C M Croce

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi A passion for discovery
    Carlo M Croce
    Kimmell Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Biol Ther 2:719-20. 2003
  2. ncbi The role of TCL1 in human T-cell leukemia
    Y Pekarsky
    Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street Philadelphia, Pennsylvania, PA 19107, USA
    Oncogene 20:5638-43. 2001
  3. ncbi Fez1/lzts1 alterations in gastric carcinoma
    A Vecchione
    Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 7:1546-52. 2001
  4. ncbi Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells
    H Ishii
    Kimmel Cancer Institute, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 61:1578-84. 2001
  5. pmc The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors
    H Ishii
    Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 96:3928-33. 1999
  6. pmc FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis
    H Ishii
    Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107 5799, USA
    Proc Natl Acad Sci U S A 98:10374-9. 2001
  7. ncbi Influence of a nonfragile FHIT transgene on murine tumor susceptibility
    K A McCorkell
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cytogenet Genome Res 118:196-203. 2007
  8. ncbi Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product
    S Numata
    Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 59:3741-7. 1999
  9. pmc Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant
    M Ottey
    Department of Microbiology Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, USA
    Br J Cancer 91:1669-77. 2004
  10. ncbi Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax
    R Prasad
    Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Oncogene 15:549-60. 1997

Collaborators

Detail Information

Publications89

  1. ncbi A passion for discovery
    Carlo M Croce
    Kimmell Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Biol Ther 2:719-20. 2003
  2. ncbi The role of TCL1 in human T-cell leukemia
    Y Pekarsky
    Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street Philadelphia, Pennsylvania, PA 19107, USA
    Oncogene 20:5638-43. 2001
    ....
  3. ncbi Fez1/lzts1 alterations in gastric carcinoma
    A Vecchione
    Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 7:1546-52. 2001
    ..CONCLUSIONS: Our findings support FEZ1/LZTS1 as a candidate tumor suppressor gene at 8p in a subtype of gastric cancer and suggest that its inactivation is attributable to several factors including genomic deletion and methylation...
  4. ncbi Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells
    H Ishii
    Kimmel Cancer Institute, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 61:1578-84. 2001
    ..Thus, adenoviral-FHIT expression can inhibit the growth of esophageal cancer cells, at least in part through caspase-dependent apoptosis, suggesting that adenoviral-FHIT infection should be explored as a therapeutic strategy...
  5. pmc The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors
    H Ishii
    Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 96:3928-33. 1999
    ..Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors...
  6. pmc FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis
    H Ishii
    Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107 5799, USA
    Proc Natl Acad Sci U S A 98:10374-9. 2001
    ..Present data show that FEZ1/LZTS1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth...
  7. ncbi Influence of a nonfragile FHIT transgene on murine tumor susceptibility
    K A McCorkell
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cytogenet Genome Res 118:196-203. 2007
    ..It is likely that the FHIT transgene is more tightly silenced in female transgenic mice, leading to a lack of protection from tumor induction...
  8. ncbi Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product
    S Numata
    Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 59:3741-7. 1999
    ..It also binds to the MAR of the immunoglobulin heavy-chain locus. Thus Bdp may contribute to the transcriptional regulation of genes involved in differentiation and tissue-specific expression...
  9. pmc Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant
    M Ottey
    Department of Microbiology Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, USA
    Br J Cancer 91:1669-77. 2004
    ..UVC surviving Fhit -/- cells appear transformed and exhibit >5-fold increased mutation frequency. This increased mutation burden could explain the susceptibility of Fhit-deficient cells in vivo to malignant transformation...
  10. ncbi Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax
    R Prasad
    Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Oncogene 15:549-60. 1997
    ..Based on similarities in structure and expression pattern, ALR is likely to play a similar role to ALL-1 and trx, although its target genes have yet to be identified...
  11. ncbi Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer
    K R Dumon
    Kimmel Cancer Center, Thomas Jefferson University, Department of Surgery, Hospital of the University of Pennsylvania, Gene Therapy Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 61:4827-36. 2001
    ..In vivo results show that FHIT gene transfer delays tumor growth and prolongs survival in a murine model mimicking human disease...
  12. ncbi Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2
    C Tatarelli
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Genomics 68:1-12. 2000
    ..Analysis of the TESTIN coding region in 26 tumor cell lines revealed three missense mutations. Our findings suggest that TESTIN may represent a candidate tumor suppressor gene at 7q31.2...
  13. pmc The tumor spectrum in FHIT-deficient mice
    N Zanesi
    Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 98:10250-5. 2001
    ..76 tumor/mouse). The similar spontaneous and induced tumor spectra observed in mice with one or both Fhit alleles inactivated suggests that Fhit may be a one-hit tumor suppressor gene in some tissues...
  14. pmc Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene
    H Arakawa
    Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 95:4573-8. 1998
    ..The results are also consistent with the suggestion that ALL1 chimeric proteins resulting from 11q23 abnormalities act in a dominant negative fashion...
  15. ncbi A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2
    Y Murakumo
    Genetics and Molecular Biology Program, Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 275:4391-7. 2000
    ..While overexpression of hREV7 does not lead to cell cycle arrest, we entertain the possibility that it may act as an adapter between DNA repair and the spindle assembly checkpoint...
  16. ncbi Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene
    S Petruk
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Science 294:1331-4. 2001
    ..Thus Trx, dCBP, and Sbf1 are closely linked, physically and functionally, in the maintenance of Hox gene expression...
  17. ncbi FRA3B and other common fragile sites: the weakest links
    K Huebner
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Nat Rev Cancer 1:214-21. 2001
    ..Inactivation of only one FHIT allele compromises this suppressor function, indicating that a 'one-hit' mechanism of tumorigenesis is operative. Are genes disrupted at other fragile sites? And, are these genes also tumour suppressors?..
  18. ncbi Structure and expression of the human FHIT gene in normal and tumor cells
    T Druck
    Department of Microbiology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 57:504-12. 1997
    ..Most of the cell lines that exhibited genomic alterations showed alteration of FHIT transcripts and absence or diminution of Fhit protein...
  19. ncbi Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene
    F Bullrich
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 61:6640-8. 2001
    ..This feature of the sequence may favor the occurrence of chromosomal rearrangements and may confer instability to the region, resulting in deletions that may inactivate an as yet unidentified tumor suppressor...
  20. pmc Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans
    Y Pekarsky
    Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 95:8744-9. 1998
    ....
  21. ncbi The role of the FHIT/FRA3B locus in cancer
    K Huebner
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennslvania 19107, USA
    Annu Rev Genet 32:7-31. 1998
    ..FRA3B thus fulfills the prophecy that fragile site alterations contribute to the neoplastic process through inactivation of a tumor suppressor gene...
  22. ncbi Molecular basis of mature T-cell leukemia
    Y Pekarsky
    Kimmel Cancer Center, 233 S 10th St, BLSB Room 1050, Philadelphia, PA 19107, USA
    JAMA 286:2308-14. 2001
    ..The available data provide important insights into the molecular mechanisms of T-cell leukemogenesis that may lead to the development of new drugs for treatment of mature T-cell leukemia...
  23. pmc FHIT gene therapy prevents tumor development in Fhit-deficient mice
    K R Dumon
    Kimmel Cancer Center, Jefferson Medical College, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 98:3346-51. 2001
    ..We therefore suggest that FHIT gene therapy could be a novel clinical approach not only in treatment of early stages of cancer, but also in prevention of human cancer...
  24. ncbi FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis
    S M Srinivasula
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 272:18542-5. 1997
    ..These findings identify a novel endogenous control point that regulates Fas/TNFR1-mediated apoptosis...
  25. ncbi Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines
    K Kastury
    Jefferson Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107 6799, USA
    Cancer Res 56:978-83. 1996
    ..Thus, it is likely that the homozygous deletion observed in these cancer cell lines harbors an important tumor suppressor gene for several tumor types...
  26. pmc huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions
    T Nakamura
    Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 97:7284-9. 2000
    ..The significance of huASH1 dual location is discussed. In particular, we consider the possibility that translocation of the protein between the junctional membrane and the nucleus may be involved in adhesion-mediated signaling...
  27. pmc Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes
    Y Pekarsky
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 96:2949-51. 1999
    ..1 region. Thus, translocations and inversions at 14q32. 1 in T cell malignancies involve two oncogenes...
  28. pmc Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes
    C Hallas
    Kimmel Cancer Institute, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 96:14418-23. 1999
    ..These data suggest a similar or complementary function of these proteins in early embryogenesis...
  29. ncbi Purification and characterization of recombinant forms of murine Tcl1 proteins
    G C Du Bois
    Department of Microbiology, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA
    Protein Expr Purif 18:277-85. 2000
    ..Initial results indicate that the mutant murine Tcl1 C86A protein is suitable for both NMR and X-ray crystallographic methods of structure determination...
  30. ncbi Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers
    H C Pace
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Biol 10:907-17. 2000
    ....
  31. ncbi The murine Fhit locus: isolation, characterization, and expression in normal and tumor cells
    Y Pekarsky
    Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 58:3401-8. 1998
    ..Several tumorigenic mouse cell lines exhibited homozygous deletions of Fhit exons. We conclude that the murine Fhit gene, like its human counterpart, is a target of alterations involved in murine carcinogenesis...
  32. ncbi Potential cancer therapy with the fragile histidine triad gene: review of the preclinical studies
    H Ishii
    Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th St, Philadelphia, PA 19107-5799, USA
    JAMA 286:2441-9. 2001
    ....
  33. ncbi Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 11q23
    C Monaco
    Kimmel Cancer Institute, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Genomics 46:217-22. 1997
    ..However, a role for these amino acid changes in the tumorigenic process could not established...
  34. pmc Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit
    T Shiraishi
    Kimmel Cancer Center, Jefferson Medical College, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 98:5722-7. 2001
    ..Thus, comparison of orthologous fragile regions has identified highly conserved sequences with possible functional roles in maintenance of fragility...
  35. pmc Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia
    R Prasad
    Jefferson Cancer Institute, Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107
    Proc Natl Acad Sci U S A 91:8107-11. 1994
    ..In this model, the partner polypeptide plays an accessory role either by repressing activity of the truncated ALL-1 protein or by blocking the function of the normal protein presumably present in the leukemic cells...
  36. pmc Muir-Torre-like syndrome in Fhit-deficient mice
    L Y Fong
    Department of Microbiology and Immunology, Christiana Care Health Systems, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 97:4742-7. 2000
    ..The visceral and sebaceous tumors, which lacked Fhit protein, were similar to those characteristic of Muir-Torre familial cancer syndrome...
  37. pmc Deregulated expression of TCL1 causes T cell leukemia in mice
    L Virgilio
    Kimmel Cancer Institute and Department of Microbiology Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 95:3885-9. 1998
    ....
  38. ncbi Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia
    Y Gu
    Jefferson Cancer Institute, Jefferson Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Cancer Res 54:2327-30. 1994
    ..We conclude that while there is no specific sequence element present at all the breakpoints, the high density of Alu sequences in the breakpoint cluster region possibly makes the latter more prone to recombination events...
  39. ncbi The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
    M Ohta
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Cell 84:587-97. 1996
    ..Aberrant transcripts of the FHIT locus were found in approximately 50% of esophageal, stomach, and colon carcinomas...
  40. ncbi The FHIT gene 3p14.2 is abnormal in lung cancer
    G Sozzi
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cell 85:17-26. 1996
    ..Small cell lung cancer tumors and cell lines were analyzed by Southern blotting and showed rearranged BamHI fragments. These data suggest a critical role of the FHIT gene in lung carcinogenesis...
  41. pmc Ectopic TAL-1/SCL expression in phenotypically normal or leukemic myeloid precursors: proliferative and antiapoptotic effects coupled with a differentiation blockade
    G L Condorelli
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541, USA
    Mol Cell Biol 17:2954-69. 1997
    ..e., requirement for the integrity of the tal-1 bHLH domain and cell cycle checkpoints in the host cell, particularly p53), and (iii) provide new experimental models to further investigate these mechanisms...
  42. ncbi Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors
    D Rasio
    Kimmel Cancer Institute and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 57:2378-83. 1997
    ..We have examined the hRAD54 gene in several breast tumors and breast tumor cell lines and, although the gene region appears to be deleted in several tumors, at present we have found no coding sequence mutations...
  43. ncbi ATM mutations in B-cell chronic lymphocytic leukemia
    F Bullrich
    Kimmel Cancer Institute and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 59:24-7. 1999
    ..We show that the ATM gene is mutated in a fraction of B-CLLs and that mutations can be present in the germ line of patients, suggesting that ATM heterozygotes may be predisposed to B-CLL...
  44. pmc Loss of FHIT expression in transitional cell carcinoma of the urinary bladder
    R Baffa
    Department of Urology, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Pathol 156:419-24. 2000
    ..These results suggested that loss of Fhit expression may be as important in the development of bladder cancer as it is for other neoplasms caused by environmental carcinogens...
  45. pmc Identification of the TCL1 gene involved in T-cell malignancies
    L Virgilio
    Jefferson Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107
    Proc Natl Acad Sci U S A 91:12530-4. 1994
    ..The TCL1 gene sequence, which, to our knowledge, shows no sequence homology with other human genes, is preferentially expressed early in T- and B-lymphocyte differentiation...
  46. pmc Akt phosphorylates and regulates the orphan nuclear receptor Nur77
    Y Pekarsky
    Kimmel Cancer Institute, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 98:3690-4. 2001
    ....
  47. ncbi Characterization and localization of the TCL-1 oncogene product
    T B Fu
    Jefferson Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107
    Cancer Res 54:6297-301. 1994
    ..Thus, TCL-1 may represent a member of a novel family of genes involved in lymphoid proliferation and/or survival and in T cell malignancies...
  48. ncbi Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia
    H Mabuchi
    Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 61:2870-7. 2001
    ....
  49. pmc The human homologue of the retroviral oncogene qin maps to chromosome 14q13
    K Kastury
    Jefferson Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107
    Proc Natl Acad Sci U S A 91:3616-8. 1994
    ..2-->14q32, between the TCR and IGH loci. Further analysis by fluorescence in situ hybridization techniques with a human QIN genomic clone refined the human QIN gene localization to 14q13...
  50. pmc Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies
    Z Q Fu
    Kimmel Cancer Center and Department of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 95:3413-8. 1998
    ..The structural similarity suggests that MTCP-1 and TCL-1 form a unique family of beta barrel proteins that is predicted to bind small hydrophobic ligands and function in cell regulation...
  51. ncbi Common fragile genes
    A Matsuyama
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Eur J Histochem 48:29-36. 2004
    ..The common features of these two common fragile genes are summarized, and suggest clues to understanding the relation between genomic instability and tumor biology...
  52. pmc Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function
    G Condorelli
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107 5541, USA
    Proc Natl Acad Sci U S A 98:9977-82. 2001
    ..We also implicate Caspase3 in determining myocardial infarct size after ischemia-reperfusion injury, because its cardiomyocyte-specific overexpression increases infarct size...
  53. ncbi Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3
    F Bullrich
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA
    Genomics 36:362-5. 1996
    ..Here we report the chromosomal mapping of CPP32 to 4q34, MCH2 to 4q25, and MCH3 to 10q25...
  54. ncbi T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice
    G L Condorelli
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 56:5113-9. 1996
    ..These data indicate that TAL-1, expressed in T cells, is per se a potent oncogene, which may exert a key leukemogenetic role in the majority of T-cell acute lymphoblastic leukemias...
  55. ncbi hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis
    T Bocker
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University and Medical College, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 59:816-22. 1999
    ..hMSH5 interacts specifically with hMSH4, confirming the generality of functional heterodimeric interactions in the eukaryotic MutS homologue, which also includes hMSH2-hMSH3 and hMSH2-hMSH6...
  56. ncbi Definition and refinement of chromosome 8p regions of loss of heterozygosity in gastric cancer
    R Baffa
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 6:1372-7. 2000
    ..Initial steps were taken toward the identification of this gene, which is likely to play an important role in the pathogenesis of gastric cancer and of other tumors as well...
  57. ncbi Cervical dysplasia, ploidy, and human papillomavirus status correlate with loss of Fhit expression
    A Vecchione
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 7:1306-12. 2001
    ....
  58. pmc Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit
    H C Pace
    Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 95:5484-9. 1998
    ....
  59. pmc Cancer and the FRA3B/FHIT fragile locus: it's a HIT
    K Huebner
    Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107, USA
    Br J Cancer 88:1501-6. 2003
    ....
  60. ncbi Chromosomal localization of four human zinc finger cDNAs
    K Huebner
    Jefferson Cancer Institute, Thomas Jefferson Medical College, Philadelphia, PA 19107
    Hum Genet 91:217-22. 1993
    ....
  61. ncbi Purification and characterization of recombinant forms of TCL-1 and MTCP-1 proteins
    G C Du Bois
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Protein Expr Purif 12:215-25. 1998
    ..Initial results have indicated that the MTCP-1 protein with the His tag removed is suitable for both NMR and X-ray crystallographic methods of structure determination...
  62. ncbi Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations
    G Cimino
    Jefferson Cancer Institute, Jefferson Cancer Center, Philadelphia, Pennsylvania
    Cancer Res 51:6712-4. 1991
    ..The breakpoints cluster in a small DNA region of less than 5.8 kilobases...
  63. pmc Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient
    G Russo
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140
    Proc Natl Acad Sci U S A 86:602-6. 1989
    ..Comigration of high-molecular weight DNA fragments involved with t(7;14) and t(14;14) translocations suggests the presence of a cluster of breakpoints in the 14q32.1 region, the site of a putative oncogene, TCL1...
  64. ncbi A novel zinc finger gene is fused to EWS in small round cell tumor
    T Mastrangelo
    Istituto Nazionale Tumori, Milano, Italy
    Oncogene 19:3799-804. 2000
    ..A rearrangement of the second ZSG allele was also found in tumor cells. This is the first example of an intra-chromosomal rearrangement of chromosome 22, undetectable by cytogenetics, activating EWS in soft tissue sarcoma...
  65. ncbi Expression of TCL1 in hematologic disorders
    J Roos
    Institute of Pathology, University of Berne, Berne, Switzerland
    Pathobiology 69:59-66. 2001
    ..CONCLUSIONS: We propose that TCL1 expression especially in high-grade B cell non-Hodgkin's lymphomas might interfere with B cell differentiation and promote the transition from low- to high-grade lymphoma...
  66. ncbi elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints
    V N Rao
    Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
    Science 244:66-70. 1989
    ..This suggests the possibility that rearrangements of elk loci may be involved in pathogenesis of certain tumors...
  67. ncbi Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins
    T Rozovskaia
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Oncogene 19:351-7. 2000
    ..SET-SET interactions might act in integrating the activity of ALL-1 (TRX and ASH1) protein molecules, simultaneously positioned at different maintenance elements and directing expression of the same or different target genes...
  68. pmc Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements
    T Rozovskaia
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 100:7853-8. 2003
    ..The extensive analysis described here pinpointed genes that might have a direct role in pathogenesis...
  69. ncbi The gene that encodes the human CD20 (B1) differentiation antigen is located on chromosome 11 near the t(11;14)(q13;q32) translocation site
    T F Tedder
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 142:2555-9. 1989
    ..These results raise the possibility that alterations in the expression of the CD20 gene may result after the t(11;14) chromosomal alteration...
  70. pmc ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia
    E Canaani
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel 76100
    Br J Cancer 90:756-60. 2004
    ..Here, we describe the unique features of ALL-1-associated leukaemias, and recent progress in understanding molecular mechanisms involved in the activity of the ALL-1 protein and of its Drosophila homologue TRITHORAX...
  71. ncbi Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers
    E Donti
    Istituto di Clinica Medica I, Policlinico Monteluce, Universita di Perugia, Italy
    Hum Genet 84:391-5. 1990
    ..By in situ hybridization experiments and analysis of interspecific somatic cell hybrids we mapped the HF.10 gene to 3p21-22, a chromosome region frequently involved in karyotypic rearrangements associated with lung and renal cancer...
  72. pmc Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice
    T Fujishita
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Br J Cancer 91:1571-4. 2004
    ..These results suggest that Fhit plays important roles in systemic tumour suppression and in the integrity of mucosal structure of the intestines...
  73. pmc Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering
    K Huebner
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140
    Am J Hum Genet 48:726-40. 1991
    ..In addition, Kox genes at 8q24, 17p13, and 22q11--and perhaps other Kox genes--are located near recurrent chromosomal translocation breakpoints. Others, such as those on 7p and 7q, may be near regions specifically active in T cells...
  74. ncbi Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential
    S Semba
    Comprehensive Cancer Center and Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, 43210, USA
    Oncogene 25:2860-72. 2006
    ..The results indicate that the Fhit Y114 residue plays a critical role in Fhit-induced apoptosis, occurring through inactivation of the PI3K-Akt-survivin signal pathway...
  75. pmc The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex
    O Rozenblatt-Rosen
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 95:4152-7. 1998
    ....
  76. ncbi Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family
    J M Petock
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Acta Crystallogr D Biol Crystallogr 57:1545-51. 2001
    ..7 A for Mtcp1, despite the low 12-13% sequence identity. The molecular surfaces of all three structures showed a common planar region which is likely to be involved in protein-protein interactions...
  77. ncbi Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality
    T Rozovskaia
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Oncogene 20:874-8. 2001
    ..The present work suggests that upregulation of Meis1, HoxA9, and possibly HoxA10 might also play a role in pathogenesis of acute lymphocytic and acute myeloid leukemias associated with ALL-1 fusions...
  78. ncbi The murine Tcl1 oncogene: embryonic and lymphoid cell expression
    M G Narducci
    Istituto Dermopatico dell Immacolata IRCCS, Rome
    Oncogene 15:919-26. 1997
    ..Characterization of the murine Tcl1 gene will help in developing a mouse model of CLL and would provide the best opportunity to study and decipher the role of TCL1 in malignant transformation...
  79. ncbi Exon structure and promoter identification of STIM1 (alias GOK), a human gene causing growth arrest of the human tumor cell lines G401 and RD
    S Sabbioni
    Department of Experimental Medicine, Section of Microbiology, and Interdepartmental Center for Biotechnology, University of Ferrara, Ferrara, Italy
    Cytogenet Cell Genet 86:214-8. 1999
    ....
  80. ncbi The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
    Y Gu
    Jefferson Cancer Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Cell 71:701-8. 1992
    ..This suggests that each 11q23 abnormality gives rise to a specific oncogenic fusion protein...
  81. pmc Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway
    G Baldassarre
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 98:7970-5. 2001
    ..Therefore, the HMGI-C/T-mediated chronic stimulation of the IL-2/IL-15 pathway could be responsible for the onset of NK-T/NK cell lymphomas in HMGI-C/T TG mice...
  82. ncbi ATM mutations in cancer families
    I Vorechovsky
    Karolinska Institute, Department of Bioscience NOVUM, Huddinge, Sweden
    Cancer Res 56:4130-3. 1996
    ..Although the proportion of A-T carriers in this sample seems to be higher than expected by chance, larger studies and pooled data sets will be required to establish that an A-T allele confers cancer susceptibility in heterozygotes...
  83. ncbi Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase
    L D Barnes
    Department of Biochemistry, University of Texas Health Science Center, San Antonio 78284 7760, USA
    Biochemistry 35:11529-35. 1996
    ..Also, Fhit is the first HIT protein in which the histidine residues have been demonstrated by mutagenesis to be critical for function...
  84. pmc A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts
    L Vitelli
    Department of Hematology Oncology, Istituto Superiore di Sanita, 00161 Rome, Italy
    Mol Cell Biol 20:5330-42. 2000
    ..These data indicate that this pentameric complex assembled in maturing erythroblasts plays an important regulatory role in c-kit downmodulation; hypothetically, the complex may regulate the expression of other critical erythroid genes...
  85. ncbi Fragile histidine triad gene and skin cancer
    N Zanesi
    Kimmel Cancer Center, Thomas Jefferson University-BLSB, 1050, 233 South 10th Street, Philadelphia, PA 19107, USA
    Eur J Dermatol 11:401-4. 2001
    ..Because cancer cells lacking in FHIT are defective in apoptosis, we propose the Fhit-deficient mouse as a model to understand a possible proapoptotic mechanism deficiency in the human syndrome...
  86. pmc Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases
    Q Ma
    Jefferson Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107 5541
    Proc Natl Acad Sci U S A 90:6350-4. 1993
    ..Finally, we report that All-1 resides in the proximal portion of mouse chromosome 9 and is a candidate for a mutation that results in skeletal transformations during embryonic development...
  87. ncbi Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias
    J Erikson
    Science 229:784-6. 1985
    ..2...
  88. pmc Trithorax and ASH1 interact directly and associate with the trithorax group-responsive bxd region of the Ultrabithorax promoter
    T Rozovskaia
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Cell Biol 19:6441-7. 1999
    ..Collectively, these results suggest that TRX and ASH1 are components that interact either within trxG protein complexes or between complexes that act in close proximity on regulatory DNA to maintain Ubx transcription...
  89. ncbi Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma
    M Negrini
    Cell 49:455-63. 1987
    ..Expression is tissue-specific in adult tissues: spleen and thymus express the highest level of mbcl-2 transcripts. The mbcl-2 gene maps to mouse chromosome 1...