Y Zhang

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Regulatory mechanisms of mitogen-activated kinase signaling
    Y Zhang
    Department of Immunology, MD Anderson Cancer Center, Unit 906, 7455 Fannin, Houston, Texas 77030, USA
    Cell Mol Life Sci 64:2771-89. 2007
  2. pmc Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice
    Y E Yu
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    Proc Natl Acad Sci U S A 97:4683-8. 2000
  3. pmc Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice
    M Zhao
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 21:7243-55. 2001
  4. ncbi request reprint Control of p53 ubiquitination and nuclear export by MDM2 and ARF
    Y Zhang
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cell Growth Differ 12:175-86. 2001
  5. pmc The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice
    Y Li
    Breast Center, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Br J Cancer 98:1380-8. 2008
  6. pmc Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
    Y Zhang
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:878-83. 2002
  7. ncbi request reprint A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1)
    L V Nazareth
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 13:2065-75. 1999
  8. pmc Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation
    Y Zhang
    Department of Oncology, DNAX Research Institute, Palo Alto, California 94304 1104, USA
    Mol Cell Biol 21:5190-9. 2001
  9. ncbi request reprint Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast
    Y Zhang
    Department of Pharmacology, Kobe University School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 275:35600-6. 2000
  10. ncbi request reprint Multiple actin-related proteins of Saccharomyces cerevisiae are present in the nucleus
    M Harata
    Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Division of Life Science, Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai 981 8555, Japan
    J Biochem 128:665-71. 2000

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Regulatory mechanisms of mitogen-activated kinase signaling
    Y Zhang
    Department of Immunology, MD Anderson Cancer Center, Unit 906, 7455 Fannin, Houston, Texas 77030, USA
    Cell Mol Life Sci 64:2771-89. 2007
    ..In this review, we summarize recent advances in understanding the regulation of MAPK cascades and the roles of MAP kinases and their regulators in development and in immune responses...
  2. pmc Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice
    Y E Yu
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    Proc Natl Acad Sci U S A 97:4683-8. 2000
    ..The absence of TP1 may partially be compensated for by TP2 and P2 precursor, but this dysregulation of nucleoprotein replacement results in an abnormal pattern of chromatin condensation and in reduced fertility...
  3. pmc Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice
    M Zhao
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 21:7243-55. 2001
    ....
  4. ncbi request reprint Control of p53 ubiquitination and nuclear export by MDM2 and ARF
    Y Zhang
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cell Growth Differ 12:175-86. 2001
    ..The biochemical mechanisms of ubiquitination and nuclear export that underlie the functions of ARF and MDM2 in p53 control continue to emerge...
  5. pmc The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice
    Y Li
    Breast Center, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Br J Cancer 98:1380-8. 2008
    ..Such rexinoid-regulated genes also represent potential biomarkers to assess the response of rexinoid treatment in clinical trials...
  6. pmc Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
    Y Zhang
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:878-83. 2002
    ..The ability of extending life expectancy of T effectors, in line with a decrease in its expression following prolonged T cell activation, suggests a key role for IEX-1 in regulating T cell homeostasis during immune responses...
  7. ncbi request reprint A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1)
    L V Nazareth
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 13:2065-75. 1999
    ..Although many inactivating mutations have been identified in androgen insensitivity syndrome patients, to our knowledge, this is the first characterization of an inactivating mutation identified in human prostate cancer...
  8. pmc Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation
    Y Zhang
    Department of Oncology, DNAX Research Institute, Palo Alto, California 94304 1104, USA
    Mol Cell Biol 21:5190-9. 2001
    ..Our experiments demonstrate that disruption of the Mad2-Cdc20 interaction perturbs the mitotic checkpoint, leading to premature activation of the APC, sensitizing the cells to the cytotoxic effects of microtubule-inhibiting drugs...
  9. ncbi request reprint Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast
    Y Zhang
    Department of Pharmacology, Kobe University School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 275:35600-6. 2000
    ..These data suggest that fission yeast PI(4)P5K Its3 functions coordinately with calcineurin and plays a key role in cytokinesis, and that the plasma membrane localization of Its3 is the crucial event in cytokinesis...
  10. ncbi request reprint Multiple actin-related proteins of Saccharomyces cerevisiae are present in the nucleus
    M Harata
    Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Division of Life Science, Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai 981 8555, Japan
    J Biochem 128:665-71. 2000
    ....
  11. ncbi request reprint Chromosomal localization, expression pattern, and promoter analysis of the mouse gene encoding adipocyte-specific secretory protein Acrp30
    K Das
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA
    Biochem Biophys Res Commun 280:1120-9. 2001
    ..Finally, we have characterized the mouse Acrp30 promoter in tissue culture cells. We propose that Acrp30 promoter has the potential to drive strong adipocyte specific heterologous gene expression in transgenic mice...
  12. ncbi request reprint A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
    Y Zhang
    Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, NC 27599-7295, USA
    Science 292:1910-5. 2001
    ..Serine-15-phosphorylated p53 induced by ultraviolet irradiation was not exported. Thus, DNA damage-induced phosphorylation may achieve optimal p53 activation by inhibiting both MDM2 binding to, and the nuclear export of, p53...
  13. ncbi request reprint Subunits coupling H+ transport and ATP synthesis in the Escherichia coli ATP synthase. Cys-Cys cross-linking of F1 subunit epsilon to the polar loop of F0 subunit c
    Y Zhang
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison 53706, USA
    J Biol Chem 270:24609-14. 1995
    ....
  14. ncbi request reprint Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them
    Y Zhang
    Department of Pharmacology and the Institute for Cell and Developmental Biology, SUNY at Stony Brook, Stony Brook, New York 11794 8651, USA
    J Biol Chem 275:35224-32. 2000
    ..These results suggest that PEA-15 may stabilize PLD or act as a PLD chaperone. The common involvement of PEA-15 and PLD in apoptosis, ERK activation, and glucose transport additionally suggests functional significance...
  15. ncbi request reprint Engineering a change in metal-ion specificity of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis-- X-ray structure analysis of site-directed mutants
    K Bunting
    Department of Crystallography, Birkbeck College, University of London, England
    Eur J Biochem 251:795-803. 1998
    ..This alteration in metal specificity may reflect on the preference of manganese ions for anionic ligands...
  16. pmc Reproducible and inexpensive probe preparation for oligonucleotide arrays
    Y Zhang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Nucleic Acids Res 29:E66-6. 2001
    ..Validation of this protocol is demonstrated by hybridizing PCR products with oligonucleotide-coated microspheres and PCR amplified cDNA with Affymetrix Cancer GeneChip microarrays...
  17. ncbi request reprint Ionizing radiation-induced apoptosis in ataxia-telangiectasia fibroblasts. Roles of caspase-9 and cellular inhibitor of apoptosis protein-1
    Y Zhang
    Department of Radiation Medicine, Division of Radiation Research, Vincent T. Lombardi Cancer Center, Georgetown University School of Medicine, Washington, D. C. 20007, USA
    J Biol Chem 276:28842-8. 2001
    ..These results indicate that the extent of IR-induced apoptosis in different AT cell lines is inversely related to the abundance of c-IAP-1 and directly related to the extent of activation of caspases-3 and 9...
  18. ncbi request reprint Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages
    Y Zhang
    Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Ther 3:697-707. 2001
    ..Moreover, DCs and macrophages may play different roles in this process in terms of their abilities to produce distinct patterns of inflammatory cytokines...
  19. ncbi request reprint Heat shock factor-4 (HSF-4a) is a repressor of HSF-1 mediated transcription
    Y Zhang
    Institute of Molecular Medicine and Genetics and Department of Radiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Cell Biochem 82:692-703. 2001
    ..Thus HSF-4a is an active repressor of HSF-1-mediated transcription. This repressor function makes the HSF-4a isoform unique within the HSF family...
  20. ncbi request reprint Identification of the motif in versican G3 domain that plays a dominant-negative effect on astrocytoma cell proliferation through inhibiting versican secretion and binding
    Y Wu
    Sunnybrook and Women's College Health Sciences Centre and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada
    J Biol Chem 276:14178-86. 2001
    ..The effect seems to depend on the expression efficiency of G3DeltaEGF, and it occurred via the carbohydrate recognition domain...
  21. ncbi request reprint Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor
    H Wang
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Science 293:853-7. 2001
    ..Our finding reveals Arg 3 of H4 as a novel methylation site by PRMT1 and indicates that Arg 3 methylation plays an important role in transcriptional regulation...
  22. ncbi request reprint Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors
    M A Schnell
    Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Ther 3:708-22. 2001
    ..These data suggest that inadvertent targeting of antigen-presenting cells following intraportal infusion of vector leads to a systemic cytokine syndrome which may be triggered by the viral capsid proteins...
  23. ncbi request reprint MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells
    Y Zhang
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 276:42534-42. 2001
    ..Additionally, the role of MAPKs in mediating UVA-stimulated DNA binding activity of STAT3 was investigated. Overall, these results suggest that UVA-induced Ser(727) phosphorylation of STAT3 may occur through MSK1 and JNKs...
  24. pmc Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3
    S A Jacobs
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, USA
    EMBO J 20:5232-41. 2001
    ..For example, the chromo domain of the yeast histone acetyltransferase Esa1 does not interact with methyl- K9 H3, but instead shows preference for unmodified H3 tail...
  25. ncbi request reprint CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK
    J Huang
    School of Basic Medical Science, Peking University Health Science Center, Beijing, People s Republic of China
    Cell Mol Life Sci 65:338-49. 2008
    ..These results clearly indicate that CCDC134 is a novel member of the secretory family and down-regulates the Raf-1/MEK/ERK and JNK/ SAPK pathways...
  26. ncbi request reprint On the human CYP2C9*13 variant activity reduction: a molecular dynamics simulation and docking study
    Y H Zhou
    State Key Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry, Jilin University, Changchun 130023, China
    Biochimie 88:1457-65. 2006
    ..Consequent docking study which is consistent with the results of the kinetic experiments by Guo et al. identifies the most important residues for enzyme-substrate complexes...
  27. pmc A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease
    A Hayes
    Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Salford M6 8HD, UK
    J Neurol Neurosurg Psychiatry 75:1475-7. 2004
    ....
  28. ncbi request reprint Functional characterisation of the recombinant tumor necrosis factors in rainbow trout, Oncorhynchus mykiss
    J Zou
    Scottish Fish Immunology Research Centre, School of Biological Sciences, Zoology Building, Tillydrone Avenue, University of Aberdeen, Aberdeen, AB24 2TZ, UK
    Dev Comp Immunol 27:813-22. 2003
    ..Western blot analysis revealed the presence of multiple forms of rTNF structures including monomeric, dimeric and trimeric forms, suggesting that formation of a homotrimeric structure may be essential for the TNF bioactivities...
  29. ncbi request reprint Predominant cellular immune response to the cartilage autoantigenic G1 aggrecan in ankylosing spondylitis and rheumatoid arthritis
    J Zou
    Department of Rheumatology, Klinikum Benjamin Franklin, Free University, Berlin, Germany
    Rheumatology (Oxford) 42:846-55. 2003
    ..Using novel and more sensitive techniques and relevant controls we sought to define the role of G1 as an autoantigen more precisely and to extend the specific analyses to the peptide level...
  30. ncbi request reprint [Polymorphism of ACE gene and its relationship with serum ACE activity in the Hans in Chengdu region]
    H Wu
    Department of Gerontology, First Affiliated Hospital, WCUMS, Chengdu 610041
    Hua Xi Yi Ke Da Xue Xue Bao 31:169-70, 179. 2000
    ..The results suggest that ACE genotype distribution be different between races, that II genotype and I allele be more frequent in Chinese, and that SACE activity be under the influence of a genetic polymorphism of ACE in Chinese...
  31. ncbi request reprint Transfection of the nm23-H1 gene into human hepatocarcinoma cell line inhibits the expression of sialyl Lewis X, alpha1,3 fucosyltransferase VII, and metastatic potential
    F Liu
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Fu Dan University Medical Center, Shanghai 200032, China
    J Cancer Res Clin Oncol 128:189-96. 2002
    ....
  32. ncbi request reprint The regulatory effect of ERK1/2 signal pathway on production of TNFalpha induced by LPS in mice Kupffer cells
    Y Zhang
    Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Chin J Traumatol 4:139-42. 2001
    ..PD98059 causes a significant and concentration-dependent reduction of TNFalpha production. ERK1/2 may be a novel target to treat clinical patient of endotoxemia...
  33. ncbi request reprint Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase
    H Wang
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell 8:1207-17. 2001
    ..Thus, our study provides a molecular explanation to the differential effects of H3-K4 and H3-K9 methylation on transcription...
  34. ncbi request reprint Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation
    J Turkson
    Molecular Oncology and Drug Discovery Programs, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 276:45443-55. 2001
    ..Altogether, we have identified a minimal peptide that inhibits Stat3 signaling and provides the conceptual basis for use of this peptide as a lead for novel peptidomimetic drug design...
  35. ncbi request reprint Mammalian sweet taste receptors
    G Nelson
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093, USA
    Cell 106:381-90. 2001
    ..Finally, we present a detailed analysis of the patterns of expression of T1Rs and T2Rs, thus providing a view of the representation of sweet and bitter taste at the periphery...
  36. ncbi request reprint Role of furin in delivery of a CTL epitope of an anthrax toxin-fusion protein
    Y Zhang
    Department of Microbiology, Kurume University School of Medicine, Fukuoka, Japan
    Microbiol Immunol 45:119-25. 2001
    ..The results suggest that furin plays a critical role in delivery of the CTL epitope of LFn fusion protein...
  37. pmc RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest
    A Lai
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 21:2918-32. 2001
    ....
  38. ncbi request reprint Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase
    Y Zhang
    Regulatory Biology Laboratory, Institute of Molecular and Cell Biology, National University of Singapore, 30 Medical Drive, Singapore 117609, Republic of Singapore
    J Biol Chem 275:25008-14. 2000
    ..We suggest that there may be a switch mechanism based on dimerization combinations, that commands cells to activate Wnt signaling or JNK activation, and to turn on specific activators of JNK in response to various environmental cues...
  39. ncbi request reprint Targeted misexpression of constitutively active BMP receptor-IB causes bifurcation, duplication, and posterior transformation of digit in mouse limb
    Z Zhang
    Department of Oral Biology, University of Oslo, Oslo, 0316, Norway
    Dev Biol 220:154-67. 2000
    ..In addition, BMPR-IB may represent a critical component in the Shh/FGF4 feedback loop by regulating Gremlin expression...
  40. ncbi request reprint Feedback phosphorylation of an RGS protein by MAP kinase in yeast
    T R Garrison
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 274:36387-91. 1999
    ..However, phosphorylation appears to slow the rate of Sst2 degradation. These findings indicate that the G protein-regulated MAP kinase in yeast can act as a feedback regulator of Sst2, itself a regulator of G protein signaling...
  41. ncbi request reprint Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1
    X Li
    Developmental, Cell, and Molecular Biology Group, Department of Botany, Duke University, Durham, North Carolina 27708 1000, USA
    Cell 98:329-39. 1999
    ..Restoration of SAR in npr1-1 by the recessive sni1 mutation indicates that wild-type SNI1 may function as a negative regulator of SAR. We cloned the SNI1 gene and found that it encodes a leucine-rich nuclear protein...
  42. ncbi request reprint Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
    Y Zhang
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    Mol Cell 3:579-91. 1999
    ..Our results suggest an ARF-regulated MDM2-dependent p53 stabilization and link the human tumor-associated mutations in ARF with a functional alteration...
  43. pmc Model of maltose-binding protein/chemoreceptor complex supports intrasubunit signaling mechanism
    Y Zhang
    Department of Biology, Texas A and M University, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 96:939-44. 1999
    ....
  44. ncbi request reprint ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    Y Zhang
    Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, 27599 3280, USA
    Cell 92:725-34. 1998
    ..Thus, deletion of the ARF-INK4a locus simultaneously impairs both the INK4a-cyclin D/CDK4-RB and the ARF-MDM2-p53 pathways...
  45. pmc A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system
    Y Zhang
    Department of Pathology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 95:2586-91. 1998
    ..These findings place DENN/MADD and JNK in important hypoxia insult-induced intracellular signaling pathways. Our conclusions are important for future studies for understanding these stress-activated mechanisms...
  46. ncbi request reprint The leptin receptor mediates apparent autocrine regulation of leptin gene expression
    Y Zhang
    Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Biochem Biophys Res Commun 240:492-5. 1997
    ..Thus, leptin appears to close a short regulatory loop controlling its own synthesis in adipose tissue...
  47. ncbi request reprint Human ovarian expression of 17 beta-hydroxysteroid dehydrogenase types 1, 2, and 3
    Y Zhang
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    J Clin Endocrinol Metab 81:3594-8. 1996
    ..Secondly, androgenic 17 beta HSD3 is not expressed in the human ovary. Thus testosterone production within the human ovary, occurring under physiological conditions, arises from either the 17 beta HSD1 or an uncharacterized isozyme...
  48. ncbi request reprint The mechanism of velocity modulated allosteric regulation in D-3-phosphoglycerate dehydrogenase. Site-directed mutagenesis of effector binding site residues
    R Al-Rabiee
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:23235-8. 1996
    ....
  49. ncbi request reprint X-ray structure analysis of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis at 2.0 Angstroms resolution reveals novel dimer-dimer interactions
    J B Cooper
    Department of Crystallography, Birbeck College, University of London, U K
    J Mol Biol 246:531-44. 1995
    ..This contrasts strongly with the other tetrameric Fe- or Mn-SODs where the dimer-dimer association is dominated by the projecting alpha alpha-turn in the N-terminal domain...
  50. ncbi request reprint Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription
    L Galarneau
    Laval University Cancer Research Center, Hôtel Dieu de Québec CHUQ, Canada
    Mol Cell 5:927-37. 2000
    ..These data along with the known epigenetic roles of Act3/Arp4 and homologs of Epl1 and Esa1 strongly support an essential role for chromatin structure modification by NuA4 in transcription regulation in vivo...
  51. ncbi request reprint Crystal structure of the extracellular domain of a human Fc gamma RIII
    Y Zhang
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555, USA
    Immunity 13:387-95. 2000
    ..Two separate parallel dimers are observed in the crystal lattice, offering intriguing models for receptor aggregation...
  52. ncbi request reprint Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation
    Y Zhang
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 276:20913-23. 2001
    ..Thus, these results suggest that activation of MAPKs, like PI 3-kinase/mTOR, may be involved in UVA-induced phosphorylation and activation of p70(S6K)...
  53. ncbi request reprint MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28
    S Zhong
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 276:12932-7. 2001
    ..These results suggest that UVB-induced H3 phosphorylation at serine 28 may be mediated by mitogen-activated protein kinases...
  54. ncbi request reprint Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation
    X Xia
    Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201, USA
    J Cell Physiol 187:209-17. 2001
    ..Ebp1 bound E2F1 indirectly via Rb in lysates of MCF-7 cells. The interaction of Ebp1 with Rb may prove to be an important mechanism of Ebp1 induced changes in cell proliferation and differentiation...
  55. ncbi request reprint Identification of differentially expressed genes following treatment of monkey kidney cells with the mycotoxin fumonisin B(1)
    Y Zhang
    Dept. of Plant Pathology, University of Nebraska, 68503, Lincoln, NE, USA
    Food Chem Toxicol 39:45-53. 2001
    ..The ability of FB(1) to alter gene expression and signal transduction pathways may be necessary for its carcinogenic and toxic effects...
  56. ncbi request reprint Differential expression and functional analysis of Pitx2 isoforms in regulation of heart looping in the chick
    X Yu
    Department of Cell and Molecular Biology, Molecular and Cell Biology Graduate Program and Center for Bioenvironmetal Research, Tulane University, New Orleans, LA 70118, USA
    Development 128:1005-13. 2001
    ..The results thus demonstrate that Pitx2c plays a crucial role in the left-right axis determination and rightward heart looping during chick embryogenesis...
  57. ncbi request reprint Organ-specific distribution of AP-1 in AP-1 luciferase transgenic mice during the maturation process
    S P Zhong
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Am J Physiol Regul Integr Comp Physiol 280:R376-81. 2001
    ..AP-1 activity and level of phosphorylated ERKs declined with maturation. These results imply that AP-1 activity mediated through an ERKs-dependent pathway may be involved in skin development...
  58. ncbi request reprint Genetic analysis of testis weight and fertility in an interspecies hybrid congenic strain for Chromosome X
    R W Elliott
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, New York State Department of Health, Buffalo 14263, USA
    Mamm Genome 12:45-51. 2001
    ..8 map units for Ihtw1. This region of the genetic map is orthologous to the region on human Chr X containing the gene for the Borjeson-Forssman-Lehman syndrome, an inherited disease in which males show microorchidism...
  59. pmc Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
    Y Zhang
    Laboratory of Cellular and Molecular Biology, Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:974-9. 2001
    ....
  60. ncbi request reprint Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cells
    K K Hiatt
    Herman B Wells Center for Pediatric Research, Departments of Microbiology/Immunology and Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:7240-5. 2001
    ..Thus, the GRDs of neurofibromin and p120GAP specify nonoverlapping functions in multiple primary cell types...
  61. ncbi request reprint Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1
    Y Zhang
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Gene 257:33-43. 2000
    ..These results parallel the arrest phenotypes associated with global disruption of zygotic gene expression, suggesting that Dim1 proteins maintain an essential function in gene expression in higher eukaryotes...
  62. ncbi request reprint Thyroid hormone stimulates acetyl-coA carboxylase-alpha transcription in hepatocytes by modulating the composition of nuclear receptor complexes bound to a thyroid hormone response element
    Y Zhang
    Department of Biochemistry, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA
    J Biol Chem 276:974-83. 2001
    ....
  63. pmc The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1
    M Furukawa
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Mol Cell Biol 20:8185-97. 2000
    ..This pathway may be commonly utilized for the assembly of other cullin ligases...
  64. pmc The catalytic consequences of experimental evolution. Studies on the subunit structure of the second (ebg) beta-galactosidase of Escherichia coli, and on catalysis by ebgab, an experimental evolvant containing two amino acid substitutions
    A C Elliott
    Department of Organic Chemistry, University of Bristol, U K
    Biochem J 282:155-64. 1992
    ..9. The alpha- and beta-deuterium secondary isotope effects on the hydrolysis of the galactosyl-enzyme of 1.08 and 1.00 are difficult to reconcile with the pyranose ring in this intermediate being in the 4C1 conformation...