Michael W Young

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Time zones: a comparative genetics of circadian clocks
    M W Young
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Rev Genet 2:702-15. 2001
  2. pmc An ultradian clock shapes genome expression in yeast
    Michael W Young
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:1118-9. 2004
  3. pmc The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period
    Shawn A Cyran
    Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 25:5430-7. 2005
  4. pmc Integration of light and temperature in the regulation of circadian gene expression in Drosophila
    Catharine E Boothroyd
    Laboratory of Genetics, The Rockefeller University, New York, New York, United States of America
    PLoS Genet 3:e54. 2007
  5. pmc Activating PER repressor through a DBT-directed phosphorylation switch
    Saul Kivimäe
    Laboratory of Genetics, The Rockefeller University, New York, New York, USA
    PLoS Biol 6:e183. 2008
  6. ncbi request reprint Molecular and statistical tools for circadian transcript profiling
    Herman Wijnen
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
    Methods Enzymol 393:341-65. 2005
  7. ncbi request reprint PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock
    Pablo Meyer
    Laboratory of Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 311:226-9. 2006
  8. pmc A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein
    Lino Saez
    Laboratory of Genetics, The Rockefeller University, New York, New York 10065, USA
    Genetics 188:591-600. 2011
  9. ncbi request reprint The 2006 Pittendrigh/Aschoff lecture: new roles for old proteins in the Drosophila circadian clock
    Pablo Meyer
    Laboratory of Genetics, The Rockefeller University, New York, NY10021, USA
    J Biol Rhythms 22:283-90. 2007
  10. pmc Control of daily transcript oscillations in Drosophila by light and the circadian clock
    Herman Wijnen
    Laboratory of Genetics, The Rockefeller University, New York, New York, USA
    PLoS Genet 2:e39. 2006

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Time zones: a comparative genetics of circadian clocks
    M W Young
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Rev Genet 2:702-15. 2001
    ..Although autoregulatory genetic networks are a consistent feature in the design of all clocks, the weight of evidence favours their independent evolutionary origins in different kingdoms...
  2. pmc An ultradian clock shapes genome expression in yeast
    Michael W Young
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:1118-9. 2004
  3. pmc The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period
    Shawn A Cyran
    Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 25:5430-7. 2005
    ..Here, we show that these effects of SGG on PER nuclear accumulation require TIM. We propose a revised clock model that incorporates this tight kinase regulation of PER and TIM nuclear entry...
  4. pmc Integration of light and temperature in the regulation of circadian gene expression in Drosophila
    Catharine E Boothroyd
    Laboratory of Genetics, The Rockefeller University, New York, New York, United States of America
    PLoS Genet 3:e54. 2007
    ..Taken together, these findings suggest that information from both light and temperature is integrated by the transcriptional clock mechanism in the adult fly head...
  5. pmc Activating PER repressor through a DBT-directed phosphorylation switch
    Saul Kivimäe
    Laboratory of Genetics, The Rockefeller University, New York, New York, USA
    PLoS Biol 6:e183. 2008
    ....
  6. ncbi request reprint Molecular and statistical tools for circadian transcript profiling
    Herman Wijnen
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
    Methods Enzymol 393:341-65. 2005
    ..Both comparative and temporal study designs are discussed, and their use in circadian research is illustrated with examples. Data analysis methods to assess periodic components in time series data are outlined in detail...
  7. ncbi request reprint PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock
    Pablo Meyer
    Laboratory of Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 311:226-9. 2006
    ..This finding points to a previously unrecognized form of temporal regulation that underlies the periodicity of the circadian clock...
  8. pmc A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein
    Lino Saez
    Laboratory of Genetics, The Rockefeller University, New York, New York 10065, USA
    Genetics 188:591-600. 2011
    ..These studies confirm that TIM is required for the nuclear localization of PER and point to a key role for the TIM NLS in the regulated nuclear accumulation of both proteins...
  9. ncbi request reprint The 2006 Pittendrigh/Aschoff lecture: new roles for old proteins in the Drosophila circadian clock
    Pablo Meyer
    Laboratory of Genetics, The Rockefeller University, New York, NY10021, USA
    J Biol Rhythms 22:283-90. 2007
    ..The authors will then introduce a novel timing mechanism uncovered by a single cell-based assay, with the new ideas and prospects for future research that it has raised...
  10. pmc Control of daily transcript oscillations in Drosophila by light and the circadian clock
    Herman Wijnen
    Laboratory of Genetics, The Rockefeller University, New York, New York, USA
    PLoS Genet 2:e39. 2006
    ....
  11. doi request reprint The in(put)s and out(put)s of the Drosophila circadian clock
    Catharine E Boothroyd
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Ann N Y Acad Sci 1129:350-7. 2008
    ..Recent studies addressing temperature as an input to, and the generation of rhythmic gene expression as an output from, the Drosophila central clock are discussed...
  12. pmc Kinetics of doubletime kinase-dependent degradation of the Drosophila period protein
    Sheyum Syed
    Laboratory of Genetics, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 286:27654-62. 2011
    ..For all the other tested DBT alleles, the study provides a simple model in which the changes in Drosophila behavioral rhythms can be explained solely by changes in the rate of PER degradation...
  13. pmc Structure of an enclosed dimer formed by the Drosophila period protein
    Heather A King
    Laboratory of Genetics, The Rockefeller University, New York, NY 10065, USA
    J Mol Biol 413:561-72. 2011
    ..Conservation of PER interaction residues among a family of PAS-AB-containing transcription factors suggests that contacts mediating closed PAS-AB dimers serve a general function...
  14. pmc insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila
    Nicholas Stavropoulos
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 72:964-76. 2011
    ..The extensive evolutionary conservation of insomniac and Cul3 suggests that protein degradation pathways may have a general role in governing the sleep and wakefulness of animals...
  15. pmc Control of sleep by cyclin A and its regulator
    Dragana Rogulja
    Laboratory of Genetics, The Rockefeller University, New York, NY 10065, USA
    Science 335:1617-21. 2012
    ..CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior...
  16. ncbi request reprint vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock
    Shawn A Cyran
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Cell 112:329-41. 2003
    ..Thus, VRI and PDP1, together with dClock itself, comprise a second feedback loop in the Drosophila clock that gives rhythmic expression of dClock, and probably of other genes, to generate accurate circadian rhythms...
  17. ncbi request reprint Posttranscriptional and posttranslational regulation of clock genes
    Emily Harms
    Laboratory of Genetics, Rockefeller University, New York, NY 10021, USA
    J Biol Rhythms 19:361-73. 2004
    ..The combined outcome of these modifications is to adjust the timing of the clock to produce a circadian oscillator that takes approximately 24 h...
  18. ncbi request reprint Post-translational enzyme activation in an animal via optimized conditional protein splicing
    Edmund C Schwartz
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Chem Biol 3:50-4. 2007
    ..This technique provides a means of controlling enzymatic function with greater speed and precision than with standard genetic techniques and is a useful tool for probing biological processes...
  19. ncbi request reprint CK1 and GSK3 in the Drosophila and mammalian circadian clock
    Emily Harms
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, Box 288, New York, NY 10021, USA
    Novartis Found Symp 253:267-77; discussion 102-9, 277-84. 2003
    ..Casein Kinase 1 has been shown to be a component of the circadian clock in mammals. Recent studies are also pointing to a role for glycogen synthase kinase 3 in the mammalian clock...
  20. ncbi request reprint Big ben rings in a lesson on biological clocks
    Michael W Young
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 36:1001-5. 2002
  21. ncbi request reprint Molecular genetics of timing in intrinsic circadian rhythm sleep disorders
    Herman Wijnen
    The Laboratory of Genetics, The Rockefeller University, New York, NY 10021, USA
    Ann Med 34:386-93. 2002
    ....
  22. doi request reprint Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock
    Tatsumori Sekine
    Division of Insect Sciences, National Institute of Agrobiological Sciences, Ohwashi 1 2, Tsukuba, Ibaraki 305 8634, Japan
    J Biol Rhythms 23:3-15. 2008
    ..Thus, caution should be used in interpreting assays that measure activity of mammalian casein kinase mutants in Drosophila, or that employ vertebrate CKI in studies of dPER phosphorylations...
  23. pmc kuzbanian-mediated cleavage of Drosophila Notch
    Toby Lieber
    Laboratory of Genetics, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 16:209-21. 2002
    ..Our data suggest that in Drosophila, kuzbanian can mediate S2 cleavage of Notch...
  24. ncbi request reprint Interplay of circadian clocks and metabolic rhythms
    Herman Wijnen
    Department of Biology, University of Virginia, Charlottesville, Virginia 22904 4328, USA
    Annu Rev Genet 40:409-48. 2006
    ..The potential connections between circadian oscillations in gene expression and circadian oscillations in metabolic activity are a major focus of this review...

Research Grants44

  1. Interdisciplinary Studies of Drosophila Rhythmic Behavior
    Michael W Young; Fiscal Year: 2010
    ..We believe our proposed genetic, cellular, and biochemical studies of Drosophila's activity/rest behavior will continue to provide insights and tools relevant to the understanding of human sleep. ..
  2. MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMS
    Michael Young; Fiscal Year: 2003
    ..In addition, a ds-RNA-based method will be used to reduce activity of clock and putative clock genes in a tissue-specific manner. ..
  3. REGULATION OF DROSOPHILA NEUROMUSCULAR DEVELOPMENT
    Michael Young; Fiscal Year: 2003
    ..e) Factors regulating Notch transport to and from the cell surface, and controlling nuclear translocation of Notch will be identified and characterized using certain transport deficient Notch proteins. ..
  4. MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMS
    Michael Young; Fiscal Year: 2002
    ..In addition, a ds-RNA-based method will be used to reduce activity of clock and putative clock genes in a tissue-specific manner. ..
  5. REGULATION OF DROSOPHILA NEUROMUSCULAR DEVELOPMENT
    Michael Young; Fiscal Year: 2002
    ..e) Factors regulating Notch transport to and from the cell surface, and controlling nuclear translocation of Notch will be identified and characterized using certain transport deficient Notch proteins. ..
  6. MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMS
    Michael Young; Fiscal Year: 2001
    ..In addition, a ds-RNA-based method will be used to reduce activity of clock and putative clock genes in a tissue-specific manner. ..
  7. REGULATION OF DROSOPHILA NEUROMUSCULAR DEVELOPMENT
    Michael Young; Fiscal Year: 2001
    ..e) Factors regulating Notch transport to and from the cell surface, and controlling nuclear translocation of Notch will be identified and characterized using certain transport deficient Notch proteins. ..
  8. MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMS
    Michael Young; Fiscal Year: 2000
    ..To this end, proteins identified through two-hybrid interactions with Per will be followed up, and a new gene, doubletime, which can be mutated to yield flies with short rhythms, will be further characterized. ..
  9. REGULATION OF DROSOPHILA NEUROMUSCULAR DEVELOPMENT
    Michael Young; Fiscal Year: 2000
    ..5) Several new Notch extracellular binding proteins that were isolate in an f1 phage biopanning screen will be tested for functional activity in vivo. ..
  10. REGULATION OF DROSOPHILA NEUROMUSCULAR DEVELOPMENT
    Michael Young; Fiscal Year: 2004
    ..e) Factors regulating Notch transport to and from the cell surface, and controlling nuclear translocation of Notch will be identified and characterized using certain transport deficient Notch proteins. ..
  11. MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMS
    Michael Young; Fiscal Year: 2004
    ..In addition, a ds-RNA-based method will be used to reduce activity of clock and putative clock genes in a tissue-specific manner. ..
  12. Interdisciplinary studies of the Drosophila Circadian Clock
    Michael Young; Fiscal Year: 2009
    ..To begin to link the clock to specific behavioral and physiological outputs, we will investigate a novel set of genes that are regulated by a paired action of light and the circadian clock. ..
  13. Interdisciplinary studies of the Drosophila Circadian Clock
    Michael Young; Fiscal Year: 2007
    ..To begin to link the clock to specific behavioral and physiological outputs, we will investigate a novel set of genes that are regulated by a paired action of light and the circadian clock. ..
  14. MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMS
    Michael Young; Fiscal Year: 2007
    ..DBT-dependent phosphorylation regulate nuclear accumulation of PER? How does PER phosphorylation influence phosphorylation of TIM? (6) Does DBT's physical association with PER put other substrates of the kinase under circadian control? ..
  15. Interdisciplinary studies of the Drosophila Circadian Clock
    Michael Young; Fiscal Year: 2006
    ..To begin to link the clock to specific behavioral and physiological outputs, we will investigate a novel set of genes that are regulated by a paired action of light and the circadian clock. ..
  16. MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMS
    Michael Young; Fiscal Year: 2006
    ..DBT-dependent phosphorylation regulate nuclear accumulation of PER? How does PER phosphorylation influence phosphorylation of TIM? (6) Does DBT's physical association with PER put other substrates of the kinase under circadian control? ..
  17. MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMS
    Michael Young; Fiscal Year: 2005
    ..DBT-dependent phosphorylation regulate nuclear accumulation of PER? How does PER phosphorylation influence phosphorylation of TIM? (6) Does DBT's physical association with PER put other substrates of the kinase under circadian control? ..
  18. MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMS
    Michael Young; Fiscal Year: 2004
    ..In addition, a ds-RNA-based method will be used to reduce activity of clock and putative clock genes in a tissue-specific manner. ..
  19. MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMS
    Michael Young; Fiscal Year: 1999
    ..To this end, proteins identified through two-hybrid interactions with Per will be followed up, and a new gene, doubletime, which can be mutated to yield flies with short rhythms, will be further characterized. ..
  20. REGULATION OF DROSOPHILA NEUROMUSCULAR DEVELOPMENT
    Michael Young; Fiscal Year: 1999
    ..5) Several new Notch extracellular binding proteins that were isolate in an f1 phage biopanning screen will be tested for functional activity in vivo. ..
  21. REGULATION OF DROSOPHILA NEUROMUSCULAR DEVELOPMENT
    Michael Young; Fiscal Year: 1993
    ..We will search for additional molecular targets for interaction with the Notch and Delta proteins. 5) A Drosophila homologue of the neuromodulin/neurogranin gene family will be characterized at the genetic, molecular and cellular levels...
  22. GENE ORGANIZATION AND FUNCTION IN D. MELANOGASTER
    Michael Young; Fiscal Year: 1980
    ....
  23. GENE ORGANIZATION AND FUNCTION IN D MELANOGASTER
    Michael Young; Fiscal Year: 1991
    ..5) Since the structure of the Notch protein suggests that it is a cell surface-bound signal or receptor, a Drosophila factor(s) which binds to Notch protein will be sought...
  24. GENE ORGANIZATION AND FUNCTION IN D MELANOGASTER
    Michael Young; Fiscal Year: 1990
    ..5) Since the structure of the Notch protein suggests that it is a cell surface-bound signal or receptor, a Drosophila factor(s) which binds to Notch protein will be sought...