Affiliation: Thomas Jefferson University
- A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicityHui Cheng
Center for Translational Medicine, The Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Circ Res 109:1401-9. 2011..Sorafenib is a KI of concern because it inhibits growth factor receptors and Raf-1/B-Raf, kinases that are upstream of extracellular signal-regulated kinases (ERKs) and signal cardiomyocyte survival in the setting of stress...
- Targeting GSK-3 family members in the heart: a very sharp double-edged swordHui Cheng
Center for Translational Medicine and Cardiology Division, Thomas Jefferson University Hospital, Philadelphia, PA, USA
J Mol Cell Cardiol 51:607-13. 2011..This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure."..
- Why do kinase inhibitors cause cardiotoxicity and what can be done about it?Hui Cheng
Center for Translational Medicine and Cardiology Division, Thomas Jefferson University, Philadelphia, PA 19107, USA
Prog Cardiovasc Dis 53:114-20. 2010..Herein we will explore the mechanisms underlying the cardiotoxicity of small-molecule KIs, hoping to explain how and why this happens, and will further examine strategies to deal with the problem...
- Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeuticsHui Cheng
Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Circ Res 106:21-34. 2010....