BABETTE S contact ZEMEL

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi request reprint Human biology at the interface of paediatrics: measuring bone mineral accretion during childhood
    Babette S Zemel
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Room 1560, Philadelphia, PA 19104 4399, USA
    Ann Hum Biol 39:402-11. 2012
  2. doi request reprint Bone mineral accretion and its relationship to growth, sexual maturation and body composition during childhood and adolescence
    Babette Zemel
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
    World Rev Nutr Diet 106:39-45. 2013
  3. ncbi request reprint Effect of zinc supplementation on growth and body composition in children with sickle cell disease
    Babette S Zemel
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, 19104 4399, USA
    Am J Clin Nutr 75:300-7. 2002
  4. doi request reprint Peripheral quantitative computed tomography in children and adolescents: the 2007 ISCD Pediatric Official Positions
    Babette Zemel
    The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
    J Clin Densitom 11:59-74. 2008
  5. ncbi request reprint Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease
    Babette S Zemel
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pediatr Res 61:607-13. 2007
  6. doi request reprint Revised pediatric reference data for the lateral distal femur measured by Hologic Discovery/Delphi dual-energy X-ray absorptiometry
    Babette S Zemel
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    J Clin Densitom 12:207-18. 2009
  7. doi request reprint The recognition and treatment of growth disorders - a 50-year retrospective
    Babette Zemel
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Hum Biol 36:496-510. 2009
  8. pmc Height adjustment in assessing dual energy x-ray absorptiometry measurements of bone mass and density in children
    Babette S Zemel
    The Children s Hospital of Philadelphia, 3535 Market Street, Room 1560, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 95:1265-73. 2010
  9. pmc Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: results of the bone mineral density in childhood study
    Babette S Zemel
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 96:3160-9. 2011
  10. doi request reprint Quantitative computed tomography and computed tomography in children
    Babette S Zemel
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    Curr Osteoporos Rep 9:284-90. 2011

Research Grants

  1. BUILDING BETTER BONES IN CHILDREN
    Babette Zemel; Fiscal Year: 2003
  2. Genome Wide Association Study of Bone Mineral Accretion During Childhood
    BABETTE S contact ZEMEL; Fiscal Year: 2010

Detail Information

Publications76

  1. doi request reprint Human biology at the interface of paediatrics: measuring bone mineral accretion during childhood
    Babette S Zemel
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Room 1560, Philadelphia, PA 19104 4399, USA
    Ann Hum Biol 39:402-11. 2012
    ..The relatively new field of paediatric bone health assessment fits this paradigm and reflects the collaboration of human biologists and paediatricians in understanding the growth of the human skeleton...
  2. doi request reprint Bone mineral accretion and its relationship to growth, sexual maturation and body composition during childhood and adolescence
    Babette Zemel
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
    World Rev Nutr Diet 106:39-45. 2013
    ..Understanding these complex relationships is essential to understanding bone metabolism during this part of the life cycle and the challenges of assessing bone health in children with medical conditions that threaten bone health...
  3. ncbi request reprint Effect of zinc supplementation on growth and body composition in children with sickle cell disease
    Babette S Zemel
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, 19104 4399, USA
    Am J Clin Nutr 75:300-7. 2002
    ..Poor growth and delayed maturation in children with sickle cell disease (SCD) may be due, in part, to mild zinc deficiency...
  4. doi request reprint Peripheral quantitative computed tomography in children and adolescents: the 2007 ISCD Pediatric Official Positions
    Babette Zemel
    The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
    J Clin Densitom 11:59-74. 2008
    ..Reference data that sufficiently characterize the normal range of variability in the population also need to be established...
  5. ncbi request reprint Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease
    Babette S Zemel
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pediatr Res 61:607-13. 2007
    ..Growth failure and maturational delay remain significant chronic problems in children with SCD-SS and are related to potentially modifiable factors such as nutritional status...
  6. doi request reprint Revised pediatric reference data for the lateral distal femur measured by Hologic Discovery/Delphi dual-energy X-ray absorptiometry
    Babette S Zemel
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    J Clin Densitom 12:207-18. 2009
    ....
  7. doi request reprint The recognition and treatment of growth disorders - a 50-year retrospective
    Babette Zemel
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Hum Biol 36:496-510. 2009
    ..These examples accentuate the need for continued participation of human biologists in the study of growth and development and the care of children...
  8. pmc Height adjustment in assessing dual energy x-ray absorptiometry measurements of bone mass and density in children
    Babette S Zemel
    The Children s Hospital of Philadelphia, 3535 Market Street, Room 1560, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 95:1265-73. 2010
    ..Adjustments using HAZ were least biased relative to HAZ and age and can be used to evaluate the effect of short or tall stature on BMC/BMD Z-scores...
  9. pmc Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: results of the bone mineral density in childhood study
    Babette S Zemel
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 96:3160-9. 2011
    ..Deficits in bone acquisition during growth may increase fracture risk. Assessment of bone health during childhood requires appropriate reference values relative to age, sex, and population ancestry to identify bone deficits...
  10. doi request reprint Quantitative computed tomography and computed tomography in children
    Babette S Zemel
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    Curr Osteoporos Rep 9:284-90. 2011
    ..These new studies will ultimately help us understand the development of sex differences in bone strength that emerge in adolescence...
  11. ncbi request reprint Evaluation of formulas for calculating total energy requirements of preadolescent children with cystic fibrosis
    Jillian Trabulsi
    Divisions of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Clin Nutr 85:144-51. 2007
    ..Care providers use one of several empirically derived formulas to calculate energy requirements, yet the validity of these formulas has seldom been tested...
  12. ncbi request reprint Rethinking growth failure in Alagille syndrome: the role of dietary intake and steatorrhea
    Alisha J Rovner
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Pediatr Gastroenterol Nutr 35:495-502. 2002
    ..To characterize the energy and nutrient intake, and the degree of fat malabsorption in children with Alagille syndrome (AGS) and to examine their cross-sectional associations with growth and nutritional status...
  13. ncbi request reprint Bone area and bone mineral content deficits in children with sickle cell disease
    Anne M Buison
    Division of Gastroenterology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 116:943-9. 2005
    ....
  14. ncbi request reprint Fecal elastase: pancreatic status verification and influence on nutritional status in children with cystic fibrosis
    Jacqueline R Cohen
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Pennsylvania, USA
    J Pediatr Gastroenterol Nutr 40:438-44. 2005
    ..To evaluate fecal elastase 1 (FE) levels in young children with cystic fibrosis and pancreatic insufficiency and to explore the relationship between FE and growth, nutrition, pulmonary status and fat absorption over a 24-month period...
  15. pmc Divergent effects of glucocorticoids on cortical and trabecular compartment BMD in childhood nephrotic syndrome
    Rachel J Wetzsteon
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Bone Miner Res 24:503-13. 2009
    ..Lower bone biomarkers were associated with greater cortical vBMD. Studies are needed to determine the fracture implications of these varied effects...
  16. ncbi request reprint Vitamin B6 status of children with sickle cell disease
    Melissa C Nelson
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    J Pediatr Hematol Oncol 24:463-9. 2002
    ..The purpose of this study was to assess vitamin B(6) status of children with SCD-SS ages 3 to 20 years and determine its relationship to growth, dietary intake, and disease severity...
  17. ncbi request reprint Interactions between growth and body composition in children treated with high-dose chronic glucocorticoids
    Bethany J Foster
    Department of Pediatrics, Division of Nephrology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Clin Nutr 80:1334-41. 2004
    ..However, despite prolonged, repeated courses of glucocorticoid, children with steroid-sensitive nephrotic syndrome (SSNS) have almost normal adult height. Little information exists on body composition...
  18. ncbi request reprint Self-assessment of sexual maturity status in children with Crohn's disease
    Joan I Schall
    Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr 141:223-9. 2002
    ..To evaluate the validity of self-assessment of sexual maturity status (SMS) in children with Crohn's disease (CD), a pediatric chronic disease that often affects growth and development...
  19. doi request reprint Bone mineral content deficits of the spine and whole body in children at time of diagnosis with celiac disease
    Muralidhar Jatla
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
    J Pediatr Gastroenterol Nutr 48:175-80. 2009
    ..The secondary aim was to examine the effect of histological grade on BMC...
  20. ncbi request reprint Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents
    Francis L Weng
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Clin Nutr 86:150-8. 2007
    ..Serum 25-hydroxyvitamin D [25(OH)D] concentrations serve as a biomarker for vitamin D stores. Prior studies have not examined the risk factors for low vitamin D concentrations in a multiethnic sample of US youth across a broad age range...
  21. ncbi request reprint Low vitamin D status in children with sickle cell disease
    Anne M Buison
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania, 19104, USA
    J Pediatr 145:622-7. 2004
    ..To examine vitamin D status in children with sickle cell disease (SCD)-SS and its relation to season and dietary intake...
  22. ncbi request reprint Resting energy expenditure is not increased in prepubertal children with Alagille syndrome
    Alisha J Rovner
    Division of Gastroenterology and Nutrition at The Children s Hospital of Philadelphia, PA 19104, USA
    J Pediatr 148:680-2. 2006
    ..We evaluated 16 subjects with AGS and 37 healthy controls and did not find a significant difference in REE (101% +/- 12%, 105% +/- 13%, respectively)...
  23. pmc Longitudinal assessment of bone density and structure in an incident cohort of children with Crohn's disease
    Sarah E Dubner
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 136:123-30. 2009
    ..The objective of this longitudinal study was to assess musculoskeletal outcomes in an incident cohort of children with CD using peripheral quantitative computed tomography (pQCT)...
  24. ncbi request reprint Infant weight gain and childhood overweight status in a multicenter, cohort study
    Nicolas Stettler
    The Children s Hospital of Philadelphia, Division of Gastroenterology and Nutrition, Philadelphia, Pennsylvania 19104 4399, USA
    Pediatrics 109:194-9. 2002
    ..To determine whether a rapid rate of weight gain in early infancy is associated with overweight status in childhood...
  25. doi request reprint Hypovitaminosis D is associated with greater body mass index and disease activity in pediatric systemic lupus erythematosus
    Tracey B Wright
    Department of Pediatrics, Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Pediatr 155:260-5. 2009
    ..To determine whether pediatric systemic lupus erythematosus (SLE) is associated with alterations in the vitamin D-parathyroid hormone (PTH) axis and to assess the relation between vitamin D deficiency and SLE activity...
  26. pmc Gender differences in body composition deficits at diagnosis in children and adolescents with Crohn's disease
    Meena Thayu
    Children s Hospital of Philadelphia Gastroenterology, Hepatology, and Nutrition, Philadelphia, Pennsylvania 19104, USA
    Inflamm Bowel Dis 13:1121-8. 2007
    ..Objectives: To quantify LM and FM in incident pediatric CD subjects and controls, and to identify determinants of LM and FM deficits...
  27. ncbi request reprint Adequacy of dietary intake declines with age in children with sickle cell disease
    Deborah A Kawchak
    Nutrition and Growth Laboratory, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Am Diet Assoc 107:843-8. 2007
    ..Dietary intake was particularly poor in adolescents. Efforts are needed to ensure dietary adequacy in children with sickle cell disease, type SS and to understand the etiology of poor dietary intake...
  28. doi request reprint Evidence-based practice recommendations for nutrition-related management of children and adults with cystic fibrosis and pancreatic insufficiency: results of a systematic review
    Virginia A Stallings
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, 3535 Market St, Philadelphia, PA 19104, USA
    J Am Diet Assoc 108:832-9. 2008
    ..These Registry data-based recommendations are presented...
  29. ncbi request reprint Vitamin A intake and elevated serum retinol levels in children and young adults with cystic fibrosis
    Asim Maqbool
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Cyst Fibros 7:137-41. 2008
    ..Individuals with cystic fibrosis (CF) and pancreatic insufficiency (PI) are at risk for fat-soluble vitamin deficiency, including vitamin A. Recent evidence suggests current practices of vitamin A intake results in elevated serum retinol...
  30. doi request reprint Observational study of bone accretion during successful weight loss in obese adolescents
    Nicolas Stettler
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 16:96-101. 2008
    ..To assess bone mineral content (BMC) among obese adolescents who lose weight during a critical period for bone accretion...
  31. doi request reprint Assessment of spine bone mineral density in juvenile idiopathic arthritis: impact of scan projection
    Sarah E Dubner
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Densitom 11:302-8. 2008
    ..In conclusion, WA-BMD may be more sensitive to disease effects in children because it selectively measures the trabecular-rich vertebral body and is independent of growth-related changes in BMC of the dense spinous processes...
  32. ncbi request reprint Clinical and genetic correlates of exercise performance in young children with cystic fibrosis
    Michael G McBride
    Division of Cardiology, The Children s Hospital of Philadelphia, PA 19104, USA
    Percept Mot Skills 110:995-1009. 2010
    ..Rather, the extent of pulmonary disease and undernutrition were associated with functional performance...
  33. pmc Interpretation of biomarkers of bone metabolism in children: impact of growth velocity and body size in healthy children and chronic disease
    Shamir Tuchman
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr 153:484-90. 2008
    ....
  34. pmc Bone density, structure, and strength in juvenile idiopathic arthritis: importance of disease severity and muscle deficits
    Jon M Burnham
    Children s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arthritis Rheum 58:2518-27. 2008
    ....
  35. doi request reprint Serum linoleic acid status as a clinical indicator of essential fatty acid status in children with cystic fibrosis
    Asim Maqbool
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr Gastroenterol Nutr 47:635-44. 2008
    ..Children with cystic fibrosis (CF) and pancreatic insufficiency (PI) are at increased risk for essential fatty acid (EFA) deficiency...
  36. pmc Deficits in bone mineral content in children and adolescents with cystic fibrosis are related to height deficits
    Andrea Kelly
    Division of Endocrinology Diabetes, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Densitom 11:581-9. 2008
    ..BMC deficits are related to altered body size, reduced LBM, and pulmonary function in children with CF. Interventions targeting improved growth, muscle mass, and pulmonary function may benefit bone health in CF...
  37. pmc Energy expenditure in obesity associated with craniopharyngioma
    Roy J Kim
    Division of Endocrinology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Childs Nerv Syst 26:913-7. 2010
    ..Obesity is a common yet incompletely understood complication of childhood craniopharyngioma. We hypothesized that craniopharyngioma is associated with specific defects in energy balance compared to obese control children...
  38. pmc Effects of sex, race, and puberty on cortical bone and the functional muscle bone unit in children, adolescents, and young adults
    Mary B Leonard
    Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 95:1681-9. 2010
    ..Sex and race differences in bone development are associated with differences in growth, maturation, and body composition...
  39. pmc Determinants of changes in linear growth and body composition in incident pediatric Crohn's disease
    Meena Thayu
    Department of Pediatrics, The Children s Hospital of Philadelphia, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 139:430-8. 2010
    ..Pediatric Crohn's disease (CD) is associated with growth, lean mass (LM), and fat mass (FM) deficits. This study assessed and identified determinants of changes in height and body composition in children with CD following...
  40. doi request reprint Progressive bone mineral content loss in children with intractable epilepsy treated with the ketogenic diet
    A G Christina Bergqvist
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Clin Nutr 88:1678-84. 2008
    ..The ketogenic diet (KD) is a high-fat, low-carbohydrate, and protein diet that effectively treats intractable epilepsy (IE)...
  41. ncbi request reprint Alterations in proximal femur geometry in children treated with glucocorticoids for Crohn disease or nephrotic syndrome: impact of the underlying disease
    Jon M Burnham
    The Children s Hospital of Philadelphia, Philadelphia PA 19104, USA
    J Bone Miner Res 22:551-9. 2007
    ..Subperiosteal width and section modulus were significantly lower in CD and greater in SSNS compared with controls, highlighting the importance of the underlying disease, persistent inflammation, and alterations in lean mass...
  42. ncbi request reprint Body-composition alterations consistent with cachexia in children and young adults with Crohn disease
    Jon M Burnham
    Department of Pediatrics, Division of Rheumatology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Clin Nutr 82:413-20. 2005
    ..Crohn disease (CD) in children is associated with low body mass index (BMI), poor growth, and delayed maturation; alterations in lean and fat mass, however, are poorly characterized...
  43. ncbi request reprint Adolescent development and energy expenditure in females with cystic fibrosis
    Virginia A Stallings
    Department of Pediatrics, Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Clin Nutr 24:737-45. 2005
    ..Relationships between sexual maturity, nutrition, resting energy expenditure (REE), and pulmonary status in females with CF and pancreatic insufficiency (PI) were evaluated...
  44. ncbi request reprint Long-term, high-dose glucocorticoids and bone mineral content in childhood glucocorticoid-sensitive nephrotic syndrome
    Mary B Leonard
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    N Engl J Med 351:868-75. 2004
    ..We determined the effects of long-term treatment with glucocorticoids on bone mineral content in children with glucocorticoid-sensitive nephrotic syndrome, a disorder with minimal known independent effects on bone...
  45. ncbi request reprint Mild to moderate cystic fibrosis is not associated with increased fracture risk in children and adolescents
    Alisha J Rovner
    Division of Gastroenterology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr 147:327-31. 2005
    ..To determine whether children and adolescents with cystic fibrosis (CF), pancreatic insufficiency (PI), and mild-to-moderate lung disease have an increased risk of fracture compared with concurrent healthy control subjects...
  46. ncbi request reprint Obesity during childhood and adolescence augments bone mass and bone dimensions
    Mary B Leonard
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia PA 19104, USA
    Am J Clin Nutr 80:514-23. 2004
    ..Studies of the effect of childhood obesity on bone accrual during growth have yielded conflicting results, largely related to the failure to adequately characterize the confounding effects of growth, maturation, and body composition...
  47. ncbi request reprint Plasma zinc and growth status in preadolescent children with cystic fibrosis
    Asim Maqbool
    Divisions of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Pediatr Gastroenterol Nutr 43:95-101. 2006
    ..To investigate plasma zinc status in relation to dietary and supplemental zinc intake, growth and pulmonary status in preadolescent children with cystic fibrosis (CF) and pancreatic insufficiency (PI)...
  48. ncbi request reprint Elevated vitamin A intake and serum retinol in preadolescent children with cystic fibrosis
    Rose C Graham-Maar
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    Am J Clin Nutr 84:174-82. 2006
    ..Long-standing vitamin A supplementation may increase the risk of vitamin A toxicity...
  49. ncbi request reprint Vitamin A status, hospitalizations, and other outcomes in young children with sickle cell disease
    Joan I Schall
    Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Pediatr 145:99-106. 2004
    ..To determine the relation of serum vitamin A status to growth, nutritional and hematologic status, and to the number of hospitalizations in children with sickle cell disease-SS (homozygous for the S allele, SCD-SS)...
  50. ncbi request reprint Body composition of children aged 1 to 12 years with biliary atresia or Alagille syndrome
    Jessica L Arvay
    The Division of Gastroenterology and Nutrition, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Pediatr Gastroenterol Nutr 40:146-50. 2005
    ..To optimize nutritional management of these conditions it is essential to understand the normal growth characteristics...
  51. ncbi request reprint DXA estimates of vertebral volumetric bone mineral density in children: potential advantages of paired posteroanterior and lateral scans
    Mary B Leonard
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Clin Densitom 9:265-73. 2006
    ..In conclusion, paired Hologic PA lateral scans may increase sensitivity to growth-related increases in trabecular BMC and density in the spine, with less bias due to magnification error...
  52. ncbi request reprint Whole body BMC in pediatric Crohn disease: independent effects of altered growth, maturation, and body composition
    Jon M Burnham
    Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Bone Miner Res 19:1961-8. 2004
    ..Adjustment for lean mass eliminated the bone deficit in CD. Steroid exposure was associated with short stature but not bone deficits relative to height...
  53. ncbi request reprint Energy balance and the accuracy of reported energy intake in preadolescent children with cystic fibrosis
    Jillian Trabulsi
    Division of Gastroenterology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Clin Nutr 84:523-30. 2006
    ..Suboptimal growth and nutritional status are common among children with cystic fibrosis (CF) and pancreatic insufficiency (PI). A better understanding of energy balance is required to improve prevention and treatment of malnutrition...
  54. ncbi request reprint Current concepts in pediatric bone disease
    Mary B Leonard
    Department of Pediatrics, Departments of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Clin North Am 49:143-73. 2002
    ..Further research is needed to characterize these changes and their use in the assessment of bone health and fracture risk in children. Only then can the impact of treatment strategies be appreciated fully...
  55. ncbi request reprint Statistical validation of air-displacement plethysmography for body composition assessment in children
    Richard F Ittenbach
    Biostatistics and Data Management Core, University of Pennsylvania School of Medicine, PA 19104, USA
    Ann Hum Biol 33:187-201. 2006
    ..Existing validation studies of air-displacement plethysmography (ADP) have been based on small, narrowly defined samples, using simple linear regression or Bland-Altman analyses...
  56. ncbi request reprint Rapid weight gain during infancy and obesity in young adulthood in a cohort of African Americans
    Nicolas Stettler
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    Am J Clin Nutr 77:1374-8. 2003
    ..Obesity is increasing in the United States. Evidence-based prevention is a public health priority and should target well-defined risk factors and critical periods...
  57. ncbi request reprint Vitamin D status in children, adolescents, and young adults with Crohn disease
    Timothy A Sentongo
    Division of Gastroenterology, Hepatology, and Nutrition, Children s Memorial Hospital, Northwestern University, Chicago, IL 60614, USA
    Am J Clin Nutr 76:1077-81. 2002
    ..Crohn disease (CD) and vitamin D deficiency are associated with decreased bone mineralization...
  58. ncbi request reprint Vitamin E status in children with cystic fibrosis and pancreatic insufficiency
    Shirley H Huang
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    J Pediatr 148:556-559. 2006
    ....
  59. ncbi request reprint Methodological agreement between two-compartment body-composition methods in children
    Anne M Buison
    Division of Gastroenterology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Hum Biol 18:470-80. 2006
    ..Further development of body-composition techniques for young children need to account for variability in age, gender, and level of fatness...
  60. ncbi request reprint Vitamin D insufficiency in steroid-sensitive nephrotic syndrome in remission
    Francis L Weng
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pediatr Nephrol 20:56-63. 2005
    ..Children with remitted SSNS may benefit from routine measurement of 25(OH)D, but the clinical significance of low 25(OH)D in this population remains unclear...
  61. ncbi request reprint Interpretation of whole body dual energy X-ray absorptiometry measures in children: comparison with peripheral quantitative computed tomography
    Mary B Leonard
    Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Bone 34:1044-52. 2004
    ..Therefore, normalizing whole body DXA bone area for height and BMC for height provided the best measures of bone dimensions and strength. DXA BMC normalized for bone area and lean mass were poor indicators of bone strength...
  62. doi request reprint Quantifying calcium intake in school age children: development and validation of the Calcium Counts! food frequency questionnaire
    Babette S Zemel
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, 3535 Market Street, Philadelphia, PA 19104, USA
    Am J Hum Biol 22:180-6. 2010
    ..The CCFFQ is especially well-suited as a tool to identify children with low calcium intakes...
  63. ncbi request reprint Vitamin D insufficiency in children, adolescents, and young adults with cystic fibrosis despite routine oral supplementation
    Alisha J Rovner
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Clin Nutr 86:1694-9. 2007
    ..Cystic fibrosis (CF) with pancreatic insufficiency is associated with poor absorption of fat and fat-soluble vitamins, including vitamin D. Pancreatic enzyme supplementation does not completely correct fat malabsorption in CF patients...
  64. pmc In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure
    Masaya Takahashi
    Department of Radiology, University of Pennsylvania Medical Center, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:4574-9. 2002
    ..Finally, this work, which was performed on a clinical scanner, has implications for evaluating patients on high-dose steroid treatment...
  65. pmc Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD
    Glenn A Ladinsky
    Division of Renal, Electrolytes and Hypertension, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Bone Miner Res 23:64-74. 2008
    ....
  66. ncbi request reprint Incidence and risk factors for weight loss during dual HIV/hepatitis C virus therapy
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 44:344-50. 2007
    ..Clinical observations suggest that patients with HIV/hepatitis C virus (HCV) may lose body weight during dual therapy, but this has not been confirmed analytically...
  67. pmc Markers of bone turnover are associated with growth and development in young subjects with sickle cell anemia
    Ellen B Fung
    Department of Hematology, The Children s Hospital and Research Center, Oakland, California, USA
    Pediatr Blood Cancer 50:620-3. 2008
    ..Markers of bone turnover correlated with growth velocity and pubertal development but not with changes in bone mass...
  68. ncbi request reprint Body composition in children with sickle cell disease
    Elizabeth M Barden
    Department of Public Health, The Commonwealth of Massachusetts, Boston, USA
    Am J Clin Nutr 76:218-25. 2002
    ..Impaired growth, poor nutritional status, and delayed skeletal and sexual maturation are common in children with sickle cell disease (SCD), yet the nature of associated body-composition deficits has not been fully described...
  69. ncbi request reprint Deficits in size-adjusted bone mass in children with Alagille syndrome
    Irene E Olsen
    Center for Epidemiology and Biostatistics and Division of Neonatology, Cincinnati Children s Hospital Medical Cente, The University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Pediatr Gastroenterol Nutr 40:76-82. 2005
    ..To describe bone status in children with Alagille syndrome (AGS) and healthy control children adjusted for age, gender and height (HT), and to identify dietary intake and AGS-related factors associated with bone status...
  70. ncbi request reprint Sensitivity of dual x-ray absorptiometry to stature and reference data source in pediatric patients: comment on the article by Stewart et al
    Jon M Burnham
    Arthritis Rheum 50:2378-9; author reply 2379-80. 2004
  71. ncbi request reprint Risk factors for glucocorticoid-induced obesity in children with steroid-sensitive nephrotic syndrome
    Bethany J Foster
    Department of Pediatrics, Division of Nephrology, Montreal Children s Hospital, McGill University School of Medicine, Montreal, Quebec, Canada
    Pediatr Nephrol 21:973-80. 2006
    ..003] in all subjects with remote glucocorticoid exposure (black and non-black). These results indicate that non-black race and increased maternal BMI are risk factors for glucocorticoid-induced obesity in subjects with recent exposure...
  72. doi request reprint High risk of vitamin D deficiency in children with sickle cell disease
    Alisha J Rovner
    Division of Epidemiology, Statistics and Prevention, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA
    J Am Diet Assoc 108:1512-6. 2008
    ..However, children with SCD-SS were at greater risk for vitamin D deficiency than healthy African-American children...
  73. ncbi request reprint Proximal femur bone geometry is appropriately adapted to lean mass in overweight children and adolescents
    Moira A Petit
    Department of Health Evaluation Sciences, Penn State University College of Medicine, 600 Centerview Drive, Suite 2200, A210, Hershey, PA 17033, USA
    Bone 36:568-76. 2005
    ..These geometric adaptations are consistent with the mechanostat hypothesis that bone strength adapts primarily to muscle forces, not to static loads represented by body weight...
  74. ncbi request reprint The bone mineral density in childhood study: bone mineral content and density according to age, sex, and race
    Heidi J Kalkwarf
    Division of General and Community Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Clin Endocrinol Metab 92:2087-99. 2007
    ..Low bone mass may increase risk of fracture. Several chronic medical conditions, medications, and lifestyle factors affect bone mineral accrual. Appropriate reference values are essential for identification of children with bone deficits...
  75. ncbi request reprint Brief report: parent perspectives of nutritional status and mealtime behaviors in children with sickle cell disease
    Monica J Mitchell
    Cincinnati Children s Hospital Medical Center University of Cincinnati School of Medicine, Cincinnati, Ohio 45229, USA
    J Pediatr Psychol 29:315-20. 2004
    ..To qualitatively evaluate parent perspectives of eating problems, nutritional status, and the potential for nutritional intervention in children with sickle cell disease (SCD)...
  76. ncbi request reprint Re: Prevalence of long bone fractures in pediatric inflammatory bowel disease
    Alisha J Rovner
    J Pediatr Gastroenterol Nutr 45:269-71; author reply 271. 2007

Research Grants6

  1. BUILDING BETTER BONES IN CHILDREN
    Babette Zemel; Fiscal Year: 2003
    ..abstract_text> ..
  2. Genome Wide Association Study of Bone Mineral Accretion During Childhood
    BABETTE S contact ZEMEL; Fiscal Year: 2010
    ....