Theoklis Zaoutis

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Treatment of invasive candidiasis in immunocompromised pediatric patients
    Brian T Fisher
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Paediatr Drugs 10:281-98. 2008
  2. pmc Invasive fungal disease in PICU: epidemiology and risk factors
    Olivier Brissaud
    Pediatric and Neonatal Intensive Care Unit, The Children s Hospital of Bordeaux, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Ann Intensive Care 2:6. 2012
  3. doi request reprint Invasive fungal infections in pediatric heart transplant recipients: incidence, risk factors, and outcomes
    Theoklis E Zaoutis
    Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Transplant 15:465-9. 2011
  4. doi request reprint Candidemia in children
    Theoklis Zaoutis
    Divisionof Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Curr Med Res Opin 26:1761-8. 2010
  5. ncbi request reprint Antifungal treatment in pediatric patients
    Theoklis E Zaoutis
    Department of Pediatrics, Division of Infectious Diseases, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Drug Resist Updat 8:235-45. 2005
  6. ncbi request reprint Zygomycosis in children: a systematic review and analysis of reported cases
    Theoklis E Zaoutis
    Department of Pediatrics and The Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Infect Dis J 26:723-7. 2007
  7. ncbi request reprint Risk factors for mortality in children with candidemia
    Theoklis E Zaoutis
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 24:736-9. 2005
  8. doi request reprint A prospective, multicenter study of caspofungin for the treatment of documented Candida or Aspergillus infections in pediatric patients
    Theoklis E Zaoutis
    Children s Hospital of Philadelphia, Division of Infectious Diseases, 34th Street and Civic Center Boulevard, CHOP North, Suite 1527, Philadelphia, PA 19104, USA
    Pediatrics 123:877-84. 2009
  9. ncbi request reprint The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis
    Theoklis E Zaoutis
    Division of General Pediatrics, The Children s Hospital of Philadelphia, PA 19104, USA
    Clin Infect Dis 41:1232-9. 2005
  10. pmc Risk factors and predictors for candidemia in pediatric intensive care unit patients: implications for prevention
    Theoklis E Zaoutis
    Division of Infectious Diseases, Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Clin Infect Dis 51:e38-45. 2010

Research Grants

  1. Risk Factors and Outcomes of Candidemia in Children
    Theoklis Zaoutis; Fiscal Year: 2007

Detail Information

Publications82

  1. ncbi request reprint Treatment of invasive candidiasis in immunocompromised pediatric patients
    Brian T Fisher
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Paediatr Drugs 10:281-98. 2008
    ....
  2. pmc Invasive fungal disease in PICU: epidemiology and risk factors
    Olivier Brissaud
    Pediatric and Neonatal Intensive Care Unit, The Children s Hospital of Bordeaux, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Ann Intensive Care 2:6. 2012
    ..In children, the mortality rate for invasive aspergillosis is 2.5 to 3.5 higher than for invasive candidiasis (respectively 70% vs. 20% and 30%)...
  3. doi request reprint Invasive fungal infections in pediatric heart transplant recipients: incidence, risk factors, and outcomes
    Theoklis E Zaoutis
    Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Transplant 15:465-9. 2011
    ..Prophylactic strategies for high-risk patients should be considered and warrants further study...
  4. doi request reprint Candidemia in children
    Theoklis Zaoutis
    Divisionof Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Curr Med Res Opin 26:1761-8. 2010
    ..Further research is needed to better establish criteria for antifungal prophylaxis in children at high risk for candidemia...
  5. ncbi request reprint Antifungal treatment in pediatric patients
    Theoklis E Zaoutis
    Department of Pediatrics, Division of Infectious Diseases, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Drug Resist Updat 8:235-45. 2005
    ....
  6. ncbi request reprint Zygomycosis in children: a systematic review and analysis of reported cases
    Theoklis E Zaoutis
    Department of Pediatrics and The Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Infect Dis J 26:723-7. 2007
    ..Zygomycosis has emerged as an increasingly important infection with a high mortality especially in immunocompromised patients. No comprehensive analysis of pediatric zygomycosis cases has been published to date...
  7. ncbi request reprint Risk factors for mortality in children with candidemia
    Theoklis E Zaoutis
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 24:736-9. 2005
    ..3) and the presence of an arterial catheter (hazard ratio, 2.4; 95% confidence interval, 1.1-5.8). Our findings help identify a group of pediatric patients that should be targeted for future interventions to prevent and treat candidemia...
  8. doi request reprint A prospective, multicenter study of caspofungin for the treatment of documented Candida or Aspergillus infections in pediatric patients
    Theoklis E Zaoutis
    Children s Hospital of Philadelphia, Division of Infectious Diseases, 34th Street and Civic Center Boulevard, CHOP North, Suite 1527, Philadelphia, PA 19104, USA
    Pediatrics 123:877-84. 2009
    ..We evaluated the safety, tolerability, and efficacy of caspofungin in pediatric patients with invasive aspergillosis, invasive candidiasis, or esophageal candidiasis...
  9. ncbi request reprint The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis
    Theoklis E Zaoutis
    Division of General Pediatrics, The Children s Hospital of Philadelphia, PA 19104, USA
    Clin Infect Dis 41:1232-9. 2005
    ....
  10. pmc Risk factors and predictors for candidemia in pediatric intensive care unit patients: implications for prevention
    Theoklis E Zaoutis
    Division of Infectious Diseases, Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Clin Infect Dis 51:e38-45. 2010
    ..Few data exist on risk factors for candidemia in pediatric intensive care unit (PICU) patients...
  11. ncbi request reprint Outcomes attributable to neonatal candidiasis
    Theoklis E Zaoutis
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Clin Infect Dis 44:1187-93. 2007
    ..The incidence of candidiasis has increased in neonatal intensive care units, and invasive candidiasis is associated with significant morbidity and mortality. However, few data exist on outcomes directly attributable to neonatal candidiasis...
  12. ncbi request reprint Clinical and molecular epidemiology of community-acquired methicillin-resistant Staphylococcus aureus infections among children with risk factors for health care-associated infection: 2001-2003
    Theoklis E Zaoutis
    Division of Infectious Diseases, Children s Hospital of Philadelphia, PA, USA
    Pediatr Infect Dis J 25:343-8. 2006
    ..The epidemiology of community-acquired MRSA (CA-MRSA) among healthy children has been recently described. However, little is known about CA-MRSA in children with underlying medical conditions...
  13. ncbi request reprint Antifungal therapy for neonatal candidiasis
    Theoklis Zaoutis
    Department of Pediatrics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Infect Dis 20:592-7. 2007
    ..This review focuses on recent data regarding antifungal prophylaxis and antifungal treatment of neonatal candidiasis...
  14. ncbi request reprint Epidemiology, outcomes, and costs of invasive aspergillosis in immunocompromised children in the United States, 2000
    Theoklis E Zaoutis
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 117:e711-6. 2006
    ..IA in adults has been well characterized; however, only a few small studies of IA in children have been reported. Therefore, the objective of this study was to describe the incidence and outcomes of children with IA...
  15. ncbi request reprint The role of group C and group G streptococci in acute pharyngitis in children
    T Zaoutis
    Department of Pediatrics, Alfred I duPont Hospital for Children, Wilmington, Delaware, USA
    Clin Microbiol Infect 10:37-40. 2004
    ..6-6.1). The low isolation rate of large-colony-forming strains of GCS and GGS indicates that even if these organisms are associated with acute, sporadic pharyngitis in paediatric patients, they represent an unusual pathogen...
  16. ncbi request reprint Risk factors for disseminated candidiasis in children with candidemia
    Theoklis E Zaoutis
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 23:635-41. 2004
    ..To determine the risk factors for disseminated infection in hospitalized children with candidemia...
  17. ncbi request reprint Risk factors for and outcomes of bloodstream infection caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species in children
    Theoklis E Zaoutis
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 115:942-9. 2005
    ..The objective of this study was to define the risk factors and outcomes associated with ESBL-EK bloodstream infections in children...
  18. pmc Prolonged intravenous therapy versus early transition to oral antimicrobial therapy for acute osteomyelitis in children
    Theoklis Zaoutis
    Division of Infectious Diseases, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, CHOP North, Suite 1527, Philadelphia, PA 19104, USA
    Pediatrics 123:636-42. 2009
    ..We sought to compare the effectiveness of early transition from intravenous to oral antimicrobial therapy versus prolonged intravenous antimicrobial therapy for the treatment of children with acute osteomyelitis...
  19. doi request reprint Safety experience with caspofungin in pediatric patients
    Theoklis Zaoutis
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 28:1132-5. 2009
    ..1) days. The most common drug-related adverse events were fever, increased AST, increased ALT, and rash; few events were serious or required treatment discontinuation. Caspofungin was well tolerated in this pediatric population...
  20. ncbi request reprint Antifungal susceptibility of Candida spp. isolated from pediatric patients: a survey of 4 children's hospitals
    Theoklis E Zaoutis
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Diagn Microbiol Infect Dis 52:295-8. 2005
    ..Furthermore, our current susceptibility data include newer antifungal agents that appear to be quite active in vitro and may provide new therapeutic options for the treatment of serious yeast infections in children...
  21. pmc Outbreak of vancomycin-resistant enterococcus colonization among pediatric oncology patients
    Sheila M Nolan
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Infect Control Hosp Epidemiol 30:338-45. 2009
    ..To detect the burden of vancomycin-resistant Enterococcus (VRE) colonization among pediatric oncology patients and to determine risk factors for VRE acquisition...
  22. doi request reprint Fluoroquinolone resistance in pediatric bloodstream infections because of Escherichia coli and Klebsiella species
    Jason Y Kim
    Division of Infectious Diseases, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Infect Control 36:70-3. 2008
    ..28-83.8). A case control study revealed no significant risk factors (including prior antibiotic use) for FQ resistance among ESBL E coli and Klebsiella species (ESBL-EK)...
  23. doi request reprint Risk factors and outcomes associated with severe clostridium difficile infection in children
    Jason Kim
    Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Pediatr Infect Dis J 31:134-8. 2012
    ..The incidence and severity of Clostridium difficile infection (CDI) is increasing among adults; however, little is known about the epidemiology of CDI among children...
  24. doi request reprint Epidemiological features of Clostridium difficile-associated disease among inpatients at children's hospitals in the United States, 2001-2006
    Jason Kim
    Center for Pediatric Clinical Effectiveness, Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pediatrics 122:1266-70. 2008
    ..Whether similar phenomena are occurring among children remains unknown. Our study describes the epidemiological features of C difficile-associated disease in hospitalized children...
  25. ncbi request reprint Neurologic complications in children hospitalized with influenza: characteristics, incidence, and risk factors
    Jason G Newland
    Division of Infectious Diseases, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Pediatr 150:306-10. 2007
    ..To determine the characteristics, incidence, and risk factors for influenza-related neurologic complications (INC)...
  26. ncbi request reprint Outcome of Escherichia coli and/or Klebsiella bloodstream infection in children with central venous catheters
    Jessica Buckley
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 28:1308-10. 2007
    ..6 [95% confidence interval {CI}, 1.39-16.30]) and receipt of total parenteral nutrition (aOR, 3.5 [95% CI, 1.1-10.8]). A significant proportion of children with catheter-associated BSI were treated successfully without catheter removal...
  27. doi request reprint Effects of highly active antiretroviral therapy (HAART) on cholesterol in HIV-1 infected children: a retrospective cohort study
    Jason Y Kim
    The Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 18:589-94. 2009
    ..To determine the extent to which different highly active antiretroviral therapy (HAART) regimens pose risks for hypercholesterolemia in children with perinatal HIV-1...
  28. doi request reprint Effect of rotavirus vaccine on reducing acute gastroenteritis in a large outpatient pediatric network
    Sheila M Nolan
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 166:232-9. 2012
    ..To measure the effect of rotavirus vaccine (RVV) on acute gastroenteritis (AGE) managed by primary care physicians in the first 2 rotatvirus seasons following the introduction of RVV...
  29. ncbi request reprint Risk factors for increasing multidrug resistance among extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species
    Emily P Hyle
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Clin Infect Dis 40:1317-24. 2005
    ..Increased reliance on carbapenems has led to increasing carbapenem resistance. Efforts to maintain current therapeutic options for ESBL-EK infections are essential...
  30. pmc Surveillance cultures for detection of methicillin-resistant Staphylococcus aureus: diagnostic yield of anatomic sites and comparison of provider- and patient-collected samples
    Ebbing Lautenbach
    Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 30:380-2. 2009
    ..Groin and perineum samples yielded positive results significantly more often for community-onset MRSA than for hospital-onset MRSA. Agreement rates between provider- and patient-collected swab specimens were excellent...
  31. pmc Risk factors for fluconazole-resistant Candida glabrata bloodstream infections
    Ingi Lee
    MSCE, Division of Infectious Diseases, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Arch Intern Med 169:379-83. 2009
    ..Candida glabrata is often associated with resistance to fluconazole therapy. However, to our knowledge, risk factors for fluconazole-resistant C glabrata BSIs have not been studied...
  32. pmc Clinical and economic outcomes of decreased fluconazole susceptibility in patients with Candida glabrata bloodstream infections
    Ingi Lee
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Infect Control 38:740-5. 2010
    ..The impact of reduced fluconazole susceptibility on clinical and economic outcomes in patients with Candida glabrata bloodstream infections (BSI) is unknown...
  33. doi request reprint Pediatric antifungal utilization: new drugs, new trends
    Priya A Prasad
    Division of Infectious Diseases, Department of Infection Prevention and Control, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Infect Dis J 27:1083-8. 2008
    ..Despite these therapeutic advances, the impact of the availability of new antifungal agents on pediatric practice is unknown...
  34. doi request reprint Antibiotic use in neonatal intensive care units and adherence with Centers for Disease Control and Prevention 12 Step Campaign to Prevent Antimicrobial Resistance
    Sameer J Patel
    Division of Infectious Diseases, Department of Pediatrics, Columbia University, New York, NY, USA
    Pediatr Infect Dis J 28:1047-51. 2009
    ....
  35. doi request reprint Previous antimicrobial exposure is associated with drug-resistant urinary tract infections in children
    Amanda A Paschke
    Children s Hospital of Philadelphia, Division of Infectious Diseases, 3615 Civic Center Blvd, ARC 1202, Philadelphia, PA 19104, USA
    Pediatrics 125:664-72. 2010
    ..The aim of this study was to evaluate the impact of previous antimicrobial exposure on the development of antimicrobial resistance in children with their first urinary tract infection (UTI)...
  36. doi request reprint Risk factors for healthcare-associated, laboratory-confirmed influenza in hospitalized pediatric patients: a case-control study
    Kateri H Leckerman
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Infect Control Hosp Epidemiol 31:421-4. 2010
    ..49 [95% confidence interval, 1.25-9.75])...
  37. doi request reprint Use of antibiotics in children hospitalized with community-acquired, laboratory-confirmed influenza
    Jennifer J Wilkes
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Pediatr 154:447-9. 2009
    ..A total of 333 of 729 (46%) patients received >2 days of treatment with antibacterial medications, of whom 36% did not have an apparent indication for therapy...
  38. ncbi request reprint Epidemiology of and risk factors for Acinetobacter species bloodstream infection in children
    Shana C Segal
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 26:920-6. 2007
    ..Acinetobacter species has emerged as an important cause of healthcare-associated bloodstream infections (BSI) in adults. Little is known about development of Acinetobacter spp. BSI in children...
  39. ncbi request reprint Investigating the association between antibiotic use and antibiotic resistance: impact of different methods of categorising prior antibiotic use
    Heather MacAdam
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Int J Antimicrob Agents 28:325-32. 2006
    ..Elucidating these issues is critical if effective strategies to curb resistance are to be designed...
  40. pmc Preferred treatment and prevention strategies for recurrent community-associated methicillin-resistant Staphylococcus aureus skin and soft-tissue infections: a survey of adult and pediatric providers
    Kara B Mascitti
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA
    Am J Infect Control 38:324-8. 2010
    ..0001). For recurrent infections, 88% of providers employed at least 1 topical decolonization strategy...
  41. ncbi request reprint Impact of inadequate initial antimicrobial therapy on mortality in infections due to extended-spectrum beta-lactamase-producing enterobacteriaceae: variability by site of infection
    Emily P Hyle
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Arch Intern Med 165:1375-80. 2005
    ..Infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species (ESBL-EK) have increased markedly in recent years. Risk factors for mortality among ESBL-EK infections have not been studied...
  42. pmc Clinical vignettes provide an understanding of antibiotic prescribing practices in neonatal intensive care units
    Sameer Patel
    Department of Pediatrics, Columbia University, New York, New York, USA
    Infect Control Hosp Epidemiol 32:597-602. 2011
    ..To use clinical vignettes to understand antimicrobial prescribing practices in neonatal intensive care units (NICUs)...
  43. doi request reprint Blood culture contamination rates after skin antisepsis with chlorhexidine gluconate versus povidone-iodine in a pediatric emergency department
    Lauren Marlowe
    University of Pennsylvania School of Medicine, Philadelphia, USA
    Infect Control Hosp Epidemiol 31:171-6. 2010
    ..To determine blood culture contamination rates after skin antisepsis with chlorhexidine, compared with povidone-iodine...
  44. doi request reprint Improving surveillance for pediatric Clostridium difficile infection: derivation and validation of an accurate case-finding tool
    Julia Shaklee
    Department of Pediatrics, Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Infect Dis J 30:e38-40. 2011
    ..Multicenter studies of CDI have been limited by the lack of valid case-finding tools. To facilitate pediatric studies of CDI, we constructed a case-finding tool using administrative data...
  45. ncbi request reprint Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials
    Patrick H Conway
    Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania, Philadelphia, PA 19104, USA
    JAMA 298:179-86. 2007
    ..The evidence regarding risk factors for recurrent urinary tract infection (UTI) and the risks and benefits of antimicrobial prophylaxis in children is scant...
  46. ncbi request reprint Lyme disease masquerading as brown recluse spider bite
    Kevin C Osterhoudt
    Poison Control Center, The Division of Emergency Medicine, The Children s Hospital of Philadelphia, PA 19104, USA
    Ann Emerg Med 39:558-61. 2002
    ..Brown recluse spider bites may be overdiagnosed in some geographic regions. Tick bite and infection with Borrelia burgdorferi should be considered in the differential diagnosis of necrotic arachnidism in regions endemic for Lyme disease...
  47. pmc Trends in the incidence of methicillin-resistant Staphylococcus aureus infection in children's hospitals in the United States
    Jeffrey S Gerber
    The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Pennsylvania, USA
    Clin Infect Dis 49:65-71. 2009
    ..The incidence of and outcomes associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in hospitalized children have been incompletely characterized...
  48. doi request reprint Risk factors for fluconazole resistance in patients with Candida glabrata bloodstream infection: potential impact of control group selection on characterizing the association between previous fluconazole use and fluconazole resistance
    Ingi Lee
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Infect Control 38:456-60. 2010
    ..Although Candida glabrata is an emerging infection, risk factors for fluconazole resistance in patients with C glabrata bloodstram infection (BSI) have not been well elucidated...
  49. doi request reprint Risk factors for renal failure in pediatric patients with acute myeloid leukemia: a retrospective cohort study
    Brian T Fisher
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatr Blood Cancer 55:655-61. 2010
    ..This study aims to evaluate the rate of ARF in AML patients and to delineate the impact of age, race, various co-morbid conditions and antimicrobial agents on the development of ARF...
  50. doi request reprint Prevalence of Proteus mirabilis in skin abscesses of the axilla
    Rakesh D Mistry
    Division of Emergency Medicine, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr 156:850-1. 2010
    ..In this report, we describe a high prevalence of Proteus mirabilis, a Gram-negative bacillus, in skin abscesses of the axilla, which has potential implications for selection of antimicrobial therapy...
  51. doi request reprint Epidemiology of cryptococcal infection in hospitalized children
    Neha S Joshi
    Department of General Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 29:e91-5. 2010
    ..Despite the fact that many studies were conducted in adults, limited data exist for pediatric patients...
  52. doi request reprint Variability in antibiotic use at children's hospitals
    Jeffrey S Gerber
    Division of Infectious Diseases, Children s Hospital of Philadelphia, CHOP North, Suite 1518, Philadelphia, PA 19104, USA
    Pediatrics 126:1067-73. 2010
    ..Variation in medical practice has identified opportunities for quality improvement in patient care. The degree of variation in the use of antibiotics in children's hospitals is unknown...
  53. doi request reprint Cefepime and mortality in pediatric acute myelogenous leukemia: a retrospective cohort study
    Brian T Fisher
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 28:971-5. 2009
    ..We evaluated the association of cefepime and other beta-lactam antibiotic exposures with all cause in-hospital mortality in pediatric AML patients...
  54. doi request reprint Hospitalizations for coccidioidomycosis at forty-one children's hospitals in the United States
    Brian T Fisher
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 29:243-7. 2010
    ..We describe the characteristics of initial and subsequent hospitalizations in children with coccidioidomycosis...
  55. ncbi request reprint Fever following international travel: what's bugging this child?
    Samir S Shah
    Divisions of General Pediatrics and Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Case Rev 3:44-6. 2003
  56. ncbi request reprint Incidence, complications, and risk factors for prolonged stay in children hospitalized with community-acquired influenza
    Susan E Coffin
    Division of General Pediatrics, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 119:740-8. 2007
    ....
  57. ncbi request reprint Device-related infections in children
    Samir S Shah
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatr Clin North Am 52:1189-208, x. 2005
    ..New technologies, such as antimicrobial-impregnated central venous catheters and ventricular shunts, show promise in reducing the infection rates of these devices...
  58. ncbi request reprint Complications of central venous catheters used for the treatment of acute hematogenous osteomyelitis
    Rebecca Ruebner
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatrics 117:1210-5. 2006
    ..To determine the complications and risk factors for complications associated with using central venous catheters (CVCs) for the treatment of acute hematogenous osteomyelitis (AHO)...
  59. doi request reprint Evaluation of an antimicrobial stewardship program at a pediatric teaching hospital
    Talene A Metjian
    Department of Pharmacy Services, The Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 27:106-11. 2008
    ..Despite increased awareness about the benefits of these programs, few pediatric ASPs exist and fewer comprehensive studies evaluate their effects...
  60. ncbi request reprint Neurological and neuromuscular disease as a risk factor for respiratory failure in children hospitalized with influenza infection
    Ron Keren
    Division of General Pediatrics, Pediatric Generalist Research Group, Department of Medicine, The Children s Hospital of Philadelphia, PA 19104, USA
    JAMA 294:2188-94. 2005
    ..Little is known about the relative contribution of each of these chronic medical conditions to the development of serious influenza-associated complications...
  61. doi request reprint Beyond cat scratch disease: widening spectrum of Bartonella henselae infection
    Todd A Florin
    Division of General Pediatrics, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 121:e1413-25. 2008
    ..This review summarizes current knowledge regarding the microbiology, clinical manifestations, diagnostic techniques, and treatment of B. henselae infection...
  62. ncbi request reprint Direct medical cost of influenza-related hospitalizations in children
    Ron Keren
    Children s Hospital of Philadelphia, 3535 Market St, Room 1524, Philadelphia, PA 19104, USA
    Pediatrics 118:e1321-7. 2006
    ..Our goal was to determine the cost of influenza-related hospitalization in children with community-acquired laboratory-confirmed influenza and to identify predictors of high hospitalization costs...
  63. doi request reprint Emergency department treatment failures for skin infections in the era of community-acquired methicillin-resistant Staphylococcus aureus
    Rakesh D Mistry
    Department of Pediatrics, Division of Emergency Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pediatr Emerg Care 27:21-6. 2011
    ..Despite rapidly increasing incidence of skin and soft tissue infections (SSTIs) presenting to emergency departments (EDs), outcome data for these infections are limited...
  64. ncbi request reprint Infection control, hospital epidemiology, and patient safety
    Susan E Coffin
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Infect Dis Clin North Am 19:647-65. 2005
    ..Children also are at significant risk of nosocomial transmission of common pediatric viral illness, such as respiratory syncytial virus and varicella. In addition, pediatric patients have unique or incompletely developed immune system...
  65. doi request reprint Risk factors for catheter-associated bloodstream infections in a Pediatric Cardiac Intensive Care Unit
    Priya A Prasad
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Infect Dis J 29:812-5. 2010
    ..Catheter-associated bloodstream infections (CA-BSIs) are an important complication of care in children hospitalized with complex congenital heart disease; however, little is known about risk factors for CA-BSI in these patients...
  66. ncbi request reprint Observational trial of antibiotic-coated central venous catheters in critically ill pediatric patients
    Anjali Chelliah
    University of Pennsylvania School of Medicine, Department of Pediatrics, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 26:816-20. 2007
    ..Randomized trials have demonstrated that the use of central venous catheters (CVC) coated with antiseptic solutions reduces rates of CABSI in adult patients; however, their efficacy in children has not been evaluated...
  67. ncbi request reprint The categorization of prior antibiotic use: impact on the identification of risk factors for drug resistance in case control studies
    Leanne B Gasink
    Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Infect Control 35:638-42. 2007
    ..aeruginosa as models (IRPA), we aimed to examine the effect of different approaches to classification of prior antibiotic use (i.e., class versus spectrum) on the identification of risk factors for antibiotic resistance...
  68. ncbi request reprint The clinical and molecular epidemiology of community- and healthcare-acquired rotavirus gastroenteritis
    Michael J Smith
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, PA, USA
    Pediatr Infect Dis J 27:54-8. 2008
    ..Rotavirus is the most common etiologic agent of healthcare-acquired diarrhea in pediatric patients. There has been little published information on healthcare-acquired rotavirus infection...
  69. ncbi request reprint Bloodstream infection caused by Stenotrophomonas maltophilia in children
    Jessica Kagen
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 26:508-12. 2007
    ..Little is known about development of S. maltophilia bacteremia in children. The objective of this study was to define risk factors and outcomes associated with S. maltophilia BSI in children...
  70. ncbi request reprint Hospitalizations for endemic mycoses: a population-based national study
    Jaclyn H Chu
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Clin Infect Dis 42:822-5. 2006
    ..6 and 28.7 cases per 1 million children and adults, respectively). Crude mortality rates were 5% and 7% among children and adults, respectively...
  71. pmc Clostridium difficile infection is associated with increased risk of death and prolonged hospitalization in children
    Julia Shaklee Sammons
    Division of Infectious Diseases, and Department of Perelman School of Medicine, University of Pennsylvania, Pennsylvania, USA
    Clin Infect Dis 57:1-8. 2013
    ..Clostridium difficile infection (CDI) is associated with significant morbidity and mortality among adults. However, outcomes are poorly defined among children...
  72. pmc Epidemiology, risk factors and outcome of Candida parapsilosis bloodstream infection in children
    John Dotis
    3rd Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, Greece
    Pediatr Infect Dis J 31:557-60. 2012
    ..Candida parapsilosis constitutes a common Candida spp. isolated in children with candidemia. Few data exist on risk factors and outcome of candidemia caused by C. parapsilosis in pediatric patients...
  73. ncbi request reprint Emergency preparedness for pandemic influenza
    Richard J Scarfone
    University of Pennsylvania School of Medicine, Philadelphia PA, USA
    Pediatr Emerg Care 22:661-8; quiz 669-70. 2006
  74. ncbi request reprint Neurocognitive functioning in pediatric human immunodeficiency virus infection: effects of combined therapy
    Manisha C Shanbhag
    Division of General Pediatrics, Childrens Hospital of Philadelphia, Philadelphia, PA 19103, USA
    Arch Pediatr Adolesc Med 159:651-6. 2005
    ....
  75. doi request reprint Treatment with oseltamivir in children hospitalized with community-acquired, laboratory-confirmed influenza: review of five seasons and evaluation of an electronic reminder
    Jennifer J Wilkes
    Division of Infectious Diseases, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Hosp Med 4:171-8. 2009
    ..When initiated within 48 hours of the onset of symptoms, oseltamivir has been shown to reduce severity and length of influenza illness. Few studies have evaluated the use of oseltamivir in patients hospitalized with influenza...
  76. ncbi request reprint Multidrug-resistant organisms in general pediatrics
    Theoklis Zaoutis
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatr Ann 31:313-20. 2002
  77. ncbi request reprint Prolonged fever: getting to the heart of the matter
    Reza Daugherty
    Division of Emergency Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    Pediatr Case Rev 3:174-7. 2003
  78. ncbi request reprint Immunosuppressants, infection, and inflammation
    Daniel J Lovell
    Division Immunologic Infectious Disease, Children s Hospital of Philadelphia, PA 19104, USA
    Clin Immunol 113:137-9. 2004
  79. ncbi request reprint Early differentiation of Lyme from enteroviral meningitis
    Samir S Shah
    Divisions of Infectious Diseases, The Children s Hospital of Philadelphia, PA, USA
    Pediatr Infect Dis J 24:542-5. 2005
    ..This distinction is clinically important because pathogen-specific diagnostic test results are not available immediately and only patients with Lyme meningitis require parenteral antibiotic therapy...
  80. doi request reprint Pediatric invasive aspergillosis: a multicenter retrospective analysis of 139 contemporary cases
    Ana Burgos
    Division of Pediatric Hematology Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Pediatrics 121:e1286-94. 2008
    ..Invasive aspergillosis has been well characterized in adults; however, the incidence and analysis of risk factors, diagnostic tools, treatments, and outcomes have not been well described for a large cohort of pediatric patients...
  81. ncbi request reprint Epidemiology and outcome of zygomycosis: a review of 929 reported cases
    Maureen M Roden
    Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Infect Dis 41:634-53. 2005
    ..Zygomycosis is an increasingly emerging life-threatening infection. There is no single comprehensive literature review that describes the epidemiology and outcome of this disease...
  82. ncbi request reprint Suppurative intracranial complications of sinusitis in previously healthy children
    Megan H Bair-Merritt
    Pediatric Generalist Research Group, Division of General Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Infect Dis J 24:384-6. 2005
    ..Most cases were male adolescents who presented with vomiting in addition to typical sinusitis symptoms. Neurologic signs were often absent. Streptococcus milleri group organisms, along with anaerobes, were common pathogens...

Research Grants2

  1. Risk Factors and Outcomes of Candidemia in Children
    Theoklis Zaoutis; Fiscal Year: 2007
    This award will prepare Theoklis Zaoutis, M.D., for a career as an independent investigator in Pediatric Infectious Disease epidemiology, with a particular focus on fungal infections and the use of antimicrobial agents...