C Y Yu

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Molecular genetics of the human MHC complement gene cluster
    C Y Yu
    Children s Hospital Research Foundation, and Department of Pediatrics, The Ohio State University, Columbus, Ohio
    Exp Clin Immunogenet 15:213-30. 1998
  2. ncbi request reprint Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA
    Z Yang
    Children s Hospital Research Foundation, 700 Children s Drive, Columbus, Ohio, 43205, USA
    Genomics 53:338-47. 1998
  3. ncbi request reprint Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication
    L Shen
    Children s Hospital Research Foundation, Columbus, Ohio 43205
    J Biol Chem 269:8466-76. 1994
  4. ncbi request reprint An unequal crossover between the RCCX modules of the human MHC leading to the presence of a CYP21B gene and a tenascin TNXB/TNXA-RP2 recombinant between C4A and C4B genes in a patient with juvenile rheumatoid arthritis
    K L Rupert
    Children s Hospital Research Foundation, Columbus, Ohio, USA
    Exp Clin Immunogenet 16:81-97. 1999
  5. ncbi request reprint Modular variations of the human major histocompatibility complex class III genes for serine/threonine kinase RP, complement component C4, steroid 21-hydroxylase CYP21, and tenascin TNX (the RCCX module). A mechanism for gene deletions and disease associat
    Z Yang
    Children s Hospital Research Foundation, Columbus, Ohio 43205, USA
    J Biol Chem 274:12147-56. 1999
  6. ncbi request reprint Organizations and gene duplications of the human and mouse MHC complement gene clusters
    Z Yang
    Children s Research Institute, The Ohio State University, Columbus, OH 43205 2696, USA
    Exp Clin Immunogenet 17:1-17. 2000
  7. pmc The human DEVH-box protein Ski2w from the HLA is localized in nucleoli and ribosomes
    X Qu
    Children s Hospital Research Foundation, Molecular, Cellular and Developmental Biology Program, Department of Pediatrics, The Ohio StateUniversity, Columbus, OH 43205 2696, USA
    Nucleic Acids Res 26:4068-77. 1998
  8. pmc The complex nature of serum C3 and C4 as biomarkers of lupus renal flare
    D J Birmingham
    The Ohio State University, Columbus, OH 43210, USA
    Lupus 19:1272-80. 2010
  9. pmc Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family
    A W Dangel
    Wexner Institute for Pediatric Research, Children s Hospital Research Foundation, Columbus, OH 43205, USA
    Nucleic Acids Res 23:2120-6. 1995
  10. ncbi request reprint Of mice and men: the relevance of the mouse to the study of human SLE
    D J Birmingham
    The Department of Internal Medicine, The Heart Lung Research Institute, The Ohio State University, Columbus, USA
    Immunol Res 24:211-24. 2001

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Molecular genetics of the human MHC complement gene cluster
    C Y Yu
    Children s Hospital Research Foundation, and Department of Pediatrics, The Ohio State University, Columbus, Ohio
    Exp Clin Immunogenet 15:213-30. 1998
    ..The complete genomic DNA sequence between C2 and TNX is now available. This should facilitate a complete documentation of polymorphisms, mutations and disease associations for the MCGC...
  2. ncbi request reprint Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA
    Z Yang
    Children s Hospital Research Foundation, 700 Children s Drive, Columbus, Ohio, 43205, USA
    Genomics 53:338-47. 1998
    ..The ubiquitous expression pattern suggests that these four genes are probably housekeeping genes...
  3. ncbi request reprint Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication
    L Shen
    Children s Hospital Research Foundation, Columbus, Ohio 43205
    J Biol Chem 269:8466-76. 1994
    ..Duplication of the RCCX modules probably occurred before the speciation of great apes and humans as they contain the same breakpoint region of RP and Gene X gene duplication...
  4. ncbi request reprint An unequal crossover between the RCCX modules of the human MHC leading to the presence of a CYP21B gene and a tenascin TNXB/TNXA-RP2 recombinant between C4A and C4B genes in a patient with juvenile rheumatoid arthritis
    K L Rupert
    Children s Hospital Research Foundation, Columbus, Ohio, USA
    Exp Clin Immunogenet 16:81-97. 1999
    ..Elucidation of the breakpoint region provides further evidence for the instability of the MHC class III gene region as a result of the RCCX modular variation...
  5. ncbi request reprint Modular variations of the human major histocompatibility complex class III genes for serine/threonine kinase RP, complement component C4, steroid 21-hydroxylase CYP21, and tenascin TNX (the RCCX module). A mechanism for gene deletions and disease associat
    Z Yang
    Children s Hospital Research Foundation, Columbus, Ohio 43205, USA
    J Biol Chem 274:12147-56. 1999
    ..Elucidation of the DNA sequence for the recombination breakpoint region and sequence analyses yielded definitive proof for an unequal crossover between TNXA from a bimodular chromosome and TNXB from a monomodular chromosome...
  6. ncbi request reprint Organizations and gene duplications of the human and mouse MHC complement gene clusters
    Z Yang
    Children s Research Institute, The Ohio State University, Columbus, OH 43205 2696, USA
    Exp Clin Immunogenet 17:1-17. 2000
    ..The modular duplications of human and mouse RP-C4-CYP21-TNX (RCCX) are sharply different as SKI2W2 is absent in the human MCGC, and TNXA and RP2 are smaller in size but higher in sequence conservation in humans...
  7. pmc The human DEVH-box protein Ski2w from the HLA is localized in nucleoli and ribosomes
    X Qu
    Children s Hospital Research Foundation, Molecular, Cellular and Developmental Biology Program, Department of Pediatrics, The Ohio StateUniversity, Columbus, OH 43205 2696, USA
    Nucleic Acids Res 26:4068-77. 1998
    ..Indirect immunofluorescence experiments showed that human Ski2w is localized in the nucleoli and in the cytoplasm. In essence, human Ski2w is present at the sites of ribosome biogenesis and protein synthesis...
  8. pmc The complex nature of serum C3 and C4 as biomarkers of lupus renal flare
    D J Birmingham
    The Ohio State University, Columbus, OH 43210, USA
    Lupus 19:1272-80. 2010
    ....
  9. pmc Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family
    A W Dangel
    Wexner Institute for Pediatric Research, Children s Hospital Research Foundation, Columbus, OH 43205, USA
    Nucleic Acids Res 23:2120-6. 1995
    ....
  10. ncbi request reprint Of mice and men: the relevance of the mouse to the study of human SLE
    D J Birmingham
    The Department of Internal Medicine, The Heart Lung Research Institute, The Ohio State University, Columbus, USA
    Immunol Res 24:211-24. 2001
    ..Thus, generalizing the results of the mouse studies to human SLE and other human IC diseases must be done with caution...
  11. ncbi request reprint The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates
    A W Dangel
    Children s Hospital Research Foundation, Columbus, OH 43205
    Immunogenetics 40:425-36. 1994
    ..It is possible that members of HERV-K(C4) are involved in genetic instabilities including the RCCX modules, and in protecting the host genome from retroviral attack through an antisense strategy...
  12. ncbi request reprint Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC class III region
    Z Yang
    Children s Research Institute, 700 Children s Drive, Columbus, Ohio 43205 2664, USA
    Front Biosci 6:D927-35. 2001
    ....
  13. ncbi request reprint Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4
    C A Blanchong
    Children s Research Institute, 700 Children s Drive, Columbus, OH 43205 2696, USA
    Int Immunopharmacol 1:365-92. 2001
    ..An undesirable accompanying byproduct of this phenomenon is the inherent deleterious recombinations among the RCCX constituents leading to autoimmune and genetic disorders...
  14. pmc Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity
    C Y Yu
    EMBO J 5:2873-81. 1986
    ..Our structural data on the C4A and C4B polymorphism pattern suggests a gene conversion-like mechanism is operating in mixing the generally discrete serological phenotypes between C4A and C4B...
  15. ncbi request reprint The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene
    C Y Yu
    Department of Biochemistry, Oxford University, U K
    J Immunol 146:1057-66. 1991
    ..A PvuII restriction length polymorphism has been detected within the region of DNA coding for C4a. The intergenic region between C4 and the neighboring 21-hydroxylase gene, CYP21, is approximately 3028 bp in size...
  16. ncbi request reprint Fine mapping of S31, a gene responsible for hybrid embryo-sac abortion in rice (Oryza sativa L.)
    Z G Zhao
    National Key Laboratory for Crop Genetics and Germplasm Enhancement, Jiangsu Plant Gene Engineering Research Center, Nanjing Agricultural University, Nanjing 210095, China
    Planta 226:1087-96. 2007
    ....
  17. ncbi request reprint Genetic distances revealed by morphological characters, isozymes, proteins and RAPD markers and their relationships with hybrid performance in oilseed rape (Brassica napus L.)
    C Y Yu
    College of Agronomy, Northwest Sci Tech University of Agriculture and Forestry, Yangling, Shaanxi, 712100, PR China
    Theor Appl Genet 110:511-8. 2005
    ..The information obtained in this study on the genetic diversity of the parental lines does not appear to be reliable for predicting F1 yield and heterosis...
  18. ncbi request reprint Intraspecific relationship analysis by DNA markers and in vitro cytotoxic and antioxidant activity in Eleutherococcus senticosus
    C Y Yu
    Division of Applied Plant Sciences, College of Agriculture and Life Sciences, Kangwon National University, Chunchon 200 701, South Korea
    Toxicol In Vitro 17:229-36. 2003
    ..In the cytotoxic effects were evaluated on seven human cancer cell lines, the values of 50% growth inhibition (GI(50)) were mostly below 30 microg/ml for crude extracts to be considered as significantly active...
  19. ncbi request reprint Tree-based linkage and association analyses of asthma
    H Zhang
    Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut, USA
    Genet Epidemiol 21:S317-22. 2001
    ..Consistent and strong evidence of linkage and association to markers on chromosomes 1 and 11 is revealed. Linkage to chromosome 16 in one data set and association with D6S276 in the other data set are also detected...
  20. ncbi request reprint The mouse DNA binding protein Rc for the kappa B motif of transcription and for the V(D)J recombination signal sequences contains composite DNA-protein interaction domains and belongs to a new family of large transcriptional proteins
    L C Wu
    Department of Medical Biochemistry, Ohio State Biochemistry Program, College of Medicine, Columbus 43210, USA
    Genomics 35:415-24. 1996
    ..The major histocompatibility complex class I gene enhancer binding proteins MBP1 and MBP2 are other representatives of this ZAS protein family...
  21. ncbi request reprint Polymorphism of human complement component C4
    K T Belt
    Immunogenetics 21:173-80. 1985
    ....
  22. pmc Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia
    N R Rodrigues
    EMBO J 6:1653-61. 1987
    ..In addition, comparison of the 21-hydroxylase B gene sequence with other published sequences indicates that this microsomal cytochrome P-450 may be polymorphic...
  23. ncbi request reprint Deficiency of human complement protein C4 due to identical frameshift mutations in the C4A and C4B genes
    M L Lokki
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 162:3687-93. 1999
    ..Among the possible genetic mechanisms that produce identical mutations is both genes, the most likely is a mutation in C4A followed by a gene conversion to generate the mutated C4B allele...
  24. pmc Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters
    J H Kim
    Department of Genetics, University of California, Davis 95616
    Nucleic Acids Res 17:5687-700. 1989
    ....
  25. pmc A physical map linking the five CD1 human thymocyte differentiation antigen genes
    C Y Yu
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 8:3727-32. 1989
    ..The genes are evenly spaced in the complex except for the distance between CD1D and CD1A, which is two to three times greater than the average...