Jianhua Yu

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation
    Rossana Trotta
    Department of Molecular Virology, Immunology, and Medical Genetics, Colelge of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Blood 105:3011-8. 2005
  2. pmc NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human
    Jianhua Yu
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA
    J Clin Invest 121:1456-70. 2011
  3. pmc TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia
    Jianhua Yu
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Blood 113:5558-67. 2009
  4. pmc Location and cellular stages of natural killer cell development
    Jianhua Yu
    Division of Hematology, Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, OH 43210, USA Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, OH 43210, USA Electronic address
    Trends Immunol 34:573-82. 2013
  5. pmc Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia
    Jianhua Yu
    Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e55934. 2013
  6. ncbi Transcriptional control of human T-BET expression: the role of Sp1
    Jianhua Yu
    Division of Hematology Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Eur J Immunol 37:2549-61. 2007
  7. pmc Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia
    Shujun Liu
    Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 17:333-47. 2010
  8. pmc CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets
    Jianhua Yu
    Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
    Blood 115:274-81. 2010
  9. pmc TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells
    Rossana Trotta
    Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
    J Immunol 181:3784-92. 2008
  10. pmc MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
    Ramiro Garzon
    Department of Medicine, Ohio State University, Columbus, 43210, USA
    Blood 113:6411-8. 2009

Detail Information

Publications45

  1. ncbi Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation
    Rossana Trotta
    Department of Molecular Virology, Immunology, and Medical Genetics, Colelge of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Blood 105:3011-8. 2005
    ....
  2. pmc NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human
    Jianhua Yu
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA
    J Clin Invest 121:1456-70. 2011
    ..Thus, IL-15 signaling and NKp46 may be useful targets in the treatment of patients with T-LGL or NKT leukemia...
  3. pmc TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia
    Jianhua Yu
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Blood 113:5558-67. 2009
    ..Collectively, our data suggest that TSC-22 normally contributes to the regulation of HPC function and is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK LGL leukemia...
  4. pmc Location and cellular stages of natural killer cell development
    Jianhua Yu
    Division of Hematology, Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, OH 43210, USA Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, OH 43210, USA Electronic address
    Trends Immunol 34:573-82. 2013
    ..In this review, we summarize recent advances in understanding sites and cellular stages of NK cell development in humans and mice. ..
  5. pmc Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia
    Jianhua Yu
    Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e55934. 2013
    ....
  6. ncbi Transcriptional control of human T-BET expression: the role of Sp1
    Jianhua Yu
    Division of Hematology Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Eur J Immunol 37:2549-61. 2007
    ....
  7. pmc Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia
    Shujun Liu
    Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 17:333-47. 2010
    ....
  8. pmc CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets
    Jianhua Yu
    Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
    Blood 115:274-81. 2010
    ..This supports the notion that, in vivo, human CD56(bright) NK cells progress through a continuum of differentiation that ends with a CD94(low)CD56(dim) phenotype...
  9. pmc TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells
    Rossana Trotta
    Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
    J Immunol 181:3784-92. 2008
    ..This effect was accentuated in cells overexpressing SMAD3. Collectively, our results indicate that TGF-beta inhibits CD16-mediated human NK cell IFN-gamma production and ADCC, and these effects are mediated via SMAD3...
  10. pmc MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
    Ramiro Garzon
    Department of Medicine, Ohio State University, Columbus, 43210, USA
    Blood 113:6411-8. 2009
    ....
  11. pmc Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue
    Tiffany Hughes
    Integrated Biomedical Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Immunity 32:803-14. 2010
    ..Thus, cDC-derived IL-1beta preserves and expands IL-1R1(hi)IL-22(+)AHR(+) iNK cells, potentially influencing human mucosal innate immunity during infection...
  12. pmc The PP2A inhibitor SET regulates natural killer cell IFN-gamma production
    Rossana Trotta
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Exp Med 204:2397-405. 2007
    ..Thus, SET expression is essential for suppressing PP2A phosphatase activity that would otherwise limit NK cell antitumoral and/or antiinflammatory functions by impairing NK cell production of IFN-gamma...
  13. pmc Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cells
    Brian Becknell
    Medical Scientist Program, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Blood 109:2481-7. 2007
    ..Thus, Hlx expression in activated NK cells temporally controls and limits the monokine-induced production of IFN-gamma, in part through the targeted depletion of STAT4...
  14. ncbi Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells
    Jianhua Yu
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University College of Medicine and School of Public Health, Columbus, Ohio 43210, USA
    Immunity 24:575-90. 2006
    ..Collectively, our data suggest that pro- and antiinflammatory cytokine signaling reciprocally antagonize each other in an effort to prevail in the regulation of NK cell IFN-gamma production...
  15. pmc Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia
    Shujun Liu
    Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Blood 111:2364-73. 2008
    ..Our results unveil the Sp1/NF-kappaB pathway as a modulator of DNA methyltransferase activity in human cancer and identify bortezomib as a novel epigenetic-targeting drug...
  16. pmc NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors
    Christopher A Alvarez-Breckenridge
    Medical Scientist Training Program, Ohio State University Medical Center, Columbus, Ohio, USA
    Nat Med 18:1827-34. 2012
    ..These results demonstrate that glioblastoma virotherapy is limited partially by an antiviral NK cell response involving specific NCRs, uncovering new potential targets to enhance cancer virotherapy...
  17. pmc Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells
    Don M Benson
    Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210 1240, USA
    Blood 113:2706-14. 2009
    ..The effect results at least in part via enhanced MAPK-mediated modulation of p27 and CDK4. Collectively the data reveal a novel mechanism by which SCF enhances cellular proliferation in combination with IL-2/15 in primary human NK cells...
  18. pmc A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia
    Akihiko Yokohama
    Department of Molecular Virology, Immunology, and Medical Genetics, Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University College of Medicine, Columbus, OH, United States
    Leuk Res 34:203-9. 2010
    ..The LGLL blasts are cytolytic and produce IFN-gammaex vivo. Cytogenetic analysis revealed trisomy of chromosome 17 and/or 15. This model should provide opportunities to develop effective standard therapies for this fatal disease...
  19. pmc MicroRNAs activate natural killer cells through Toll-like receptor signaling
    Shun He
    Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Blood 121:4663-71. 2013
    ..This may be important in the normal host defense against infection and/or malignant transformation...
  20. pmc The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development
    Il Kyoo Park
    Human Cancer Genetics Program, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Blood 113:2470-7. 2009
    ....
  21. pmc In vivo role of Flt3 ligand and dendritic cells in NK cell homeostasis
    Martin Guimond
    Department of Molecular Virology, The Ohio State University, Columbus, OH43210, USA
    J Immunol 184:2769-75. 2010
    ..In summary, a CD11c(hi) DC population expressing IL-15 is required to maintain NK cell homeostasis under conditions of normal cellularity and also is required to mediate Flt3 ligand-induced NK cell expansion in vivo...
  22. doi Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: evidence for augmented NK cell function complementing ADCC
    Shauna M Collins
    Biomedical Sciences Program, The Ohio State University, Columbus, OH, USA
    Cancer Immunol Immunother 62:1841-9. 2013
    ..Taken together, these data suggest elotuzumab may enhance NK cell function directly and confer anti-MM efficacy by means beyond ADCC alone...
  23. pmc CD94 defines phenotypically and functionally distinct mouse NK cell subsets
    Jianhua Yu
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 183:4968-74. 2009
    ..Collectively, our data suggest that CD94 is an Ag that can be used to identify functionally distinct NK cell subsets in mice and could also be relevant to late-stage mouse NK cell development...
  24. pmc The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells
    Rossana Trotta
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center, 460 West 12th Ave, Columbus, OH 43210, USA
    Blood 117:2378-84. 2011
    ..These data provide evidence that granzyme B gene expression and therefore human NK-cell cytotoxicity can be regulated by the PP2A-SET interplay...
  25. pmc The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody
    Don M Benson
    Division of Hematology Oncology, The Ohio State University Medical Center, Columbus, OH, USA
    Blood 116:2286-94. 2010
    ..A phase 2 clinical trial of CT-011 in combination with lenalidomide for patients with MM should be considered...
  26. pmc Axl/Gas6 pathway positively regulates FLT3 activation in human natural killer cell development
    Il Kyoo Park
    The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
    Eur J Immunol 43:2750-5. 2013
    ..Collectively, our data suggest that the Axl/Gas6 pathway contributes to normal human NK-cell development at least in part via its positive regulatory effect on FLT3 signaling in CD34⁺ HPCs...
  27. pmc LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosis
    Payal Mehta
    The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 6:e21175. 2011
    ..Consistent with this, suppression of LyGDI expression resulted in significantly enhanced FcγR-mediated phagocytosis...
  28. pmc Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma
    Sri Vidya Kondadasula
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Arthur G James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH, USA
    Blood 111:4173-83. 2008
    ..These data suggest that dual recruitment of FcgammaRIIIa and the IL-12R to lipid raft microdomains allows for enhanced activation of downstream signaling events that lead to IFN-gamma production...
  29. ncbi Efficient infection of human natural killer cells with an EBV/retroviral hybrid vector
    Brian Becknell
    Medical Scientist Program, Integrated Biomedical Graduate Program, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    J Immunol Methods 296:115-23. 2005
    ....
  30. pmc Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
    Shu Hao Hsu
    Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH, USA
    J Clin Invest 122:2871-83. 2012
    ....
  31. pmc Evidence for a stepwise program of extrathymic T cell development within the human tonsil
    Susan McClory
    Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA
    J Clin Invest 122:1403-15. 2012
    ..Thus, we provide evidence of a role for the human tonsil in a comprehensive program of extrathymic T cell development...
  32. pmc The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon
    Christopher A Alvarez-Breckenridge
    Medical Scientist Training Program, The Ohio State University Medical Center and The James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA
    J Virol 86:4566-77. 2012
    ..These findings indicate that one of the avenues by which VPA enhances oHSV efficacy is through initial suppression of immune cell recruitment and inhibition of inflammatory cell pathways within NK cells...
  33. pmc Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22
    Tiffany Hughes
    Integrated Biomedical Graduate Program, The Ohio State University College of Medicine, Columbus, Ohio, USA
    Blood 113:4008-10. 2009
    ..In summary, stage 3 iNK cells are highly enriched for IL-22 and IL-26 messenger RNA, and IL-22 protein production, but do not express IL-17A or IL-17F...
  34. ncbi Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells
    Shujun Liu
    Division of Hematology, The Ohio State University, 320 West 10th Avenue, Columbus, OH 43210, USA
    J Pharmacol Exp Ther 321:953-60. 2007
    ....
  35. pmc The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis
    Shujun Liu
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 6:e17161. 2011
    ..In this report we demonstrated the role of ZAS3 in bone resorption by examining the signaling mechanisms involved in osteoclastogenesis...
  36. pmc IκBζ augments IL-12- and IL-18-mediated IFN-γ production in human NK cells
    Yashaswini Kannan
    Pulmonary, Allergy, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, OH, USA
    Blood 117:2855-63. 2011
    ..These results suggest that IκBζ functions as an important regulator of IFN-γ in human NK cells, further expanding the class of IκBζ-modulated genes...
  37. pmc Allergy and inflammatory transcriptome is predominantly negatively correlated with CD133 expression in glioblastoma
    Judith A Schwartzbaum
    School of Public Health, Division of Epidemiology, Ohio State University, Columbus, Ohio 43210, USA
    Neuro Oncol 12:320-7. 2010
    ..However, IL-17 and NCAM-1 may play proinflammatory and immunosuppressive roles, respectively, during the late stage of glioblastoma progression. Our findings suggest that immune function continues to change as the tumor progresses...
  38. ncbi Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia
    Shujun Liu
    Divisions of Hematology Oncology, Department of Internal Medicine and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
    Cancer Res 65:1277-84. 2005
    ..These results suggest a novel mechanism for gene silencing mediated by RUNX1/MTG8 and support the combination of HDAC and DNMT inhibitors as a novel therapeutic approach for t(8;21) AML...
  39. doi Curcumin is a potent DNA hypomethylation agent
    Zhongfa Liu
    Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 W 12th St, Columbus, OH 43210, USA
    Bioorg Med Chem Lett 19:706-9. 2009
    ..SssI with an IC(50) of 30 nM, but no inhibitory activity of hexahydrocurcumin up to 100 microM. In addition, curcumin can induce global DNA hypomethylation in a leukemia cell line...
  40. pmc Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma
    Amy Haseley
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio, USA
    Cancer Res 72:1353-62. 2012
    ..Furthermore, they suggest therapeutic interventions to inhibit CCN1-integrin α6 interactions to sensitize gliomas to viral oncolysis...
  41. pmc Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer
    Yong Peng
    Department of Molecular Virology, Immunology, and Medical Genetics and Division of Hematology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210
    Proc Natl Acad Sci U S A 110:15043-8. 2013
    ..Our findings support the role for miR-486 loss in lung cancer and suggest a potential biological link to p53. ..
  42. pmc A covalently stabilized lipid-polycation-DNA (sLPD) vector for antisense oligonucleotide delivery
    Xiaojuan Yang
    Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Pharm 8:709-15. 2011
    ....
  43. pmc Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
    Giulia Fulci
    Dardinger Center for Neuro oncology and Neurosciences, Department of Neurological Surgery, James Cancer Hospital and Solove Research Institute, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:12873-8. 2006
    ..Our results reveal molecular and cellular mechanisms that inhibit intratumoral spread of HSV and suggest a therapeutic path for improving the efficacy of virotherapy as a treatment for cancer...
  44. pmc Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia
    Michael A Caligiuri
    Integrated Biomeducal Graduate Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 23240, USA
    Blood 110:1022-4. 2007
    ..Short-interfering RNA knockdown of mutant c-CBL present in MOLM-13 cells was growth inhibitory. In summary, novel mutations in c-CBL and CBL-b have been identified in human AML and may represent potential targets for novel therapeutics...
  45. pmc Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells
    Christopher A Alvarez-Breckenridge
    Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, USA
    Adv Virol 2012:702839. 2012
    ..In this review we discuss the current literature on the NK response to oncolytic viral infection and how future studies clarify this intricate response...