X-k Zhang

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi request reprint Vitamin A and apoptosis in prostate cancer
    X K Zhang
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Endocr Relat Cancer 9:87-102. 2002
  2. ncbi request reprint Determinants of retinoid X receptor transcriptional antagonism
    Claudio N Cavasotto
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 47:4360-72. 2004
  3. ncbi request reprint Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest
    Marcia I Dawson
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Med Chem 47:3518-36. 2004
  4. ncbi request reprint Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells
    Sharon Y James
    Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 63:3531-8. 2003
  5. ncbi request reprint Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells
    Ming Li
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 21:411-8. 2002
  6. ncbi request reprint Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells
    Guo quan Chen
    The Burnham Institute, Cancer Center, La Jolla, CA 92037, USA
    Int J Cancer 99:171-8. 2002
  7. ncbi request reprint Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid
    Marcia I Dawson
    Department of Medicinal Chemistry, Molecular Medicine Research Institute, Mountain View, La Jolla, CA 94043, USA
    Curr Med Chem 9:623-37. 2002
  8. ncbi request reprint Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor
    Feng Lin
    Burnham Institute, Cancer Center, La Jolla, California 92037, USA
    J Biol Chem 277:21414-22. 2002
  9. pmc Mass-spectrometric analysis of agonist-induced retinoic acid receptor gamma conformational change
    Valerie J Peterson
    Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, U S A
    Biochem J 362:173-81. 2002
  10. pmc The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis
    Siva Kumar Kolluri
    The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2525-30. 2005

Collaborators

  • Marcia Dawson
  • S M Lippman
  • Siva Kumar Kolluri
  • Sharon Y James
  • Valerie J Peterson
  • Feng Lin
  • Guo quan Chen
  • Claudio N Cavasotto
  • Mark Leid
  • Ming Li
  • Wen Liu
  • Lorenzo M Leoni
  • Dennis A Carson
  • Maripat Corr
  • Howard B Cottam
  • Michele Bernasconi
  • Desheng Lu
  • Peter D Hobbs
  • Ruben Abagyan
  • Ananyo A Bhattacharya
  • Robert C Liddington
  • Gang Liu
  • Siva K Kolluri
  • Machender R Madduru
  • Xiaoming Liu
  • Xiao Chun Xu
  • Bingzhen Lin
  • Max L Deinzer
  • Shumei Song
  • Elisabeth Barofsky
  • Kai Chia Feng
  • Reuben Lotan

Detail Information

Publications10

  1. ncbi request reprint Vitamin A and apoptosis in prostate cancer
    X K Zhang
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Endocr Relat Cancer 9:87-102. 2002
    ..TR3, therefore, represents an unexplored molecule that may be an ideal target for developing new agents for prostate cancer therapy...
  2. ncbi request reprint Determinants of retinoid X receptor transcriptional antagonism
    Claudio N Cavasotto
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 47:4360-72. 2004
    ..The antagonist also blocked activation of RAR subtypes alpha and beta by 9-cis-RA but not that of RARgamma...
  3. ncbi request reprint Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest
    Marcia I Dawson
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Med Chem 47:3518-36. 2004
    ..As a result, the position of RARgamma helix H12 in forming the coactivator-binding site was impacted in a manner consistent with the experimental effect of each analogue on RARgamma transcriptional activation...
  4. ncbi request reprint Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells
    Sharon Y James
    Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 63:3531-8. 2003
    ....
  5. ncbi request reprint Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells
    Ming Li
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 21:411-8. 2002
    ..Our data demonstrated that anticancer effect of RAR-beta may be related to its ability to suppress COX-2 expression and support that the loss of RAR-beta expression may contribute to esophageal carcinogenesis...
  6. ncbi request reprint Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells
    Guo quan Chen
    The Burnham Institute, Cancer Center, La Jolla, CA 92037, USA
    Int J Cancer 99:171-8. 2002
    ....
  7. ncbi request reprint Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid
    Marcia I Dawson
    Department of Medicinal Chemistry, Molecular Medicine Research Institute, Mountain View, La Jolla, CA 94043, USA
    Curr Med Chem 9:623-37. 2002
    ....
  8. ncbi request reprint Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor
    Feng Lin
    Burnham Institute, Cancer Center, La Jolla, California 92037, USA
    J Biol Chem 277:21414-22. 2002
    ..Thus, COUP-TF, through its physical interaction with AP-1, promotes anticancer effects of retinoids by potentiating their anti-AP-1 activity...
  9. pmc Mass-spectrometric analysis of agonist-induced retinoic acid receptor gamma conformational change
    Valerie J Peterson
    Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, U S A
    Biochem J 362:173-81. 2002
    ..This technique should be generally applicable to other members of the nuclear receptor superfamily that undergo an induced structural alteration upon agonist or antagonist binding, DNA binding and/or protein-protein interaction...
  10. pmc The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis
    Siva Kumar Kolluri
    The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2525-30. 2005
    ..These results document that pharmacologic antagonism of RXRalpha transactivation is achievable and can have profound inhibitory effects in cancer development...