Research Topics
Genomes and Genes | Remedios Castelló-CrosSummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Publications
Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasisRemedios Castelló-Cros
The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 10:2021-34. 2011..Thus, the secretion and remodeling of extracellular matrix components (such as PAI-1/2) can directly regulate both (1) autophagy in stromal fibroblasts and (2) epithelial tumor cell mitochondrial metabolism...- Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosisRemedios Castelló-Cros
The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 10:2140-50. 2011..Finally, Cav-1 (-/-) null mice are also a pre-clinical model for a "lethal" tumor micro-environment, possibly explaining the link between fibrosis, tumor progression, and cancer metastasis... 
Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic couplingGemma Migneco
Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 9:2412-22. 2010....- The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblastsGloria Bonuccelli
Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 9:1960-71. 2010..We also identify the stromal expression of PKM2 and LDH-B as new candidate biomarkers for the "Reverse Warburg Effect" or "Stromal-Epithelial Metabolic Coupling" in human breast cancers... - Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migrationFranco Capozza
Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Res 72:2262-74. 2012..Together, our findings show that Cav1 may regulate different mechanisms during primary melanoma tumor growth and metastatic dissemination... - The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stromaStephanos Pavlides
Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Cell Cycle 8:3984-4001. 2009..Thus, an absence of stromal Cav-1 may be a biomarker for the "Reverse Warburg Effect," explaining its powerful predictive value... - Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matricesRemedios Castelló-Cros
Fox Chase Cancer Center, Philadelphia, PA, USA
Methods Mol Biol 522:275-305. 2009..It describes how to produce and characterize fibroblast-derived 3D matrices. Finally, it describes how to test matrix permissiveness by analyzing the morphology of cancer cells cultured within various 3D matrices... - Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrinsRemedios Castelló-Cros
Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
BMC Cancer 9:94. 2009..The goal of this study was to analyze the direct effects of staged stroma-derived extracellular matrices on breast cancer cell behavior...