Research Topics
Species | B M BomanSummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Detail Information
Publications
Human colon cancer stem cells: a new paradigm in gastrointestinal oncologyBruce M Boman
Helen Graham Cancer Center, Christiana Care Health System, 4701 Ogletown Stanton Rd, Newark, DE 19713, USA
J Clin Oncol 26:2828-38. 2008....
Colonic crypt changes during adenoma development in familial adenomatous polyposis: immunohistochemical evidence for expansion of the crypt base cell populationBruce M Boman
Division of Genetic and Preventive Medicine, Kimmel Cancer Center, 1100 Walnut St, Suite 400, Thomas Jefferson University, Philadelphia PA 19107, USA
Am J Pathol 165:1489-98. 2004....
Computer modeling implicates stem cell overproduction in colon cancer initiationB M Boman
Division of Genetic and Preventive Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 61:8408-11. 2001..This suggests that APC regulates the number of stem cells in the colonic crypt and when the cells become mutant, an expansion of the crypt stem cell population results...- Symmetric division of cancer stem cells--a key mechanism in tumor growth that should be targeted in future therapeutic approachesB M Boman
Division of Preventive and Genetic Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Clin Pharmacol Ther 81:893-8. 2007.... - Tumor-specific expression of anti-mdr1 ribozyme selectively restores chemosensitivity in multidrug-resistant colon-adenocarcinoma cellsZ Gao
TX Inc, Philadelphia, PA, USA
Int J Cancer 82:346-52. 1999..These results indicate that our anti-mdr1 ribozyme is expressed only in CEA-producing colon-cancer cells and reverses their drug resistance selectively... - How dysregulated colonic crypt dynamics cause stem cell overpopulation and initiate colon cancerBruce M Boman
Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Cancer Res 68:3304-13. 2008.... - Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancerT Zhang
Division of Genetic and Preventive Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cancer Res 61:8664-7. 2001.... - Colorectal cancer staging and adjuvant chemotherapyA Gelmann
Division of Clinical Pharmacology, Departments of Medicine and Biochemistry and Molecular Pharmacology, Jefferson Medical College, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107, USA
Expert Opin Pharmacother 1:737-55. 2000.... - Development of cross-resistance to tamoxifen in raloxifene-treated breast carcinoma cellsZ O Gao
Division of Genetic and Preventive Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Anticancer Res 22:1379-83. 2002..While the resistance to tamoxifen is considerably less marked (1000-fold less), it is large enough to raise the question as to whether patients who become resistant to raloxifene will benefit by switching to tamoxifen or vice versa... - One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposisAnthony T Yeung
Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
Cancer Res 68:7579-86. 2008..These changes may represent the earliest biomarkers of colorectal cancer development, potentially leading to the identification of molecular targets for cancer prevention... - Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutationsRadka Stoyanova
Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cancer Biol Ther 3:1313-21. 2004..Detectable effects of "one-hit" represent early molecular changes in tumorigenesis that may serve as targets for chemopreventive intervention... - Searchable high-resolution 2D gel proteome of the human colon cryptBhavinkumar B Patel
Division of Basic Science, Medical Science, and Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
J Proteome Res 6:2232-8. 2007..These interactive, searchable, hyperlink-enabled proteome maps and gene ontology analyses will facilitate future studies to discover the earliest markers and intervention targets during progression to colon cancer... - Immunoassay for wild-type protein in lymphocytes predicts germline mutations in patients at risk for hereditary colorectal cancerJeremy Z Fields
CA*TX Inc, Gladwyne, Pennsylvania, USA
J Lab Clin Med 143:59-66. 2004.... - The chemopreventive agent sulindac attenuates expression of the antiapoptotic protein survivin in colorectal carcinoma cellsTao Zhang
Division of Genetic and Preventive Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Pharmacol Exp Ther 308:434-7. 2004..This suggests that the beta-catenin:Tcf-4:survivin mechanism may be a useful target for therapy or chemoprevention of colon cancer... - Cancer stem cells: a step toward the cureBruce M Boman
J Clin Oncol 26:2795-9. 2008 - Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cellsN Shane Cutler
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2279, USA
Cancer Res 63:1748-51. 2003..This mechanism may have relevance to maintenance of cells in the normal crypt and to clonal expansion of mutant colonocytes during tumorigenesis... - Staging intra-abdominal desmoid tumors in familial adenomatous polyposis: a search for a uniform approach to a troubling diseaseJames Church
Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Dis Colon Rectum 48:1528-34. 2005..CONCLUSION: A way of staging intra-abdominal desmoid tumors is proposed to facilitate stratification by disease severity during collaborative studies of various treatments...