Research Topics
Genomes and Genes | Inna ChervonevaSummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Publications
Relative quantification based on logistic models for individual polymerase chain reactionsInna Chervoneva
Division of Biostatistics, Department of Clinical Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
Stat Med 26:5596-611. 2007..Real kinetic RT-PCR data are used to compare the proposed and standard methods. The methods are applied to the clinical data from the ongoing study of guanylyl cyclase C as a biomarker for colorectal cancer...- Statistical algorithm for assuring similar efficiency in standards and samples for absolute quantification by real-time reverse transcription polymerase chain reactionInna Chervoneva
Division of Biostatistics, Thomas Jefferson University, Philadelphia, PA 19107, USA
Anal Biochem 348:198-208. 2006..These studies demonstrate that elimination of kinetic outliers from calibration standards and test samples improves the accuracy of absolute transcript quantification by RT-PCR... 
Increased SIAH expression predicts ductal carcinoma in situ (DCIS) progression to invasive carcinomaKathryn C Behling
Department of Pathology, Thomas Jefferson University and Kimmel Cancer Center, Philadelphia, PA 19107, USA
Breast Cancer Res Treat 129:717-24. 2011..23, P = 0.067). In conclusion, SIAH may represent a useful prognostic biomarker that predicts DCIS progression to invasive breast cancer...
Selection of optimal reference genes for normalization in quantitative RT-PCRInna Chervoneva
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
BMC Bioinformatics 11:253. 2010..Current methods of selecting reference genes make an assumption of independence in their innate variation. This assumption is not always justified, which may lead to selecting a suboptimal set of reference genes...- The influence of prognostic factors and adjuvant chemoradiation on survival after pancreaticoduodenectomy for ampullary carcinomaTimothy N Showalter
Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USA
J Gastrointest Surg 15:1411-6. 2011..Decisions regarding adjuvant therapy are influenced by factors such as nodal status, stage, and grade, but the influence of these individual variables on survival is unclear... - Constrained S-estimators for linear mixed effects models with covariance componentsInna Chervoneva
Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA
Stat Med 30:1735-50. 2011..The proposed methodology is applied to jointly analyze repeated measures on three cholesterol components, HDL, LDL, and triglycerides... - Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestinePeng Li
Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1100 Walnut St MOB 810, Philadelphia, PA 19107, USA
Am J Pathol 171:1847-58. 2007..In the context of uniform loss of GC-C signaling during tumorigenesis, dysregulation of those homeostatic processes may contribute to mechanisms underlying colon cancer... - Effects of antiepileptic drugs on lipids, homocysteine, and C-reactive proteinScott Mintzer
Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Ann Neurol 65:448-56. 2009..We sought to determine whether these drugs have an effect on cholesterol and other serological markers of vascular risk... - The effectiveness of low-frequency stimulation for mapping cortical functionAndro Zangaladze
Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Epilepsia 49:481-7. 2008..To establish the efficacy and safety of low-frequency electrical stimulation for cortical brain mapping... - Clinical need for continuous glucose monitoring in the hospitalJeffrey I Joseph
The Artificial Pancreas Center, Department of Anesthesiology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Diabetes Sci Technol 3:1309-18. 2009..Numerous available and up-and-coming technologies are targeted for the hospital patient population. Advantages and limitations of these devices are discussed herewith in... - Non-enzymatic glycation of type I collagen diminishes collagen-proteoglycan binding and weakens cell adhesionKristin L Reigle
Department of Medicine, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5099, USA
J Cell Biochem 104:1684-98. 2008..Therefore in vivo, collagen glycation may weaken PG-collagen interactions, thereby disrupting matrix integrity and cell-collagen interactions, adhesion, and migration... - Overexpression of matrix metalloproteinase 9 in tumor epithelial cells correlates with colorectal cancer metastasisDavid S Zuzga
Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Clin Transl Sci 1:136-41. 2008..Thus, cancer cell MMP-9 represents a novel, selective prognostic and predictive factor that may be exploited for more effective disease stage stratification and therapeutic regimen selection in patients with colorectal cancer... - Prognostic significance of lymph node metastases and ratio in esophageal cancerMatthew Wilson
Department of Surgery, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Surg Res 146:11-5. 2008..The incidence of carcinoma of the distal esophagus and GE junction is rapidly increasing. A large single-center experience was reviewed to determine the impact of lymph node positivity and ratio on survival... - A general approach for two-stage analysis of multilevel clustered non-Gaussian dataInna Chervoneva
Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Biometrics 62:752-9. 2006.... - Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cellsPhilip R Debruyne
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Gastroenterology 130:1191-206. 2006..The present studies examine the expression of GC-C in normal tissues and tumors from esophagus and stomach and mechanisms regulating its expression by acid and bile acids... - A multivariate test for population bioequivalenceInna Chervoneva
Department of Pharmacology and Experimental Therapeutics, Division of Biostatistics, Thomas Jefferson University, Philadelphia, PA 19107, U S A
Stat Med 26:1208-23. 2007..The proposed methodology is illustrated with an example of testing equivalence of the spray pattern of nasal sprays... - Prognostic markers and long-term outcomes in ductal carcinoma in situ of the breast treated with excision alonePhoebe Holmes
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
Cancer 117:3650-7. 2011..We analyzed the significance of biological markers and tumor characteristics in predicting recurrence in a large series of DCIS patients with long-term follow-up treated with breast conservation surgery (BCS) alone... - Tumor-derived interleukin-10 as a prognostic factor in stage III patients undergoing adjuvant treatment with an autologous melanoma cell vaccineAmit Mahipal
Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA
Cancer Immunol Immunother 60:1039-45. 2011.... - Latency to first seizure after temporal lobectomy predicts long-term outcomeSarah E Buckingham
Jefferson Medical College, Philadelphia, Pennsylvania, USA
Epilepsia 51:1987-93. 2010..Little is known about the prognostic significance of the time from surgery to first seizure relapse in predicting long-term outcome... - Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrenceAgnieszka K Witkiewicz
Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA
Cancer Biol Ther 10:391-6. 2010..Thus, stromal CD10 and SPARC expression levels are promising markers of DCIS recurrence and warrant evaluation in larger prospective studies... - Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon developmentGuiyun Zhang
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Cell Biochem 98:1436-49. 2006..Our findings indicate that decorin is a key regulatory molecule and that the temporal switch from biglycan to decorin is an important event in the coordinate regulation of fibrillogenesis and tendon development... - Importance of margin extent as a predictor of outcome after adjuvant radiotherapy for Gleason score 7 pT3N0 prostate cancerRichard K Valicenti
Department of Radiation Oncology, Jefferson Medical College and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Int J Radiat Oncol Biol Phys 58:1093-7. 2004.... - Prostate-specific antigen and insulin-like growth factor binding protein-3 in nipple aspirate fluid are associated with breast cancerEdward R Sauter
Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cancer Detect Prev 26:149-57. 2002..001). When considered jointly, only NAF PSA was significant. Therefore, NAF PSA, and to a lesser extent NAF IGFBP-3 and serum PSA, seem to be important predictors of breast cancer... - Circulating testosterone and prostate-specific antigen in nipple aspirate fluid and tissue are associated with breast cancerEdward R Sauter
Department of Surgery, Thomas Jefferson University Hospital, 1025 Walnut Street, Suite 605, Philadelphia, PA 19107, USA
Environ Health Perspect 110:241-6. 2002..NAF and serum PSA levels in postmenopausal women are correlated, suggesting that as laboratory assessment of PSA becomes more sensitive, serum PSA may become useful in identifying women with breast cancer... - The prognostic significance of multiple morphologic features and biologic markers in ductal carcinoma in situ of the breast: a study of a large cohort of patients treated with surgery aloneDennis B Cornfield
Department of Pathology, Health Network Laboratories Lehigh Valley Hospital, Allentown, Pennsylvania 18103, USA
Cancer 100:2317-27. 2004..To the authors' knowledge, very little is known regarding the prognostic significance of the many biologic markers that have been studied in DCIS in the past decade...