    Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    AIDS 23:2397-404. 2009
  7. pmc Vitamin D deficiency and its relation to bone mineral density and liver fibrosis in HIV-HCV coinfection
    Diala El-Maouche
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 18:237-42. 2013
  8. ncbi request reprint Liver enzyme flares and occult hepatitis B in persons with chronic hepatitis C infection
    Rajesh Kannangai
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Clin Virol 39:101-5. 2007
  9. doi request reprint Relationship of liver disease stage and antiviral therapy with liver-related events and death in adults coinfected with HIV/HCV
    Berkeley N Limketkai
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    JAMA 308:370-8. 2012
  10. pmc Limited uptake of hepatitis C treatment among injection drug users
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Community Health 33:126-33. 2008

Collaborators

Detail Information

Publications66

  1. pmc Highly active anti-hepatitis C therapy: seven lessons from HIV
    David L Thomas
    Johns Hopkins School of Medicine, Baltimore, MD, USA
    Antivir Ther 17:1183-8. 2012
    ..This paper considers seven important lessons learned with HIV and the degree to which they should be anticipated with HCV...
  2. pmc Provisional guidance on the use of hepatitis C virus protease inhibitors for treatment of hepatitis C in HIV-infected persons
    David L Thomas
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Clin Infect Dis 54:979-83. 2012
    ..Pending results of ongoing investigations, this article represents provisional guidance on the use of HCV PIs in HIV-infected persons...
  3. ncbi request reprint Rapid fibrosis progression among HIV/hepatitis C virus-co-infected adults
    Mark S Sulkowski
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    AIDS 21:2209-16. 2007
    ....
  4. pmc Incidence and risk factors for steatosis progression in adults coinfected with HIV and hepatitis C virus
    Tinsay A Woreta
    The Johns Hopkins Hospital University School of Medicine, Baltimore, Maryland 21287, USA
    Gastroenterology 140:809-17. 2011
    ..We prospectively examined the natural history of steatosis in patients coinfected with HIV and HCV who attended an urban HIV clinic...
  5. ncbi request reprint Progression of liver fibrosis among injection drug users with chronic hepatitis C
    Lucy E Wilson
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21231 1002, USA
    Hepatology 43:788-95. 2006
    ..In this setting with low fibrosis prevalence, FibroSURE, ALT, and APRI tests predict insignificant fibrosis; however, further work is needed to find noninvasive markers of significant liver fibrosis...
  6. pmc Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution
    Ashwin Balagopal
    Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    AIDS 23:2397-404. 2009
    ..Although hepatic macrophages (Kupffer cells) clear most microbial translocation products and can be infected by HIV, their fate in HIV progression has not been carefully investigated...
  7. pmc Vitamin D deficiency and its relation to bone mineral density and liver fibrosis in HIV-HCV coinfection
    Diala El-Maouche
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 18:237-42. 2013
    ..Fractures and cirrhosis are major causes of morbidity and mortality among HIV-HCV-coinfected individuals. It is not known whether vitamin D deficiency is associated with these outcomes...
  8. ncbi request reprint Liver enzyme flares and occult hepatitis B in persons with chronic hepatitis C infection
    Rajesh Kannangai
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Clin Virol 39:101-5. 2007
    ..Given that typical chronic HBV infections often have periodic flairs in viral replication and liver damage, we hypothesized that occult HBV may also have flares in viral replication that are associated with increased liver enzymes...
  9. doi request reprint Relationship of liver disease stage and antiviral therapy with liver-related events and death in adults coinfected with HIV/HCV
    Berkeley N Limketkai
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    JAMA 308:370-8. 2012
    ..Human immunodeficiency virus (HIV) accelerates hepatitis C virus (HCV) disease progression; however, the effect of liver disease stage and antiviral therapy on the risk of clinical outcomes is incompletely understood...
  10. pmc Limited uptake of hepatitis C treatment among injection drug users
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Community Health 33:126-33. 2008
    ..Low HCV treatment effectiveness was observed in this IDU population. Comprehensive integrated care strategies that incorporate education, case-management and peer support are needed to improve care and treatment of HCV-infected IDUs...
  11. pmc Changes in blood-borne infection risk among injection drug users
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Infect Dis 203:587-94. 2011
    ..Population-level hepatitis C virus (HCV) infection incidence is a surrogate for community drug-related risk...
  12. pmc Human immunodeficiency virus-related microbial translocation and progression of hepatitis C
    Ashwin Balagopal
    Division of Infectious Diseases, Viral Hepatitis Center, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Gastroenterology 135:226-33. 2008
    ..We hypothesized that HIV promotes liver disease by enhancing microbial translocation...
  13. pmc Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolution
    Xiao Hong Wang
    Viral Hepatitis Center, Div of Inf Dis, Department of Medicine, Johns Hopkins University School of Medicine, 1503 E Jefferson Street, Suite 114, Baltimore, MD 21231, USA, and Southwest Hospital, Chongqing, People s Republic of China
    J Virol 81:6513-22. 2007
    ..Thus, in a small but carefully matched cohort we found evidence for rapid neutral evolution of HCV in persons with rapid progression of hepatic fibrosis, suggesting higher turnover of infected cells...
  14. pmc Protective interleukin-28B genotype affects hepatitis C virus clearance, but does not contribute to HIV-1 control in a cohort of African-American elite controllers/suppressors
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    AIDS 25:385-7. 2011
    ..Thus, it appears that this SNP is not associated with the elite control of HIV-1 infection...
  15. pmc Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts
    Priya Duggal
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Intern Med 158:235-45. 2013
    ..Chinese translation..
  16. ncbi request reprint The effect of antiretroviral therapy on liver disease among adults with HIV and hepatitis C coinfection
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD 21205 0003, USA
    Hepatology 41:123-31. 2005
    ..Recognition of bridging fibrosis and cirrhosis in some but not most patients underscores the importance of identifying and treating liver disease in HIV/HCV coinfected persons...
  17. pmc Genetic protection against hepatitis B virus conferred by CCR5Delta32: Evidence that CCR5 contributes to viral persistence
    Chloe L Thio
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Virol 81:441-5. 2007
    ....
  18. ncbi request reprint Predictors of hepatitis C virus RNA levels in a prospective cohort study of drug users
    Dawn A Fishbein
    Department of Medicine, Mount Sinai School of Medicine, New, York, NY 10029, USA
    J Acquir Immune Defic Syndr 41:471-6. 2006
    ..The predictors of higher HCV RNA levels found in this longitudinal study are consistent with those of prior cross-sectional studies. Further studies are warranted to determine if treatment of alcohol use affects HCV RNA levels...
  19. ncbi request reprint Prospective evaluation of community-acquired acute-phase hepatitis C virus infection
    Andrea L Cox
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Infect Dis 40:951-8. 2005
    ....
  20. pmc Divergent and convergent evolution after a common-source outbreak of hepatitis C virus
    Stuart C Ray
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Exp Med 201:1753-9. 2005
    ..These data suggest that vaccines for genetically diverse viruses may be more effective if they represent consensus sequence, rather than a human isolate...
  21. pmc Controlled HIV viral replication, not liver disease severity associated with low bone mineral density in HIV/HCV co-infection
    Diala El-Maouche
    Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Hepatol 55:770-6. 2011
    ..To evaluate the prevalence and risk factors for low bone mineral density (BMD) in persons co-infected with HIV and Hepatitis C...
  22. ncbi request reprint CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection
    Dale M Netski
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, 21231, USA
    J Infect Dis 195:857-63. 2007
    ..These disease interactions may result in part from impairment of B cell function, which is CD4(+) T cell dependent...
  23. ncbi request reprint The association of hepatitis C prevalence, activity, and genotype with HIV infection in a cohort of New York City drug users
    Lynne Strasfeld
    Division of Infectious Diseases, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
    J Acquir Immune Defic Syndr 33:356-64. 2003
    ..However, a substantial degree of the person-to-person variability in the prevalence and level of detectable HCV RNA remains unexplained...
  24. ncbi request reprint The effect of HAART and HCV infection on the development of hyperglycemia among HIV-infected persons
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Acquir Immune Defic Syndr 33:577-84. 2003
    ..DESIGN Retrospective cohort analysis of 1230 persons on their first HAART regimen who had at least 1 random glucose measurement before and during antiretroviral therapy...
  25. pmc Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus
    Timothy L Mosbruger
    Johns Hopkins University, Baltimore, MD, USA
    J Infect Dis 201:1371-80. 2010
    ..In this large-scale analysis of 1426 genotyped SNPs in 112 candidate genes, we identified 4 gene regions that are likely candidates for a role in HCV clearance or persistence in both African Americans and European Americans...
  26. pmc Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B
    Chloe L Thio
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 181:7944-7. 2008
    ....
  27. ncbi request reprint High prevalence of occult hepatitis B in Baltimore injection drug users
    Michael Torbenson
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Hepatology 39:51-7. 2004
    ..20 years). In conclusion, although further research is needed to assess its clinical significance, there is a high prevalence of occult HBV infection in this cohort of HCV-infected injection drug users...
  28. ncbi request reprint Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavir
    Mark S Sulkowski
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    AIDS 18:2277-84. 2004
    ....
  29. pmc Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome
    Ann L Truelove
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA
    Int J Immunogenet 35:255-64. 2008
    ..01-0.04). These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis...
  30. pmc Assessment of liver fibrosis by transient elastography in persons with hepatitis C virus infection or HIV-hepatitis C virus coinfection
    Gregory D Kirk
    Department of Epidemiology, Schools of Public Health and Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Clin Infect Dis 48:963-72. 2009
    ..We compared elastography with histologic methods among hepatitis C virus (HCV)-infected and human immunodeficiency virus (HIV)-HCV-coinfected participants in an urban, predominantly black study population...
  31. pmc HIV, age, and the severity of hepatitis C virus-related liver disease: a cohort study
    Gregory D Kirk
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Ann Intern Med 158:658-66. 2013
    ..Persons with HIV infection have been reported to develop age-related diseases at younger ages than those without HIV. Whether this finding is related to HIV infection or failure to control for other risk factors is unknown...
  32. ncbi request reprint Hepatic steatosis and antiretroviral drug use among adults coinfected with HIV and hepatitis C virus
    Mark S Sulkowski
    Division of Infectious Diseases Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    AIDS 19:585-92. 2005
    ....
  33. pmc Hepatic steatosis associated with increased central body fat by dual-energy X-ray absorptiometry and uncontrolled HIV in HIV/hepatitis C co-infected persons
    Todd T Brown
    Johns Hopkins School of Medicine, USA
    AIDS 24:811-7. 2010
    ..To evaluate the relationship between regional body composition and liver disease (fibrosis or steatosis) in HIV/HCV co-infected individuals...
  34. pmc Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection
    William O Osburn
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Gastroenterology 138:315-24. 2010
    ..We followed patients with ongoing hepatitis C virus (HCV) exposure following control of an initial HCV infection to determine whether primary control conferred protection against future persistent infections...
  35. ncbi request reprint Hepatitis C and progression of HIV disease
    Mark S Sulkowski
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St, Room 448, Baltimore, MD 21287 0003, USA
    JAMA 288:199-206. 2002
    ..Conflicting reports exist regarding the effect of hepatitis C virus (HCV) on the progression of human immunodeficiency virus (HIV) disease...
  36. ncbi request reprint Protection against persistence of hepatitis C
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
    Lancet 359:1478-83. 2002
    ..However, HCV infection and vaccination in chimpanzees has been shown to reduce the magnitude and duration of viraemia with re-challenge. We aimed to establish whether similar immunity could be achieved in man...
  37. ncbi request reprint Serum albumin as a prognostic indicator for HIV disease progression
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 22:14-21. 2006
    ....
  38. pmc Stability of liver fibrosis among HCV-infected injection drug users
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Antivir Ther 17:813-21. 2012
    ....
  39. ncbi request reprint Needlestick transmission of hepatitis C
    Mark S Sulkowski
    Johns Hopkins School of Medicine, 424 N Bond St, Baltimore, MD 21231, USA
    JAMA 287:2406-13. 2002
    ..These data underscore the importance of identifying persons with acute HCV infection and promptly referring them to experienced clinicians who can provide updated counseling and treatment...
  40. pmc High plasma interleukin-18 levels mark the acute phase of hepatitis C virus infection
    Michael A Chattergoon
    Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 204:1730-40. 2011
    ..Large-scale genome studies have found correlations between single-nucleotide polymorphisms (SNPs) in the interleukin (IL) 18 promoter and spontaneous control of hepatitis C virus (HCV), suggesting a role in clearance...
  41. pmc Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection
    Chloe L Thio
    Department of Medicine, Johns Hopkins Medical Institutions, 1503 E Jefferson Street, Baltimore, MD 21231, USA
    J Virol 78:11258-62. 2004
    ..32, P = 0.04). These data suggest that CTLA4 influences recovery from HBV infection, which is consistent with the emerging role of T regulatory cells in the pathogenesis of disease...
  42. pmc Predictors and effects of alcohol use on liver function among young HCV-infected injection drug users in a behavioral intervention
    Lydia N Drumright
    University of California, San Diego, Department of Medicine, La Jolla, CA, USA
    J Hepatol 55:45-52. 2011
    ....
  43. pmc Factors affecting serum concentrations of hepatitis C virus (HCV) RNA in HCV genotype 1-infected patients with chronic hepatitis
    John R Ticehurst
    Johns Hopkins Bayview Medical Center Clinical Laboratories and Johns Hopkins Hospital Division of Medical Microbiology, Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Clin Microbiol 45:2426-33. 2007
    ..6% of the [HCV RNA](BL) differences between individuals (R(2) = 0.046 for 1,304 patients with HAI scores; 0.043 for all 2,472 patients)...
  44. pmc Spontaneous clearance of primary acute hepatitis C virus infection correlated with high initial viral RNA level and rapid HVR1 evolution
    Lin Liu
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Hepatology 55:1684-91. 2012
    ..This linkage of host genetics, viral dynamics, and evolution provides new directions for mechanistic studies. (HEPATOLOGY 2012;55:1684-1691)...
  45. pmc Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C-infected drug users
    Supriya Munshaw
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Hepatology 56:544-54. 2012
    ..CONCLUSION: Chronic HCV is associated with hepatocyte BCHE loss years before hepatic synthetic function is impaired. These results indicate that BCHE may be involved in the pathogenesis of HCV-related fibrosis among injection drug users...
  46. ncbi request reprint Options for treatment of hepatitis C in HIV-infected persons
    David L Thomas
    Johns Hopkins School of Medicine, 1503 East Jefferson Street, Baltimore, MD 21231, USA
    J Hepatol 44:S40-3. 2006
    ..Future research must focus both on improving outcomes with currently available medications and rapidly evaluating the safety and efficacy of forthcoming antiviral compounds in HIV/HCV coinfected persons...
  47. doi request reprint Detection of liver disease in injection drug users
    David L Thomas
    Department of Medicine, Johns Hopkins School of Medicine, 1503 East Jefferson Street, Baltimore, MD 21231, USA
    J Addict Dis 27:19-24. 2008
    ....
  48. doi request reprint Low frequency of GB virus C viremia in a cohort of HIV-1-infected elite suppressors
    Joel N Blankson
    Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    AIDS 22:2398-400. 2008
    ..Thus, GB virus C does not appear to explain the nonprogressive course seen in this cohort of elite suppressors...
  49. pmc Comprehensive genetic and epigenetic analysis of occult hepatitis B from liver tissue samples
    Perumal Vivekanandan
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Clin Infect Dis 46:1227-36. 2008
    ..Recently, it has been shown that HBV has CpG islands that are methylated, raising the possibility that epigenetic changes may also be important...
  50. ncbi request reprint A framework for understanding factors that affect access and utilization of treatment for hepatitis C virus infection among HCV-mono-infected and HIV/HCV-co-infected injection drug users
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
    AIDS 19:S179-89. 2005
    ....
  51. ncbi request reprint Humoral immune response in acute hepatitis C virus infection
    Dale M Netski
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Infect Dis 41:667-75. 2005
    ..We investigated the specificity, titer, and neutralizing potential of antibody responses to acute infection by examining 12 injection drug users before, during, and after infection...
  52. ncbi request reprint Changes in hepatitis B virus DNA levels with acute HIV infection
    Chloe L Thio
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 38:1024-9. 2004
    ..Acute HIV infection is not consistently associated with an increased blood HBV DNA level. Additional research is needed to understand the mechanism for the unexpected reductions in HBV DNA levels associated with acute HIV infection...
  53. ncbi request reprint Hepatitis C in the HIV-infected patient
    Mark S Sulkowski
    Viral Hepatitis Section, Division of Infectious Diseases, Johns Hopkins School of Medicine, Suite 102, 424 North Bond Street, Baltimore, MD 21231, USA
    Clin Liver Dis 7:179-94. 2003
    ..Future efforts should include prospective studies that demonstrate the natural history and optimal management of HIV/HCV-coinfected patients, including the feasibility of liver transplantation...
  54. pmc Hepatitis C virus (HCV) core antigen assay to detect ongoing HCV infection in thai injection drug users
    Dale M Netski
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland
    J Clin Microbiol 42:1631-6. 2004
    ..Reproducibility, low technical requirements, and high throughput should make this assay useful for clinical or research monitoring of HCV levels during active infection...
  55. pmc Mannose binding lectin genotypes influence recovery from hepatitis B virus infection
    Chloe L Thio
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Virol 79:9192-6. 2005
    ..76; 95% CI, 1.02 to 3.01; P = 0.04). These data are consistent with the hypothesis that functional MBL plays a central role in the pathogenesis of acute hepatitis B...
  56. pmc Cellular immune selection with hepatitis C virus persistence in humans
    Andrea L Cox
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Exp Med 201:1741-52. 2005
    ..015). These findings reveal two distinct mechanisms of sequence evolution involved in HCV persistence: viral escape from CD8+ T cell responses and optimization of replicative capacity...
  57. pmc Genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis C virus genotype 4 infection in an Egyptian cohort
    Fuat Kurbanov
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Infect Dis 204:1391-4. 2011
    ..3% vs 57.9%; P = .0006). Individuals with clearance were 3.4 (95% confidence interval, 1.8-6.5) times more likely to have C/C genotype. Thus, IL28B plays a role in spontaneous clearance of HCV genotype 4 in North Africa...
  58. pmc Exceeding the limits of liver histology markers
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 1830 E Monument St, Room 455 ID, Baltimore, MD 21287, USA
    J Hepatol 50:36-41. 2009
    ..We characterized the magnitude of the impact of error in the "gold standard" on the observed diagnostic accuracy of surrogate markers...
  59. pmc Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    David L Thomas
    Johns Hopkins University, Division of Infectious Diseases, Baltimore, Maryland 21205, USA
    Nature 461:798-801. 2009
    ..To our knowledge, this is the strongest and most significant genetic effect associated with natural clearance of HCV, and these results implicate a primary role for IL28B in resolution of HCV infection...
  60. pmc CD4+ T cell depletion in an untreated HIV type 1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load
    Adriana Andrade
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Infect Dis 46:e78-82. 2008
    ..Our data suggest that immune activation can cause CD4(+) T cell depletion even when HIV-1 replication appears to be controlled by host factors...
  61. ncbi request reprint Advances in the treatment of hepatitis C virus infection
    David L Thomas
    The Johns Hopkins University, Baltimore, MD, USA
    Top Antivir Med 20:5-10. 2012
    ..This article summarizes a presentation by David L. Thomas, MD, MPH, at the IAS-USA live continuing medical education course held in New York City in October 2011...
  62. pmc IL28B and the control of hepatitis C virus infection
    Ashwin Balagopal
    Division of Infectious Diseases, Center for Viral Hepatitis, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Gastroenterology 139:1865-76. 2010
    ..We review the genetic studies that uncovered the association between IL28B and HCV clearance, the biology of IFN-λ3, the clinical implications of the genetic association, and areas of future research...
  63. ncbi request reprint HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
    Chloe L Thio
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lancet 360:1921-6. 2002
    ..Our aim was to examine liver-related mortality among people at risk for HIV-1 and HBV infections...
  64. pmc Discordance between CD4+ T-lymphocyte counts and percentages in HIV-infected persons with liver fibrosis
    Cassidy W Claassen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Clin Infect Dis 54:1806-13. 2012
    ..We investigated whether earlier stages of liver fibrosis prior to cirrhosis were associated with discordance between CD4 count (CD4N) and CD4 percentage (CD4%) in HIV-infected patients...
  65. ncbi request reprint Epidemiology and natural history of hepatitis C virus infection in injection drug users: implications for treatment
    Mark S Sulkowski
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Infect Dis 40:S263-9. 2005
    ..Solutions to the problem of HCV infection among IDUs must account for these facts...
  66. pmc Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C
    Andrea L Cox
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hepatology 42:104-12. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...