Research Topics
Genomes and Genes | R BaffaSummaryAffiliation: Thomas Jefferson University Country: USA Publications
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Publications
MicroRNA expression profiling of male breast cancerMatteo Fassan
Department of Urology, Thomas Jefferson University Kimmel Cancer Center, 1112 College Building, 1025 Walnut Street, PA 19107, USA
Breast Cancer Res 11:R58. 2009....- Collecting duct carcinoma of the kidney: an immunohistochemical study of 11 casesAndrea Vecchione
Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA, 19107, USA
BMC Urol 4:11. 2004..In order to gain an insight into the biology of this tumor we evaluated the expression of five genes involved in the development of renal cancer (FEZ1/LZTS1, FHIT, TP53, P27kip1, and BCL2)... 
MicroRNA expression profiling of human metastatic cancers identifies cancer gene targetsRaffaele Baffa
Department of Urology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USA
J Pathol 219:214-21. 2009..Our results suggest that specific miRNAs may be directly involved in cancer metastasis and that they may represent a novel diagnostic tool in the characterization of metastatic cancer gene targets...- Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesisRaffaele Baffa
Department of Urology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Carcinogenesis 29:846-8. 2008..Therefore, LZTS1 may become an excellent target for gene therapy in advanced bladder carcinoma... 
Molecular genetics of bladder cancer: targets for diagnosis and therapyR Baffa
Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Exp Clin Cancer Res 25:145-60. 2006..Capitalizing on these alterations will allow early detection, providing important prognostic information and unique targets for gene therapy and other therapeutic approaches...- Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cellsH Ishii
Kimmel Cancer Institute, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 61:1578-84. 2001..Thus, adenoviral-FHIT expression can inhibit the growth of esophageal cancer cells, at least in part through caspase-dependent apoptosis, suggesting that adenoviral-FHIT infection should be explored as a therapeutic strategy... - Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancerK R Dumon
Kimmel Cancer Center, Thomas Jefferson University, Department of Surgery, Hospital of the University of Pennsylvania, Gene Therapy Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
Cancer Res 61:4827-36. 2001..In vivo results show that FHIT gene transfer delays tumor growth and prolongs survival in a murine model mimicking human disease... - Fez1/lzts1 alterations in gastric carcinomaA Vecchione
Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Clin Cancer Res 7:1546-52. 2001..CONCLUSIONS: Our findings support FEZ1/LZTS1 as a candidate tumor suppressor gene at 8p in a subtype of gastric cancer and suggest that its inactivation is attributable to several factors including genomic deletion and methylation... - Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell linesK Kastury
Jefferson Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107 6799, USA
Cancer Res 56:978-83. 1996..Thus, it is likely that the homozygous deletion observed in these cancer cell lines harbors an important tumor suppressor gene for several tumor types... - FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosisH Ishii
Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107 5799, USA
Proc Natl Acad Sci U S A 98:10374-9. 2001..Present data show that FEZ1/LZTS1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth... - Potential cancer therapy with the fragile histidine triad gene: review of the preclinical studiesH Ishii
Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th St, Philadelphia, PA 19107-5799, USA
JAMA 286:2441-9. 2001.... - MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancerA Vecchione
Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Oncogene 28:257-69. 2009..Our findings support the hypothesis that MITOSTATIN has many hallmarks of a classical tumor suppressor in solid tumors and may play an important role in cancer development and progression... - Loss of FHIT expression in transitional cell carcinoma of the urinary bladderR Baffa
Department of Urology, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Am J Pathol 156:419-24. 2000..These results suggested that loss of Fhit expression may be as important in the development of bladder cancer as it is for other neoplasms caused by environmental carcinogens... - FHIT gene therapy prevents tumor development in Fhit-deficient miceK R Dumon
Kimmel Cancer Center, Jefferson Medical College, 233 South 10th Street, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 98:3346-51. 2001..We therefore suggest that FHIT gene therapy could be a novel clinical approach not only in treatment of early stages of cancer, but also in prevention of human cancer... - The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumorsH Ishii
Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 96:3928-33. 1999..Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors... - Molecular genetics of prostate cancer: clinical translational opportunitiesA Vecchione
Department of Urology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA 19107, USA
J Exp Clin Cancer Res 26:25-37. 2007..This review aims to identify trends in PC research and suggests potential clinical applications for diagnosis, prognosis, prevention and treatment... - Definition and refinement of chromosome 8p regions of loss of heterozygosity in gastric cancerR Baffa
Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
Clin Cancer Res 6:1372-7. 2000..Initial steps were taken toward the identification of this gene, which is likely to play an important role in the pathogenesis of gastric cancer and of other tumors as well... - The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancersM Ohta
Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
Cell 84:587-97. 1996..Aberrant transcripts of the FHIT locus were found in approximately 50% of esophageal, stomach, and colon carcinomas... - Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancerDimitrios Iliopoulos
Department of Microbiology Immunology, Philadelphia, PA 19107, USA
Oncogene 24:1625-33. 2005..Differential methylation in cancerous vs adjacent tissues suggests that WWOX and FHIT hypermethylation analyses could enrich a panel of DNA methylation markers... - Structure and expression of the human FHIT gene in normal and tumor cellsT Druck
Department of Microbiology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
Cancer Res 57:504-12. 1997..Most of the cell lines that exhibited genomic alterations showed alteration of FHIT transcripts and absence or diminution of Fhit protein... - Micro-RNA profiling in kidney and bladder cancersFedra Gottardo
Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Urol Oncol 25:387-92. 2007..To study the role of the micro-RNAs in human kidney and bladder cancer, we analyzed the expression profile of 245 micro-RNAs in kidney and bladder primary tumors... - Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: a region of high loss of heterozygosity in gastric cancerC Schmutte
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 57:3010-5. 1997..At present, we have found no evidence that TDG is central to the development of gastric cancer, limiting the importance of TDG in T:G mismatch repair and subsequent carcinogenesis... - Familial cancer associated with a polymorphism in ARLTS1George Adrian Calin
Thomas Jefferson University, Philadelphia, USA
N Engl J Med 352:1667-76. 2005..The finding of hemizygous or homozygous deletions at band 14 on chromosome 13 in a variety of neoplasms suggests the presence of a tumor-suppressor locus telomeric to the RB1 gene... - Loss of WWOX expression in gastric carcinomaRami I Aqeilan
Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Clin Cancer Res 10:3053-8. 2004..3-24.1. To investigate the role of the WWOX gene in the development of gastric carcinoma, we examined a large series of primary adenocarcinomas and nine gastric cancer cell lines for the expression of Wwox... - Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitorDomenico D'Arca
Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Urol Oncol 28:189-94. 2010.... - Inactivation of the FHIT gene favors bladder cancer developmentAndrea Vecchione
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Clin Cancer Res 10:7607-12. 2004..c. tumor growth in nude mice. These findings suggest the important role of Fhit in bladder cancer development and support the effort to additionally investigate a FHIT-based gene therapy... - FEZ1/LZTS1 is down-regulated in high-grade bladder cancer, and its restoration suppresses tumorigenicity in transitional cell carcinoma cellsAndrea Vecchione
Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Am J Pathol 160:1345-52. 2002..These results suggest that FEZ1/LZTS1 gene plays a role in the development of TCC of the urinary bladder by acting as a bona fide tumor suppressor gene both in vitro and in vivo... - The FHIT gene 3p14.2 is abnormal in lung cancerG Sozzi
Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
Cell 85:17-26. 1996..Small cell lung cancer tumors and cell lines were analyzed by Southern blotting and showed rearranged BamHI fragments. These data suggest a critical role of the FHIT gene in lung carcinogenesis... - Expression and transcriptional regulation of caspase-14 in simple and complex epitheliaG Pistritto
Center for Apoptosis Research, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cell Death Differ 9:995-1006. 2002.... - An antimetastatic role for decorin in breast cancerSilvia Goldoni
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Am J Pathol 173:844-55. 2008..In contrast, AG879 failed to have any effect. Our data support a role for decorin as a powerful and effective therapeutic agent against breast cancer due to its inhibition of both primary tumor growth and metastatic spreading... - Regression of upper gastric cancer in mice by FHIT gene deliveryHideshi Ishii
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
FASEB J 17:1768-70. 2003..This dramatic reduction in tumor burden emphasizes the efficacy of targeting the FHIT apoptotic pathway for tumor eradication... - A novel interaction between perlecan protein core and progranulin: potential effects on tumor growthEva M Gonzalez
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 278:38113-6. 2003..Thus, progranulin/perlecan interaction could contribute to a fine regulation of tumor angiogenesis and could ultimately affect cancer growth... - Intracellular redistribution of nuclear and nucleolar proteins during differentiation of 32D murine hemopoietic cellsXiao Tu
Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
Exp Cell Res 288:119-30. 2003..This nucleo-cytoplasmic shuttle may play a significant role in the changes in gene expression that occur during differentiation... - Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancerClay E S Comstock
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Clin Cancer Res 15:5338-49. 2009..Here, the frequency, tumor relevance, and mechanisms controlling cyclin D1b were challenged... - Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer developmentAndrea Vecchione
Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
Cancer Cell 11:275-89. 2007..Accordingly, Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice... - Loss of Fhit expression is associated with poorer survival in gastric cancer but is not an independent prognostic markerEmma Bragantini
Dipartimento di Patologia, Sezione Anatomia Patologica, Universita di Verona, Strada Le Grazie, 8, 37134, Verona, Italy
J Cancer Res Clin Oncol 132:45-50. 2006..050). While loss of Fhit correlates with poorer survival in univariate analysis, it is not an independent prognostic factor in multivariate analysis and is thus not of clinical utility... - Cancer prevention and therapy in a preclinical mouse model: impact of FHIT virusesHideshi Ishii
Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
Curr Gene Ther 4:53-63. 2004..The strong proapoptotic activity following Fhit infection of cancer cells strengthens the case for further exploration of FHIT gene therapy in cancer prevention and treatment...