Research Topics
| Xiaodong ZhangSummaryAffiliation: The University of Texas Country: USA Publications
| Collaborators
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Detail Information
Publications
A sensitivity-guided algorithm for automated determination of IMRT objective function parametersXiaodong Zhang
Department of Radiation Physics, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
Med Phys 33:2935-44. 2006..Our preliminary study indicates that the SGPO method may be an effective and practical way to improve IMRT planning...
A methodology for automatic intensity-modulated radiation treatment planning for lung cancerXiaodong Zhang
Department of Radiation Physics, Unit 94, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
Phys Med Biol 56:3873-93. 2011..We conclude that the mdaccAutoPlan system can potentially improve the quality and consistency of treatment planning for lung cancer...
Effect of anatomic motion on proton therapy dose distributions in prostate cancer treatmentXiaodong Zhang
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 67:620-9. 2007..To determine the dosimetric impact of interfraction anatomic movements in prostate cancer patients receiving proton therapy...- Parameterization of multiple Bragg curves for scanning proton beams using simultaneous fitting of multiple curvesXiaodong Zhang
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Phys Med Biol 56:7725-35. 2011..Our method would be a valuable tool to analyze measured Bragg curves without the need for time-consuming measurements and correctly describe multiple Bragg curves using a closed analytical expression... - Intensity-modulated proton therapy reduces the dose to normal tissue compared with intensity-modulated radiation therapy or passive scattering proton therapy and enables individualized radical radiotherapy for extensive stage IIIB non-small-cell lung cancXiaodong Zhang
Division of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Int J Radiat Oncol Biol Phys 77:357-66. 2010.... - Incorporating partial shining effects in proton pencil-beam dose calculationYupeng Li
Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
Phys Med Biol 53:605-16. 2008..In a prostate patient, we found that dose calculation without considering partial shining effect underestimated the femoral head and skin dose... - Four-dimensional computed tomography-based treatment planning for intensity-modulated radiation therapy and proton therapy for distal esophageal cancerXiaodong Zhang
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 72:278-87. 2008.... - 4D Proton treatment planning strategy for mobile lung tumorsYixiu Kang
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Int J Radiat Oncol Biol Phys 67:906-14. 2007..To investigate strategies for designing compensator-based 3D proton treatment plans for mobile lung tumors using four-dimensional computed tomography (4DCT) images... - A comprehensive comparison of IMRT and VMAT plan quality for prostate cancer treatmentEnzhuo M Quan
Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Int J Radiat Oncol Biol Phys 83:1169-78. 2012..We performed a comprehensive comparative study of the plan quality between volumetric-modulated arc therapy (VMAT) and intensity-modulated radiation therapy (IMRT) for the treatment of prostate cancer... - Impact of using different four-dimensional computed tomography data sets to design proton treatment plans for distal esophageal cancerXiaoning Pan
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Int J Radiat Oncol Biol Phys 73:601-9. 2009..To study the impact of selecting different data sets from four-dimensional computed tomography (4D CT) imaging during proton treatment planning in patients with distal esophageal cancer... - External-beam accelerated partial breast irradiation using multiple proton beam configurationsXiaochun Wang
Department of Radiation Physics, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 80:1464-72. 2011.... - Effects of interfractional motion and anatomic changes on proton therapy dose distribution in lung cancerZhouguang Hui
Department of Radiation Phyiscs, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Int J Radiat Oncol Biol Phys 72:1385-95. 2008..Proton doses are sensitive to intra- and interfractional anatomic changes. We analyzed the effects of interfractional anatomic changes in doses to lung tumors treated with proton therapy... - Automated volumetric modulated Arc therapy treatment planning for stage III lung cancer: how does it compare with intensity-modulated radio therapy?Enzhuo M Quan
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Int J Radiat Oncol Biol Phys 84:e69-76. 2012.... - Speed and convergence properties of gradient algorithms for optimization of IMRTXiaodong Zhang
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Med Phys 31:1141-52. 2004.... - Proton stereotactic body radiation therapy for clinically challenging cases of centrally and superiorly located stage I non-small-cell lung cancerSteven P Register
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Int J Radiat Oncol Biol Phys 80:1015-22. 2011.... - Use of deformed intensity distributions for on-line modification of image-guided IMRT to account for interfractional anatomic changesRadhe Mohan
Department of Radiation Physics, Unit 94, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 61:1258-66. 2005..In this paper, we report the development of one such intermediate method that takes into account anatomic changes by deforming the intensity distributions of each beam based on deformations of anatomy as seen in the beam's-eye-view... - Influence of robust optimization in intensity-modulated proton therapy with different dose delivery techniquesWei Liu
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Med Phys 39:3089-101. 2012..They also compared conventional and robust optimization of IMPT-DET with three-dimensional IMPT (IMPT-3D) to gain understanding about how plan robustness is achieved... - A 4D IMRT planning method using deformable image registration to improve normal tissue sparing with contemporary delivery techniquesXiaoqiang Li
Department of Radiation Physics, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA
Radiat Oncol 6:83. 2011..The dose volume histograms of cumulative 4D doses to the PTV50, clinical target volume, lung, spinal cord, liver, and heart on the 4D repeat CTs for the two patients were similar to those for the 4D dose at the time of original planning... - Development of methods for beam angle optimization for IMRT using an accelerated exhaustive search strategyXiaochun Wang
Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
Int J Radiat Oncol Biol Phys 60:1325-37. 2004.... - An efficient dose calculation strategy for intensity modulated proton therapyYupeng Li
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Phys Med Biol 56:N71-84. 2011..By using an advanced lung cancer case that would demand large computing resources by conventional optimization approach, we show how our method may potentially help improve IMPT treatment planning in real clinical situations... - Robust optimization of intensity modulated proton therapyWei Liu
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Med Phys 39:1079-91. 2012..In this paper, a method that takes the uncertainties into account during plan optimization is used to mitigate the influence of uncertainties in IMPT... - Proton radiotherapy for liver tumors: dosimetric advantages over photon plansXiaochun Wang
Department of Radiation Physics, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Med Dosim 33:259-67. 2008..In conclusion, our study suggests the dosimetric benefits of proton radiotherapy over photon radiotherapy. These dosimetric advantages of proton plans may permit further dose escalation with lower risk of complications... - Monte Carlo simulations for configuring and testing an analytical proton dose-calculation algorithmWayne Newhauser
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Phys Med Biol 52:4569-84. 2007..The model presented here provided a means to reduce by several months the time required to prepare an analytical treatment planning system for patient treatments... - Effectiveness of noncoplanar IMRT planning using a parallelized multiresolution beam angle optimization method for paranasal sinus carcinomaXiaochun Wang
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 63:594-601. 2005..To determine the effectiveness of noncoplanar beam configurations and the benefit of plans using fewer but optimally placed beams designed by a parallelized multiple-resolution beam angle optimization (PMBAO) approach... - Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in Stage I or Stage III non-small-cell lung cancerJoe Y Chang
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 65:1087-96. 2006..To compare dose-volume histograms (DVH) in patients with non-small-cell lung cancer (NSCLC) treated by photon or proton radiotherapy... - Dynamically accumulated dose and 4D accumulated dose for moving tumorsHeng Li
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Med Phys 39:7359-67. 2012.... - Use of treatment log files in spot scanning proton therapy as part of patient-specific quality assuranceHeng Li
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030
Med Phys 40:021703. 2013..The analysis tool developed here could be useful for assessing spot position uncertainty and thus dose uncertainty for any patient receiving spot scanning proton beam therapy... - Beyond Gaussians: a study of single-spot modeling for scanning proton dose calculationYupeng Li
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Phys Med Biol 57:983-97. 2012..The results of this study may be helpful in improving dose calculation accuracy and simplifying beam commissioning and treatment planning processes for spot scanning proton therapy... - Optimal treatment planning for skull base chordoma: photons, protons, or a combination of both?Mylin A Torres
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 74:1033-9. 2009..We compared dosimetry of proton (PR), intensity modulated radiation therapy (IMRT) photon (PH), and combined PR and IMRT PH (PP) irradiation of skull base chordomas to determine the most optimal technique... - A novel patch-field design using an optimized grid filter for passively scattered proton beamsYupeng Li
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Phys Med Biol 52:N265-75. 2007..An L-shaped head and neck tumor was used to demonstrate the validity of the proposed algorithm. A robustness analysis with focus on range uncertainty effect is carried out... - Uncertainty incorporated beam angle optimization for IMPT treatment planningWenhua Cao
Department of Industrial Engineering, University of Houston, Houston, Texas 77204, USA
Med Phys 39:5248-56. 2012..This study focuses on potential benefits of BAO on intensity-modulated proton therapy (IMPT) that recently began available to clinical cancer treatment... - Beam angle optimization and reduction for intensity-modulated radiation therapy of non-small-cell lung cancersH Helen Liu
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 65:561-72. 2006..To optimize beam angles and reduce the number of beams used for intensity-modulated radiation therapy (IMRT) of non-small-cell lung cancer (NSCLC)... - Tumor-derived extracellular mutations of PTPRT /PTPrho are defective in cell adhesionJianshi Yu
Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, Euclid Avenue, Cleveland, OH 44106, USA
Mol Cancer Res 6:1106-13. 2008..Our results suggest that PTPrho may play an important role in cell-cell adhesion and that mutational inactivation of this phosphatase could promote tumor migration and metastasis... - Effect of surgical castration on risk factors for arteriosclerosis of patients with prostate cancerTao Xu
Department of Urology, Peking University People's Hospital, Beijing 100044, China
Chin Med J (Engl) 115:1336-40. 2002..501; P < 0.001). CONCLUSIONS: At 8 months follow-up of the study subjects, we found that lower androgen levels have adverse effects on lipid metabolism, coagulative function and insulin sensitivity, related to arteriosclerosis in men... - A link between sequence conservation and domain motion within the AAA+ familyGraham R Smith
Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
J Struct Biol 146:189-204. 2004..Extrapolation of subdomain movements from one MD simulation enables us to produce a structure in close agreement with cryo-EM experiments... - Antimetastatic effect of a lipophilic ascorbic acid derivative with antioxidation through inhibition of tumor invasionJianwen Liu
School of Pharmacy, East China University of Science and Technology, Mailbox 268, 130 Meilong Road, Shanghai, 200237, P R China
Cancer Chemother Pharmacol 57:584-90. 2006..The aim of the present study is to investigate the stability, the antioxidation and the antimetastatic effects of three lipophilic AA derivatives in vitro as well as in vivo... - Subchronic toxicity and toxicokinetics of LZB, a new proton pump inhibitor, after 13-week repeated oral administration in dogsYu Mao
Center of Evaluation for Drug Safety, Second Military Medical University, Shanghai 200433, China
Regul Toxicol Pharmacol 50:75-86. 2008..The toxicological target could be stomach, liver, hematological system and nervous system... - Procedures for a dynamical system on {0,1}n with DNA moleculesDongmei Xiao
Department of Mathematics, Shanghai Jiao Tong University, Shanghai 200030, PR China
Biosystems 84:207-16. 2006..Based on the operation for cycling shift, dynamic behavior of an operator on {0,1}n is investigated by DNA molecules... - Development of an HPLC method for the determination of salidroside in beagle dog plasma after administration of salidroside injection: application to a pharmacokinetics studyYu Mao
Center of Evaluation for Drug Safety, Second Military Medical University, Shanghai, China
J Sep Sci 30:3218-22. 2007..v. administration of a single 75 mg/kg (5 mL/kg) dose were 96.16 +/- 8.59 microg/mL, 180.3 +/- 30.6 microg h/mL, 189.3 +/- 32.1 microg h/mL, and 2.006 +/- 0.615 h, respectively... - A phase II trial of paclitaxel and cisplatin in patients with advanced squamous-cell carcinoma of the esophagusXiaodong Zhang
Department of Gastrointestinal Medicine, Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing Cancer Hospital, Beijing, China
Am J Clin Oncol 31:29-33. 2008..To evaluate the response rate, survival, and toxicities of paclitaxel plus cisplatin combination in patients with advanced or metastatic squamous-cell carcinoma of the esophagus... - High-throughput mutational analysis of the human cancer genomePatrick C Ma
University Hospitals of Cleveland, Division of Hematology Oncology, Department of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH 44106, USA
Pharmacogenomics 7:597-612. 2006..Personalized cancer therapy based on tumor-specific mutations will be a realistic goal in the near future... - Mechanism of methanol oxidation by quinoprotein methanol dehydrogenaseXiaodong Zhang
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA
Proc Natl Acad Sci U S A 104:745-9. 2007..By this means, the endothermic oxidation-reduction reaction is pulled such that the overall conversion of MeOH to CH(2)(OH)(2) is exothermic... - Catalytic mechanism and product specificity of rubisco large subunit methyltransferase: QM/MM and MD investigationsXiaodong Zhang
Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106, USA
Biochemistry 46:5505-14. 2007..Future studies will determine whether the product specificity of lysine (mono, di, and tri) methyltransferases is determined by the formation of water channels...