Gene Wei Ming Yeo

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. pmc Splicing regulators: targets and drugs
    Gene Wei Ming Yeo
    Crick Jacobs Center for Computational and Theoretical Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Genome Biol 6:240. 2005
  2. pmc Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements
    Gene W Yeo
    Crick Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, United States of America
    PLoS Genet 3:e85. 2007
  3. pmc Alternative splicing events identified in human embryonic stem cells and neural progenitors
    Gene W Yeo
    Crick Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, USA
    PLoS Comput Biol 3:1951-67. 2007
  4. pmc An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells
    Gene W Yeo
    Crick Jacobs Center for Theoretical and Computational Biology, Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Struct Mol Biol 16:130-7. 2009
  5. pmc Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model
    Hairi Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Proc Natl Acad Sci U S A 105:20179-84. 2008
  6. doi request reprint Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells
    Gene W Yeo
    Laboratory of Genetics, Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Hum Mol Genet 17:R67-75. 2008
  7. doi request reprint Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice
    Sandrine Thuret
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Hippocampus 19:658-69. 2009
  8. pmc L1 retrotransposition in human neural progenitor cells
    Nicole G Coufal
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 460:1127-31. 2009
  9. pmc Transcriptional signature and memory retention of human-induced pluripotent stem cells
    Maria C N Marchetto
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California, USA
    PLoS ONE 4:e7076. 2009
  10. doi request reprint A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells
    Andrew Hinton
    Pediatric Diabetes Research Center, Stem Cell Program, University of California, San Diego, La Jolla, California, USA
    Stem Cells Dev 19:797-807. 2010

Collaborators

  • Fred Gage
  • Alysson Muotri
  • Amy E Pasquinelli
  • M Marsala
  • John Moran
  • Beate Winner
  • Michael T Lovci
  • Dimitrios G Zisoulis
  • Andrew Hinton
  • Sandrine Thuret
  • Maria C N Marchetto
  • Nicole G Coufal
  • Hairi Li
  • Kasey R Hutt
  • Mike Wilson
  • Brian Maurer
  • Ivka Afrikanova
  • Melissa L Wilbert
  • Alberto Hayek
  • Tiffany Y Liang
  • Charles C King
  • Stefan Aigner
  • Yangling Mu
  • Osamu Kainohana
  • Grace E Peng
  • Jose L Garcia-Perez
  • Nicolas Toni
  • Maria Morell
  • K Sue O'Shea
  • Xiang Dong Fu
  • Young Soo Kwon
  • Michael G Rosenfeld

Detail Information

Publications11

  1. pmc Splicing regulators: targets and drugs
    Gene Wei Ming Yeo
    Crick Jacobs Center for Computational and Theoretical Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Genome Biol 6:240. 2005
    ....
  2. pmc Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements
    Gene W Yeo
    Crick Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, United States of America
    PLoS Genet 3:e85. 2007
    ..Our results demonstrate that ISREs are crucial building blocks in understanding general and tissue-specific AS regulation and the biological pathways and functions regulated by these AS events...
  3. pmc Alternative splicing events identified in human embryonic stem cells and neural progenitors
    Gene W Yeo
    Crick Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, USA
    PLoS Comput Biol 3:1951-67. 2007
    ..In summary, a new methodology for exon array analysis was introduced, leading to new insights into the complexity of AS in human embryonic stem cells and their transition to neural stem cells...
  4. pmc An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells
    Gene W Yeo
    Crick Jacobs Center for Theoretical and Computational Biology, Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Struct Mol Biol 16:130-7. 2009
    ..These findings suggest that FOX2 functions as a critical regulator of a splicing network, and we further show that FOX2 is important for the survival of human embryonic stem cells...
  5. pmc Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model
    Hairi Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Proc Natl Acad Sci U S A 105:20179-84. 2008
    ..This study provides a general guide for analysis of gene expression and alternative splicing by deep sequencing...
  6. doi request reprint Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells
    Gene W Yeo
    Laboratory of Genetics, Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Hum Mol Genet 17:R67-75. 2008
    ..An integrative view of the different levels will hopefully provide much needed insight into understanding stem cell biology...
  7. doi request reprint Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice
    Sandrine Thuret
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Hippocampus 19:658-69. 2009
    ..Together, these results suggest that adult neurogenesis is correlated with spatial learning and visual recognition learning, possibly by modulating morphological plasticity in the dentate gyrus...
  8. pmc L1 retrotransposition in human neural progenitor cells
    Nicole G Coufal
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 460:1127-31. 2009
    ..These data suggest that de novo L1 retrotransposition events may occur in the human brain and, in principle, have the potential to contribute to individual somatic mosaicism...
  9. pmc Transcriptional signature and memory retention of human-induced pluripotent stem cells
    Maria C N Marchetto
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California, USA
    PLoS ONE 4:e7076. 2009
    ..Moreover, the episomal reprogramming strategy represents a safe way to generate human iPSCs for clinical purposes and basic research...
  10. doi request reprint A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells
    Andrew Hinton
    Pediatric Diabetes Research Center, Stem Cell Program, University of California, San Diego, La Jolla, California, USA
    Stem Cells Dev 19:797-807. 2010
    ..Examination of potential mRNA targets showed that TIMM8A is repressed by ectopic miR-375 expression in pluripotent hESCs...
  11. pmc Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
    Dimitrios G Zisoulis
    Department of Biology, Stem Cell Program, University of California, San Diego, La Jolla, California, USA
    Nat Struct Mol Biol 17:173-9. 2010
    ..Furthermore, our analyses revealed a striking enrichment of Argonaute binding sites in genes important for miRNA function, suggesting an autoregulatory role that may confer robustness to the miRNA pathway...