Zhong Wei Zhang

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. ncbi request reprint A critical window for experience-dependent plasticity at whisker sensory relay synapse in the thalamus
    Hao Wang
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Neurosci 28:13621-8. 2008
  2. pmc Essential role of postsynaptic NMDA receptors in developmental refinement of excitatory synapses
    Zhong Wei Zhang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 110:1095-100. 2013
  3. pmc Transforming growth factor-beta1 impairs neuropathic pain through pleiotropic effects
    Stefania Echeverry
    The Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
    Mol Pain 5:16. 2009
  4. pmc MeCP2 is required for normal development of GABAergic circuits in the thalamus
    Zhong Wei Zhang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Neurophysiol 103:2470-81. 2010
  5. ncbi request reprint Developmental refinement in the mammalian thalamus
    Zhong Wei Zhang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Crit Rev Neurobiol 18:49-59. 2006
  6. pmc Elimination of redundant synaptic inputs in the absence of synaptic strengthening
    Hao Wang
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Neurosci 31:16675-84. 2011
  7. pmc Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures
    Wen Zhang
    The Jackson Laboratory, Bar Harbor, Maine 04609
    J Neurosci 34:2754-63. 2014
  8. pmc Adenylate cyclase 1 promotes strengthening and experience-dependent plasticity of whisker relay synapses in the thalamus
    Hao Wang
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Physiol 589:5649-62. 2011
  9. pmc A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice
    Rebecca M Boumil
    The Jackson Laboratory, Bar Harbor, Maine, USA
    PLoS Genet 6:. 2010
  10. ncbi request reprint Canadian Association of Neurosciences review: postnatal development of the mammalian neocortex: role of activity revisited
    Zhong Wei Zhang
    Centre de Recherche Universite Laval Robert Giffard, Department of Psychiatry, Laval University School of Medicine, Quebec, QC
    Can J Neurol Sci 33:158-69. 2006

Research Grants

  1. Synaptic Refinement in the Thalamus
    Zhong Wei Zhang; Fiscal Year: 2009
  2. Synaptic Refinement in the Thalamus
    Zhong Wei Zhang; Fiscal Year: 2010

Collaborators

  • Hong Liu
  • Hao Wang
  • Tobias Moser
  • Wen Zhang
  • Wayne N Frankel
  • Rebecca M Boumil
  • Stefania Echeverry
  • Dany Arsenault
  • Barbara Beyer
  • Matthew Peterson
  • Verity A Letts
  • Connie L Mahaffey
  • Monica C Roberts
  • Christine Lenz
  • Alexandra Haw
  • Ji Zhang
  • Xiang Qun Shi

Detail Information

Publications12

  1. ncbi request reprint A critical window for experience-dependent plasticity at whisker sensory relay synapse in the thalamus
    Hao Wang
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Neurosci 28:13621-8. 2008
    ..Thus, P12-P13 is a critical period for experience-dependent refinement at the whisker sensory relay synapse in the VPm...
  2. pmc Essential role of postsynaptic NMDA receptors in developmental refinement of excitatory synapses
    Zhong Wei Zhang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 110:1095-100. 2013
    ..Our data support a model in which activation of NMDARs in postsynaptic neurons initiates synaptic refinement...
  3. pmc Transforming growth factor-beta1 impairs neuropathic pain through pleiotropic effects
    Stefania Echeverry
    The Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
    Mol Pain 5:16. 2009
    ..Emerging data implicate neuroimmune interaction in the initiation and maintenance of chronic pain hypersensitivity...
  4. pmc MeCP2 is required for normal development of GABAergic circuits in the thalamus
    Zhong Wei Zhang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Neurophysiol 103:2470-81. 2010
    ..Our findings suggest that MeCP2 differentially regulates the development of GABAergic synapses in excitatory and inhibitory neurons in the thalamus...
  5. ncbi request reprint Developmental refinement in the mammalian thalamus
    Zhong Wei Zhang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Crit Rev Neurobiol 18:49-59. 2006
    ..This article aims to provide a brief overview of recent findings and current ideas about the refinement of relay synapses in the thalamus...
  6. pmc Elimination of redundant synaptic inputs in the absence of synaptic strengthening
    Hao Wang
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Neurosci 31:16675-84. 2011
    ....
  7. pmc Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures
    Wen Zhang
    The Jackson Laboratory, Bar Harbor, Maine 04609
    J Neurosci 34:2754-63. 2014
    ..Together, these results suggest that MeCP2 in cortical excitatory neurons plays a critical role in the regulation of GABAergic transmission and cortical excitability. ..
  8. pmc Adenylate cyclase 1 promotes strengthening and experience-dependent plasticity of whisker relay synapses in the thalamus
    Hao Wang
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Physiol 589:5649-62. 2011
    ..Our findings underline a role for AC1 in experience-dependent plasticity of excitatory synapses...
  9. pmc A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice
    Rebecca M Boumil
    The Jackson Laboratory, Bar Harbor, Maine, USA
    PLoS Genet 6:. 2010
    ..We speculate that the emergence of more specialized forms of DNM1 may be important in organisms with complex neuronal function...
  10. ncbi request reprint Canadian Association of Neurosciences review: postnatal development of the mammalian neocortex: role of activity revisited
    Zhong Wei Zhang
    Centre de Recherche Universite Laval Robert Giffard, Department of Psychiatry, Laval University School of Medicine, Quebec, QC
    Can J Neurol Sci 33:158-69. 2006
    ..Neurotransmitters including acetylcholine, serotonin, and gamma-Aminobutyric acid (GABA) may have key roles in the regulation of spontaneous activity, and in the maturation of synapses in the developing brain...
  11. pmc Developmental remodelling of the lemniscal synapse in the ventral basal thalamus of the mouse
    Dany Arsenault
    Centre de Recherche Universite Laval Robert Giffard, 2601, de la Canardière, F 6500 Québec, QC, G1J 2G3 Canada
    J Physiol 573:121-32. 2006
    ..These results suggest that the lemniscal synapse in the ventral basal thalamus undergoes extensive refinement during the second week, and that sensory experience has a rather limited role in this process...
  12. ncbi request reprint Maturation of layer V pyramidal neurons in the rat prefrontal cortex: intrinsic properties and synaptic function
    Zhong Wei Zhang
    Centre de Recherche Universite Laval Robert Giffard, Departement de Psychiatrie, Faculte de Medecine, Universite Laval, Quebec City G1J 2G3, Canada
    J Neurophysiol 91:1171-82. 2004
    ..These findings suggest that the intrinsic properties of neurons and the properties of synaptic inputs develop concomitantly during early life...

Research Grants2

  1. Synaptic Refinement in the Thalamus
    Zhong Wei Zhang; Fiscal Year: 2009
    ....
  2. Synaptic Refinement in the Thalamus
    Zhong Wei Zhang; Fiscal Year: 2010
    ....