Michael W Young

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Circadian rhythms. Marking time for a kingdom
    M W Young
    Laboratory of Genetics and National Science Foundation Center for Biological Timing, The Rockefeller University, New York, NY 10021
    Science 288:451-3. 2000
  2. ncbi request reprint The molecular control of circadian behavioral rhythms and their entrainment in Drosophila
    M W Young
    National Science Foundation Science and Technology Center for Biological Timing, Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 67:135-52. 1998
  3. ncbi request reprint Diverse roles for the Notch receptor in the development of D. melanogaster
    M W Young
    Laboratory of Genetics and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Perspect Dev Neurobiol 4:345-55. 1997
  4. ncbi request reprint Life's 24-hour clock: molecular control of circadian rhythms in animal cells
    M W Young
    Laboratory of Genetics, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Trends Biochem Sci 25:601-6. 2000
  5. pmc The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period
    Shawn A Cyran
    Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 25:5430-7. 2005
  6. pmc Integration of light and temperature in the regulation of circadian gene expression in Drosophila
    Catharine E Boothroyd
    Laboratory of Genetics, The Rockefeller University, New York, New York, United States of America
    PLoS Genet 3:e54. 2007
  7. pmc Activating PER repressor through a DBT-directed phosphorylation switch
    Saul Kivimäe
    Laboratory of Genetics, The Rockefeller University, New York, New York, USA
    PLoS Biol 6:e183. 2008
  8. ncbi request reprint Molecular and statistical tools for circadian transcript profiling
    Herman Wijnen
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
    Methods Enzymol 393:341-65. 2005
  9. ncbi request reprint The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon
    B Kloss
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Cell 94:97-107. 1998
  10. ncbi request reprint Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock
    B Kloss
    Laboratory of Genetics and, National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 30:699-706. 2001

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Circadian rhythms. Marking time for a kingdom
    M W Young
    Laboratory of Genetics and National Science Foundation Center for Biological Timing, The Rockefeller University, New York, NY 10021
    Science 288:451-3. 2000
  2. ncbi request reprint The molecular control of circadian behavioral rhythms and their entrainment in Drosophila
    M W Young
    National Science Foundation Science and Technology Center for Biological Timing, Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 67:135-52. 1998
    ..The recent discovery of PER homologues in mice and humans suggests that a related mechanism controls mammalian circadian behavioral rhythms...
  3. ncbi request reprint Diverse roles for the Notch receptor in the development of D. melanogaster
    M W Young
    Laboratory of Genetics and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Perspect Dev Neurobiol 4:345-55. 1997
    ..Biochemical approaches, and exhaustive structure function studies in transgenic Drosophila are beginning to reveal how this receptor is activated, and point to a range of physical interactions with other proteins...
  4. ncbi request reprint Life's 24-hour clock: molecular control of circadian rhythms in animal cells
    M W Young
    Laboratory of Genetics, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Trends Biochem Sci 25:601-6. 2000
    ..These are assembled from the cycling RNA and protein products of a small group of genes that are conserved throughout the animal kingdom...
  5. pmc The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period
    Shawn A Cyran
    Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 25:5430-7. 2005
    ..Here, we show that these effects of SGG on PER nuclear accumulation require TIM. We propose a revised clock model that incorporates this tight kinase regulation of PER and TIM nuclear entry...
  6. pmc Integration of light and temperature in the regulation of circadian gene expression in Drosophila
    Catharine E Boothroyd
    Laboratory of Genetics, The Rockefeller University, New York, New York, United States of America
    PLoS Genet 3:e54. 2007
    ..Taken together, these findings suggest that information from both light and temperature is integrated by the transcriptional clock mechanism in the adult fly head...
  7. pmc Activating PER repressor through a DBT-directed phosphorylation switch
    Saul Kivimäe
    Laboratory of Genetics, The Rockefeller University, New York, New York, USA
    PLoS Biol 6:e183. 2008
    ....
  8. ncbi request reprint Molecular and statistical tools for circadian transcript profiling
    Herman Wijnen
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
    Methods Enzymol 393:341-65. 2005
    ..Both comparative and temporal study designs are discussed, and their use in circadian research is illustrated with examples. Data analysis methods to assess periodic components in time series data are outlined in detail...
  9. ncbi request reprint The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon
    B Kloss
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Cell 94:97-107. 1998
    ..DBT is capable of binding to PER in vitro and in Drosophila cells, suggesting that a physical association of PER and DBT regulates PER phosphorylation and accumulation in vivo...
  10. ncbi request reprint Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock
    B Kloss
    Laboratory of Genetics and, National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 30:699-706. 2001
    ..The varying associations of PER, DBT and TIM appear to determine the onset and duration of nuclear PER function within the Drosophila clock...
  11. ncbi request reprint vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock
    Shawn A Cyran
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Cell 112:329-41. 2003
    ..Thus, VRI and PDP1, together with dClock itself, comprise a second feedback loop in the Drosophila clock that gives rhythmic expression of dClock, and probably of other genes, to generate accurate circadian rhythms...
  12. ncbi request reprint Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription
    A M Sangoram
    Department of Neurobiology and Physiology and National Science Foundation, Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Neuron 21:1101-13. 1998
    ..Taken together, these results demonstrate that mTim and hTIM are mammalian orthologs of timeless and provide a framework for a basic circadian autoregulatory loop in mammals...
  13. ncbi request reprint PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock
    Pablo Meyer
    Laboratory of Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 311:226-9. 2006
    ..This finding points to a previously unrecognized form of temporal regulation that underlies the periodicity of the circadian clock...
  14. ncbi request reprint Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock
    A Rothenfluh
    Laboratory of Genetics, and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Curr Biol 10:1399-402. 2000
    ..We conclude that, in wild-type flies, the previously defined PER'short domain' [7,8] may regulate the activity of DBT on PER...
  15. ncbi request reprint Cycling vrille expression is required for a functional Drosophila clock
    J Blau
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 99:661-71. 1999
    ..We also show that dCLOCK and VRI independently regulate levels of a neuropeptide, pigment dispersing factor, which appears to regulate overt behavior...
  16. ncbi request reprint double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation
    J L Price
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Cell 94:83-95. 1998
    ..This would promote a delay between per/tim transcription and PER/TIM complex function, which is essential for molecular rhythmicity...
  17. pmc A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein
    Lino Saez
    Laboratory of Genetics, The Rockefeller University, New York, New York 10065, USA
    Genetics 188:591-600. 2011
    ..These studies confirm that TIM is required for the nuclear localization of PER and point to a key role for the TIM NLS in the regulated nuclear accumulation of both proteins...
  18. pmc Kinetics of doubletime kinase-dependent degradation of the Drosophila period protein
    Sheyum Syed
    Laboratory of Genetics, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 286:27654-62. 2011
    ..For all the other tested DBT alleles, the study provides a simple model in which the changes in Drosophila behavioral rhythms can be explained solely by changes in the rate of PER degradation...
  19. pmc Specific genetic interference with behavioral rhythms in Drosophila by expression of inverted repeats
    S Martinek
    Laboratory of Genetics, and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Genetics 156:1717-25. 2000
    ..As an example, we show that inverted-repeat-mediated interference with the period gene produces a hypomorphic period phenotype. A selective decrease of period RNA appears to be a component of the cellular response...
  20. ncbi request reprint A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock
    S Martinek
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, NY 10021, USA
    Cell 105:769-79. 2001
    ..Our results indicate a role for SGG/GSK-3 in TIMELESS phosphorylation and in the regulated nuclear translocation of the PERIOD/TIMELESS heterodimer...
  21. ncbi request reprint Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock
    M P Myers
    Howard Hughes Medical Institute, New York, NY 10021, USA
    Science 271:1736-40. 1996
    ..The phase of these rhythms was differentially advanced or delayed by light pulses delivered at different times of day, corresponding with phase shifts induced in the behavioral rhythms...
  22. ncbi request reprint Positional cloning and sequence analysis of the Drosophila clock gene, timeless
    M P Myers
    Howard Hughes Medical Institute, National Science Foundation Science and Technology Center for Biological Timing, and Laboratory of Genetics, Rockefeller University, New York, NY 10021, USA
    Science 270:805-8. 1995
    ..Absence of sequence similarity to the PER dimerization motif (PAS) indicates that direct interaction between PER and TIM would require a heterotypic protein association...
  23. pmc Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless
    J L Price
    Laboratory of Genetics, Rockefeller University, New York, NY 10021, USA
    EMBO J 14:4044-9. 1995
    ..The effects of tim on behavioral rhythms and per RNA cycling are therefore likely to involve effects on PER protein through previously proposed feedback mechanisms...
  24. doi request reprint The in(put)s and out(put)s of the Drosophila circadian clock
    Catharine E Boothroyd
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Ann N Y Acad Sci 1129:350-7. 2008
    ..Recent studies addressing temperature as an input to, and the generation of rhythmic gene expression as an output from, the Drosophila central clock are discussed...
  25. ncbi request reprint CK1 and GSK3 in the Drosophila and mammalian circadian clock
    Emily Harms
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, Box 288, New York, NY 10021, USA
    Novartis Found Symp 253:267-77; discussion 102-9, 277-84. 2003
    ..Casein Kinase 1 has been shown to be a component of the circadian clock in mammals. Recent studies are also pointing to a role for glycogen synthase kinase 3 in the mammalian clock...
  26. ncbi request reprint The 2006 Pittendrigh/Aschoff lecture: new roles for old proteins in the Drosophila circadian clock
    Pablo Meyer
    Laboratory of Genetics, The Rockefeller University, New York, NY10021, USA
    J Biol Rhythms 22:283-90. 2007
    ..The authors will then introduce a novel timing mechanism uncovered by a single cell-based assay, with the new ideas and prospects for future research that it has raised...
  27. pmc Control of daily transcript oscillations in Drosophila by light and the circadian clock
    Herman Wijnen
    Laboratory of Genetics, The Rockefeller University, New York, New York, USA
    PLoS Genet 2:e39. 2006
    ....
  28. ncbi request reprint A TIMELESS-independent function for PERIOD proteins in the Drosophila clock
    A Rothenfluh
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Neuron 26:505-14. 2000
    ..Conversion of PER/TIM heterodimers to nuclear PER proteins appears to be required to complete transcriptional repression and terminate each circadian molecular cycle...
  29. pmc Isolation and analysis of six timeless alleles that cause short- or long-period circadian rhythms in Drosophila
    A Rothenfluh
    Laboratory of Genetics, and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Genetics 156:665-75. 2000
    ..The lengthened period is partly caused by delayed nuclear translocation of TIM(L1) protein, shown directly by immunocytochemistry and indirectly by an analysis of the phase response curve of tim(L1) flies...
  30. ncbi request reprint Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless
    A Sehgal
    Howard Hughes Medical Institute, National Science Foundation Science and Technology Center for Biological Timing, Rockefeller University, New York, NY 10021
    Science 263:1603-6. 1994
    ..Genetic mapping places tim on the left arm of the second chromosome between dumpy (dp) and decapentaplegic (dpp)...
  31. ncbi request reprint Block in nuclear localization of period protein by a second clock mutation, timeless
    L B Vosshall
    Howard Hughes Medical Institute, National Science Foundation Science and Technology Center for Biological Timing, and Laboratory of Genetics, Rockefeller University, New York, NY 10021
    Science 263:1606-9. 1994
    ..This suggests that a segment of PER inhibits nuclear localization in tim mutants. The tim gene may have a role in establishing rhythms of PER abundance and nuclear localization in wild-type flies...
  32. pmc Comparison of chromosomal DNA composing timeless in Drosophila melanogaster and D. virilis suggests a new conserved structure for the TIMELESS protein
    M P Myers
    National Science Foundation Science and Technology Center for Biological Timing and Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Nucleic Acids Res 25:4710-4. 1997
    ..melanogaster. TIM translation may be affected by multiple AUG codons that appear to have been conserved in sequences composing the 5'-untranslated tim mRNA leader...
  33. pmc insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila
    Nicholas Stavropoulos
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 72:964-76. 2011
    ..The extensive evolutionary conservation of insomniac and Cul3 suggests that protein degradation pathways may have a general role in governing the sleep and wakefulness of animals...
  34. pmc Control of sleep by cyclin A and its regulator
    Dragana Rogulja
    Laboratory of Genetics, The Rockefeller University, New York, NY 10065, USA
    Science 335:1617-21. 2012
    ..CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior...
  35. ncbi request reprint Posttranscriptional and posttranslational regulation of clock genes
    Emily Harms
    Laboratory of Genetics, Rockefeller University, New York, NY 10021, USA
    J Biol Rhythms 19:361-73. 2004
    ..The combined outcome of these modifications is to adjust the timing of the clock to produce a circadian oscillator that takes approximately 24 h...
  36. ncbi request reprint Molecular genetics of timing in intrinsic circadian rhythm sleep disorders
    Herman Wijnen
    The Laboratory of Genetics, The Rockefeller University, New York, NY 10021, USA
    Ann Med 34:386-93. 2002
    ....
  37. pmc A Drosophila PIAS homologue negatively regulates stat92E
    A Betz
    Laboratories of Molecular Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:9563-8. 2001
    ..To this end we use a LOF allele and conditionally overexpressed dpias in JAK-STAT pathway mutant backgrounds. We conclude that the correct dpias/stat92E ratio is crucial for blood cell and eye development...
  38. ncbi request reprint Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
    T Lieber
    Laboratory of Genetics, Rockefeller University, New York, New York 10021
    Genes Dev 7:1949-65. 1993
    ..The cytoplasmic domain of Notch contains nuclear localization sequences that function in cultured cells, and one of the Notch antineurogenic proteins, the cytoplasmic domain, accumulates in nuclei in vivo...
  39. ncbi request reprint A PER/TIM/DBT interval timer for Drosophila's circadian clock
    L Saez
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
    Cold Spring Harb Symp Quant Biol 72:69-74. 2007
    ..The cultured cell assay provides a potent system to study interactions among new and known genes involved in the generation of circadian behavior...
  40. pmc Structure of an enclosed dimer formed by the Drosophila period protein
    Heather A King
    Laboratory of Genetics, The Rockefeller University, New York, NY 10065, USA
    J Mol Biol 413:561-72. 2011
    ..Conservation of PER interaction residues among a family of PAS-AB-containing transcription factors suggests that contacts mediating closed PAS-AB dimers serve a general function...
  41. ncbi request reprint New short period mutations of the Drosophila clock gene per
    M K Baylies
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Neuron 9:575-81. 1992
    ..Possibly mutations in the region eliminate a regulatory function provided by this segment, or substantially increase stability of the mutant protein...
  42. ncbi request reprint Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells
    L B Vosshall
    Laboratory of Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Neuron 15:345-60. 1995
    ..When we genetically removed all external photoreceptor cells, rhythms persisted in these transgenic animals. This suggests that a few central brain cells producing glass and per are capable of generating biological rhythms...
  43. pmc Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
    S Kidd
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021 6399 USA
    Genes Dev 12:3728-40. 1998
    ..Localization studies in cultured cells and embryos suggest that Su(H) plays a role in this regulation, with the relative levels of Delta, N and Su(H) determining whether a N/Su(H) complex enters the nucleus...
  44. ncbi request reprint Molecular anatomy of a light-sensitive circadian pacemaker in Drosophila
    M W Young
    National Science Foundation Science and Technology Center for Biological Timing, Howard Hughes Medical Institute, New York, New York, USA
    Cold Spring Harb Symp Quant Biol 61:279-84. 1996
  45. ncbi request reprint Time zones: a comparative genetics of circadian clocks
    M W Young
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Rev Genet 2:702-15. 2001
    ..Although autoregulatory genetic networks are a consistent feature in the design of all clocks, the weight of evidence favours their independent evolutionary origins in different kingdoms...
  46. ncbi request reprint Post-translational enzyme activation in an animal via optimized conditional protein splicing
    Edmund C Schwartz
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Chem Biol 3:50-4. 2007
    ..This technique provides a means of controlling enzymatic function with greater speed and precision than with standard genetic techniques and is a useful tool for probing biological processes...
  47. pmc Further evidence for function of the Drosophila Notch protein as a transmembrane receptor
    D Lyman
    Laboratory of Genetics, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 90:10395-9. 1993
    ..N60g11 and l(1)NB produce related gain-of-function phenotypes. It is proposed that l(1)NB produces an extracellular modification of the protein that stimulates aberrant intracellular signaling by the Notch cytoplasmic domain...
  48. pmc Identification and characterization of a p53 homologue in Drosophila melanogaster
    S Jin
    Laboratory of Cancer Biology, Genetics, and Molecular Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:7301-6. 2000
    ..It appears that p53 is structurally and functionally conserved from flies to mammals. Drosophila will provide a useful genetic system to the further study of the p53 network...
  49. ncbi request reprint Big ben rings in a lesson on biological clocks
    Michael W Young
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 36:1001-5. 2002
  50. pmc kuzbanian-mediated cleavage of Drosophila Notch
    Toby Lieber
    Laboratory of Genetics, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 16:209-21. 2002
    ..Our data suggest that in Drosophila, kuzbanian can mediate S2 cleavage of Notch...
  51. pmc An ultradian clock shapes genome expression in yeast
    Michael W Young
    Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:1118-9. 2004
  52. ncbi request reprint Single amino acid substitutions in EGF-like elements of Notch and Delta modify Drosophila development and affect cell adhesion in vitro
    T Lieber
    Laboratory of Genetics, Rockefeller University, New York, New York 10021
    Neuron 9:847-59. 1992
    ..Dlsup5 does not improve adhesiveness of spl in vitro, so suppression in vivo may involve altered developmental signaling by spl-Dlsup5 complexes, rather than modified cell adhesion...
  53. ncbi request reprint Circadian regulation of gene expression systems in the Drosophila head
    A Claridge-Chang
    Laboratories of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 32:657-71. 2001
    ..Data collected from three different clock mutants (per(0), tim(01), and Clk(Jrk)), are consistent with both known and novel regulatory mechanisms controlling circadian transcription...
  54. pmc In situ localization of the per clock protein during development of Drosophila melanogaster
    L Saez
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021 6399
    Mol Cell Biol 8:5378-85. 1988
    ..The protein accumulated in or around nuclei in some cells and appeared to be cytoplasmic in others...
  55. ncbi request reprint Igloo, a GAP-43-related gene expressed in the developing nervous system of Drosophila
    V A Neel
    Laboratory of Genetics, Rockefeller University, New York, NY 10021
    Development 120:2235-43. 1994
    ..As the Drosophila gene encodes two proteins, each with multiple calmodulin-binding domains and repeated sites for PKC phosphorylation, it may afford functions provided by the family of vertebrate genes...
  56. ncbi request reprint Structure and distribution of the Notch protein in developing Drosophila
    S Kidd
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Genes Dev 3:1113-29. 1989
    ..In the eye and embryonic ectoderm, uniform expression on cells interacting to produce different developmental lineages from a single primordium suggests that Notch alone may not be sufficient to elaborate cell fates...
  57. ncbi request reprint A role for the Drosophila neurogenic genes in mesoderm differentiation
    V Corbin
    Laboratory of Genetics, Rockefeller University, New York, New York
    Cell 67:311-23. 1991
    ..We propose that the signal produced by the neurogenic genes is a general one, effective in both ectoderm and mesoderm...
  58. ncbi request reprint Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus
    M R Kelley
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Cell 51:539-48. 1987
    ..EGF-like elements in a second region of the Notch protein appear to govern its interaction with the product of Enhancer of split, another neurogenic locus of D. melanogaster...
  59. doi request reprint Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock
    Tatsumori Sekine
    Division of Insect Sciences, National Institute of Agrobiological Sciences, Ohwashi 1 2, Tsukuba, Ibaraki 305 8634, Japan
    J Biol Rhythms 23:3-15. 2008
    ..Thus, caution should be used in interpreting assays that measure activity of mammalian casein kinase mutants in Drosophila, or that employ vertebrate CKI in studies of dPER phosphorylations...
  60. ncbi request reprint Interplay of circadian clocks and metabolic rhythms
    Herman Wijnen
    Department of Biology, University of Virginia, Charlottesville, Virginia 22904 4328, USA
    Annu Rev Genet 40:409-48. 2006
    ..The potential connections between circadian oscillations in gene expression and circadian oscillations in metabolic activity are a major focus of this review...