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Accurate mass measurement at enhanced mass-resolution on a triple quadrupole mass-spectrometer for the identification of a reaction impurity and collisionally-induced fragment ions of cabergolineGary Paul
Thermo Finnigan, 265 Davidson Avenue, Suite 101, Somerset, NJ 08873, USA
Rapid Commun Mass Spectrom 17:561-8. 2003..The differences between the accurate mass measurements and exact masses calculated for the proposed fragment ions were 1.9 and 2.1 mmu, with standard deviations of 0.4 and 0.8 mmu, respectively, for replicate determinations...
LiF:Mg,Cu,P glow curve shape dependence on heating rateL Z Luo
Thermo Electron Corporation, 26400 Broadway Avenue, Oakwood Village, OH 44146, USA
Radiat Prot Dosimetry 119:184-90. 2006..The curves are deconvoluted using the new Harshaw Glow Curve Analyser (GCA) program. Results of the study are presented, as well as possible explanations as to the observed effects...
The dose-response of Harshaw TLD-700HK J Velbeck
Thermo Electron Corporation, 26400 Broadway Avenue, Oakwood Village, OH 44146 USA
Radiat Prot Dosimetry 119:255-8. 2006..The simple glow curve structure provides insignificant fade, eliminating special oven preparation methods experienced by other materials. The work presented in this paper quantifies the performance of Harshaw TLD-700H in extended ranges...
Simultaneous analysis of prostanoids using liquid chromatography/high-field asymmetric waveform ion mobility spectrometry/tandem mass spectrometryJames Kapron
Ionalytics, M50 IPF, 1200 Montreal Rd, Ottawa, ON, K1A 0R6 Canada
Rapid Commun Mass Spectrom 20:1504-10. 2006..Generally, the LC-FRM chromatograms were more selective than the LC-SRM chromatograms. Its potential was demonstrated by analysis of prostanoids in guinea pig lumbar spinal cord homogenate...
Enhanced sequence coverage of proteins in human cerebrospinal fluid using multiple enzymatic digestion and linear ion trap LC-MS/MSRoger G Biringer
Scientific Instruments Division of Thermo Electron Corporation, 355 River Oaks Parkway, San Jose, CA 95134, USA
Brief Funct Genomic Proteomic 5:144-53. 2006..Maximal sequence coverage was achieved by combining digest results from both GluC and trypsin. These results have implications for future studies to identify CSF proteins and their post-translational modifications...
Three steps to an equipment planning process that worksEarnie Heard
Government Division Sales, Thermo Asset Management Services, USA
Biomed Instrum Technol 40:219-21. 2006
Type testing the Model 6600 plus automatic TLD readerK J Velbeck
Thermo Electron Corporation, 26400 Broadway Avenue, Oakwood Village, OH 44146, USA
Radiat Prot Dosimetry 120:303-6. 2006..The new TLD reader was found to meet all the IEC criteria by large margins and appears well suited for whole body, extremity and environmental dosimetry applications, with a high degree of dosimetric performance...
Avoiding physicochemical artefacts in early ADME-Tox experimentsRobert S DeWitte
New Pharma R and D Solutions, Thermo Electron Corporation, 5344 John Lucas Drive, Burlington, Ontario L7L 6A6, Canada
Drug Discov Today 11:855-9. 2006..Many of the concepts translate directly to the HTS context...
A hierarchical screening methodology for physicochemical/ADME/Tox profilingRobert S DeWitte
New Pharma R and D Solutions, Thermo Electron Corporation, 5344 John Lucas Drive, Burlington, Ontario L7L 6A6, Canada
Expert Opin Drug Metab Toxicol 2:805-17. 2006..The authors propose a hierarchical screening strategy and describe the implementation of an automated system designed to support that strategy efficiently...
Orbitrap mass analyzer--overview and applications in proteomicsMichaela Scigelova
Thermo Electron Corp, Hemel Hempstead, UK
Proteomics 6:16-21. 2006..The focus is on reviewing examples of protein identification with bottom-up and top-down approaches, and detection of post-translational modifications...
Protein analysis in human cerebrospinal fluid: Physiological aspects, current progress and future challengesAndreas F Huhmer
Proteomics, Finnigan Mass Spectrometry, Thermo Electron, San Jose, CA 95134, USA
Dis Markers 22:3-26. 2006..We also discuss necessary development in methodology in order to have the highest impact on the study of the molecular composition of CSF proteins...
A novel approach for identification and characterization of glycoproteins using a hybrid linear ion trap/FT-ICR mass spectrometerScott M Peterman
Thermo Electron Corporation, Somerset, New Jersey 08873, USA
J Am Soc Mass Spectrom 17:168-79. 2006..In addition, over 95% of the total protein sequence was identified in one analytical run...
Combating the unseenAlan Matta
Occup Health Saf 72:78-80. 2003
Global protein identification and quantification technology using two-dimensional liquid chromatography nanospray mass spectrometryDirk Chelius
Proteomics Division, Thermo Finnigan Corporation, 355 River Oaks Parkway, San Jose, California 95134, USA
Anal Chem 75:6658-65. 2003..This global protein identification and quantification technology should prove to be a valuable means for comparing proteomes in biological samples subjected to differential treatments...
Comprehensive two-dimensional gas chromatography using large sample volume injection for the determination of polynuclear aromatic hydrocarbons in complex matricesDaniela Cavagnino
Thermo Finnigan Italia S p A, Strada Rivoltana, Rodano, Milan 20090, Italy
J Chromatogr A 1019:211-20. 2003..A dedicated data system is presented for acquiring and managing GC x GC data: three-dimensional and color plot visualization, peaks integration, identification and quantitation are functions available with the software...
An optical thin film assay incorporating rhinovirus protease inhibitors as detector reagentsAnna Ettinger
Thermo Electron Corp, 331 South 104th Street, Louisville, CO 80027, USA
Antiviral Res 61:153-9. 2004..A rapid (20 min) OIA test was developed using a 15 atom spacer biotinylated inhibitor (4). Forty different HRV serotypes were studied and thirty three serotypes of these 40 were detected (80%)...
A new concept for isotope ratio monitoring liquid chromatography/mass spectrometryMichael Krummen
Thermo Electron Corporation, Finnigan Advanced Mass Spectrometry, Barkhausenstrasse 2, D 28197 Bremen, Germany
Rapid Commun Mass Spectrom 18:2260-6. 2004..The wide range of chromatographic methods enables the analysis of compounds never before amenable to isotope ratio mass spectrometry techniques and may lead to the development of many new assays...
Application of rapid, electrochemical Flash Titration to total acidity and alkalinity determinations in buffers, foods, and beveragesXiaowen Wen
Thermo Electron Corp, Environmental Instruments Division, Water Analysis, 166 Cummings Center, Beverly, MA 01915, USA
J AOAC Int 87:1208-17. 2004..Analysis costs were reduced both through time saving and reduction or elimination of hazardous liquid titrant disposal, by the use of the Flash Titration method...
Do diligence. A look at the 10 most common errors in medical equipment maintenance invoicesSusan M Kruk
USCS, Thermo Electron Corporation, Brookfield, Wisconsin, USA
Health Facil Manage 18:34-6. 2005
The use of a hybrid linear trap/FT-ICR mass spectrometer for on-line high resolution/high mass accuracy bottom-up sequencingScott M Peterman
265 Davidson Ave, Suite 101, Somerset, NJ 08873, USA
J Biomol Tech 16:112-24. 2005..Comparisons of protein sequence coverage are presented for product ion detection in the linear trap and ICR cell...
Asset management: the big pictureDeborah C Deinstadt
Healthc Financ Manage 59:86-8, 90-3. 2005..A key preliminary step is to thoroughly assess the existing equipment base. A critical objective is to ensure that there are open lines of communication among the teams charged with managing the plan's various phases...
ChromAlign: A two-step algorithmic procedure for time alignment of three-dimensional LC-MS chromatographic surfacesRovshan G Sadygov
Thermo Electron Corporation, 355 River Oaks Parkway, San Jose, California 95134, USA
Anal Chem 78:8207-17. 2006..ChromAlign accurately aligns the LC-MS surfaces we studied. In these examples, we discuss various aspects of the alignment by ChromAlign, such as constant time axis shifts and warping of chromatographic surfaces...
