Qiang Zhang

Summary

Affiliation: The Hamner Institutes for Health Sciences
Country: USA

Publications

  1. doi request reprint Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment
    Qiang Zhang
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 School of Public Health, China Medical University, Shenyang, China and Unilever, Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, UK
    Toxicol Sci 147:302-16. 2015
  2. pmc Ultrasensitive response motifs: basic amplifiers in molecular signalling networks
    Qiang Zhang
    Center for Dose Response Modeling, Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Open Biol 3:130031. 2013
  3. pmc All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Qiang Zhang
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, NC 27709, USA
    Toxicol Appl Pharmacol 268:17-26. 2013
  4. pmc Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Syst Biol 4:40. 2010
  5. pmc Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 237:345-56. 2009
  6. pmc A systems biology perspective on Nrf2-mediated antioxidant response
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:84-97. 2010
  7. pmc Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis
    Yongyong Hou
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:462-72. 2012
  8. pmc Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage
    Bei Yang
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 264:315-23. 2012
  9. pmc Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes
    Rui Zhao
    School of Forensic Medicine, China Medical University, Shenyang, China
    Environ Health Perspect 120:583-9. 2012
  10. pmc Divergent effects of sulforaphane on basal and glucose-stimulated insulin secretion in β-cells: role of reactive oxygen species and induction of endogenous antioxidants
    Jingqi Fu
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, Durham, North Carolina 27709, USA
    Pharm Res 30:2248-59. 2013

Collaborators

Detail Information

Publications41

  1. doi request reprint Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment
    Qiang Zhang
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 School of Public Health, China Medical University, Shenyang, China and Unilever, Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire, UK
    Toxicol Sci 147:302-16. 2015
    ....
  2. pmc Ultrasensitive response motifs: basic amplifiers in molecular signalling networks
    Qiang Zhang
    Center for Dose Response Modeling, Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Open Biol 3:130031. 2013
    ..These dynamic properties are in turn responsible for higher-level cellular behaviours, such as cell fate determination, homeostasis and biological rhythm...
  3. pmc All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Qiang Zhang
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, NC 27709, USA
    Toxicol Appl Pharmacol 268:17-26. 2013
    ..In conclusion, the present study revealed the mode and specific pathway mechanisms by which the environmental immunosuppressant TCDD suppresses B cell differentiation...
  4. pmc Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Syst Biol 4:40. 2010
    ..This humoral immune response is suppressed by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxin-like compounds, which belong to the family of aryl hydrocarbon receptor (AhR) agonists...
  5. pmc Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 237:345-56. 2009
    ..Feedforward control, often operating in combination with negative feedback regulation in a homeostatic system, may be a general control theme responsible for steady-state hormesis...
  6. pmc A systems biology perspective on Nrf2-mediated antioxidant response
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:84-97. 2010
    ..Our analysis highlights some possible adverse effects of these widely consumed antioxidants...
  7. pmc Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis
    Yongyong Hou
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:462-72. 2012
    ....
  8. pmc Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage
    Bei Yang
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 264:315-23. 2012
    ....
  9. pmc Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes
    Rui Zhao
    School of Forensic Medicine, China Medical University, Shenyang, China
    Environ Health Perspect 120:583-9. 2012
    ..Human exposure to inorganic arsenic, a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer...
  10. pmc Divergent effects of sulforaphane on basal and glucose-stimulated insulin secretion in β-cells: role of reactive oxygen species and induction of endogenous antioxidants
    Jingqi Fu
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, Durham, North Carolina 27709, USA
    Pharm Res 30:2248-59. 2013
    ..Since reactive oxygen species (ROS) can function as signaling intermediates for glucose-stimulated insulin secretion (GSIS), we hypothesize that exogenously boosting cellular antioxidant capacity dampens signaling ROS and GSIS...
  11. pmc Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response
    Peng Xue
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Biochem Biophys Res Commun 407:360-5. 2011
    ....
  12. pmc Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome
    Peng Xue
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Diabetes 62:845-54. 2013
    ..Our findings support a novel role for Nrf2 in regulating adipose development and function, by which Nrf2 controls the capacity of WAT expansion and insulin sensitivity and maintains glucose and lipid homeostasis...
  13. pmc ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:77-83. 2010
    ..In addition, we summarized our recent findings that persistent oxidative stress due to absence of uncoupling protein 2 activates cellular adaptive response which is associated with impaired pancreatic beta-cell function...
  14. doi request reprint Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes
    Yanyan Chen
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA The First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Toxicol Appl Pharmacol 273:435-41. 2013
    ..The inhibition of ARE signaling may be a potential underlying mechanism by which INH attenuates cellular antioxidant response contributing to various complications. ..
  15. pmc Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress
    Jingqi Fu
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:864-70. 2010
    ..Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating cellular adaptive response to oxidative stress...
  16. pmc A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Sudin Bhattacharya
    Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 115:51-65. 2010
    ..Second, TCDD may also disrupt the maintenance of the immune response by depleting the pool of available plasma cells through dedifferentiation...
  17. pmc Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages
    Courtney G Woods
    Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:27-36. 2009
    ..These findings confirm an Nrf2-centric mechanism of action of HOCl in mouse macrophages and provide evidence of interactions between Nrf2, inflammatory, and other stress pathways...
  18. pmc Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response
    Yongyong Hou
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 121:237-43. 2013
    ..However, the mechanisms for the diabetogenic effect of iAs are still largely unknown. White adipose tissue (WAT) actively stores and releases energy and maintains lipid and glucose homeostasis...
  19. doi request reprint BAG3 sensitizes cancer cells exposed to DNA damaging agents via direct interaction with GRP78
    De Hui Kong
    Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang 110001, China Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China
    Biochim Biophys Acta 1833:3245-53. 2013
    ..Overall, these results suggested that through direct interaction BAG3 could prevent the antiapoptotic effect of GRP78 upon genotoxic stress. ..
  20. pmc CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion
    Hongzhi Zheng
    1 The First Affiliated Hospital, China Medical University, Shenyang, China
    Antioxid Redox Signal 22:819-31. 2015
    ..We investigated both the in vitro and in vivo effects of deficiency of nuclear factor-erythroid 2-related factor 1 (Nrf1) in β-cells on β-cell function and glucose homeostasis...
  21. doi request reprint Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells
    Hui Peng
    The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC, USA Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China
    Toxicol Appl Pharmacol 292:1-7. 2016
    ....
  22. pmc BAG3-dependent noncanonical autophagy induced by proteasome inhibition in HepG2 cells
    Bao Qin Liu
    Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, China
    Autophagy 9:905-16. 2013
    ..Moreover, we found that noncanonical autophagy mediated by BAG3 suppresses responsiveness of HepG2 cells to proteasome inhibitors...
  23. doi request reprint Computational systems biology and dose-response modeling in relation to new directions in toxicity testing
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina
    J Toxicol Environ Health B Crit Rev 13:253-76. 2010
    ..In parallel, dissemination of computational systems biology techniques and other analytical tools among practicing toxicologists and risk assessment professionals will help accelerate implementation of the new toxicity testing vision...
  24. doi request reprint Keap1 silencing boosts lipopolysaccharide-induced transcription of interleukin 6 via activation of nuclear factor κB in macrophages
    Peng Lv
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 272:697-702. 2013
    ..Given the importance of IL6 in the inflammatory response, the Keap1-IKKβ-NF-κB pathway may be a novel target for treatment and prevention of inflammation and associated disorders...
  25. doi request reprint Upregulation of let-7a inhibits vascular smooth muscle cell proliferation in vitro and in vein graft intimal hyperplasia in rats
    Hui Cao
    Department of Vascular Surgery, The First Affiliated Hospital, China Medical University, Shenyang, China
    J Surg Res 192:223-33. 2014
    ..In this study, we assessed the impact of let-7a microRNA (miRNA) on the proliferation of VSMCs...
  26. pmc A deterministic map of Waddington's epigenetic landscape for cell fate specification
    Sudin Bhattacharya
    Division of Computational Biology, Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Syst Biol 5:85. 2011
    ..However the question of whether the epigenetic landscape can be mapped out quantitatively to provide a predictive model of cellular differentiation remains largely unanswered...
  27. pmc Dose response relationship in anti-stress gene regulatory networks
    Qiang Zhang
    Division of Computational Biology, CIIT Centers for Health Research, Research Triangle Park, North Carolina, United States of America
    PLoS Comput Biol 3:e24. 2007
    ..This work would help biologists and especially toxicologists to better assess and predict the cellular impact brought about by biological stressors...
  28. ncbi request reprint Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 226:236-43. 2008
    ..Taken together, we provide direct evidence that HOCl activates Nrf2-mediated antioxidant response, which protects cells from oxidative damage...
  29. doi request reprint Protective Role of Nuclear Factor E2-Related Factor 2 against Acute Oxidative Stress-Induced Pancreatic β -Cell Damage
    Jingqi Fu
    Program of Environmental Toxicology, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, China
    Oxid Med Cell Longev 2015:639191. 2015
    ....
  30. pmc Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways
    Sudin Bhattacharya
    Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e20887. 2011
    ..In this vein, we also discuss how the proposed strategy for toxicity testing might be applied to the toxicity pathways associated with DNA damage and repair...
  31. pmc Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses
    Qiang Zhang
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 122:1261-70. 2014
    ..Empirical evaluations may show consistency with thresholds, but the main evidence has to come from mechanistic considerations...
  32. pmc Binary gene induction and protein expression in individual cells
    Qiang Zhang
    Division of Computational Biology, CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Theor Biol Med Model 3:18. 2006
    ..Support for each of these two mechanisms arises primarily from experimental studies measuring reporter proteins in individual cells, rather than from direct measurement of induction events at the gene template...
  33. ncbi request reprint Reactive oxygen species as a signal in glucose-stimulated insulin secretion
    Jingbo Pi
    Endocrine Biology Program, The Hamner Institutes for Health Sciences, 6 Davis Dr, Research Triangle Park, NC 27709, USA
    Diabetes 56:1783-91. 2007
    ..Taken together, these findings suggest that H2O2 derived from glucose metabolism is one of the metabolic signals for insulin secretion, whereas oxidative stress may disturb its signaling function...
  34. doi request reprint Implication of Nrf2 and ATF4 in differential induction of CHOP by proteasome inhibition in thyroid cancer cells
    Zhi Hong Zong
    Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, China
    Biochim Biophys Acta 1823:1395-404. 2012
    ..This study highlights the molecular mechanisms by which ATF4 and Nrf2 can control CHOP induction in thyroid cancer cells by proteasome inhibition...
  35. pmc Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells
    Lijuan Zhan
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Free Radic Biol Med 53:758-68. 2012
    ....
  36. doi request reprint Dose-response modeling of etoposide-induced DNA damage response
    Zhenhong Li
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Sci 137:371-84. 2014
    ..Future studies will determine how well this initial modeling effort agrees with a broader set of experimental studies on pathway responses by examining a more diverse group of DNA-damaging compounds. ..
  37. pmc Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches
    Sudin Bhattacharya
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences Research Triangle Park, NC, USA
    Front Physiol 3:462. 2012
    ..The model initially focuses on reactive metabolite-induced DILI in response to administration of acetaminophen, and spans multiple biological scales...
  38. doi request reprint Hyperhomocysteinaemia, low folate concentrations and MTHFR C677T mutation in abdominal aortic aneurysm
    Hui Cao
    First Affiliated Hospital, China Medical University, Shenyang, China
    Vasa 43:181-8. 2014
    ..However, the association of Hcy, vitamin B12, and folate in patients with AAA has not been studied in China. This study was conducted with the aim to evaluate the relationship of vitamin B12, folic acid, and Hcy levels in AAA...
  39. doi request reprint Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment
    Yeyejide Adeleye
    Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK
    Toxicology 332:102-11. 2015
    ..This paper therefore describes the current progress in an ongoing research effort aimed at providing a pathways-based, proof-of-concept in vitro-only safety assessment for a consumer use product. ..
  40. doi request reprint Metabolic profile and assessment of occupational arsenic exposure in copper- and steel-smelting workers in China
    Shuhua Xi
    Department of Environmental and Occupational Health, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, 110001, Shenyang, People s Republic of China
    Int Arch Occup Environ Health 84:347-53. 2011
    ..Analyze the urine arsenic (As) metabolite profiles of workers in copper-and special steel-smelting plants and explore the potential occupationally As exposure as well as the individual arsenicosis risk...
  41. ncbi request reprint [Effect of RNA interference targeting mammalian target of rapamycin on the proliferation of vascular smooth muscle cell and the intimal hyperplasia]
    Xin Hua Hu
    Department of Vascular Surgery, First Affiliated Hospital, China Medical University, Shenyang, China
    Zhonghua Yi Xue Za Zhi 87:58-62. 2007
    ..To construct RNA interference (RNAi) vector of mammalian target of rapamycin (mTOR) and study the effect on the proliferation of vascular smooth muscle cell (VSMC) and the intimal hyperplasia (IH)...