XIAOBO contact ZHOU

Summary

Affiliation: The Methodist Hospital
Country: USA

Publications

  1. pmc A novel cell segmentation method and cell phase identification using Markov model
    Xiaobo Zhou
    The Methodist Hospital Research Institute, Weill Medical College, Cornell University, Houston, TX 77030, USA
    IEEE Trans Inf Technol Biomed 13:152-7. 2009
  2. pmc Drug inhibition profile prediction for NFκB pathway in multiple myeloma
    Huiming Peng
    Department of Radiology, The Methodist Hospital Research Institute and Weill Cornell Medical College, Houston, Texas, United States of America
    PLoS ONE 6:e14750. 2011
  3. pmc Prediction of S-glutathionylation sites based on protein sequences
    Chenglei Sun
    Institute of Systems Biology, Shanghai University, Shanghai, China
    PLoS ONE 8:e55512. 2013
  4. pmc Reversible jump MCMC approach for peak identification for stroke SELDI mass spectrometry using mixture model
    Yuan Wang
    Center for Biotechnology and Informatics, The Methodist Hospital Research Institute, and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA
    Bioinformatics 24:i407-13. 2008
  5. pmc Pattern-selection based power analysis and discrimination of low- and high-grade myelodysplastic syndromes study using SNP arrays
    Xiaorong Yang
    Department of Radiology, The Methodist Hospital Research Institute, Weill Medical College, Cornell University, Center for Biotechnology and Informatics, Houston, Texas, United States of America
    PLoS ONE 4:e5054. 2009
  6. pmc Computer-assisted lip diagnosis on Traditional Chinese Medicine using multi-class support vector machines
    Fufeng Li
    Laboratory of Information Access and Synthesis of TCM Four Diagnosis, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
    BMC Complement Altern Med 12:127. 2012
  7. pmc Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: incorporating EGFR signaling pathway and angiogenesis
    Xiaoqiang Sun
    Department of Radiology, The Methodist Hospital Research Institute, Weil Cornell Medical College, Houston, TX 77030, USA
    BMC Bioinformatics 13:218. 2012
  8. pmc A computational model for compressed sensing RNAi cellular screening
    Hua Tan
    Department of Radiology, The Methodist Hospital Research Institute, Weill Medical College of Cornell University, Houston, TX 77030, USA
    BMC Bioinformatics 13:337. 2012
  9. pmc Cancer bioinformatics: detection of chromatin states, SNP-containing motifs, and functional enrichment modules
    Xiaobo Zhou
    Center for Bioinformatics and Systems Biology, Wake Forest University School of Medicine, Winston Salem, NC 27103, USA
    Chin J Cancer 32:153-4. 2013
  10. pmc A system mathematical model of a cell-cell communication network in amyotrophic lateral sclerosis
    Hongwei Shao
    Methodist Hospital Research Institute, 6670 Bertner Avenue, Houston, USA
    Mol Biosyst 9:398-406. 2013

Collaborators

  • Fuhai Li
  • King Li
  • Hongwei Li
  • Jun Wang
  • Chung Che Chang
  • Federico A Monzon
  • Jun Yan
  • Ping Wang
  • Zheng Xia
  • Wai Ki Ching
  • Limin Li
  • Hua Tan
  • Le Zhang
  • Zheng Yin
  • Stephen T C Wong
  • Chenglei Sun
  • Hongwei Shao
  • Jiguang Bao
  • Xiaoqiang Sun
  • Costas Strouthos
  • Huiming Peng
  • Dominik Beck
  • Jianguo Wen
  • Zhu Hong You
  • Xianwen Ren
  • Xiaorong Yang
  • Petronela Ancuta
  • Yuan Wang
  • Luonan Chen
  • Xing Ming Zhao
  • Ying He
  • Zheng zheng Shi
  • Jing Fan
  • Jennifer G Dy
  • Miriam B Brandl
  • Phillip Zhe Sun
  • Paul Webb
  • Steve Ayers
  • Tuan D Pham
  • Beini Jiang
  • Yukun Wu
  • Jing Su
  • Jeff Chang
  • Kyungsook Han
  • Xiang Sun Zhang
  • De Shuang Huang
  • Ling Yun Wu
  • Vanessa Sue Wacleche
  • Vikas Misra
  • Dana Gabuzda
  • Annie Gosselin
  • Lingyun Wu
  • Kuang Yu Liu
  • Wan Ting Huang
  • Chris Bakal
  • Honghui Wang
  • Lixiu Yao
  • Youxian Sun
  • Norbert Perrimon

Detail Information

Publications23

  1. pmc A novel cell segmentation method and cell phase identification using Markov model
    Xiaobo Zhou
    The Methodist Hospital Research Institute, Weill Medical College, Cornell University, Houston, TX 77030, USA
    IEEE Trans Inf Technol Biomed 13:152-7. 2009
    ..Using the context information of time-lapse data, the phases of cell nuclei are identified accurately via a Markov model. Experimental results show that the proposed system is effective for nuclei segmentation and phase identification...
  2. pmc Drug inhibition profile prediction for NFκB pathway in multiple myeloma
    Huiming Peng
    Department of Radiology, The Methodist Hospital Research Institute and Weill Cornell Medical College, Houston, Texas, United States of America
    PLoS ONE 6:e14750. 2011
    ....
  3. pmc Prediction of S-glutathionylation sites based on protein sequences
    Chenglei Sun
    Institute of Systems Biology, Shanghai University, Shanghai, China
    PLoS ONE 8:e55512. 2013
    ..879 in 5-fold cross-validation, which demonstrates the predictive power of our proposed method. The datasets used in this work are available at http://csb.shu.edu.cn/SGDB...
  4. pmc Reversible jump MCMC approach for peak identification for stroke SELDI mass spectrometry using mixture model
    Yuan Wang
    Center for Biotechnology and Informatics, The Methodist Hospital Research Institute, and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA
    Bioinformatics 24:i407-13. 2008
    ....
  5. pmc Pattern-selection based power analysis and discrimination of low- and high-grade myelodysplastic syndromes study using SNP arrays
    Xiaorong Yang
    Department of Radiology, The Methodist Hospital Research Institute, Weill Medical College, Cornell University, Center for Biotechnology and Informatics, Houston, Texas, United States of America
    PLoS ONE 4:e5054. 2009
    ....
  6. pmc Computer-assisted lip diagnosis on Traditional Chinese Medicine using multi-class support vector machines
    Fufeng Li
    Laboratory of Information Access and Synthesis of TCM Four Diagnosis, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
    BMC Complement Altern Med 12:127. 2012
    ..In this paper, we design a computer-assisted classification model to provide an automatic and quantitative approach for the diagnosis of TCM based on the lip images...
  7. pmc Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: incorporating EGFR signaling pathway and angiogenesis
    Xiaoqiang Sun
    Department of Radiology, The Methodist Hospital Research Institute, Weil Cornell Medical College, Houston, TX 77030, USA
    BMC Bioinformatics 13:218. 2012
    ....
  8. pmc A computational model for compressed sensing RNAi cellular screening
    Hua Tan
    Department of Radiology, The Methodist Hospital Research Institute, Weill Medical College of Cornell University, Houston, TX 77030, USA
    BMC Bioinformatics 13:337. 2012
    ..The traditional RNAi screening scheme, in which one siRNA is designed to knockdown one specific mRNA target, needs a large library of siRNAs and turns out to be time-consuming and expensive...
  9. pmc Cancer bioinformatics: detection of chromatin states, SNP-containing motifs, and functional enrichment modules
    Xiaobo Zhou
    Center for Bioinformatics and Systems Biology, Wake Forest University School of Medicine, Winston Salem, NC 27103, USA
    Chin J Cancer 32:153-4. 2013
    ....
  10. pmc A system mathematical model of a cell-cell communication network in amyotrophic lateral sclerosis
    Hongwei Shao
    Methodist Hospital Research Institute, 6670 Bertner Avenue, Houston, USA
    Mol Biosyst 9:398-406. 2013
    ..In the future, if we combine the side effects of different therapies, this model can be used to optimize the therapeutic strategies so that they can effectively improve survival rates and quality of life for patients with ALS...
  11. pmc Developing a multiscale, multi-resolution agent-based brain tumor model by graphics processing units
    Le Zhang
    Department of Mathematical Sciences, Michigan Technological University, Houghton, MI 49931, USA
    Theor Biol Med Model 8:46. 2011
    ..Therefore, the new model has great potential for simulating and predicting real-time GBM progression, if real experimental data are incorporated...
  12. pmc Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston TX, USA
    J Hematol Oncol 2:47. 2009
    ..The goal of the current study was to evaluate the genetic similarities and differences among PL, DLBCL (AIDS-related and non AIDS-related) and PCM using array-based comparative genomic hybridization...
  13. pmc An information-flow-based model with dissipation, saturation and direction for active pathway inference
    Xianwen Ren
    Academy of Mathematics and Systems Science, Chinese Academy of Sciences, 100190, Beijing, China
    BMC Syst Biol 4:72. 2010
    ..Previous methods design different heuristics but do not describe explicitly the behaviours of the information flow...
  14. pmc Semi-supervised drug-protein interaction prediction from heterogeneous biological spaces
    Zheng Xia
    Bioinformatics and Bioengineering Program, The Methodist Hospital Research Institute, Weill Medical College, Cornell University, Houston, TX 77030, USA
    BMC Syst Biol 4:S6. 2010
    ..Furthermore, our semi-supervised learning method integrates known drug-protein interaction network information as well as chemical structure and genomic sequence data...
  15. pmc Integrative analysis of next generation sequencing for small non-coding RNAs and transcriptional regulation in Myelodysplastic Syndromes
    Dominik Beck
    Bioengineering and Bioinformatics Program, Department of Pathology, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX, 77030, USA
    BMC Med Genomics 4:19. 2011
    ..Little is known about small regulatory RNAs and how they contribute to pathogenesis, progression and transcriptome changes in MDS...
  16. pmc Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets
    Petronela Ancuta
    CRCHUM, Universite de Montreal, INSERM Unit 743, Montreal, Quebec, Canada
    BMC Genomics 10:403. 2009
    ..CD16+ Mo produce pro-inflammatory cytokines and are expanded in certain inflammatory conditions including sepsis and HIV infection...
  17. pmc High content image analysis for human H4 neuroglioma cells exposed to CuO nanoparticles
    Fuhai Li
    The Center for Biomedical Informatics, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA
    BMC Biotechnol 7:66. 2007
    ..This system has been proved to be an essential tool in our study...
  18. pmc NSMAP: a method for spliced isoforms identification and quantification from RNA-Seq
    Zheng Xia
    Department of Radiology, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    BMC Bioinformatics 12:162. 2011
    ..Novel study on isoform inference and estimation purely from RNA-Seq without annotation information is desirable...
  19. pmc Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens
    Zheng Yin
    Center for Bioinformatics, The Methodist Hospital Research Institute and Weill Cornell College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    BMC Bioinformatics 9:264. 2008
    ..Arbitrarily extracted information causes biased analysis, while combining the complete existing datasets with each new image is intractable in high-throughput screens...
  20. pmc A semi-supervised learning approach to predict synthetic genetic interactions by combining functional and topological properties of functional gene network
    Zhu Hong You
    Intelligent Computing Lab, Institute of Intelligent Machine, Chinese Academy of Science, P O Box 1130, Hefei, Anhui 230031, China
    BMC Bioinformatics 11:343. 2010
    ..Therefore, an accurate computational approach to predict genetic interaction is highly desirable, and such methods have the potential of alleviating the bottleneck on experiment design...
  21. pmc Conditional random pattern model for copy number aberration detection
    Fuhai Li
    Center for Bioengineering and Informatics, Department of Radiology, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA
    BMC Bioinformatics 11:200. 2010
    ..Thus, more sophisticated statistical models are needed to make the CNAs detection, using the low SNR signals, more robust and reliable...
  22. pmc Predicting enzyme targets for cancer drugs by profiling human metabolic reactions in NCI-60 cell lines
    Limin Li
    Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA
    BMC Bioinformatics 11:501. 2010
    ..Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic reactions suggests a potential way to discover drug targets...
  23. doi request reprint Identification of biomarkers for risk stratification of cardiovascular events using genetic algorithm with recursive local floating search
    Xiaobo Zhou
    Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Cornell University, Houston, TX 77030, USA
    Proteomics 9:2286-94. 2009
    ..The method has been applied to SELDI/MALDI MS datasets to discover an optimized panel of protein biomarkers to distinguish disease from control...