Qiang Zhang

Summary

Affiliation: The Hamner Institutes for Health Sciences
Country: USA

Publications

  1. pmc Ultrasensitive response motifs: basic amplifiers in molecular signalling networks
    Qiang Zhang
    Center for Dose Response Modeling, Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Open Biol 3:130031. 2013
  2. pmc All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Qiang Zhang
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, NC 27709, USA
    Toxicol Appl Pharmacol 268:17-26. 2013
  3. pmc Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Syst Biol 4:40. 2010
  4. pmc A systems biology perspective on Nrf2-mediated antioxidant response
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:84-97. 2010
  5. pmc Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 237:345-56. 2009
  6. pmc Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis
    Yongyong Hou
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:462-72. 2012
  7. pmc Divergent effects of sulforaphane on basal and glucose-stimulated insulin secretion in β-cells: role of reactive oxygen species and induction of endogenous antioxidants
    Jingqi Fu
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, Durham, North Carolina 27709, USA
    Pharm Res 30:2248-59. 2013
  8. pmc Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage
    Bei Yang
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 264:315-23. 2012
  9. pmc Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response
    Peng Xue
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Biochem Biophys Res Commun 407:360-5. 2011
  10. pmc Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome
    Peng Xue
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Diabetes 62:845-54. 2013

Collaborators

Detail Information

Publications27

  1. pmc Ultrasensitive response motifs: basic amplifiers in molecular signalling networks
    Qiang Zhang
    Center for Dose Response Modeling, Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Open Biol 3:130031. 2013
    ..These dynamic properties are in turn responsible for higher-level cellular behaviours, such as cell fate determination, homeostasis and biological rhythm...
  2. pmc All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Qiang Zhang
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, NC 27709, USA
    Toxicol Appl Pharmacol 268:17-26. 2013
    ..In conclusion, the present study revealed the mode and specific pathway mechanisms by which the environmental immunosuppressant TCDD suppresses B cell differentiation...
  3. pmc Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Syst Biol 4:40. 2010
    ..This humoral immune response is suppressed by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxin-like compounds, which belong to the family of aryl hydrocarbon receptor (AhR) agonists...
  4. pmc A systems biology perspective on Nrf2-mediated antioxidant response
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:84-97. 2010
    ..Our analysis highlights some possible adverse effects of these widely consumed antioxidants...
  5. pmc Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 237:345-56. 2009
    ..Feedforward control, often operating in combination with negative feedback regulation in a homeostatic system, may be a general control theme responsible for steady-state hormesis...
  6. pmc Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis
    Yongyong Hou
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:462-72. 2012
    ....
  7. pmc Divergent effects of sulforaphane on basal and glucose-stimulated insulin secretion in β-cells: role of reactive oxygen species and induction of endogenous antioxidants
    Jingqi Fu
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, Durham, North Carolina 27709, USA
    Pharm Res 30:2248-59. 2013
    ..Since reactive oxygen species (ROS) can function as signaling intermediates for glucose-stimulated insulin secretion (GSIS), we hypothesize that exogenously boosting cellular antioxidant capacity dampens signaling ROS and GSIS...
  8. pmc Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage
    Bei Yang
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 264:315-23. 2012
    ....
  9. pmc Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response
    Peng Xue
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Biochem Biophys Res Commun 407:360-5. 2011
    ....
  10. pmc Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome
    Peng Xue
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Diabetes 62:845-54. 2013
    ..Our findings support a novel role for Nrf2 in regulating adipose development and function, by which Nrf2 controls the capacity of WAT expansion and insulin sensitivity and maintains glucose and lipid homeostasis...
  11. pmc ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:77-83. 2010
    ..In addition, we summarized our recent findings that persistent oxidative stress due to absence of uncoupling protein 2 activates cellular adaptive response which is associated with impaired pancreatic beta-cell function...
  12. ncbi request reprint Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes
    Yanyan Chen
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA The First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Toxicol Appl Pharmacol 273:435-41. 2013
    ..The inhibition of ARE signaling may be a potential underlying mechanism by which INH attenuates cellular antioxidant response contributing to various complications. ..
  13. pmc Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages
    Courtney G Woods
    Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:27-36. 2009
    ..These findings confirm an Nrf2-centric mechanism of action of HOCl in mouse macrophages and provide evidence of interactions between Nrf2, inflammatory, and other stress pathways...
  14. pmc A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Sudin Bhattacharya
    Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 115:51-65. 2010
    ..Second, TCDD may also disrupt the maintenance of the immune response by depleting the pool of available plasma cells through dedifferentiation...
  15. pmc Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress
    Jingqi Fu
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:864-70. 2010
    ..Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating cellular adaptive response to oxidative stress...
  16. pmc Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response
    Yongyong Hou
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 121:237-43. 2013
    ..However, the mechanisms for the diabetogenic effect of iAs are still largely unknown. White adipose tissue (WAT) actively stores and releases energy and maintains lipid and glucose homeostasis...
  17. doi request reprint Computational systems biology and dose-response modeling in relation to new directions in toxicity testing
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina
    J Toxicol Environ Health B Crit Rev 13:253-76. 2010
    ..In parallel, dissemination of computational systems biology techniques and other analytical tools among practicing toxicologists and risk assessment professionals will help accelerate implementation of the new toxicity testing vision...
  18. pmc A deterministic map of Waddington's epigenetic landscape for cell fate specification
    Sudin Bhattacharya
    Division of Computational Biology, Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Syst Biol 5:85. 2011
    ..However the question of whether the epigenetic landscape can be mapped out quantitatively to provide a predictive model of cellular differentiation remains largely unanswered...
  19. pmc Dose response relationship in anti-stress gene regulatory networks
    Qiang Zhang
    Division of Computational Biology, CIIT Centers for Health Research, Research Triangle Park, North Carolina, United States of America
    PLoS Comput Biol 3:e24. 2007
    ..This work would help biologists and especially toxicologists to better assess and predict the cellular impact brought about by biological stressors...
  20. ncbi request reprint Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 226:236-43. 2008
    ..Taken together, we provide direct evidence that HOCl activates Nrf2-mediated antioxidant response, which protects cells from oxidative damage...
  21. doi request reprint Keap1 silencing boosts lipopolysaccharide-induced transcription of interleukin 6 via activation of nuclear factor κB in macrophages
    Peng Lv
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 272:697-702. 2013
    ..Given the importance of IL6 in the inflammatory response, the Keap1-IKKβ-NF-κB pathway may be a novel target for treatment and prevention of inflammation and associated disorders...
  22. pmc Binary gene induction and protein expression in individual cells
    Qiang Zhang
    Division of Computational Biology, CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Theor Biol Med Model 3:18. 2006
    ..Support for each of these two mechanisms arises primarily from experimental studies measuring reporter proteins in individual cells, rather than from direct measurement of induction events at the gene template...
  23. ncbi request reprint Reactive oxygen species as a signal in glucose-stimulated insulin secretion
    Jingbo Pi
    Endocrine Biology Program, The Hamner Institutes for Health Sciences, 6 Davis Dr, Research Triangle Park, NC 27709, USA
    Diabetes 56:1783-91. 2007
    ..Taken together, these findings suggest that H2O2 derived from glucose metabolism is one of the metabolic signals for insulin secretion, whereas oxidative stress may disturb its signaling function...
  24. pmc Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells
    Lijuan Zhan
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Free Radic Biol Med 53:758-68. 2012
    ....
  25. pmc Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways
    Sudin Bhattacharya
    Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e20887. 2011
    ..In this vein, we also discuss how the proposed strategy for toxicity testing might be applied to the toxicity pathways associated with DNA damage and repair...
  26. pmc Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches
    Sudin Bhattacharya
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences Research Triangle Park, NC, USA
    Front Physiol 3:462. 2012
    ..The model initially focuses on reactive metabolite-induced DILI in response to administration of acetaminophen, and spans multiple biological scales...
  27. doi request reprint Dose-response modeling of etoposide-induced DNA damage response
    Zhenhong Li
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Sci 137:371-84. 2014
    ..Future studies will determine how well this initial modeling effort agrees with a broader set of experimental studies on pathway responses by examining a more diverse group of DNA-damaging compounds. ..