X-k Zhang

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi Vitamin A and apoptosis in prostate cancer
    X K Zhang
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Endocr Relat Cancer 9:87-102. 2002
  2. ncbi Determinants of retinoid X receptor transcriptional antagonism
    Claudio N Cavasotto
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 47:4360-72. 2004
  3. ncbi Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest
    Marcia I Dawson
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Med Chem 47:3518-36. 2004
  4. ncbi Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells
    Sharon Y James
    Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 63:3531-8. 2003
  5. ncbi Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells
    Ming Li
    Department of Clinical Cancer Prevention, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 21:411-8. 2002
  6. ncbi Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells
    Guo-quan Chen
    The Burnham Institute, Cancer Center, La Jolla, CA 92037, USA
    Int J Cancer 99:171-8. 2002
  7. ncbi Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid
    Marcia I Dawson
    Department of Medicinal Chemistry, Molecular Medicine Research Institute, Mountain View, La Jolla, CA 94043, USA
    Curr Med Chem 9:623-37. 2002
  8. ncbi Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor
    Feng Lin
    Burnham Institute, Cancer Center, La Jolla, California 92037, USA
    J Biol Chem 277:21414-22. 2002
  9. ncbi Mass-spectrometric analysis of agonist-induced retinoic acid receptor gamma conformational change
    Valerie J Peterson
    Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, U.S.A
    Biochem J 362:173-81. 2002
  10. ncbi The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis
    Siva Kumar Kolluri
    The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2525-30. 2005

Collaborators

  • Marcia Dawson
  • S M Lippman
  • Sharon Y James
  • Siva Kumar Kolluri
  • Valerie J Peterson
  • Feng Lin
  • Guo-quan Chen
  • Claudio N Cavasotto
  • Mark Leid
  • Ming Li
  • Lorenzo M Leoni
  • Dennis A Carson
  • Desheng Lu
  • Wen Liu
  • Maripat Corr
  • Michele Bernasconi
  • Howard B Cottam
  • Ruben Abagyan
  • Peter D Hobbs
  • Robert C Liddington
  • Ananyo A Bhattacharya
  • Gang Liu
  • Siva K Kolluri
  • Kai-Chia Feng
  • Max L Deinzer
  • Bingzhen Lin
  • Reuben Lotan
  • Machender R Madduru
  • Shumei Song
  • Elisabeth Barofsky
  • Xiao-Chun Xu
  • Xiaoming Liu
  • Guo quan Chen

Detail Information

Publications10

  1. ncbi Vitamin A and apoptosis in prostate cancer
    X K Zhang
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Endocr Relat Cancer 9:87-102. 2002
    ..TR3, therefore, represents an unexplored molecule that may be an ideal target for developing new agents for prostate cancer therapy...
  2. ncbi Determinants of retinoid X receptor transcriptional antagonism
    Claudio N Cavasotto
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 47:4360-72. 2004
    ..The antagonist also blocked activation of RAR subtypes alpha and beta by 9-cis-RA but not that of RARgamma...
  3. ncbi Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest
    Marcia I Dawson
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Med Chem 47:3518-36. 2004
    ..As a result, the position of RARgamma helix H12 in forming the coactivator-binding site was impacted in a manner consistent with the experimental effect of each analogue on RARgamma transcriptional activation...
  4. ncbi Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells
    Sharon Y James
    Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 63:3531-8. 2003
    ....
  5. ncbi Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells
    Ming Li
    Department of Clinical Cancer Prevention, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 21:411-8. 2002
    ..Our data demonstrated that anticancer effect of RAR-beta may be related to its ability to suppress COX-2 expression and support that the loss of RAR-beta expression may contribute to esophageal carcinogenesis...
  6. ncbi Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells
    Guo-quan Chen
    The Burnham Institute, Cancer Center, La Jolla, CA 92037, USA
    Int J Cancer 99:171-8. 2002
    ....
  7. ncbi Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid
    Marcia I Dawson
    Department of Medicinal Chemistry, Molecular Medicine Research Institute, Mountain View, La Jolla, CA 94043, USA
    Curr Med Chem 9:623-37. 2002
    ....
  8. ncbi Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor
    Feng Lin
    Burnham Institute, Cancer Center, La Jolla, California 92037, USA
    J Biol Chem 277:21414-22. 2002
    ..Thus, COUP-TF, through its physical interaction with AP-1, promotes anticancer effects of retinoids by potentiating their anti-AP-1 activity...
  9. ncbi Mass-spectrometric analysis of agonist-induced retinoic acid receptor gamma conformational change
    Valerie J Peterson
    Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, U.S.A
    Biochem J 362:173-81. 2002
    ..This technique should be generally applicable to other members of the nuclear receptor superfamily that undergo an induced structural alteration upon agonist or antagonist binding, DNA binding and/or protein-protein interaction...
  10. ncbi The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis
    Siva Kumar Kolluri
    The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2525-30. 2005
    ..These results document that pharmacologic antagonism of RXRalpha transactivation is achievable and can have profound inhibitory effects in cancer development...