Research Topics
Genomes and Genes | Yanping ZhangSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruptionMin Huang
Department of Medicine, Division of Oncology, Stanford University, Stanford, CA 94305 5796, USA
Leuk Res 32:131-41. 2008..The ability of AVN-944 to induce apoptosis in a number of leukemic cell lines supports its potential utility in the treatment of hematologic malignancies...
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathwayYanping Zhang
Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cell Biol 23:8902-12. 2003..We suggest that L11 functions as a negative regulator of HDM2 and that there might exist in vivo an L11-HDM2-p53 pathway for monitoring ribosomal integrity...- The ARF-B23 connection: implications for growth control and cancer treatmentYanping Zhang
Department of Molecular and Cellular Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
Cell Cycle 3:259-62. 2004..The ability of ARF to block cell cycle progression through the MDM2-p53 pathway and to suppress ribosomal biogenesis through B23 suggest a role for ARF in coordinating inhibitions of growth and proliferation... - Inhibition of HDM2 and activation of p53 by ribosomal protein L23Aiwen Jin
Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
Mol Cell Biol 24:7669-80. 2004.... - Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferationKoji Itahana
Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Mol Cell 12:1151-64. 2003..Together, our results reveal a molecular mechanism of ARF in regulating ribosome biogenesis and cell proliferation via inhibiting B23, and suggest a nucleolar role of ARF in surveillance of oncogenic insults... - Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activationKrishna P Bhat
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
EMBO J 23:2402-12. 2004..Growth inhibition, presumably through suppression of rRNA production in the nucleolus, facilitates translocation of L11 to the nucleoplasm, thus activating p53 through inhibiting HDM2... - Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitinationKevin O'Keefe
Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Mol Cell Biol 23:6396-405. 2003..Our data provide new insight into the mechanism and regulation of p53 nucleocytoplasmic shuttling and degradation... - Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradationMikael S Lindström
Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
Mol Cell Biol 27:1056-68. 2007..Hence, the MDM2 central zinc finger plays a critical role in mediating MDM2's interaction with ribosomal proteins and its ability to degrade p53, and these roles are disrupted by human cancer-associated MDM2 mutations... - Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactionsMikael S Lindström
Department of Radiation Oncology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA
Cell Cycle 6:434-7. 2007..Here we further discuss these findings and propose the existence of a ribosomal protein-MDM2-p53 surveillance network responsible for monitoring the stability of the transition between cell growth and division... - Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferationMikael S Lindström
Department of Radiation Oncology, University of North Carolina School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7512, USA
J Biol Chem 283:15568-76. 2008..Our results suggest that B23 selectively stores, and protects ribosomal protein S9 in nucleoli and therefore could facilitate ribosome biogenesis... - Nitric oxide induces phosphorylation of p53 and impairs nuclear exportNicole Schneiderhan
Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
Oncogene 22:2857-68. 2003..This was verified by heterokaryon analysis. We conclude that attenuated nuclear export contributes to stabilization and activation of p53 under the influence of NO... - B23 and ARF: friends or foes?Mikael S Lindström
Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
Cell Biochem Biophys 46:79-90. 2006..Finally, the functional significance of the ARF-B23 interaction for tumor development and the prospects for novel cancer therapies are evaluated... - Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanismMu Shui Dai
Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health and Science University, Portland, Oregon 97239
J Biol Chem 281:24304-13. 2006..These results suggest that L11, unlike L5 and L23, differentially regulates the levels of ubiquitinated p53 and MDM2 and inhibits the turnover and activity of MDM2 through a post-ubiquitination mechanism... - Essential role of the B23/NPM core domain in regulating ARF binding and B23 stabilityTakeharu Enomoto
Department of Radiation Oncology, University of North Carolina at Chapel Hill, NC 27599 7512, USA
J Biol Chem 281:18463-72. 2006..B23 core mutants displayed increased ubiquitination and proteasomal degradation. We conclude that the functional integrity of the B23 core motif is required for stability, efficient nucleolar localization as well as ARF binding... - Nuclear import of the stem-loop binding protein and localization during the cell cycleJudith A Erkmann
Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Mol Biol Cell 16:2960-71. 2005..In contrast, we were unable to identify an in vivo role for Transportin-SR2 in SLBP nuclear localization. Thus, only the Impalpha/Impbeta pathway contributes to SLBP nuclear import in HeLa cells... - Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2Yoko Itahana
Department of Radiation Oncology, University of North Carolina at Chapel Hill, Box 7512, 101 Manning Dr, Chapel Hill, NC 27514, USA
Mol Cell Biol 26:4675-89. 2006..Thus, the function of SENP2 is regulated by both nucleocytoplasmic shuttling and polyubiquitin-mediated degradation... - Unlocking the Mdm2-p53 loop: ubiquitin is the keyHilary V Clegg
Lineberger Comprehensive Cancer Center and Curriculum in Genetics and Molecular Biology, School of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27514, USA
Cell Cycle 7:287-92. 2008..We will also discuss additional research questions that may be addressed using our mouse model... - Targeting prostate cancer with conditionally replicative adenovirus using PSMA enhancerSang-Jin Lee
Department of Urology, Indiana University, Indianapolis, IN 46202, USA
Mol Ther 10:1051-8. 2004..These studies suggest that PSME-driven replication-competent adenovirus may be a new therapeutic modality for prostate cancer patients after hormone ablation therapy... 
Mitochondrial p32 is a critical mediator of ARF-induced apoptosisKoji Itahana
Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
Cancer Cell 13:542-53. 2008..These findings provide a potential explanation for the frequent human cancer mutations targeting the ARF C terminus...