Yan Chen

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. ncbi request reprint A dose-volume histogram based optimization algorithm for ultrasound guided prostate implants
    Y Chen
    Department of Radiation Oncology, Stanford University School of Medicine, California 94305, USA
    Med Phys 27:2286-92. 2000
  2. ncbi request reprint A deterministic iterative least-squares algorithm for beam weight optimization in conformal radiotherapy
    Yan Chen
    Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Phys Med Biol 47:1647-58. 2002
  3. ncbi request reprint A graph-searching method for MLC leaf sequencing under constraints
    Yan Chen
    Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Med Phys 31:1504-11. 2004
  4. pmc Stereotactic body radiotherapy as an alternative to brachytherapy in gynecologic cancer
    Gregory J Kubicek
    Department of Radiation Oncology, Cooper University Hospital, Camden, NJ 08103, USA
    Biomed Res Int 2013:898953. 2013
  5. doi request reprint Dose-volume effects on brainstem dose tolerance in radiosurgery
    Jinyu Xue
    Department of Radiation Oncology, Cooper University Hospital, Camden, New Jersey 08103, USA
    J Neurosurg 117:189-96. 2012
  6. doi request reprint Dosimetric investigation of accelerated partial breast irradiation (APBI) using CyberKnife
    Qianyi Xu
    Department of Radiation Oncology, Cooper University Hospital, Camden, NJ 08103, USA
    Med Phys 39:6621-8. 2012
  7. ncbi request reprint Dosimetric investigation of high dose rate, gated IMRT
    Teh Lin
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Med Phys 35:5079-87. 2008
  8. ncbi request reprint A method to improve spatial resolution and smoothness of intensity profiles in IMRT treatment planning
    Qing Hou
    Key Laboratory of Radiation Physics and Technology, Sichuan University, Ministry of Education, Chengdu 610064, China
    Med Phys 31:1339-47. 2004
  9. ncbi request reprint Beam orientation optimization for IMRT by a hybrid method of the genetic algorithm and the simulated dynamics
    Qing Hou
    Key Lab for Radiation Physics and Technology, Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China
    Med Phys 30:2360-7. 2003
  10. ncbi request reprint An optimization algorithm for intensity modulated radiotherapy--the simulated dynamics with dose-volume constraints
    Qing Hou
    Key Lab for Radiation Physics and Technology, Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China
    Med Phys 30:61-8. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint A dose-volume histogram based optimization algorithm for ultrasound guided prostate implants
    Y Chen
    Department of Radiation Oncology, Stanford University School of Medicine, California 94305, USA
    Med Phys 27:2286-92. 2000
    ..To avoid being trapped in a less optimal local minimum, the optimization process is repeated. The final plan is selected from a pool of optimized plans obtained from a series of randomized initial seed configurations...
  2. ncbi request reprint A deterministic iterative least-squares algorithm for beam weight optimization in conformal radiotherapy
    Yan Chen
    Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Phys Med Biol 47:1647-58. 2002
    ..The method is robust in solving difficult clinical cases using either aperture or pencil beam based planning techniques for intensity-modulated radiation therapy...
  3. ncbi request reprint A graph-searching method for MLC leaf sequencing under constraints
    Yan Chen
    Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Med Phys 31:1504-11. 2004
    ..Using two collimator angles results in decreases in the required number of segments and the number of monitor units that can be as much as 20%...
  4. pmc Stereotactic body radiotherapy as an alternative to brachytherapy in gynecologic cancer
    Gregory J Kubicek
    Department of Radiation Oncology, Cooper University Hospital, Camden, NJ 08103, USA
    Biomed Res Int 2013:898953. 2013
    ..However, some patients are unable to tolerate brachytherapy for medical or other reasons. For these patients, stereotactic body radiotherapy (SBRT) offers an alternative form of treatment...
  5. doi request reprint Dose-volume effects on brainstem dose tolerance in radiosurgery
    Jinyu Xue
    Department of Radiation Oncology, Cooper University Hospital, Camden, New Jersey 08103, USA
    J Neurosurg 117:189-96. 2012
    ..The authors present their set of data and compare it with currently cited information on brainstem dose tolerance associated with conventional fractionated radiation therapy and hypofractionated radiation treatment of other diseases...
  6. doi request reprint Dosimetric investigation of accelerated partial breast irradiation (APBI) using CyberKnife
    Qianyi Xu
    Department of Radiation Oncology, Cooper University Hospital, Camden, NJ 08103, USA
    Med Phys 39:6621-8. 2012
    ..To investigate the dosimetric feasibility of accelerated partial breast irradiation (APBI) using CyberKnife...
  7. ncbi request reprint Dosimetric investigation of high dose rate, gated IMRT
    Teh Lin
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Med Phys 35:5079-87. 2008
    ..Nonetheless, for the concern of patient care and safety, a patient specific QA should be performed as usual for IMRT plans for high dose rate deliveries...
  8. ncbi request reprint A method to improve spatial resolution and smoothness of intensity profiles in IMRT treatment planning
    Qing Hou
    Key Laboratory of Radiation Physics and Technology, Sichuan University, Ministry of Education, Chengdu 610064, China
    Med Phys 31:1339-47. 2004
    ....
  9. ncbi request reprint Beam orientation optimization for IMRT by a hybrid method of the genetic algorithm and the simulated dynamics
    Qing Hou
    Key Lab for Radiation Physics and Technology, Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China
    Med Phys 30:2360-7. 2003
    ..g., the smoothness of intensity profiles, for the selection of the optimal plan among the degenerate configurations for treatment delivery...
  10. ncbi request reprint An optimization algorithm for intensity modulated radiotherapy--the simulated dynamics with dose-volume constraints
    Qing Hou
    Key Lab for Radiation Physics and Technology, Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China
    Med Phys 30:61-8. 2003
    ..In addition to the convenience of implementation, our method can achieve a high computational efficiency with the understanding of the dynamic behavior of the system...
  11. pmc Molecular brightness determined from a generalized form of Mandel's Q-parameter
    Alvaro Sanchez-Andres
    School of Physics and Astronomy, University of Minnesota, 116 Church Street SE, Minneapolis, MN 55455, USA
    Biophys J 89:3531-47. 2005
    ..In addition, we monitor protein association of the ligand-binding domain of retinoid X receptor in the presence and absence of 9-cis-retinoic acid by Q(tau) analysis...
  12. pmc Probing protein oligomerization in living cells with fluorescence fluctuation spectroscopy
    Yan Chen
    School of Physics and Astronomy, University of Minnesota, 116 Church Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 100:15492-7. 2003
    ..Resolving protein interactions in a cell is an important step in understanding cellular function on a molecular level. Brightness analysis promises to develop into an important tool for determining protein complex formation in cells...
  13. pmc Fluorescence fluctuation spectroscopy in the presence of immobile fluorophores
    Joseph P Skinner
    School of Physics and Astronomy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biophys J 94:2349-60. 2008
    ..We successfully recovered the brightness of the mobile fraction of H2B-EGFP...
  14. ncbi request reprint Application of Multivariate curve resolution-alternating least square methods on the resolution of overlapping CE peaks from different separation conditions
    Fang Zhang
    Institute of Analytical Science, Northwest University, Xi an, People s Republic of China
    Electrophoresis 28:3674-83. 2007
    ....
  15. pmc Dual-color photon counting histogram analysis of mRFP1 and EGFP in living cells
    Lindsey N Hillesheim
    School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, USA
    Biophys J 91:4273-84. 2006
    ..We successfully resolved this mixture of fusion proteins with a single dual-color PCH measurement. These results highlight the potential of dual-color PCH to directly detect and quantify protein mixtures in living cells...
  16. pmc Dual-color photon-counting histogram
    Yan Chen
    School of Physics and Astronomy, University of Minnesota, 116 Church St, SE Minneapolis, MN 55455, USA
    Biophys J 88:2177-92. 2005
    ..We quantify the influence of these filters on dual-color PCH analysis and determine the optimal transition wavelength of the dichroic mirror for the CFP-YFP pair...
  17. pmc Large-scale cDNA transfection screening for genes related to cancer development and progression
    Dafang Wan
    National Laboratory for Oncogenes and Related Genes, Cancer Institute of Shanghai Jiao Tong University, 25 Ln 2200 Xie Tu Road, Shanghai 200032, People s Republic of China
    Proc Natl Acad Sci U S A 101:15724-9. 2004
    ..It offers a better understanding of the basic machinery of oncogenesis, including previously undescribed systemic regulatory mechanisms, and also provides a tool for gene discovery with potential clinical applications...
  18. pmc Position-sensitive scanning fluorescence correlation spectroscopy
    Joseph P Skinner
    School of Physics and Astronomy, University of Minnesota, Minneapolis, 55455, USA
    Biophys J 89:1288-301. 2005
    ..To demonstrate the feasibility of the technique for applications in living cells we present data of enhanced green fluorescent protein measured in the nucleus of COS cells...