Adam C Berger

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. doi Five year results of US intergroup/RTOG 9704 with postoperative CA 19-9 ≤90 U/mL and comparison to the CONKO-001 trial
    Adam C Berger
    Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 84:e291-7. 2012
  2. doi Oncologic efficacy is not compromised, and may be improved with minimally invasive esophagectomy
    Adam C Berger
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    J Am Coll Surg 212:560-6; discussion 566-8. 2011
  3. pmc Postresection CA 19-9 predicts overall survival in patients with pancreatic cancer treated with adjuvant chemoradiation: a prospective validation by RTOG 9704
    Adam C Berger
    Thomas Jefferson University, Philadelphia, PA, USA
    J Clin Oncol 26:5918-22. 2008
  4. doi Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula? A randomized, prospective, dual-institution trial
    Adam C Berger
    Department of Surgery, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA
    J Am Coll Surg 208:738-47; discussion 747-9. 2009
  5. ncbi Morbidity and mortality are not increased after induction chemoradiotherapy followed by esophagectomy in patients with esophageal cancer
    Adam C Berger
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Semin Oncol 32:S16-20. 2005
  6. doi Lymph node ratio is an important and independent prognostic factor for patients with stage III melanoma
    Adam C Berger
    Department of Surgery, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Surg Oncol 105:15-20. 2012
  7. pmc The influence of total nodes examined, number of positive nodes, and lymph node ratio on survival after surgical resection and adjuvant chemoradiation for pancreatic cancer: a secondary analysis of RTOG 9704
    Timothy N Showalter
    Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 81:1328-35. 2011
  8. doi The influence of prognostic factors and adjuvant chemoradiation on survival after pancreaticoduodenectomy for ampullary carcinoma
    Timothy N Showalter
    Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USA
    J Gastrointest Surg 15:1411-6. 2011
  9. ncbi Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival
    Adam C Berger
    Department of Surgical Oncology, and Division of Biostatistics, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Clin Oncol 23:4330-7. 2005
  10. doi Major perioperative morbidity does not affect long-term survival in patients undergoing esophagectomy for cancer of the esophagus or gastroesophageal junction
    Brent T Xia
    Department of Surgery, Thomas Jefferson University, 1100 Walnut Street, MOB, Suite 500, Philadelphia, PA 19147, USA
    World J Surg 37:408-15. 2013

Collaborators

Detail Information

Publications41

  1. doi Five year results of US intergroup/RTOG 9704 with postoperative CA 19-9 ≤90 U/mL and comparison to the CONKO-001 trial
    Adam C Berger
    Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 84:e291-7. 2012
    ..This report analyzes 5-year survival by serum level of tumor marker CA 19-9 of ≤90 vs >90 U/mL and compares results to the those of the CONKO-001 trial...
  2. doi Oncologic efficacy is not compromised, and may be improved with minimally invasive esophagectomy
    Adam C Berger
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    J Am Coll Surg 212:560-6; discussion 566-8. 2011
    ..Minimally invasive approaches are being increasingly used. We compare our growing series of minimally invasive (combined thoracoscopic and laparoscopic) esophagectomies (MIEs) with a series of open transthoracic esophagectomies...
  3. pmc Postresection CA 19-9 predicts overall survival in patients with pancreatic cancer treated with adjuvant chemoradiation: a prospective validation by RTOG 9704
    Adam C Berger
    Thomas Jefferson University, Philadelphia, PA, USA
    J Clin Oncol 26:5918-22. 2008
    ..CA 19-9 is an important tumor marker in patients with pancreatic adenocarcinoma. A secondary end point of Radiation Therapy Oncology Group trial 9704 was prospective evaluation of the ability of postresectional CA 19-9 to predict survival...
  4. doi Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula? A randomized, prospective, dual-institution trial
    Adam C Berger
    Department of Surgery, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA
    J Am Coll Surg 208:738-47; discussion 747-9. 2009
    ..We tested the hypothesis that a duct to mucosa pancreaticojejunostomy would reduce the PF rate...
  5. ncbi Morbidity and mortality are not increased after induction chemoradiotherapy followed by esophagectomy in patients with esophageal cancer
    Adam C Berger
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Semin Oncol 32:S16-20. 2005
    ..5 days). Esophagectomy can be performed safely with low mortality and acceptable morbidity following neoadjuvant chemotherapy and radiation with no increase in hospital stay for patients with complications...
  6. doi Lymph node ratio is an important and independent prognostic factor for patients with stage III melanoma
    Adam C Berger
    Department of Surgery, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Surg Oncol 105:15-20. 2012
    ..The incidence of melanoma is dramatically increasing worldwide. We hypothesized that the ratio of metastatic to examined lymph node ratio (LNR) would be the most important prognostic factor for stage III patients...
  7. pmc The influence of total nodes examined, number of positive nodes, and lymph node ratio on survival after surgical resection and adjuvant chemoradiation for pancreatic cancer: a secondary analysis of RTOG 9704
    Timothy N Showalter
    Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 81:1328-35. 2011
    ....
  8. doi The influence of prognostic factors and adjuvant chemoradiation on survival after pancreaticoduodenectomy for ampullary carcinoma
    Timothy N Showalter
    Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USA
    J Gastrointest Surg 15:1411-6. 2011
    ..Decisions regarding adjuvant therapy are influenced by factors such as nodal status, stage, and grade, but the influence of these individual variables on survival is unclear...
  9. ncbi Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival
    Adam C Berger
    Department of Surgical Oncology, and Division of Biostatistics, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Clin Oncol 23:4330-7. 2005
    ..A large single-center experience was reviewed to determine which treatment-related variables could predict survival and recurrence...
  10. doi Major perioperative morbidity does not affect long-term survival in patients undergoing esophagectomy for cancer of the esophagus or gastroesophageal junction
    Brent T Xia
    Department of Surgery, Thomas Jefferson University, 1100 Walnut Street, MOB, Suite 500, Philadelphia, PA 19147, USA
    World J Surg 37:408-15. 2013
    ..We reviewed our large institutional experience to evaluate the impact of postoperative complications on the long-term survival of patients undergoing resection for curative intent...
  11. ncbi The metastatic/examined lymph node ratio is an important prognostic factor after pancreaticoduodenectomy for pancreatic adenocarcinoma
    Adam C Berger
    Department of Surgical Oncology, Division of Biostatistics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am Surg 70:235-40; discussion 240. 2004
    ..After curative PD for pancreatic cancer, the ratio of metastatic to examined lymph nodes is an important prognostic factor and should be evaluated in stratification schemes for future clinical trials investigating adjuvant treatments...
  12. doi Does intraoperative radiation therapy improve local tumor control in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma? A propensity score analysis
    Timothy N Showalter
    Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    Ann Surg Oncol 16:2116-22. 2009
    ..Locoregional recurrence (LRR) is an important factor after pancreaticoduodenectomy (PD) for pancreatic cancer. Intraoperative radiation therapy (IORT) administered to the resection bed may improve local tumor control...
  13. doi Implementation of a critical pathway for distal pancreatectomy at an academic institution
    Eugene P Kennedy
    Department of Surgery, Jefferson Medical College, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Suite 605 College Building, Philadelphia, PA 19107, USA
    J Gastrointest Surg 13:938-44. 2009
    ..This study was designed to identify quantifiable parameters to track performance improvements brought about by the implementation of a critical pathway for complex alimentary tract surgery...
  14. doi Impact of obesity on perioperative morbidity and mortality after pancreaticoduodenectomy
    Timothy K Williams
    Department of Surgery, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Disease Center, Philadelphia, PA 19107, USA
    J Am Coll Surg 208:210-7. 2009
    ..Obesity has been implicated as a risk factor for perioperative and postoperative complications. The aim of this study was to determine the impact of obesity on morbidity and mortality in patients undergoing pancreaticoduodenectomy (PD)...
  15. pmc Prognostic significance of lymph node metastases and ratio in esophageal cancer
    Matthew Wilson
    Department of Surgery, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Surg Res 146:11-5. 2008
    ..The incidence of carcinoma of the distal esophagus and GE junction is rapidly increasing. A large single-center experience was reviewed to determine the impact of lymph node positivity and ratio on survival...
  16. doi Serum blood urea nitrogen and serum albumin on the first postoperative day predict pancreatic fistula and major complications after pancreaticoduodenectomy
    Daniel M Relles
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    J Gastrointest Surg 17:326-31. 2013
    ..We set out to determine the impact of blood urea nitrogen (BUN) and albumin on POD 1 for patients undergoing PD...
  17. doi Surgical Apgar score predicts perioperative morbidity in patients undergoing pancreaticoduodenectomy at a high-volume center
    M Mura Assifi
    Department of Surgery and Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, 1100 Walnut Street, MOB, Suite 500, Philadelphia, PA 19107, USA
    J Gastrointest Surg 16:275-81. 2012
    ..Numerous studies have evaluated factors to predict patients at risk. The aim of this study was to determine whether the surgical Apgar score (SAS) predicts perioperative morbidity and mortality...
  18. doi Margin positive pancreaticoduodenectomy is superior to palliative bypass in locally advanced pancreatic ductal adenocarcinoma
    Harish Lavu
    Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Gastrointest Surg 13:1937-46; discussion 1946-7. 2009
    ....
  19. doi Tumor recurrence is independent of pancreatic fistula in patients after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma
    M Mura Assifi
    Department of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA
    J Am Coll Surg 217:621-7. 2013
    ..The purpose of our study was to determine if a relationship exists between PF and tumor recurrence (both peritoneal and local) in patients after PD for pancreatic ductal adenocarcinoma...
  20. ncbi Undetectable preoperative levels of serum CA 19-9 correlate with improved survival for patients with resectable pancreatic adenocarcinoma
    Adam C Berger
    Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Ann Surg Oncol 11:644-9. 2004
    ..Serum levels of CA19-9 have been shown to correlate with both recurrence and survival in patients with pancreatic cancer. However, little is known about the prognosis for patients with undetectable levels of serum CA19-9...
  21. doi Optimal technical management of stump closure following distal pancreatectomy: a retrospective review of 215 cases
    Lisa J Harris
    Department of Surgery, Thomas Jefferson University, 1100 Walnut Street, MOB Suite 500, Philadelphia, PA 19107, USA
    J Gastrointest Surg 14:998-1005. 2010
    ..Pancreatic fistula (PF) is a major source of morbidity following distal pancreatectomy (DP). Our aim was to identify risk factors related to PF following DP and to determine the impact of technique of transection and stump closure...
  22. ncbi Outcomes in patients with mucosal melanomas
    Deborah S Keller
    Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania
    J Surg Oncol 108:516-20. 2013
    ..Our goal was to evaluate the different subtypes of mucosal melanoma and describe specific variables that predict outcomes...
  23. ncbi Neoadjuvant therapy and biliary decompression lower biliary and pancreatic juice vascular endothelial growth factor levels in patients with periampullary adenocarcinoma
    Adam C Berger
    Department of Surgical Oncology, Division of Biostatistics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Am Surg 70:169-73; discussion 173-4. 2004
    ..Preoperative CRT and BD significantly reduce these levels in patients with periampullary cancers. Antiangiogenic therapy aimed at interrupting the VEGF pathway appears to be a logical target in periampullary cancer...
  24. ncbi Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes
    Adam C Berger
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    J Clin Oncol 23:8706-12. 2005
    ..Colorectal cancer is the second leading cause of cancer deaths in the United States, with poor survival predicted by regional lymph node (LN) metastasis. The impact of LN ratio (LNR) on survival is unknown in this disease...
  25. ncbi Malignant melanoma presenting as obstructive jaundice secondary to metastasis to the Ampulla of Vater
    Joshua A Marks
    Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    JOP 11:173-5. 2010
    ..Malignant melanoma commonly metastasizes to the small intestine where it can cause pain, bleeding, and obstruction. However, jaundice from metastatic melanoma is relatively uncommon...
  26. doi Does diabetes mellitus influence pathologic complete response and tumor downstaging after neoadjuvant chemoradiation for esophageal and gastroesophageal cancer? A two-institution report
    Shayna L Showalter
    Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Surg Oncol 101:43-6. 2010
    ..The goal of this study was to determine if DM affects response to neoadjuvant CRT in the management of gastroesophageal carcinoma...
  27. ncbi Initiation of a critical pathway for pancreaticoduodenectomy at an academic institution--the first step in multidisciplinary team building
    Eugene P Kennedy
    Department of Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Am Coll Surg 204:917-23; discussion 923-4. 2007
    ..This study was designed to track performance improvements brought about by the implementation of a critical pathway for complex alimentary tract surgery...
  28. doi Laparoscopic approaches to gastric gastrointestinal stromal tumors: an institutional review of 57 cases
    Michael J Pucci
    Department of Surgery, Division of General Surgery, Thomas Jefferson University, Fifth Floor Medical Office Building, 1100 Walnut Street, Philadelphia, PA 19107, USA
    Surg Endosc 26:3509-14. 2012
    ..The purpose of this study is to review our experience with laparoscopic resection, report our short-term outcomes, and offer our perspective on the technical nuances involved in handling these neoplasms...
  29. ncbi Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival
    Jonathan R Brody
    Department of Surgery, Thomas Jefferson University Philadelphia, Philadelphia, PA 19107, USA
    Cell Cycle 8:1930-4. 2009
    ..These data support the notion that metastatic MM cells select for expression of IDO to evade immunologic detection. Therefore, inhibition of IDO in MM patients may be a useful treatment strategy...
  30. doi Altered drainage patterns in patients with melanoma and previous axillary dissection
    Caitlyn Johnson
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    J Dermatol 40:564-6. 2013
    ..Sentinel lymph node mapping is still an important adjunct in patients with melanoma despite previous axillary dissection. ..
  31. ncbi Metastatic melanoma causing jejunal intussusception
    Tania Mucci
    Department of Surgery, Thomas Jefferson University, 1100 Walnut Street, MOB, Suite 500, Philadelphia, PA 19107, USA
    J Gastrointest Surg 11:1755-7. 2007
    ..Exploration revealed jejunojejunal intussusception and resection provided excellent palliation...
  32. ncbi Malignant melanoma of the gallbladder: a report of two cases and review of the literature
    Mary K Samplaski
    Department of Surgery, Thomas Jefferson University Hospital, 1100 Walnut Street, MOB, Suite 500, Philadelphia, PA 19107, USA
    J Gastrointest Surg 12:1123-6. 2008
    ..We review the published literature for gallbladder melanoma, both primary and metastatic to determine the role of surgery in this disease...
  33. pmc TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells
    Michele B Weiss
    Department of Cancer Biology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 72:6382-92. 2012
    ..Together, these studies mechanistically show a previously unrecognized interplay between ERK1/2, TWIST1, and MMP-1 that is likely significant in the progression of melanoma toward metastasis...
  34. ncbi Noninvasive staging of esophageal carcinoma
    Adam C Berger
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Surg Res 117:127-33. 2004
  35. doi Hemorrhagic hepatic cyst: report of a case and review of the literature with emphasis on clinical approach and management
    Zhi Ven Fong
    Department of Surgery, Jefferson Medical College, Thomas Jefferson University, 1100 Walnut Street, 5th Floor, Philadelphia, PA 19107, USA
    J Gastrointest Surg 16:1782-9. 2012
    ..Even when accurately diagnosed, there has been a lack of consensus on the optimal treatment strategy. After presenting our experience with a patient treated via laparoscopy, we aimed to conduct a review of the literature on HHCs...
  36. ncbi A murine model of ex vivo angiogenesis using aortic disks grown in fibrin clot
    Adam C Berger
    Division of Surgical Research, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Microvasc Res 68:179-87. 2004
    ..Antiangiogenic agents may be most effective if administered before development of accelerated vessel growth...
  37. doi Extra-gastrointestinal stromal tumor of the pancreas: case report and a review of the literature
    Shayna L Showalter
    Department of Surgery, Thomas Jefferson University, 1015 Walnut St, Curtis Building, Suite 620, Philadelphia, PA 19107, USA
    Arch Surg 143:305-8. 2008
    ..Primary pancreatic GI stromal tumors are very rare, with only 4 previous cases reported...
  38. doi Selectively starving cancer cells through dietary manipulation: methods and clinical implications
    Brittany A Simone
    Department of Radiation Oncology, Kimmel Cancer Center and Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA
    Future Oncol 9:959-76. 2013
    ..This article will delineate three commonly used methods of dietary manipulation to assess the potential of each as a regimen for cancer therapy. ..
  39. ncbi John Chalmers DaCosta (1863-1933): restoration of the old operating table
    Madalyn G Peters
    Department of Surgery, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Am Surg 79:232-4. 2013
    ..The old table currently stands proudly in the entranceway of the Department of Surgery where it will remain as a cherished symbol of the early beginnings of surgical practice and education...
  40. pmc Preoperative FDG-PET/CT Is an Important Tool in the Management of Patients with Thick (T4) Melanoma
    Rodrigo Arrangoiz
    Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Dermatol Res Pract 2012:614349. 2012
    ..Additionally 20 patients had incidental findings that required further workup. In this subset of patients, we feel there is a benefit to PET/CT, and further studies should be performed to validate our findings...
  41. ncbi A yeast model system for functional analysis of the Niemann-Pick type C protein 1 homolog, Ncr1p
    Adam C Berger
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Traffic 6:907-17. 2005
    ..These findings establish S. cerevisiae as a model system that can be exploited to analyze the molecular consequences of patient mutations in NPC1 and provide the basis for future genetic studies using yeast...