Yanping Zhang

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruption
    Min Huang
    Department of Medicine, Division of Oncology, Stanford University, Stanford, CA 94305 5796, USA
    Leuk Res 32:131-41. 2008
  2. pmc Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
    Yanping Zhang
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 23:8902-12. 2003
  3. ncbi request reprint The ARF-B23 connection: implications for growth control and cancer treatment
    Yanping Zhang
    Department of Molecular and Cellular Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cell Cycle 3:259-62. 2004
  4. pmc Inhibition of HDM2 and activation of p53 by ribosomal protein L23
    Aiwen Jin
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Mol Cell Biol 24:7669-80. 2004
  5. ncbi request reprint Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation
    Koji Itahana
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 12:1151-64. 2003
  6. pmc Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation
    Krishna P Bhat
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    EMBO J 23:2402-12. 2004
  7. pmc Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination
    Kevin O'Keefe
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Mol Cell Biol 23:6396-405. 2003
  8. pmc Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation
    Mikael S Lindström
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Mol Cell Biol 27:1056-68. 2007
  9. ncbi request reprint Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactions
    Mikael S Lindström
    Department of Radiation Oncology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA
    Cell Cycle 6:434-7. 2007
  10. pmc Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation
    Mikael S Lindström
    Department of Radiation Oncology, University of North Carolina School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7512, USA
    J Biol Chem 283:15568-76. 2008

Collaborators

  • Krishna P Bhat
  • Yue Xiong
  • Ryuji Kobayashi
  • U Kutay
  • Edward T Yeh
  • WILLIAM F contact MARZLUFF
  • Mikael S Lindström
  • Koji Itahana
  • Aiwen Jin
  • Yoko Itahana
  • Kevin O'Keefe
  • Hilary V Clegg
  • Min Huang
  • Chad Deisenroth
  • Mu Shui Dai
  • Takeharu Enomoto
  • Judith A Erkmann
  • Sang Jin Lee
  • Nicole Schneiderhan
  • Beverly Mitchell
  • YanShan Ji
  • Gabrielle White Wolf
  • Yetao Jin
  • Hua Lu
  • Steven R Grossman
  • Xiao Xin Sun
  • Hengming Ke
  • Dingding Shi
  • Jian Dong
  • Eric J Wagner
  • Chaeyong Jung
  • Sang Don Lee
  • Kyung Hee Bae
  • Meei Huey Jeng
  • Xiong Li
  • Hong Sup Kim
  • Thomas Gardner
  • Chinghai Kao
  • Bernhard Brüne
  • Andreja Budde
  • Huiping Li
  • David Hawke

Detail Information

Publications19

  1. ncbi request reprint Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruption
    Min Huang
    Department of Medicine, Division of Oncology, Stanford University, Stanford, CA 94305 5796, USA
    Leuk Res 32:131-41. 2008
    ..The ability of AVN-944 to induce apoptosis in a number of leukemic cell lines supports its potential utility in the treatment of hematologic malignancies...
  2. pmc Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
    Yanping Zhang
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 23:8902-12. 2003
    ..We suggest that L11 functions as a negative regulator of HDM2 and that there might exist in vivo an L11-HDM2-p53 pathway for monitoring ribosomal integrity...
  3. ncbi request reprint The ARF-B23 connection: implications for growth control and cancer treatment
    Yanping Zhang
    Department of Molecular and Cellular Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cell Cycle 3:259-62. 2004
    ..The ability of ARF to block cell cycle progression through the MDM2-p53 pathway and to suppress ribosomal biogenesis through B23 suggest a role for ARF in coordinating inhibitions of growth and proliferation...
  4. pmc Inhibition of HDM2 and activation of p53 by ribosomal protein L23
    Aiwen Jin
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Mol Cell Biol 24:7669-80. 2004
    ....
  5. ncbi request reprint Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation
    Koji Itahana
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 12:1151-64. 2003
    ..Together, our results reveal a molecular mechanism of ARF in regulating ribosome biogenesis and cell proliferation via inhibiting B23, and suggest a nucleolar role of ARF in surveillance of oncogenic insults...
  6. pmc Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation
    Krishna P Bhat
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    EMBO J 23:2402-12. 2004
    ..Growth inhibition, presumably through suppression of rRNA production in the nucleolus, facilitates translocation of L11 to the nucleoplasm, thus activating p53 through inhibiting HDM2...
  7. pmc Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination
    Kevin O'Keefe
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Mol Cell Biol 23:6396-405. 2003
    ..Our data provide new insight into the mechanism and regulation of p53 nucleocytoplasmic shuttling and degradation...
  8. pmc Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation
    Mikael S Lindström
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Mol Cell Biol 27:1056-68. 2007
    ..Hence, the MDM2 central zinc finger plays a critical role in mediating MDM2's interaction with ribosomal proteins and its ability to degrade p53, and these roles are disrupted by human cancer-associated MDM2 mutations...
  9. ncbi request reprint Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactions
    Mikael S Lindström
    Department of Radiation Oncology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA
    Cell Cycle 6:434-7. 2007
    ..Here we further discuss these findings and propose the existence of a ribosomal protein-MDM2-p53 surveillance network responsible for monitoring the stability of the transition between cell growth and division...
  10. pmc Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation
    Mikael S Lindström
    Department of Radiation Oncology, University of North Carolina School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7512, USA
    J Biol Chem 283:15568-76. 2008
    ..Our results suggest that B23 selectively stores, and protects ribosomal protein S9 in nucleoli and therefore could facilitate ribosome biogenesis...
  11. ncbi request reprint Nitric oxide induces phosphorylation of p53 and impairs nuclear export
    Nicole Schneiderhan
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    Oncogene 22:2857-68. 2003
    ..This was verified by heterokaryon analysis. We conclude that attenuated nuclear export contributes to stabilization and activation of p53 under the influence of NO...
  12. ncbi request reprint B23 and ARF: friends or foes?
    Mikael S Lindström
    Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cell Biochem Biophys 46:79-90. 2006
    ..Finally, the functional significance of the ARF-B23 interaction for tumor development and the prospects for novel cancer therapies are evaluated...
  13. pmc Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism
    Mu Shui Dai
    Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health and Science University, Portland, Oregon 97239
    J Biol Chem 281:24304-13. 2006
    ..These results suggest that L11, unlike L5 and L23, differentially regulates the levels of ubiquitinated p53 and MDM2 and inhibits the turnover and activity of MDM2 through a post-ubiquitination mechanism...
  14. ncbi request reprint Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability
    Takeharu Enomoto
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, NC 27599 7512, USA
    J Biol Chem 281:18463-72. 2006
    ..B23 core mutants displayed increased ubiquitination and proteasomal degradation. We conclude that the functional integrity of the B23 core motif is required for stability, efficient nucleolar localization as well as ARF binding...
  15. pmc Nuclear import of the stem-loop binding protein and localization during the cell cycle
    Judith A Erkmann
    Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Biol Cell 16:2960-71. 2005
    ..In contrast, we were unable to identify an in vivo role for Transportin-SR2 in SLBP nuclear localization. Thus, only the Impalpha/Impbeta pathway contributes to SLBP nuclear import in HeLa cells...
  16. pmc Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
    Yoko Itahana
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Box 7512, 101 Manning Dr, Chapel Hill, NC 27514, USA
    Mol Cell Biol 26:4675-89. 2006
    ..Thus, the function of SENP2 is regulated by both nucleocytoplasmic shuttling and polyubiquitin-mediated degradation...
  17. ncbi request reprint Unlocking the Mdm2-p53 loop: ubiquitin is the key
    Hilary V Clegg
    Lineberger Comprehensive Cancer Center and Curriculum in Genetics and Molecular Biology, School of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Cell Cycle 7:287-92. 2008
    ..We will also discuss additional research questions that may be addressed using our mouse model...
  18. ncbi request reprint Targeting prostate cancer with conditionally replicative adenovirus using PSMA enhancer
    Sang Jin Lee
    Department of Urology, Indiana University, Indianapolis, IN 46202, USA
    Mol Ther 10:1051-8. 2004
    ..These studies suggest that PSME-driven replication-competent adenovirus may be a new therapeutic modality for prostate cancer patients after hormone ablation therapy...
  19. doi request reprint Mitochondrial p32 is a critical mediator of ARF-induced apoptosis
    Koji Itahana
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cancer Cell 13:542-53. 2008
    ..These findings provide a potential explanation for the frequent human cancer mutations targeting the ARF C terminus...