Affiliation: The Rockefeller University
- Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP dataChaolin Zhang
Laboratory of Molecular Neuro Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York, USA
Nat Biotechnol 29:607-14. 2011..CIMS analysis provides a general and more precise means of mapping protein-RNA interactions than currently available methods and insight into the biochemical properties of such interactions in living tissues...
- Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controlsChaolin Zhang
Laboratory of Molecular Neuro Oncology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Science 329:439-43. 2010..Thus, we have developed a general approach to understanding mammalian RNA regulation at the systems level...
- Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brainDonny D Licatalosi
Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York 10065, USA
Genes Dev 26:1626-42. 2012..Thus, Ptbp2 inhibition of a discrete set of adult neuronal exons underlies early brain development prior to neuronal differentiation and is essential for postnatal survival...
- Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitabilityGulayse Ince-Dunn
Laboratory of Molecular Neuro Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Neuron 75:1067-80. 2012..The genome-wide analysis of nElavl targets reveals that one function of neuron-specific RNABPs is to control excitation-inhibition balance in the brain...
- NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizureTaesun Eom
Laboratory of Molecular Neuro Oncology, Rockefeller University, New York, United States
elife 2:e00178. 2013..The data reveal a hidden means of dynamic RNA regulation linking electrical activity to splicing and protein output, and of mediating homeostatic excitation/inhibition balance in neurons.DOI:http://dx.doi.org/10.7554/eLife.00178.001...
- FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autismJennifer C Darnell
Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, NY 10065, USA
Cell 146:247-61. 2011..In addition, they provide insight into the molecular basis of the cognitive and allied defects in FXS and ASD and suggest multiple targets for clinical intervention...