Xiaodong Zhang

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint A sensitivity-guided algorithm for automated determination of IMRT objective function parameters
    Xiaodong Zhang
    Department of Radiation Physics, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Med Phys 33:2935-44. 2006
  2. pmc Effect of anatomic motion on proton therapy dose distributions in prostate cancer treatment
    Xiaodong Zhang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 67:620-9. 2007
  3. doi request reprint Parameterization of multiple Bragg curves for scanning proton beams using simultaneous fitting of multiple curves
    Xiaodong Zhang
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Phys Med Biol 56:7725-35. 2011
  4. doi request reprint A methodology for automatic intensity-modulated radiation treatment planning for lung cancer
    Xiaodong Zhang
    Department of Radiation Physics, Unit 94, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Phys Med Biol 56:3873-93. 2011
  5. pmc Intensity-modulated proton therapy reduces the dose to normal tissue compared with intensity-modulated radiation therapy or passive scattering proton therapy and enables individualized radical radiotherapy for extensive stage IIIB non-small-cell lung canc
    Xiaodong Zhang
    Division of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Int J Radiat Oncol Biol Phys 77:357-66. 2010
  6. pmc Four-dimensional computed tomography-based treatment planning for intensity-modulated radiation therapy and proton therapy for distal esophageal cancer
    Xiaodong Zhang
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 72:278-87. 2008
  7. doi request reprint A fully automated method for CT-on-rails-guided online adaptive planning for prostate cancer intensity modulated radiation therapy
    Xiaoqiang Li
    Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Int J Radiat Oncol Biol Phys 86:835-41. 2013
  8. doi request reprint Incorporating partial shining effects in proton pencil-beam dose calculation
    Yupeng Li
    Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Phys Med Biol 53:605-16. 2008
  9. ncbi request reprint 4D Proton treatment planning strategy for mobile lung tumors
    Yixiu Kang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 67:906-14. 2007
  10. pmc A comprehensive comparison of IMRT and VMAT plan quality for prostate cancer treatment
    Enzhuo M Quan
    Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 83:1169-78. 2012

Detail Information

Publications51

  1. ncbi request reprint A sensitivity-guided algorithm for automated determination of IMRT objective function parameters
    Xiaodong Zhang
    Department of Radiation Physics, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Med Phys 33:2935-44. 2006
    ..Our preliminary study indicates that the SGPO method may be an effective and practical way to improve IMRT planning...
  2. pmc Effect of anatomic motion on proton therapy dose distributions in prostate cancer treatment
    Xiaodong Zhang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 67:620-9. 2007
    ..To determine the dosimetric impact of interfraction anatomic movements in prostate cancer patients receiving proton therapy...
  3. doi request reprint Parameterization of multiple Bragg curves for scanning proton beams using simultaneous fitting of multiple curves
    Xiaodong Zhang
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Phys Med Biol 56:7725-35. 2011
    ..Our method would be a valuable tool to analyze measured Bragg curves without the need for time-consuming measurements and correctly describe multiple Bragg curves using a closed analytical expression...
  4. doi request reprint A methodology for automatic intensity-modulated radiation treatment planning for lung cancer
    Xiaodong Zhang
    Department of Radiation Physics, Unit 94, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Phys Med Biol 56:3873-93. 2011
    ..We conclude that the mdaccAutoPlan system can potentially improve the quality and consistency of treatment planning for lung cancer...
  5. pmc Intensity-modulated proton therapy reduces the dose to normal tissue compared with intensity-modulated radiation therapy or passive scattering proton therapy and enables individualized radical radiotherapy for extensive stage IIIB non-small-cell lung canc
    Xiaodong Zhang
    Division of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Int J Radiat Oncol Biol Phys 77:357-66. 2010
    ....
  6. pmc Four-dimensional computed tomography-based treatment planning for intensity-modulated radiation therapy and proton therapy for distal esophageal cancer
    Xiaodong Zhang
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 72:278-87. 2008
    ....
  7. doi request reprint A fully automated method for CT-on-rails-guided online adaptive planning for prostate cancer intensity modulated radiation therapy
    Xiaoqiang Li
    Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Int J Radiat Oncol Biol Phys 86:835-41. 2013
    ....
  8. doi request reprint Incorporating partial shining effects in proton pencil-beam dose calculation
    Yupeng Li
    Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Phys Med Biol 53:605-16. 2008
    ..In a prostate patient, we found that dose calculation without considering partial shining effect underestimated the femoral head and skin dose...
  9. ncbi request reprint 4D Proton treatment planning strategy for mobile lung tumors
    Yixiu Kang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 67:906-14. 2007
    ..To investigate strategies for designing compensator-based 3D proton treatment plans for mobile lung tumors using four-dimensional computed tomography (4DCT) images...
  10. pmc A comprehensive comparison of IMRT and VMAT plan quality for prostate cancer treatment
    Enzhuo M Quan
    Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 83:1169-78. 2012
    ..We performed a comprehensive comparative study of the plan quality between volumetric-modulated arc therapy (VMAT) and intensity-modulated radiation therapy (IMRT) for the treatment of prostate cancer...
  11. pmc External-beam accelerated partial breast irradiation using multiple proton beam configurations
    Xiaochun Wang
    Department of Radiation Physics, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 80:1464-72. 2011
    ....
  12. doi request reprint Impact of using different four-dimensional computed tomography data sets to design proton treatment plans for distal esophageal cancer
    Xiaoning Pan
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 73:601-9. 2009
    ..To study the impact of selecting different data sets from four-dimensional computed tomography (4D CT) imaging during proton treatment planning in patients with distal esophageal cancer...
  13. pmc Effects of interfractional motion and anatomic changes on proton therapy dose distribution in lung cancer
    Zhouguang Hui
    Department of Radiation Phyiscs, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 72:1385-95. 2008
    ..Proton doses are sensitive to intra- and interfractional anatomic changes. We analyzed the effects of interfractional anatomic changes in doses to lung tumors treated with proton therapy...
  14. pmc Use of treatment log files in spot scanning proton therapy as part of patient-specific quality assurance
    Heng Li
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Med Phys 40:021703. 2013
    ....
  15. pmc Automated volumetric modulated Arc therapy treatment planning for stage III lung cancer: how does it compare with intensity-modulated radio therapy?
    Enzhuo M Quan
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Int J Radiat Oncol Biol Phys 84:e69-76. 2012
    ....
  16. ncbi request reprint Speed and convergence properties of gradient algorithms for optimization of IMRT
    Xiaodong Zhang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Med Phys 31:1141-52. 2004
    ....
  17. pmc Proton stereotactic body radiation therapy for clinically challenging cases of centrally and superiorly located stage I non-small-cell lung cancer
    Steven P Register
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Int J Radiat Oncol Biol Phys 80:1015-22. 2011
    ....
  18. ncbi request reprint Use of deformed intensity distributions for on-line modification of image-guided IMRT to account for interfractional anatomic changes
    Radhe Mohan
    Department of Radiation Physics, Unit 94, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 61:1258-66. 2005
    ..In this paper, we report the development of one such intermediate method that takes into account anatomic changes by deforming the intensity distributions of each beam based on deformations of anatomy as seen in the beam's-eye-view...
  19. pmc Influence of robust optimization in intensity-modulated proton therapy with different dose delivery techniques
    Wei Liu
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Med Phys 39:3089-101. 2012
    ..They also compared conventional and robust optimization of IMPT-DET with three-dimensional IMPT (IMPT-3D) to gain understanding about how plan robustness is achieved...
  20. pmc A 4D IMRT planning method using deformable image registration to improve normal tissue sparing with contemporary delivery techniques
    Xiaoqiang Li
    Department of Radiation Physics, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Radiat Oncol 6:83. 2011
    ..The dose volume histograms of cumulative 4D doses to the PTV50, clinical target volume, lung, spinal cord, liver, and heart on the 4D repeat CTs for the two patients were similar to those for the 4D dose at the time of original planning...
  21. ncbi request reprint Development of methods for beam angle optimization for IMRT using an accelerated exhaustive search strategy
    Xiaochun Wang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 60:1325-37. 2004
    ..g., selecting 7 of 36 uniformly spaced coplanar beams would require the intercomparison of 8,347,680 IMRT plans)...
  22. doi request reprint An efficient dose calculation strategy for intensity modulated proton therapy
    Yupeng Li
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Phys Med Biol 56:N71-84. 2011
    ..By using an advanced lung cancer case that would demand large computing resources by conventional optimization approach, we show how our method may potentially help improve IMPT treatment planning in real clinical situations...
  23. pmc Preliminary evaluation of multifield and single-field optimization for the treatment planning of spot-scanning proton therapy of head and neck cancer
    Enzhuo M Quan
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Med Phys 40:081709. 2013
    ....
  24. pmc Robust optimization of intensity modulated proton therapy
    Wei Liu
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Med Phys 39:1079-91. 2012
    ..In this paper, a method that takes the uncertainties into account during plan optimization is used to mitigate the influence of uncertainties in IMPT...
  25. ncbi request reprint Effectiveness of noncoplanar IMRT planning using a parallelized multiresolution beam angle optimization method for paranasal sinus carcinoma
    Xiaochun Wang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 63:594-601. 2005
    ..To determine the effectiveness of noncoplanar beam configurations and the benefit of plans using fewer but optimally placed beams designed by a parallelized multiple-resolution beam angle optimization (PMBAO) approach...
  26. doi request reprint Proton radiotherapy for liver tumors: dosimetric advantages over photon plans
    Xiaochun Wang
    Department of Radiation Physics, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Med Dosim 33:259-67. 2008
    ..In conclusion, our study suggests the dosimetric benefits of proton radiotherapy over photon radiotherapy. These dosimetric advantages of proton plans may permit further dose escalation with lower risk of complications...
  27. ncbi request reprint Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in Stage I or Stage III non-small-cell lung cancer
    Joe Y Chang
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 65:1087-96. 2006
    ..To compare dose-volume histograms (DVH) in patients with non-small-cell lung cancer (NSCLC) treated by photon or proton radiotherapy...
  28. ncbi request reprint Monte Carlo simulations for configuring and testing an analytical proton dose-calculation algorithm
    Wayne Newhauser
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Phys Med Biol 52:4569-84. 2007
    ..The model presented here provided a means to reduce by several months the time required to prepare an analytical treatment planning system for patient treatments...
  29. ncbi request reprint On the interplay effects with proton scanning beams in stage III lung cancer
    Yupeng Li
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and Applied Research, Varian Medical Systems, Palo Alto, California 94304
    Med Phys 41:021721. 2014
    ..To assess the dosimetric impact of interplay between spot-scanning proton beam and respiratory motion in intensity-modulated proton therapy (IMPT) for stage III lung cancer...
  30. pmc Dynamically accumulated dose and 4D accumulated dose for moving tumors
    Heng Li
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Med Phys 39:7359-67. 2012
    ....
  31. pmc Beyond Gaussians: a study of single-spot modeling for scanning proton dose calculation
    Yupeng Li
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Phys Med Biol 57:983-97. 2012
    ..The results of this study may be helpful in improving dose calculation accuracy and simplifying beam commissioning and treatment planning processes for spot scanning proton therapy...
  32. ncbi request reprint Optimal treatment planning for skull base chordoma: photons, protons, or a combination of both?
    Mylin A Torres
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 74:1033-9. 2009
    ..We compared dosimetry of proton (PR), intensity modulated radiation therapy (IMRT) photon (PH), and combined PR and IMRT PH (PP) irradiation of skull base chordomas to determine the most optimal technique...
  33. ncbi request reprint A novel patch-field design using an optimized grid filter for passively scattered proton beams
    Yupeng Li
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Phys Med Biol 52:N265-75. 2007
    ..An L-shaped head and neck tumor was used to demonstrate the validity of the proposed algorithm. A robustness analysis with focus on range uncertainty effect is carried out...
  34. pmc Patient-specific quantification of respiratory motion-induced dose uncertainty for step-and-shoot IMRT of lung cancer
    Heng Li
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030
    Med Phys 40:121712. 2013
    ..The objective of this study was to quantify respiratory motion-induced dose uncertainty at the planning stage for step-and-shoot intensity-modulated radiation therapy (IMRT) using an analytical technique...
  35. pmc Uncertainty incorporated beam angle optimization for IMPT treatment planning
    Wenhua Cao
    Department of Industrial Engineering, University of Houston, Houston, Texas 77204, USA
    Med Phys 39:5248-56. 2012
    ..This study focuses on potential benefits of BAO on intensity-modulated proton therapy (IMPT) that recently began available to clinical cancer treatment...
  36. ncbi request reprint Beam angle optimization and reduction for intensity-modulated radiation therapy of non-small-cell lung cancers
    H Helen Liu
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 65:561-72. 2006
    ..To optimize beam angles and reduce the number of beams used for intensity-modulated radiation therapy (IMRT) of non-small-cell lung cancer (NSCLC)...
  37. doi request reprint Incorporating deliverable monitor unit constraints into spot intensity optimization in intensity-modulated proton therapy treatment planning
    Wenhua Cao
    Department of Industrial Engineering, University of Houston, Houston, TX 77204, USA
    Phys Med Biol 58:5113-25. 2013
    ..This approach therefore allows IMPT plans to adopt all possible spot spacings optimally. Moreover, dosimetric benefits can be achieved using smaller spot spacings. ..
  38. ncbi request reprint Multifield optimization intensity modulated proton therapy for head and neck tumors: a translation to practice
    Steven J Frank
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas Electronic address
    Int J Radiat Oncol Biol Phys 89:846-53. 2014
    ..We report the first clinical experience and toxicity of multifield optimization (MFO) intensity modulated proton therapy (IMPT) for patients with head and neck tumors...
  39. ncbi request reprint Quantification of beam complexity in intensity-modulated radiation therapy treatment plans
    Weiliang Du
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030
    Med Phys 41:021716. 2014
    ..In this study, The authors have sought to develop metrics to characterize different aspects of beam complexity and investigate the beam complexity for IMRT plans of different disease sites...
  40. doi request reprint Improving spot-scanning proton therapy patient specific quality assurance with HPlusQA, a second-check dose calculation engine
    Dennis Mackin
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030
    Med Phys 40:121708. 2013
    ..The authors also showed how HPlusQA can be used within the current PSQA framework...
  41. ncbi request reprint A link between sequence conservation and domain motion within the AAA+ family
    Graham R Smith
    Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Struct Biol 146:189-204. 2004
    ..Extrapolation of subdomain movements from one MD simulation enables us to produce a structure in close agreement with cryo-EM experiments...
  42. ncbi request reprint Antimetastatic effect of a lipophilic ascorbic acid derivative with antioxidation through inhibition of tumor invasion
    Jianwen Liu
    School of Pharmacy, East China University of Science and Technology, Mailbox 268, 130 Meilong Road, Shanghai, 200237, P R China
    Cancer Chemother Pharmacol 57:584-90. 2006
    ..The aim of the present study is to investigate the stability, the antioxidation and the antimetastatic effects of three lipophilic AA derivatives in vitro as well as in vivo...
  43. ncbi request reprint Procedures for a dynamical system on {0,1}n with DNA molecules
    Dongmei Xiao
    Department of Mathematics, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Biosystems 84:207-16. 2006
    ..Based on the operation for cycling shift, dynamic behavior of an operator on {0,1}n is investigated by DNA molecules...
  44. ncbi request reprint Effect of surgical castration on risk factors for arteriosclerosis of patients with prostate cancer
    Tao Xu
    Department of Urology, Peking University People s Hospital, Beijing 100044, China
    Chin Med J (Engl) 115:1336-40. 2002
    ..To analyze the effect of castration on risk factors for arteriosclerosis of patients with prostate cancer...
  45. ncbi request reprint High-throughput mutational analysis of the human cancer genome
    Patrick C Ma
    University Hospitals of Cleveland, Division of Hematology Oncology, Department of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH 44106, USA
    Pharmacogenomics 7:597-612. 2006
    ..Personalized cancer therapy based on tumor-specific mutations will be a realistic goal in the near future...
  46. pmc Mechanism of methanol oxidation by quinoprotein methanol dehydrogenase
    Xiaodong Zhang
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 104:745-9. 2007
    ..By this means, the endothermic oxidation-reduction reaction is pulled such that the overall conversion of MeOH to CH(2)(OH)(2) is exothermic...
  47. ncbi request reprint Catalytic mechanism and product specificity of rubisco large subunit methyltransferase: QM/MM and MD investigations
    Xiaodong Zhang
    Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106, USA
    Biochemistry 46:5505-14. 2007
    ..Future studies will determine whether the product specificity of lysine (mono, di, and tri) methyltransferases is determined by the formation of water channels...
  48. ncbi request reprint Development of an HPLC method for the determination of salidroside in beagle dog plasma after administration of salidroside injection: application to a pharmacokinetics study
    Yu Mao
    Center of Evaluation for Drug Safety, Second Military Medical University, Shanghai, China
    J Sep Sci 30:3218-22. 2007
    ..v. administration of a single 75 mg/kg (5 mL/kg) dose were 96.16 +/- 8.59 microg/mL, 180.3 +/- 30.6 microg h/mL, 189.3 +/- 32.1 microg h/mL, and 2.006 +/- 0.615 h, respectively...
  49. doi request reprint A phase II trial of paclitaxel and cisplatin in patients with advanced squamous-cell carcinoma of the esophagus
    Xiaodong Zhang
    Department of Gastrointestinal Medicine, Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing Cancer Hospital, Beijing, China
    Am J Clin Oncol 31:29-33. 2008
    ..To evaluate the response rate, survival, and toxicities of paclitaxel plus cisplatin combination in patients with advanced or metastatic squamous-cell carcinoma of the esophagus...
  50. pmc Tumor-derived extracellular mutations of PTPRT /PTPrho are defective in cell adhesion
    Jianshi Yu
    Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, Euclid Avenue, Cleveland, OH 44106, USA
    Mol Cancer Res 6:1106-13. 2008
    ..Our results suggest that PTPrho may play an important role in cell-cell adhesion and that mutational inactivation of this phosphatase could promote tumor migration and metastasis...
  51. ncbi request reprint Subchronic toxicity and toxicokinetics of LZB, a new proton pump inhibitor, after 13-week repeated oral administration in dogs
    Yu Mao
    Center of Evaluation for Drug Safety, Second Military Medical University, Shanghai 200433, China
    Regul Toxicol Pharmacol 50:75-86. 2008
    ..The toxicological target could be stomach, liver, hematological system and nervous system...