Athena Zuppa

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi request reprint Methods for pharmacokinetic analysis in young children
    Adam S Himebauch
    The Children s Hospital of Philadelphia, Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Main Building, Suite 7C26, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    Expert Opin Drug Metab Toxicol 10:497-509. 2014
  2. pmc Prescribing habits and caregiver satisfaction with resources for dosing children: rationale for more informative dosing guidance
    Jeffrey S Barrett
    Department of Pediatrics, Division of Clinical Pharmacology and Therapeutics, The Children s Hospital of Philadelphia, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA
    BMC Pediatr 11:25. 2011
  3. doi request reprint Understanding renal replacement therapy and dosing of drugs in pediatric patients with kidney disease
    Athena F Zuppa
    Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Clin Pharmacol 52:134S-40S. 2012
  4. doi request reprint Population pharmacokinetics of ketorolac in neonates and young infants
    Athena F Zuppa
    Division of Clinical Pharmacology and Therapeutics, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Ther 16:143-6. 2009
  5. doi request reprint Pharmacokinetics and pharmacodynamics in the critically ill child
    Athena F Zuppa
    The Children s Hospital of Philadelphia, Abramson Research Center, 3516 Civic Center Boulevard, Suite 916 H, Philadelphia, PA 19104, USA
    Pediatr Clin North Am 55:735-55, xii. 2008
  6. ncbi request reprint An informatics approach to assess pediatric pharmacotherapy: design and implementation of a hospital drug utilization system
    Athena Zuppa
    Clinical Pharmacology and Therapeutics, Abramson Research Center, Suite 916 J, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    J Clin Pharmacol 47:1172-80. 2007
  7. ncbi request reprint Population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing stage I reconstruction
    Athena F Zuppa
    Division of Clinical Pharmacology and Therapeutics, Department of Pediatrics, Abramson Research Center, Philadelphia, Pennsylvania 19104 4318, USA
    Anesth Analg 102:1062-9. 2006
  8. ncbi request reprint The effect of a thyroid hormone infusion on vasopressor support in critically ill children with cessation of neurologic function
    Athena F Zuppa
    Department of Anesthesia and Critical Care Medicine, Division of Critical Care Medicine, Children s Hospital of Philadelphia, USA
    Crit Care Med 32:2318-22. 2004
  9. ncbi request reprint Sensitive and specific liquid chromatography-tandem mass spectrometric method for the quantitation of dexmedetomidine in pediatric plasma
    James I Lee
    Division of Clinical Pharmacology and Therapeutics, Department of Pediatrics, Abramson Research Center 916H, Philadelphia, PA 19104 4399, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 852:195-201. 2007
  10. pmc Population pharmacokinetics of dexmedetomidine in infants after open heart surgery
    Felice Su
    Division of Clinical Pharmacology and Therapeutics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Anesth Analg 110:1383-92. 2010

Detail Information

Publications14

  1. doi request reprint Methods for pharmacokinetic analysis in young children
    Adam S Himebauch
    The Children s Hospital of Philadelphia, Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Main Building, Suite 7C26, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    Expert Opin Drug Metab Toxicol 10:497-509. 2014
    ..Ideally, these efforts will then not only provide informed and individualized dosing for pediatric patients but will also provide new methods and algorithms for broader use of new pharmacotherapeutic agents or applications. ..
  2. pmc Prescribing habits and caregiver satisfaction with resources for dosing children: rationale for more informative dosing guidance
    Jeffrey S Barrett
    Department of Pediatrics, Division of Clinical Pharmacology and Therapeutics, The Children s Hospital of Philadelphia, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA
    BMC Pediatr 11:25. 2011
    ....
  3. doi request reprint Understanding renal replacement therapy and dosing of drugs in pediatric patients with kidney disease
    Athena F Zuppa
    Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Clin Pharmacol 52:134S-40S. 2012
    ..Furthermore, the pediatric patient presents additional concerns because of developmental factors in children that affect both pharmacokinetics of drugs...
  4. doi request reprint Population pharmacokinetics of ketorolac in neonates and young infants
    Athena F Zuppa
    Division of Clinical Pharmacology and Therapeutics, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Ther 16:143-6. 2009
    ..The clearance values in these neonates and younger group of infants are greater than that reported for older children and adults...
  5. doi request reprint Pharmacokinetics and pharmacodynamics in the critically ill child
    Athena F Zuppa
    The Children s Hospital of Philadelphia, Abramson Research Center, 3516 Civic Center Boulevard, Suite 916 H, Philadelphia, PA 19104, USA
    Pediatr Clin North Am 55:735-55, xii. 2008
    ..Many medications are prescribed for children based on dosing guidance from adult studies, however. Care providers must be cautious of the high risk for drug interactions and adverse reactions in the intensive care setting...
  6. ncbi request reprint An informatics approach to assess pediatric pharmacotherapy: design and implementation of a hospital drug utilization system
    Athena Zuppa
    Clinical Pharmacology and Therapeutics, Abramson Research Center, Suite 916 J, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    J Clin Pharmacol 47:1172-80. 2007
    ..The creation of a national or even global drug utilization network would facilitate the examination of geographical and/or socioeconomic influences in drug utilization and prescribing practices in general...
  7. ncbi request reprint Population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing stage I reconstruction
    Athena F Zuppa
    Division of Clinical Pharmacology and Therapeutics, Department of Pediatrics, Abramson Research Center, Philadelphia, Pennsylvania 19104 4318, USA
    Anesth Analg 102:1062-9. 2006
    ..6 mL x kg(-1) x min(-1)) by postoperative day 4. In the postoperative setting of markedly impaired renal function, an infusion rate of 0.2 microg x kg(-1) x min(-1) should be considered...
  8. ncbi request reprint The effect of a thyroid hormone infusion on vasopressor support in critically ill children with cessation of neurologic function
    Athena F Zuppa
    Department of Anesthesia and Critical Care Medicine, Division of Critical Care Medicine, Children s Hospital of Philadelphia, USA
    Crit Care Med 32:2318-22. 2004
    ..To determine the impact of a thyroid hormone infusion (T4) on the vasopressor requirements in children with cessation of neurologic function (i.e., brain death) during evaluation for organ recovery..
  9. ncbi request reprint Sensitive and specific liquid chromatography-tandem mass spectrometric method for the quantitation of dexmedetomidine in pediatric plasma
    James I Lee
    Division of Clinical Pharmacology and Therapeutics, Department of Pediatrics, Abramson Research Center 916H, Philadelphia, PA 19104 4399, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 852:195-201. 2007
    ..This method is robust and has been successfully employed in a pharmacokinetic study of Dex in infants postoperative from cardiac surgery...
  10. pmc Population pharmacokinetics of dexmedetomidine in infants after open heart surgery
    Felice Su
    Division of Clinical Pharmacology and Therapeutics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Anesth Analg 110:1383-92. 2010
    ..Only limited pharmacokinetic data are available for pediatric patients. The primary aim of this study was to determine the pharmacokinetics of dexmedetomidine in infants after open heart surgery...
  11. doi request reprint Application of Individualized Bayesian Urea Kinetic Modeling to pediatric hemodialysis
    Olivera Marsenic
    Laboratory for Applied PK PD, Division of Clinical Pharmacology and Therapeutics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    ASAIO J 56:246-53. 2010
    ..This study suggests that the IBKM can be used in a pediatric HD setting and accurately predict Ceq in children using only pre-HD and immediately post-HD BUN...
  12. ncbi request reprint Drug utilization in the pediatric intensive care unit: monitoring prescribing trends and establishing prioritization of pharmacotherapeutic evaluation of critically ill children
    Athena F Zuppa
    Department of Pediatrics, Division of Clinical Pharmacology and Therapeutics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Clin Pharmacol 45:1305-12. 2005
    ....
  13. ncbi request reprint Untying the Gordian knot
    Felice Su
    Anesth Analg 104:993; author reply 993-4. 2007
  14. ncbi request reprint Propofol pharmacokinetics
    Athena F Zuppa
    Pediatr Crit Care Med 4:124-5. 2003

Research Grants4

  1. Improving Drug Development for the Critically Ill Child
    Athena Zuppa; Fiscal Year: 2007
    ..This intensive didactic and mentored training will allow for the development of a future independent pediatric clinical investigator. ..
  2. Impact of Pharmacology on Duration of Ventilation in Patients with Resp Failure
    Athena F Zuppa; Fiscal Year: 2010
    ....