Eric Zorrilla

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats
    Valentina Sabino
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 189:175-86. 2006
  2. ncbi request reprint Corticotropin releasing factor: a key role in the neurobiology of addiction
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA Electronic address
    Front Neuroendocrinol 35:234-44. 2014
  3. pmc Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, United States of America Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 8:e63942. 2013
  4. doi request reprint Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA Electronic address
    Brain Behav Immun 37:45-53. 2014
  5. pmc Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA Electronic address
    Neurosci Biobehav Rev 37:1932-45. 2013
  6. pmc Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Drug Alcohol Depend 128:175-86. 2013
  7. pmc Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Addict Biol 17:300-8. 2012
  8. ncbi request reprint Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat
    Eric P Zorrilla
    Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 177:324-35. 2005
  9. pmc Progress in corticotropin-releasing factor-1 antagonist development
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Drug Discov Today 15:371-83. 2010
  10. ncbi request reprint Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats
    E P Zorrilla
    CVN7, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 158:374-81. 2001

Detail Information

Publications61

  1. ncbi request reprint Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats
    Valentina Sabino
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 189:175-86. 2006
    ..The role of positive vs negative ethanol reinforcement in ethanol intake of Sardinian alcohol-preferring (sP) rats is unclear...
  2. ncbi request reprint Corticotropin releasing factor: a key role in the neurobiology of addiction
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA Electronic address
    Front Neuroendocrinol 35:234-44. 2014
    ..The results support the hypothesis that brain CRF-CRF1 systems contribute to the etiology and maintenance of addiction. ..
  3. pmc Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, United States of America Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 8:e63942. 2013
    ..Utilization of CRF2 antagonists, such as astressin2-B, at doses that are more subtype-selective, can better clarify the significance of brain CRF2 systems in stress-related behavior. ..
  4. doi request reprint Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA Electronic address
    Brain Behav Immun 37:45-53. 2014
    ..Here, we tested the hypothesis that IL-18 modulates weight gain, energy intake, whole-body energy expenditure, and utilization of lipid as a fuel substrate in high-fat diet fed mice...
  5. pmc Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA Electronic address
    Neurosci Biobehav Rev 37:1932-45. 2013
    ..The ancient amygdala-to-striatum pathways remain a current functional thread not only for stimulus-response valuation, but also for the psychopathological plasticity that underlies addiction-related memory, craving and relapse. ..
  6. pmc Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Drug Alcohol Depend 128:175-86. 2013
    ....
  7. pmc Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Addict Biol 17:300-8. 2012
    ..Increased availability of cocaine promotes greater tissue CRF levels in these extrahypothalamic brain regions, changes associated here with a model of cocaine dependence...
  8. ncbi request reprint Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat
    Eric P Zorrilla
    Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 177:324-35. 2005
    ..Many attempts to understand ingestion have sought to clarify the control of meals. Little is known about the effects of the anorexogenic hormone leptin on meal patterning...
  9. pmc Progress in corticotropin-releasing factor-1 antagonist development
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Drug Discov Today 15:371-83. 2010
    ..The therapeutic utility of CRF(1) antagonists should soon be clearer: several small molecules are currently in Phase II/III clinical trials for depression, anxiety and irritable bowel syndrome...
  10. ncbi request reprint Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats
    E P Zorrilla
    CVN7, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 158:374-81. 2001
    ..One proposed mechanism for these alterations is dysregulation of corticotropin-releasing factor (CRF) neurocircuitry...
  11. pmc Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge
    E P Zorrilla
    The Harold L Dorris Neurological Research Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Physiol Behav 91:479-85. 2007
    ..p. 1 IU/kg) in vivo. The results support the hypotheses that galanin-GALR1 systems help adapt food intake and metabolism to changes in dietary fat and modulate glucose disposition in mice...
  12. pmc Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
    Eric P Zorrilla
    Harold L Dorris Neurological Research Institute, Committee on the Neurobiology of Addictive Disorders, and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:11097-102. 2007
    ..The data suggest that endogenous IL-18 signaling modulates food intake, metabolism, and adiposity during adulthood and might be a central or peripheral pharmacological target for controlling energy homeostasis...
  13. ncbi request reprint The therapeutic potential of CRF1 antagonists for anxiety
    Eric P Zorrilla
    Department of Neuropharmacology, The Scripps Research Institute, CVN 7, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Expert Opin Investig Drugs 13:799-828. 2004
    ..Several clinical candidates have entered Phase I/II trials. However, unmet challenges await resolution during further discovery, clinical development and therapeutic application of CRF1 antagonists...
  14. ncbi request reprint Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat
    Eric P Zorrilla
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res 952:188-99. 2002
    ....
  15. ncbi request reprint Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity
    Eric P Zorrilla
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 310:1027-34. 2004
    ..The results suggest the existence of distinct forms of CRF1- and CRF2-mediated anorexia...
  16. ncbi request reprint Nibbling at CRF receptor control of feeding and gastrocolonic motility
    Eric P Zorrilla
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Pharmacol Sci 24:421-7. 2003
    ..These findings have important physiological implications and suggest targeted approaches for the pharmacotherapy of obesity and stress-related functional gastrointestinal and eating disorders...
  17. ncbi request reprint Measuring meals: structure of prandial food and water intake of rats
    Eric P Zorrilla
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1450-67. 2005
    ..Thus log-survivorship analysis is not appropriate for identifying meal breakpoints, and the consideration of drinking in meal definitions can provide a better estimate of meal structure...
  18. ncbi request reprint Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors
    Eric P Zorrilla
    Neurocrine Biosciences, Inc, La Jolla, CA, USA
    Brain Res 952:200-10. 2002
    ..These findings are consistent with the hypothesis that CRF receptor agonists affect performance in tests of learning and memory by increasing arousal...
  19. pmc CRF system recruitment mediates dark side of compulsive eating
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20016-20. 2009
    ....
  20. ncbi request reprint Unlimited access to heroin self-administration: independent motivational markers of opiate dependence
    Scott A Chen
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Neuropsychopharmacology 31:2692-707. 2006
    ..showed a dose-dependent reduction in heroin intake. Changes in the pattern of drug and food intake in the present unlimited heroin access model may serve as independent motivational markers for the transition to a drug-dependent state...
  21. pmc MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist
    Heather N Richardson
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, 92037 California, USA
    Pharmacol Biochem Behav 88:497-510. 2008
    ....
  22. pmc Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval
    Eva M Fekete
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 32:1052-68. 2007
    ..The results implicate the VMN and PVN of the hypothalamus as sites for Ucn 3-CRF(2) control of food intake...
  23. ncbi request reprint Reduction of anxiety after restricted feeding in the rat: implication for eating disorders
    Koki Inoue
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Biol Psychiatry 55:1075-81. 2004
    ..Eating-disorder patients exhibit not only abnormal eating attitudes but also pathologic anxiety-like behaviors. The specific nature of the relationship between dieting and anxiety-like behavior is unknown...
  24. ncbi request reprint Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior
    Alon Chen
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 26:5500-10. 2006
    ..The differential phenotype of urocortin 2 deficiency in female and male mice may imply a role for urocortin 2 in these gender differences...
  25. pmc Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout
    Kathleen Chu
    Molecular and Integrative Neurosciences Department, SV 142, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92036, USA
    Pharmacol Biochem Behav 86:813-21. 2007
    ..In addition, a model is presented that may be useful for studies examining underlying mechanisms of the ethanol addiction process as well as for testing potential therapeutics...
  26. ncbi request reprint Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats
    Yu Zhao
    Molecular and Integrative Neurosciences Department, Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol Clin Exp Res 31:1505-15. 2007
    ..The purpose of the present experiment was to characterize susceptibility to stress and anxiogenic stimuli in rats over an extended time period following ethanol withdrawal...
  27. ncbi request reprint Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats
    Luis Stinus
    Laboratoire de Neuropsychobiologie des Desadaptations, Universite de Bordeaux II, Bordeaux, Cedex, France
    Neuropsychopharmacology 30:90-8. 2005
    ..In addition, these results suggest that CRF1 antagonists can block the aversive stimulus effects of opiate withdrawal and may be potential therapeutic targets for opiate dependence...
  28. pmc Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala
    Zhiguo Nie
    Burnham Institute for Medical Research, La Jolla, CA, USA
    ScientificWorldJournal 9:68-85. 2009
    ....
  29. pmc CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats
    Sheila E Specio
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 196:473-82. 2008
    ..However, the involvement of activation of CRF(1) receptors in rats self-administering cocaine with extended access is unknown...
  30. ncbi request reprint Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats
    Scott A Chen
    Department of Molecular and Integrative Neurosciences, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 320:180-93. 2007
    ..The results demonstrate that rats will self-administer nicotine to the point of producing dependence, as measured by somatic signs, resistance to extinction, and measures of food intake...
  31. pmc Vaccination against weight gain
    Eric P Zorrilla
    Department of Molecular and Integrative Neurosciences, The Harold L Dorris Neurological Research Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:13226-31. 2006
    ..Effects were not attributable to nonspecific inflammatory responses. Vaccination against the endogenous hormone ghrelin can slow weight gain in rats by decreasing feed efficiency...
  32. pmc Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake
    Vez Repunte-Canonigo
    Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 1339:1-10. 2010
    ..Altogether, the data implicate K-ras-regulated pathways in the regulation of excessive alcohol drinking after a history of dependence...
  33. pmc Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats
    Thomas N Greenwell
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, USA
    Addict Biol 14:130-43. 2009
    ..The results demonstrate that blockade of the CRF-CRF(1) receptor system attenuates the increased heroin intake of rats with extended access to the drug...
  34. pmc The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration
    Thomas N Greenwell
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, United States
    Pharmacol Biochem Behav 91:295-302. 2009
    ..The data suggest that the alpha1 adrenergic system may contribute to mechanisms that promote dependence in rats with extended access...
  35. pmc Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs
    Eva M Fekete
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Front Neuroendocrinol 28:1-27. 2007
    ..Further understanding the unique functions of urocortin 1, urocortin 2, and urocortin 3 action may uncover other therapeutic opportunities...
  36. pmc CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:17198-203. 2007
    ..Overactivation of the CRF-CRF(1) system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction...
  37. pmc Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis
    Walter Francesconi
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 29:5389-401. 2009
    ..Thus, changes in the intrinsic properties of jcBNST neurons mediated by chronic activation of the CRF system may contribute to the persistent emotional dysregulation associated with protracted withdrawal...
  38. pmc Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin
    Remi Martin-Fardon
    The Scripps Research Institute, Molecular and Integrative Neurosciences Department, SP30 2120, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 1314:145-61. 2010
    ....
  39. pmc Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor
    George F Koob
    The Scripps Research Institute, Committee on the Neurobiology of Addictive Disorders, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Curr Opin Investig Drugs 11:63-71. 2010
    ....
  40. pmc Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 67:831-9. 2010
    ..Ethanol augments CeA GABA release in ethanol-naive rats and mice...
  41. ncbi request reprint 14-Methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 192:537-46. 2007
    ..14-methoxymetopon is a centrally acting, selective micro opioid receptor agonist with greater systemic antinociceptive potency than morphine and a putatively improved therapeutic index...
  42. ncbi request reprint Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist
    Glenn R Valdez
    Department of Neuropharmacology, CVN7, Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res 980:206-12. 2003
    ....
  43. ncbi request reprint Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence
    Glenn R Valdez
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol 29:55-60. 2003
    ..Results of the current experiment demonstrated that continuous exposure to ethanol over a 3-week period leads to an increased behavioral responsiveness to stress, which seems to be regulated by CRF...
  44. ncbi request reprint Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor
    Glenn R Valdez
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 26:1494-501. 2002
    ..The objective of the present study was to investigate the role of CRF in the regulation of ethanol self-administration and to examine the behavioral stress response during acute withdrawal and protracted abstinence...
  45. ncbi request reprint Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide
    Glenn R Valdez
    Department of Neuropharmacology, CVN7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 943:142-50. 2002
    ..Thus, hUcn II exhibits mild motor suppressive effects and delayed anxiolytic-like effects, suggesting a time-dependent role for hUcn II in the regulation of stress-related behavior...
  46. pmc Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats
    Cindy K Funk
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 61:78-86. 2007
    ..Here, we used an animal model of ethanol dependence to test the effects of CRF(1) receptor antagonists on excessive ethanol self-administration in dependent rats...
  47. pmc Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA or
    J Physiol 583:487-504. 2007
    ..Because central CRF(2) stimulation retains full anorectic efficacy at higher doses in the DIO model, manipulating this neuropeptidergic system might yield new therapeutic approaches for diet-induced obesity...
  48. ncbi request reprint Transgenic mice with a reduced core body temperature have an increased life span
    Bruno Conti
    Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 314:825-8. 2006
    ..Thus, modest, sustained reduction of core body temperature prolonged life span independent of altered diet or CR...
  49. ncbi request reprint FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 32:1069-81. 2007
    ..5 mg/kg) female rats (n=48) in the elevated plus-maze. Thus, benzodiazepine receptor inverse agonists preferentially lessen the maintenance of feeding in female rats, effects opposite to those of palatable food...
  50. pmc Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests
    Xiaoying Lu
    The Harold L Dorris Neurological Institute, Department of Molecular and Integrative Neurosciences, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 42:387-97. 2008
    ..The present findings are consistent with a predicted antidepressant-like effect of GalR2 signaling, suggesting that GalR2 might be a valid drug target for depressive disorders...
  51. pmc Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1066-76. 2008
    ..The results suggest that intermittent access to highly preferred food, as practiced by many restrained eaters, may progressively decrease the acceptability of less palatable foods, and may promote relapse to more rewarding alternatives...
  52. pmc Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders CNAD, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Psychoneuroendocrinology 34:38-49. 2009
    ..The present diet cycling procedure may model consummatory, anxiety-related, and metabolic effects of qualitative dieting in humans...
  53. doi request reprint Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance
    Olivia Osborn
    The Harold L Dorris Neurological Research Institute, and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Swiss Med Wkly 138:665-73. 2008
    ..This review highlights results of studies in mice which indicate important roles for these proinflammatory cytokines during the development of obesity and insulin resistance, and in the treatment of type 2 diabetes...
  54. pmc The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropsychopharmacology 34:1482-93. 2009
    ....
  55. pmc Sigma-1 receptor knockout mice display a depressive-like phenotype
    Valentina Sabino
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Brain Res 198:472-6. 2009
    ..The results further suggest that Sig-1Rs inversely modulate depressive-like behavior...
  56. ncbi request reprint Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:524-35. 2008
    ..Such rats show changes in ingestive, metabolic, endocrine, and anxiety-related measures, which resemble features of binge eating disorders or obesity...
  57. pmc Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention
    Marian L Logrip
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    CNS Drugs 25:271-87. 2011
    ..CRF receptor antagonists, by reducing the motivational effects of drug withdrawal and protracted abstinence, are proposed to be novel therapeutic targets for drug abuse and addiction...
  58. ncbi request reprint Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene"
    Antoine Tabarin
    Laboratoire Homéostasie Allostasie Pathologie, EA 3666, University of Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
    Diabetes 54:3510-6. 2005
    ....
  59. pmc Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice
    Alexander V Mayorov
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:17487-92. 2008
    ....
  60. ncbi request reprint Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat
    Koki Inoue
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    J Pharmacol Exp Ther 305:385-93. 2003
    ..hUcn II is a promising neuropeptide for investigating the role of the CRF(2) receptor in ingestive behavior...
  61. ncbi request reprint Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood
    Heather N Richardson
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Endocrinology 147:2506-17. 2006
    ..The present data exemplify the differential sensitivity of the developing nervous and endocrine systems to stress, depending on not only gender but also the nature of the stressful experience endured by the mother during pregnancy...

Research Grants13

  1. Role of the CRF2 Receptor in Ingestive Behavior
    Eric Zorrilla; Fiscal Year: 2005
    ..The proposed studies will address these questions as well to understand better the role of the CRF2 receptor in feeding behavior. ..
  2. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  3. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric Zorrilla; Fiscal Year: 2009
    ....
  4. Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral Bases
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  5. Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral Bases
    Eric Zorrilla; Fiscal Year: 2009
    ....
  6. Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral Bases
    Eric Zorrilla; Fiscal Year: 2009
    ....
  7. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric Zorrilla; Fiscal Year: 2009
    ....
  8. Programmed adiposity: genetic in utero and postnatal determinants
    Eric Zorrilla; Fiscal Year: 2007
    ....
  9. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric Zorrilla; Fiscal Year: 2007
    ....
  10. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric Zorrilla; Fiscal Year: 2006
    ....
  11. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric P Zorrilla; Fiscal Year: 2010
    ....