R Baffa

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer
    A Vecchione
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Oncogene 28:257-69. 2009
  2. pmc Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells
    Matteo Fassan
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e19771. 2011
  3. pmc Targeted therapies in the management of metastatic bladder cancer
    Matteo Fassan
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Biologics 1:393-406. 2007
  4. pmc MicroRNA expression profiling of male breast cancer
    Matteo Fassan
    Department of Urology, Thomas Jefferson University Kimmel Cancer Center, 1112 College Building, 1025 Walnut Street, PA 19107, USA
    Breast Cancer Res 11:R58. 2009
  5. pmc Collecting duct carcinoma of the kidney: an immunohistochemical study of 11 cases
    Andrea Vecchione
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA, 19107, USA
    BMC Urol 4:11. 2004
  6. doi request reprint MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets
    Raffaele Baffa
    Department of Urology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USA
    J Pathol 219:214-21. 2009
  7. ncbi request reprint Molecular genetics of bladder cancer: targets for diagnosis and therapy
    R Baffa
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Exp Clin Cancer Res 25:145-60. 2006
  8. doi request reprint Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis
    Raffaele Baffa
    Department of Urology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Carcinogenesis 29:846-8. 2008
  9. ncbi request reprint Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells
    H Ishii
    Kimmel Cancer Institute, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 61:1578-84. 2001
  10. ncbi request reprint Fez1/lzts1 alterations in gastric carcinoma
    A Vecchione
    Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 7:1546-52. 2001

Collaborators

Detail Information

Publications39

  1. pmc MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer
    A Vecchione
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Oncogene 28:257-69. 2009
    ..Our findings support the hypothesis that MITOSTATIN has many hallmarks of a classical tumor suppressor in solid tumors and may play an important role in cancer development and progression...
  2. pmc Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells
    Matteo Fassan
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e19771. 2011
    ....
  3. pmc Targeted therapies in the management of metastatic bladder cancer
    Matteo Fassan
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Biologics 1:393-406. 2007
    ..A review of literature published on the targeted therapy for metastatic bladder cancer is presented, focusing on the molecular pathways shut down by the new therapeutic agents...
  4. pmc MicroRNA expression profiling of male breast cancer
    Matteo Fassan
    Department of Urology, Thomas Jefferson University Kimmel Cancer Center, 1112 College Building, 1025 Walnut Street, PA 19107, USA
    Breast Cancer Res 11:R58. 2009
    ....
  5. pmc Collecting duct carcinoma of the kidney: an immunohistochemical study of 11 cases
    Andrea Vecchione
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA, 19107, USA
    BMC Urol 4:11. 2004
    ..In order to gain an insight into the biology of this tumor we evaluated the expression of five genes involved in the development of renal cancer (FEZ1/LZTS1, FHIT, TP53, P27kip1, and BCL2)...
  6. doi request reprint MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets
    Raffaele Baffa
    Department of Urology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USA
    J Pathol 219:214-21. 2009
    ..Our results suggest that specific miRNAs may be directly involved in cancer metastasis and that they may represent a novel diagnostic tool in the characterization of metastatic cancer gene targets...
  7. ncbi request reprint Molecular genetics of bladder cancer: targets for diagnosis and therapy
    R Baffa
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Exp Clin Cancer Res 25:145-60. 2006
    ..Capitalizing on these alterations will allow early detection, providing important prognostic information and unique targets for gene therapy and other therapeutic approaches...
  8. doi request reprint Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis
    Raffaele Baffa
    Department of Urology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Carcinogenesis 29:846-8. 2008
    ..Therefore, LZTS1 may become an excellent target for gene therapy in advanced bladder carcinoma...
  9. ncbi request reprint Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells
    H Ishii
    Kimmel Cancer Institute, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 61:1578-84. 2001
    ..Thus, adenoviral-FHIT expression can inhibit the growth of esophageal cancer cells, at least in part through caspase-dependent apoptosis, suggesting that adenoviral-FHIT infection should be explored as a therapeutic strategy...
  10. ncbi request reprint Fez1/lzts1 alterations in gastric carcinoma
    A Vecchione
    Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 7:1546-52. 2001
    ..CONCLUSIONS: Our findings support FEZ1/LZTS1 as a candidate tumor suppressor gene at 8p in a subtype of gastric cancer and suggest that its inactivation is attributable to several factors including genomic deletion and methylation...
  11. ncbi request reprint Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer
    K R Dumon
    Kimmel Cancer Center, Thomas Jefferson University, Department of Surgery, Hospital of the University of Pennsylvania, Gene Therapy Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 61:4827-36. 2001
    ..In vivo results show that FHIT gene transfer delays tumor growth and prolongs survival in a murine model mimicking human disease...
  12. pmc The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors
    H Ishii
    Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 96:3928-33. 1999
    ..Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors...
  13. pmc FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis
    H Ishii
    Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107 5799, USA
    Proc Natl Acad Sci U S A 98:10374-9. 2001
    ..Present data show that FEZ1/LZTS1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth...
  14. ncbi request reprint Structure and expression of the human FHIT gene in normal and tumor cells
    T Druck
    Department of Microbiology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 57:504-12. 1997
    ..Most of the cell lines that exhibited genomic alterations showed alteration of FHIT transcripts and absence or diminution of Fhit protein...
  15. ncbi request reprint Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines
    K Kastury
    Jefferson Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107 6799, USA
    Cancer Res 56:978-83. 1996
    ..Thus, it is likely that the homozygous deletion observed in these cancer cell lines harbors an important tumor suppressor gene for several tumor types...
  16. pmc Loss of FHIT expression in transitional cell carcinoma of the urinary bladder
    R Baffa
    Department of Urology, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Pathol 156:419-24. 2000
    ..These results suggested that loss of Fhit expression may be as important in the development of bladder cancer as it is for other neoplasms caused by environmental carcinogens...
  17. ncbi request reprint Potential cancer therapy with the fragile histidine triad gene: review of the preclinical studies
    H Ishii
    Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th St, Philadelphia, PA 19107-5799, USA
    JAMA 286:2441-9. 2001
    ....
  18. pmc FHIT gene therapy prevents tumor development in Fhit-deficient mice
    K R Dumon
    Kimmel Cancer Center, Jefferson Medical College, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 98:3346-51. 2001
    ..We therefore suggest that FHIT gene therapy could be a novel clinical approach not only in treatment of early stages of cancer, but also in prevention of human cancer...
  19. ncbi request reprint The FHIT gene 3p14.2 is abnormal in lung cancer
    G Sozzi
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cell 85:17-26. 1996
    ..Small cell lung cancer tumors and cell lines were analyzed by Southern blotting and showed rearranged BamHI fragments. These data suggest a critical role of the FHIT gene in lung carcinogenesis...
  20. ncbi request reprint Molecular genetics of prostate cancer: clinical translational opportunities
    A Vecchione
    Department of Urology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA 19107, USA
    J Exp Clin Cancer Res 26:25-37. 2007
    ..This review aims to identify trends in PC research and suggests potential clinical applications for diagnosis, prognosis, prevention and treatment...
  21. ncbi request reprint Definition and refinement of chromosome 8p regions of loss of heterozygosity in gastric cancer
    R Baffa
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 6:1372-7. 2000
    ..Initial steps were taken toward the identification of this gene, which is likely to play an important role in the pathogenesis of gastric cancer and of other tumors as well...
  22. ncbi request reprint Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer
    Dimitrios Iliopoulos
    Department of Microbiology Immunology, Philadelphia, PA 19107, USA
    Oncogene 24:1625-33. 2005
    ..Differential methylation in cancerous vs adjacent tissues suggests that WWOX and FHIT hypermethylation analyses could enrich a panel of DNA methylation markers...
  23. ncbi request reprint Micro-RNA profiling in kidney and bladder cancers
    Fedra Gottardo
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Urol Oncol 25:387-92. 2007
    ..To study the role of the micro-RNAs in human kidney and bladder cancer, we analyzed the expression profile of 245 micro-RNAs in kidney and bladder primary tumors...
  24. ncbi request reprint Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: a region of high loss of heterozygosity in gastric cancer
    C Schmutte
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 57:3010-5. 1997
    ..At present, we have found no evidence that TDG is central to the development of gastric cancer, limiting the importance of TDG in T:G mismatch repair and subsequent carcinogenesis...
  25. ncbi request reprint Familial cancer associated with a polymorphism in ARLTS1
    George Adrian Calin
    Thomas Jefferson University, Philadelphia, USA
    N Engl J Med 352:1667-76. 2005
    ..The finding of hemizygous or homozygous deletions at band 14 on chromosome 13 in a variety of neoplasms suggests the presence of a tumor-suppressor locus telomeric to the RB1 gene...
  26. ncbi request reprint Expression and transcriptional regulation of caspase-14 in simple and complex epithelia
    G Pistritto
    Center for Apoptosis Research, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cell Death Differ 9:995-1006. 2002
    ....
  27. ncbi request reprint Inactivation of the FHIT gene favors bladder cancer development
    Andrea Vecchione
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 10:7607-12. 2004
    ..c. tumor growth in nude mice. These findings suggest the important role of Fhit in bladder cancer development and support the effort to additionally investigate a FHIT-based gene therapy...
  28. ncbi request reprint Loss of WWOX expression in gastric carcinoma
    Rami I Aqeilan
    Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 10:3053-8. 2004
    ..3-24.1. To investigate the role of the WWOX gene in the development of gastric carcinoma, we examined a large series of primary adenocarcinomas and nine gastric cancer cell lines for the expression of Wwox...
  29. doi request reprint Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor
    Domenico D'Arca
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Urol Oncol 28:189-94. 2010
    ....
  30. pmc FEZ1/LZTS1 is down-regulated in high-grade bladder cancer, and its restoration suppresses tumorigenicity in transitional cell carcinoma cells
    Andrea Vecchione
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Pathol 160:1345-52. 2002
    ..These results suggest that FEZ1/LZTS1 gene plays a role in the development of TCC of the urinary bladder by acting as a bona fide tumor suppressor gene both in vitro and in vivo...
  31. ncbi request reprint The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
    M Ohta
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Cell 84:587-97. 1996
    ..Aberrant transcripts of the FHIT locus were found in approximately 50% of esophageal, stomach, and colon carcinomas...
  32. pmc An antimetastatic role for decorin in breast cancer
    Silvia Goldoni
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Pathol 173:844-55. 2008
    ..In contrast, AG879 failed to have any effect. Our data support a role for decorin as a powerful and effective therapeutic agent against breast cancer due to its inhibition of both primary tumor growth and metastatic spreading...
  33. ncbi request reprint Regression of upper gastric cancer in mice by FHIT gene delivery
    Hideshi Ishii
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    FASEB J 17:1768-70. 2003
    ..This dramatic reduction in tumor burden emphasizes the efficacy of targeting the FHIT apoptotic pathway for tumor eradication...
  34. ncbi request reprint A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth
    Eva M Gonzalez
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:38113-6. 2003
    ..Thus, progranulin/perlecan interaction could contribute to a fine regulation of tumor angiogenesis and could ultimately affect cancer growth...
  35. pmc Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer
    Clay E S Comstock
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 15:5338-49. 2009
    ..Here, the frequency, tumor relevance, and mechanisms controlling cyclin D1b were challenged...
  36. ncbi request reprint Intracellular redistribution of nuclear and nucleolar proteins during differentiation of 32D murine hemopoietic cells
    Xiao Tu
    Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    Exp Cell Res 288:119-30. 2003
    ..This nucleo-cytoplasmic shuttle may play a significant role in the changes in gene expression that occur during differentiation...
  37. pmc Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development
    Andrea Vecchione
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 11:275-89. 2007
    ..Accordingly, Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice...
  38. ncbi request reprint Loss of Fhit expression is associated with poorer survival in gastric cancer but is not an independent prognostic marker
    Emma Bragantini
    Dipartimento di Patologia, Sezione Anatomia Patologica, Universita di Verona, Strada Le Grazie, 8, 37134, Verona, Italy
    J Cancer Res Clin Oncol 132:45-50. 2006
    ..050). While loss of Fhit correlates with poorer survival in univariate analysis, it is not an independent prognostic factor in multivariate analysis and is thus not of clinical utility...
  39. ncbi request reprint Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses
    Hideshi Ishii
    Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    Curr Gene Ther 4:53-63. 2004
    ..The strong proapoptotic activity following Fhit infection of cancer cells strengthens the case for further exploration of FHIT gene therapy in cancer prevention and treatment...