Tomasz Zal

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Body-barrier surveillance by epidermal γδ TCRs
    Grzegorz Chodaczek
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 13:272-82. 2012
  2. ncbi request reprint Visualization of protein interactions in living cells
    Tomasz Zal
    Department of Immunology, University of Texas, MD Anderson Cancer Center, Unit 902, 7455 Fannin, Houston TX, USA
    Adv Exp Med Biol 640:183-97. 2008
  3. ncbi request reprint Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cells
    Tomasz Zal
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Traffic 7:1607-13. 2006
  4. pmc Intravital imaging of anti-tumor immune response and the tumor microenvironment
    Tomasz Zal
    Department of Immunology, University of Texas MD Anderson Cancer Center, Unit 902, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Semin Immunopathol 32:305-17. 2010
  5. pmc Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse
    Pia P Yachi
    Department of Immunology, IMM1, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 6:785-92. 2005
  6. ncbi request reprint Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality
    Pia P Yachi
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Immunity 25:203-11. 2006
  7. ncbi request reprint Using live FRET imaging to reveal early protein-protein interactions during T cell activation
    Tomasz Zal
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Curr Opin Immunol 16:674-83. 2004
  8. pmc Visualizing intermolecular interactions in T cells
    Nicholas R J Gascoigne
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 334:31-46. 2009
  9. doi request reprint Co-receptors and recognition of self at the immunological synapse
    Nicholas R J Gascoigne
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 340:171-89. 2010
  10. ncbi request reprint Using live FRET imaging to reveal early protein-protein interactions during T cell activation
    Tomasz Zal
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Curr Opin Immunol 16:418-27. 2004

Collaborators

Detail Information

Publications20

  1. pmc Body-barrier surveillance by epidermal γδ TCRs
    Grzegorz Chodaczek
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 13:272-82. 2012
    ..Thus, the γδ TCR orchestrates barrier surveillance proactively, presumably by recognizing tissue ligands expressed in the steady state...
  2. ncbi request reprint Visualization of protein interactions in living cells
    Tomasz Zal
    Department of Immunology, University of Texas, MD Anderson Cancer Center, Unit 902, 7455 Fannin, Houston TX, USA
    Adv Exp Med Biol 640:183-97. 2008
    ..A continuing challenge is extracting from the imaging data the quantitative information that is necessary to verify different models of signal transduction...
  3. ncbi request reprint Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cells
    Tomasz Zal
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Traffic 7:1607-13. 2006
    ..This report of FM4-64 as the first vital dye sensitive to the NE environment opens new ways for real-time visualization and functional studies of the NE...
  4. pmc Intravital imaging of anti-tumor immune response and the tumor microenvironment
    Tomasz Zal
    Department of Immunology, University of Texas MD Anderson Cancer Center, Unit 902, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Semin Immunopathol 32:305-17. 2010
    ....
  5. pmc Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse
    Pia P Yachi
    Department of Immunology, IMM1, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 6:785-92. 2005
    ..Thus, the interaction of CD8 with a nonstimulatory peptide-MHC complex helps mediate T cell recognition of antigen, improving the coreceptor function of CD8...
  6. ncbi request reprint Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality
    Pia P Yachi
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Immunity 25:203-11. 2006
    ..Our findings indicate that the T cell translates antigen recognition into T cell responses by differential recruitment of CD8 to the TCR...
  7. ncbi request reprint Using live FRET imaging to reveal early protein-protein interactions during T cell activation
    Tomasz Zal
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Curr Opin Immunol 16:674-83. 2004
    ..Spectral changes in fluorescence intensity and down modulation of donor lifetime are the basis for rapidly developing approaches to real-time FRET imaging. With two-photon excitation, FRET can now be extended to in vivo imaging...
  8. pmc Visualizing intermolecular interactions in T cells
    Nicholas R J Gascoigne
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 334:31-46. 2009
    ..This chapter reviews data on how these coreceptors are recruited to the immunological synapse, and how they interact when the T cell is stimulated by different ligands...
  9. doi request reprint Co-receptors and recognition of self at the immunological synapse
    Nicholas R J Gascoigne
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 340:171-89. 2010
    ..This chapter discusses the data on the role of CD4 or CD8 co-receptors in T cell activation at the immunological synapse, and the role of non stimulatory MHC-peptide complexes in aiding antigen recognition...
  10. ncbi request reprint Using live FRET imaging to reveal early protein-protein interactions during T cell activation
    Tomasz Zal
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Curr Opin Immunol 16:418-27. 2004
    ..Spectral changes in fluorescence intensity and down modulation of donor lifetime are the basis for rapidly developing approaches to real-time FRET imaging. With two-photon excitation, FRET can now be extended to in vivo imaging...
  11. ncbi request reprint A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness
    Meei Yun Lin
    Division of Biological Sciences, The Cancer Center, and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    J Immunol 174:5583-92. 2005
    ..These results indicate that members of the CaMKII family play an important role in regulation of CD8 T cell proliferation, cytotoxic effector function, and the response to restimulation...
  12. ncbi request reprint Molecular interactions at the T cell-antigen-presenting cell interface
    Nicholas R J Gascoigne
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Immunol 16:114-9. 2004
    ..Recent data show that some T-cell signalling precedes the formation of the mature form of the immunological synapse, but that full T-cell activation depends on sustained signalling, which in turn requires the synapse...
  13. ncbi request reprint Homodimerization and internalization of galanin type 1 receptor in living CHO cells
    Sebastian A Wirz
    Department of Neuropharmacology, Harold L Dorris Neurological Research Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropeptides 39:535-46. 2005
    ..Internalization and dimerization of GalR1 is shown, contributing to the regulation of galanergic signaling...
  14. pmc Photobleaching-corrected FRET efficiency imaging of live cells
    Tomasz Zal
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Biophys J 86:3923-39. 2004
    ..We demonstrate the benefits of E-FRET with photobleaching correction for timelapse and three-dimensional imaging of protein-protein interactions in the immunological synapse in living T-cells...
  15. pmc Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs
    Lisa J Ma
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Immunol 183:1044-54. 2009
    ....
  16. doi request reprint The stabilization and targeting of surfactant-synthesized gold nanorods
    Betty C Rostro-Kohanloo
    Department of Physics and Astronomy, Rice University, Houston, TX 77005, USA
    Nanotechnology 20:434005. 2009
    ..This covalent strategy should be generally applicable to other biomedical applications of gold nanorods as well as other gold nanoparticles synthesized with CTAB...
  17. ncbi request reprint Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse
    Tomasz Zal
    Deptartment of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Immunity 16:521-34. 2002
    ..This interaction is blocked by the presence of antagonist ligands without decreasing the recruitment of zeta and CD4 or preventing their partial colocalization in the immunological synapse...
  18. pmc Imaging of genetically engineered T cells by PET using gold nanoparticles complexed to Copper-64
    Parijat Bhatnagar
    Baylor College of Medicine and Texas Children s Hospital, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Houston, TX 77030, USA
    Integr Biol (Camb) 5:231-8. 2013
    ..These data demonstrate that GNPs conjugated with (64)Cu(2+) can be prepared as a radiotracer for PET and used to image T cells using an approach that has translational implications...
  19. pmc Transferring a synthetic gene circuit from yeast to mammalian cells
    Dmitry Nevozhay
    Department of Systems Biology Unit 950, The University of Texas MD Anderson Cancer Center, 7435 Fannin Street, Houston, Texas 77054, USA
    Nat Commun 4:1451. 2013
    ..The steps we have taken should be generally relevant for transferring any gene circuit from yeast into mammalian cells...
  20. pmc Phospholipid scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells
    Amjad H Talukder
    Department of Immunology, Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Res 22:1129-39. 2012
    ..Our study demonstrates that PLSCR1 is a TLR9-interacting protein that plays an important role in pDC's type 1 IFN responses by regulating TLR9 trafficking to the endosomal compartment...

Research Grants3

  1. Immune cell interactions during tumor establishment.
    Tomasz Zal; Fiscal Year: 2010
    ..This study will help identify and target the earliest cell interactions for future antimetastatic therapies. ..
  2. Subcellular regulation of gamma delta TCR in DETCs
    Tomasz Zal; Fiscal Year: 2007
    ..Our Aim 2 is to locate the molecular determinants in the structures of CD3zeta and FcRgamma which regulate incorporation of each chain into the gdTCR complex in DETCs. ..
  3. Immune cell interactions during tumor establishment.
    Tomasz Zal; Fiscal Year: 2009
    ..This study will help identify and target the earliest cell interactions for future antimetastatic therapies. ..