Research Topics
Genomes and Genes
| Jianhua YuSummaryAffiliation: The Ohio State University Country: USA Publications
| Collaborators
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Detail Information
Publications
Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulationRossana Trotta
Department of Molecular Virology, Immunology, and Medical Genetics, Colelge of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
Blood 105:3011-8. 2005....
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and humanJianhua Yu
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA
J Clin Invest 121:1456-70. 2011..Thus, IL-15 signaling and NKp46 may be useful targets in the treatment of patients with T-LGL or NKT leukemia...- TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemiaJianhua Yu
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
Blood 113:5558-67. 2009..Collectively, our data suggest that TSC-22 normally contributes to the regulation of HPC function and is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK LGL leukemia... - Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemiaJianhua Yu
Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America
PLoS ONE 8:e55934. 2013.... - Transcriptional control of human T-BET expression: the role of Sp1Jianhua Yu
Division of Hematology Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
Eur J Immunol 37:2549-61. 2007.... - Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemiaShujun Liu
Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
Cancer Cell 17:333-47. 2010.... - CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsetsJianhua Yu
Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
Blood 115:274-81. 2010..This supports the notion that, in vivo, human CD56(bright) NK cells progress through a continuum of differentiation that ends with a CD94(low)CD56(dim) phenotype... - TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cellsRossana Trotta
Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
J Immunol 181:3784-92. 2008..This effect was accentuated in cells overexpressing SMAD3. Collectively, our results indicate that TGF-beta inhibits CD16-mediated human NK cell IFN-gamma production and ADCC, and these effects are mediated via SMAD3... 
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissueTiffany Hughes
Integrated Biomedical Graduate Program, The Ohio State University, Columbus, OH 43210, USA
Immunity 32:803-14. 2010..Thus, cDC-derived IL-1beta preserves and expands IL-1R1(hi)IL-22(+)AHR(+) iNK cells, potentially influencing human mucosal innate immunity during infection...- MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1Ramiro Garzon
Department of Medicine, Ohio State University, Columbus, 43210, USA
Blood 113:6411-8. 2009.... - The PP2A inhibitor SET regulates natural killer cell IFN-gamma productionRossana Trotta
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
J Exp Med 204:2397-405. 2007..Thus, SET expression is essential for suppressing PP2A phosphatase activity that would otherwise limit NK cell antitumoral and/or antiinflammatory functions by impairing NK cell production of IFN-gamma... - NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptorsChristopher A Alvarez-Breckenridge
Medical Scientist Training Program, Ohio State University Medical Center, Columbus, Ohio, USA
Nat Med 18:1827-34. 2012..These results demonstrate that glioblastoma virotherapy is limited partially by an antiviral NK cell response involving specific NCRs, uncovering new potential targets to enhance cancer virotherapy... - A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemiaAkihiko Yokohama
Department of Molecular Virology, Immunology, and Medical Genetics, Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University College of Medicine, Columbus, OH, United States
Leuk Res 34:203-9. 2010..The LGLL blasts are cytolytic and produce IFN-gammaex vivo. Cytogenetic analysis revealed trisomy of chromosome 17 and/or 15. This model should provide opportunities to develop effective standard therapies for this fatal disease... - Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cellsDon M Benson
Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210 1240, USA
Blood 113:2706-14. 2009..The effect results at least in part via enhanced MAPK-mediated modulation of p27 and CDK4. Collectively the data reveal a novel mechanism by which SCF enhances cellular proliferation in combination with IL-2/15 in primary human NK cells... - Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemiaShujun Liu
Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
Blood 111:2364-73. 2008..Our results unveil the Sp1/NF-kappaB pathway as a modulator of DNA methyltransferase activity in human cancer and identify bortezomib as a novel epigenetic-targeting drug... - CD94 defines phenotypically and functionally distinct mouse NK cell subsetsJianhua Yu
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
J Immunol 183:4968-74. 2009..Collectively, our data suggest that CD94 is an Ag that can be used to identify functionally distinct NK cell subsets in mice and could also be relevant to late-stage mouse NK cell development... - In vivo role of Flt3 ligand and dendritic cells in NK cell homeostasisMartin Guimond
Department of Molecular Virology, The Ohio State University, Columbus, OH43210, USA
J Immunol 184:2769-75. 2010..In summary, a CD11c(hi) DC population expressing IL-15 is required to maintain NK cell homeostasis under conditions of normal cellularity and also is required to mediate Flt3 ligand-induced NK cell expansion in vivo... - The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell developmentIl Kyoo Park
Human Cancer Genetics Program, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA
Blood 113:2470-7. 2009.... - The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibodyDon M Benson
Division of Hematology Oncology, The Ohio State University Medical Center, Columbus, OH, USA
Blood 116:2286-94. 2010..A phase 2 clinical trial of CT-011 in combination with lenalidomide for patients with MM should be considered... - The PP2A inhibitor SET regulates granzyme B expression in human natural killer cellsRossana Trotta
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center, 460 West 12th Ave, Columbus, OH 43210, USA
Blood 117:2378-84. 2011..These data provide evidence that granzyme B gene expression and therefore human NK-cell cytotoxicity can be regulated by the PP2A-SET interplay... - Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cellsBrian Becknell
Medical Scientist Program, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
Blood 109:2481-7. 2007..Thus, Hlx expression in activated NK cells temporally controls and limits the monokine-induced production of IFN-gamma, in part through the targeted depletion of STAT4... - Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cellsJianhua Yu
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University College of Medicine and School of Public Health, Columbus, Ohio 43210, USA
Immunity 24:575-90. 2006..Collectively, our data suggest that pro- and antiinflammatory cytokine signaling reciprocally antagonize each other in an effort to prevail in the regulation of NK cell IFN-gamma production... - Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gammaSri Vidya Kondadasula
Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Arthur G James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH, USA
Blood 111:4173-83. 2008..These data suggest that dual recruitment of FcgammaRIIIa and the IL-12R to lipid raft microdomains allows for enhanced activation of downstream signaling events that lead to IFN-gamma production... - Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liverShu Hao Hsu
Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH, USA
J Clin Invest 122:2871-83. 2012.... - Evidence for a stepwise program of extrathymic T cell development within the human tonsilSusan McClory
Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA
J Clin Invest 122:1403-15. 2012..Thus, we provide evidence of a role for the human tonsil in a comprehensive program of extrathymic T cell development... - LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosisPayal Mehta
The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, United States of America
PLoS ONE 6:e21175. 2011..Consistent with this, suppression of LyGDI expression resulted in significantly enhanced FcγR-mediated phagocytosis... - Efficient infection of human natural killer cells with an EBV/retroviral hybrid vectorBrian Becknell
Medical Scientist Program, Integrated Biomedical Graduate Program, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
J Immunol Methods 296:115-23. 2005.... - The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferonChristopher A Alvarez-Breckenridge
Medical Scientist Training Program, The Ohio State University Medical Center and The James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA
J Virol 86:4566-77. 2012..These findings indicate that one of the avenues by which VPA enhances oHSV efficacy is through initial suppression of immune cell recruitment and inhibition of inflammatory cell pathways within NK cells... - IκBζ augments IL-12- and IL-18-mediated IFN-γ production in human NK cellsYashaswini Kannan
Pulmonary, Allergy, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, OH, USA
Blood 117:2855-63. 2011..These results suggest that IκBζ functions as an important regulator of IFN-γ in human NK cells, further expanding the class of IκBζ-modulated genes... - Allergy and inflammatory transcriptome is predominantly negatively correlated with CD133 expression in glioblastomaJudith A Schwartzbaum
School of Public Health, Division of Epidemiology, Ohio State University, Columbus, Ohio 43210, USA
Neuro Oncol 12:320-7. 2010..However, IL-17 and NCAM-1 may play proinflammatory and immunosuppressive roles, respectively, during the late stage of glioblastoma progression. Our findings suggest that immune function continues to change as the tumor progresses... - Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cellsShujun Liu
Division of Hematology, The Ohio State University, 320 West 10th Avenue, Columbus, OH 43210, USA
J Pharmacol Exp Ther 321:953-60. 2007.... - Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22Tiffany Hughes
Integrated Biomedical Graduate Program, The Ohio State University College of Medicine, Columbus, Ohio, USA
Blood 113:4008-10. 2009..In summary, stage 3 iNK cells are highly enriched for IL-22 and IL-26 messenger RNA, and IL-22 protein production, but do not express IL-17A or IL-17F... - The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesisShujun Liu
Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
PLoS ONE 6:e17161. 2011..In this report we demonstrated the role of ZAS3 in bone resorption by examining the signaling mechanisms involved in osteoclastogenesis... - Extracellular matrix protein CCN1 limits oncolytic efficacy in gliomaAmy Haseley
Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio, USA
Cancer Res 72:1353-62. 2012..Furthermore, they suggest therapeutic interventions to inhibit CCN1-integrin α6 interactions to sensitize gliomas to viral oncolysis... - Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemiaShujun Liu
Divisions of Hematology Oncology, Department of Internal Medicine and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
Cancer Res 65:1277-84. 2005..These results suggest a novel mechanism for gene silencing mediated by RUNX1/MTG8 and support the combination of HDAC and DNMT inhibitors as a novel therapeutic approach for t(8;21) AML... - Curcumin is a potent DNA hypomethylation agentZhongfa Liu
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 W 12th St, Columbus, OH 43210, USA
Bioorg Med Chem Lett 19:706-9. 2009..SssI with an IC(50) of 30 nM, but no inhibitory activity of hexahydrocurcumin up to 100 microM. In addition, curcumin can induce global DNA hypomethylation in a leukemia cell line... - A covalently stabilized lipid-polycation-DNA (sLPD) vector for antisense oligonucleotide deliveryXiaojuan Yang
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
Mol Pharm 8:709-15. 2011.... - Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responsesGiulia Fulci
Dardinger Center for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, James Cancer Hospital and Solove Research Institute, Ohio State University Medical Center, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 103:12873-8. 2006..Our results reveal molecular and cellular mechanisms that inhibit intratumoral spread of HSV and suggest a therapeutic path for improving the efficacy of virotherapy as a treatment for cancer... - Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemiaMichael A Caligiuri
Integrated Biomeducal Graduate Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 23240, USA
Blood 110:1022-4. 2007..Short-interfering RNA knockdown of mutant c-CBL present in MOLM-13 cells was growth inhibitory. In summary, novel mutations in c-CBL and CBL-b have been identified in human AML and may represent potential targets for novel therapeutics... - Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer CellsChristopher A Alvarez-Breckenridge
Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, USA
Adv Virol 2012:702839. 2012..In this review we discuss the current literature on the NK response to oncolytic viral infection and how future studies clarify this intricate response...