Research Topics
Genomes and Genes | Tomasz ZalSummaryAffiliation: The University of Texas Country: USA Publications
Research Grants
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Publications
Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cellsTomasz Zal
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Traffic 7:1607-13. 2006..This report of FM4-64 as the first vital dye sensitive to the NE environment opens new ways for real-time visualization and functional studies of the NE...
Visualization of protein interactions in living cellsTomasz Zal
Department of Immunology, University of Texas, MD Anderson Cancer Center, Unit 902, 7455 Fannin, Houston TX, USA
Adv Exp Med Biol 640:183-97. 2008..A continuing challenge is extracting from the imaging data the quantitative information that is necessary to verify different models of signal transduction...
Intravital imaging of anti-tumor immune response and the tumor microenvironmentTomasz Zal
Department of Immunology, University of Texas MD Anderson Cancer Center, Unit 902, 1515 Holcombe Blvd, Houston, TX 77030, USA
Semin Immunopathol 32:305-17. 2010....- Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapsePia P Yachi
Department of Immunology, IMM1, The Scripps Research Institute, La Jolla, California 92037, USA
Nat Immunol 6:785-92. 2005..Thus, the interaction of CD8 with a nonstimulatory peptide-MHC complex helps mediate T cell recognition of antigen, improving the coreceptor function of CD8... - Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen qualityPia P Yachi
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Immunity 25:203-11. 2006..Our findings indicate that the T cell translates antigen recognition into T cell responses by differential recruitment of CD8 to the TCR... - Using live FRET imaging to reveal early protein-protein interactions during T cell activationTomasz Zal
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Curr Opin Immunol 16:674-83. 2004..Spectral changes in fluorescence intensity and down modulation of donor lifetime are the basis for rapidly developing approaches to real-time FRET imaging. With two-photon excitation, FRET can now be extended to in vivo imaging... - Co-receptors and recognition of self at the immunological synapseNicholas R J Gascoigne
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
Curr Top Microbiol Immunol 340:171-89. 2010..This chapter discusses the data on the role of CD4 or CD8 co-receptors in T cell activation at the immunological synapse, and the role of non stimulatory MHC-peptide complexes in aiding antigen recognition... - Visualizing intermolecular interactions in T cellsNicholas R J Gascoigne
Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Top Microbiol Immunol 334:31-46. 2009..This chapter reviews data on how these coreceptors are recruited to the immunological synapse, and how they interact when the T cell is stimulated by different ligands... - Using live FRET imaging to reveal early protein-protein interactions during T cell activationTomasz Zal
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Curr Opin Immunol 16:418-27. 2004..Spectral changes in fluorescence intensity and down modulation of donor lifetime are the basis for rapidly developing approaches to real-time FRET imaging. With two-photon excitation, FRET can now be extended to in vivo imaging... - Molecular interactions at the T cell-antigen-presenting cell interfaceNicholas R J Gascoigne
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Opin Immunol 16:114-9. 2004..Recent data show that some T-cell signalling precedes the formation of the mature form of the immunological synapse, but that full T-cell activation depends on sustained signalling, which in turn requires the synapse... - A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsivenessMeei Yun Lin
Division of Biological Sciences, The Cancer Center, and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA
J Immunol 174:5583-92. 2005..These results indicate that members of the CaMKII family play an important role in regulation of CD8 T cell proliferation, cytotoxic effector function, and the response to restimulation... - Body-barrier surveillance by epidermal γδ TCRsGrzegorz Chodaczek
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Nat Immunol 13:272-82. 2012..Thus, the γδ TCR orchestrates barrier surveillance proactively, presumably by recognizing tissue ligands expressed in the steady state... - Photobleaching-corrected FRET efficiency imaging of live cellsTomasz Zal
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Biophys J 86:3923-39. 2004..We demonstrate the benefits of E-FRET with photobleaching correction for timelapse and three-dimensional imaging of protein-protein interactions in the immunological synapse in living T-cells... - Homodimerization and internalization of galanin type 1 receptor in living CHO cellsSebastian A Wirz
Department of Neuropharmacology, Harold L. Dorris Neurological Research Center, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuropeptides 39:535-46. 2005..Internalization and dimerization of GalR1 is shown, contributing to the regulation of galanergic signaling... - Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELsLisa J Ma
Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Immunol 183:1044-54. 2009.... - The stabilization and targeting of surfactant-synthesized gold nanorodsBetty C Rostro-Kohanloo
Department of Physics and Astronomy, Rice University, Houston, TX 77005, USA
Nanotechnology 20:434005. 2009..This covalent strategy should be generally applicable to other biomedical applications of gold nanorods as well as other gold nanoparticles synthesized with CTAB... - Phospholipid scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cellsAmjad H Talukder
Department of Immunology, Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Cell Res 22:1129-39. 2012..Our study demonstrates that PLSCR1 is a TLR9-interacting protein that plays an important role in pDC's type 1 IFN responses by regulating TLR9 trafficking to the endosomal compartment... - Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapseTomasz Zal
Deptartment of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Immunity 16:521-34. 2002..This interaction is blocked by the presence of antagonist ligands without decreasing the recruitment of zeta and CD4 or preventing their partial colocalization in the immunological synapse...
Research Grants
- Immune cell interactions during tumor establishment.Tomasz Zal; Fiscal Year: 2010..This study will help identify and target the earliest cell interactions for future antimetastatic therapies. ..
- Subcellular regulation of gamma delta TCR in DETCsTomasz Zal; Fiscal Year: 2007..Our Aim 2 is to locate the molecular determinants in the structures of CD3zeta and FcRgamma which regulate incorporation of each chain into the gdTCR complex in DETCs. ..