Jian Zhang


Affiliation: The Ohio State University
Country: USA


  1. Xiao Y, Qiao G, Tang J, Tang R, Guo H, Warwar S, et al. Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation. J Immunol. 2015;195:4218-27 pubmed publisher
    ..Therefore, SHP-1 regulates Cbl-b-mediated T cell responses by controlling its tyrosine phosphorylation and ubiquitination. ..
  2. Qiao G, Ying H, Zhao Y, Liang Y, Guo H, Shen H, et al. E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Rep. 2014;6:709-23 pubmed publisher
    ..Therefore, our data reveal a function for Cbl-b in the regulation of Th2 and Th9 cell differentiation. ..
  3. Qiao G, Yang L, Li Z, Williams J, Zhang J. A77 1726, the active metabolite of leflunomide, attenuates lupus nephritis by promoting the development of regulatory T cells and inhibiting IL-17-producing double negative T cells. Clin Immunol. 2015;157:166-74 pubmed publisher
    ..Taken together, our data indicate that the therapeutic effects of A77 1726 in murine LN are mediated, at least in part, by augmenting iTregs which suppress pathogenic IL-17-producing DN T cells through an Akt-dependent mechanism. ..
  4. Yang L, Qiao G, Hassan Y, Li Z, Zhang X, Kong H, et al. Program Death-1 Suppresses Autoimmune Arthritis by Inhibiting Th17 Response. Arch Immunol Ther Exp (Warsz). 2016;64:417-23 pubmed publisher
    ..Therefore, our data indicate that PD-1 dampens antigen-specific Th17 response, thus inhibiting the disease. ..
  5. Zhao Y, Guo H, Qiao G, Zucker M, Langdon W, Zhang J. E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4+CD25+ Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination. J Immunol. 2015;194:1639-45 pubmed publisher
    ..Treating Cd28(-/-) mice with a proteasome inhibitor completely rescues defective tTreg development in these mice. Therefore, Cbl-b, together with Stub1, ubiquitinate Foxp3, and regulate tTreg development. ..
  6. Yin J, Zhang J, Lu Q. The role of basic leucine zipper transcription factor E4BP4 in the immune system and immune-mediated diseases. Clin Immunol. 2017;180:5-10 pubmed publisher
    ..Here we review the regulatory mechanisms of E4BP4 engaging in not only the biological function but also the development of immune-mediated diseases, paving the way for future therapies. ..