B M Boman

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. doi request reprint Human colon cancer stem cells: a new paradigm in gastrointestinal oncology
    Bruce M Boman
    Helen Graham Cancer Center, Christiana Care Health System, 4701 Ogletown Stanton Rd, Newark, DE 19713, USA
    J Clin Oncol 26:2828-38. 2008
  2. pmc Colonic crypt changes during adenoma development in familial adenomatous polyposis: immunohistochemical evidence for expansion of the crypt base cell population
    Bruce M Boman
    Division of Genetic and Preventive Medicine, Kimmel Cancer Center, 1100 Walnut St, Suite 400, Thomas Jefferson University, Philadelphia PA 19107, USA
    Am J Pathol 165:1489-98. 2004
  3. ncbi request reprint Computer modeling implicates stem cell overproduction in colon cancer initiation
    B M Boman
    Division of Genetic and Preventive Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 61:8408-11. 2001
  4. ncbi request reprint Symmetric division of cancer stem cells--a key mechanism in tumor growth that should be targeted in future therapeutic approaches
    B M Boman
    Division of Preventive and Genetic Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 81:893-8. 2007
  5. ncbi request reprint Tumor-specific expression of anti-mdr1 ribozyme selectively restores chemosensitivity in multidrug-resistant colon-adenocarcinoma cells
    Z Gao
    TX Inc, Philadelphia, PA, USA
    Int J Cancer 82:346-52. 1999
  6. doi request reprint How dysregulated colonic crypt dynamics cause stem cell overpopulation and initiate colon cancer
    Bruce M Boman
    Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 68:3304-13. 2008
  7. ncbi request reprint Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer
    T Zhang
    Division of Genetic and Preventive Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Res 61:8664-7. 2001
  8. ncbi request reprint Colorectal cancer staging and adjuvant chemotherapy
    A Gelmann
    Division of Clinical Pharmacology, Departments of Medicine and Biochemistry and Molecular Pharmacology, Jefferson Medical College, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA
    Expert Opin Pharmacother 1:737-55. 2000
  9. ncbi request reprint Development of cross-resistance to tamoxifen in raloxifene-treated breast carcinoma cells
    Z O Gao
    Division of Genetic and Preventive Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Anticancer Res 22:1379-83. 2002
  10. pmc One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis
    Anthony T Yeung
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Cancer Res 68:7579-86. 2008

Collaborators

Detail Information

Publications17

  1. doi request reprint Human colon cancer stem cells: a new paradigm in gastrointestinal oncology
    Bruce M Boman
    Helen Graham Cancer Center, Christiana Care Health System, 4701 Ogletown Stanton Rd, Newark, DE 19713, USA
    J Clin Oncol 26:2828-38. 2008
    ....
  2. pmc Colonic crypt changes during adenoma development in familial adenomatous polyposis: immunohistochemical evidence for expansion of the crypt base cell population
    Bruce M Boman
    Division of Genetic and Preventive Medicine, Kimmel Cancer Center, 1100 Walnut St, Suite 400, Thomas Jefferson University, Philadelphia PA 19107, USA
    Am J Pathol 165:1489-98. 2004
    ....
  3. ncbi request reprint Computer modeling implicates stem cell overproduction in colon cancer initiation
    B M Boman
    Division of Genetic and Preventive Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 61:8408-11. 2001
    ..This suggests that APC regulates the number of stem cells in the colonic crypt and when the cells become mutant, an expansion of the crypt stem cell population results...
  4. ncbi request reprint Symmetric division of cancer stem cells--a key mechanism in tumor growth that should be targeted in future therapeutic approaches
    B M Boman
    Division of Preventive and Genetic Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 81:893-8. 2007
    ....
  5. ncbi request reprint Tumor-specific expression of anti-mdr1 ribozyme selectively restores chemosensitivity in multidrug-resistant colon-adenocarcinoma cells
    Z Gao
    TX Inc, Philadelphia, PA, USA
    Int J Cancer 82:346-52. 1999
    ..These results indicate that our anti-mdr1 ribozyme is expressed only in CEA-producing colon-cancer cells and reverses their drug resistance selectively...
  6. doi request reprint How dysregulated colonic crypt dynamics cause stem cell overpopulation and initiate colon cancer
    Bruce M Boman
    Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 68:3304-13. 2008
    ....
  7. ncbi request reprint Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer
    T Zhang
    Division of Genetic and Preventive Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Res 61:8664-7. 2001
    ....
  8. ncbi request reprint Colorectal cancer staging and adjuvant chemotherapy
    A Gelmann
    Division of Clinical Pharmacology, Departments of Medicine and Biochemistry and Molecular Pharmacology, Jefferson Medical College, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA
    Expert Opin Pharmacother 1:737-55. 2000
    ....
  9. ncbi request reprint Development of cross-resistance to tamoxifen in raloxifene-treated breast carcinoma cells
    Z O Gao
    Division of Genetic and Preventive Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Anticancer Res 22:1379-83. 2002
    ..While the resistance to tamoxifen is considerably less marked (1000-fold less), it is large enough to raise the question as to whether patients who become resistant to raloxifene will benefit by switching to tamoxifen or vice versa...
  10. pmc One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis
    Anthony T Yeung
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Cancer Res 68:7579-86. 2008
    ..These changes may represent the earliest biomarkers of colorectal cancer development, potentially leading to the identification of molecular targets for cancer prevention...
  11. ncbi request reprint Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations
    Radka Stoyanova
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 3:1313-21. 2004
    ..The inherently complex signaling networks of tumors result from genetic and epigenetic alterations that occur during cancer initiation and progression...
  12. ncbi request reprint Searchable high-resolution 2D gel proteome of the human colon crypt
    Bhavinkumar B Patel
    Division of Basic Science, Medical Science, and Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Proteome Res 6:2232-8. 2007
    ..These interactive, searchable, hyperlink-enabled proteome maps and gene ontology analyses will facilitate future studies to discover the earliest markers and intervention targets during progression to colon cancer...
  13. ncbi request reprint Immunoassay for wild-type protein in lymphocytes predicts germline mutations in patients at risk for hereditary colorectal cancer
    Jeremy Z Fields
    CA TX Inc, Gladwyne, Pennsylvania, USA
    J Lab Clin Med 143:59-66. 2004
    ....
  14. ncbi request reprint The chemopreventive agent sulindac attenuates expression of the antiapoptotic protein survivin in colorectal carcinoma cells
    Tao Zhang
    Division of Genetic and Preventive Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Pharmacol Exp Ther 308:434-7. 2004
    ..This suggests that the beta-catenin:Tcf-4:survivin mechanism may be a useful target for therapy or chemoprevention of colon cancer...
  15. doi request reprint Cancer stem cells: a step toward the cure
    Bruce M Boman
    J Clin Oncol 26:2795-9. 2008
  16. ncbi request reprint Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells
    N Shane Cutler
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2279, USA
    Cancer Res 63:1748-51. 2003
    ..This mechanism may have relevance to maintenance of cells in the normal crypt and to clonal expansion of mutant colonocytes during tumorigenesis...
  17. ncbi request reprint Staging intra-abdominal desmoid tumors in familial adenomatous polyposis: a search for a uniform approach to a troubling disease
    James Church
    Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 48:1528-34. 2005
    ..The relative rarity and the clinical heterogeneity of intra-abdominal desmoid tumors make randomized studies difficult to do. In this article a staging system is proposed to make multi-institutional studies easier...