Edward T Yeh

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint CRP as a mediator of disease
    Edward T H Yeh
    Research Center for Cardiovascular Diseases, University of Texas Houston Health Science Center, USA
    Circulation 109:II11-4. 2004
  2. ncbi request reprint The potential role of antiplatelet agents in modulating inflammatory markers in atherothrombosis
    E T H Yeh
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, and Coronary Care Unit and Vascular Research, Grady Memorial Hospital, Atlanta, GA, USA
    J Thromb Haemost 4:2308-16. 2006
  3. pmc A novel approach to studying transformation of human stem cells into cardiac cells in vivo
    Edward T H Yeh
    Department of Cardiology, The University of Texas, MD Anderson Cancer Center, Brown Foundation Institute of Moleclar Medicine for the Prevention of Human Diseases, Houston, USA
    Can J Cardiol 22:66B-71B. 2006
  4. ncbi request reprint Cardiotoxicity induced by chemotherapy and antibody therapy
    Edward T H Yeh
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Annu Rev Med 57:485-98. 2006
  5. ncbi request reprint Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo
    Edward T H Yeh
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Tex, USA
    Circulation 108:2070-3. 2003
  6. pmc SUMOylation and De-SUMOylation: wrestling with life's processes
    Edward T H Yeh
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:8223-7. 2009
  7. doi request reprint Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management
    Edward T H Yeh
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Cardiol 53:2231-47. 2009
  8. ncbi request reprint High-sensitivity C-reactive protein as a risk assessment tool for cardiovascular disease
    Edward T H Yeh
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Clin Cardiol 28:408-12. 2005
  9. ncbi request reprint C-reactive protein: the pawn has been promoted to queen
    Edward T H Yeh
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 449, Houston, TX 77030 4095, USA
    Curr Atheroscler Rep 5:101-5. 2003
  10. ncbi request reprint Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management
    Edward T H Yeh
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Tex 77030 4095, USA
    Circulation 109:3122-31. 2004

Research Grants

Collaborators

Detail Information

Publications39

  1. ncbi request reprint CRP as a mediator of disease
    Edward T H Yeh
    Research Center for Cardiovascular Diseases, University of Texas Houston Health Science Center, USA
    Circulation 109:II11-4. 2004
    ..Antiatherosclerotic drugs may be exerting some of their beneficial effects by inhibiting the harmful effects of CRP...
  2. ncbi request reprint The potential role of antiplatelet agents in modulating inflammatory markers in atherothrombosis
    E T H Yeh
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, and Coronary Care Unit and Vascular Research, Grady Memorial Hospital, Atlanta, GA, USA
    J Thromb Haemost 4:2308-16. 2006
    ..Ongoing studies will provide further insight into routine assessment of inflammatory markers as a guide to the management of patients with atherothrombosis...
  3. pmc A novel approach to studying transformation of human stem cells into cardiac cells in vivo
    Edward T H Yeh
    Department of Cardiology, The University of Texas, MD Anderson Cancer Center, Brown Foundation Institute of Moleclar Medicine for the Prevention of Human Diseases, Houston, USA
    Can J Cardiol 22:66B-71B. 2006
    ..This analytical method should provide a novel approach to identifying the mechanisms of stem cell transformation into cardiomyocytes in vivo...
  4. ncbi request reprint Cardiotoxicity induced by chemotherapy and antibody therapy
    Edward T H Yeh
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Annu Rev Med 57:485-98. 2006
    ..Strategies to monitor for and to manage these effects are discussed in this review...
  5. ncbi request reprint Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo
    Edward T H Yeh
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Tex, USA
    Circulation 108:2070-3. 2003
    ..We investigated whether these cells could also transdifferentiate into human cardiomyocytes, mature endothelial cells, and smooth muscle cells in vivo...
  6. pmc SUMOylation and De-SUMOylation: wrestling with life's processes
    Edward T H Yeh
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:8223-7. 2009
    ..This review will focus on the de-SUMOylating enzymes with special attention to their biological function...
  7. doi request reprint Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management
    Edward T H Yeh
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Cardiol 53:2231-47. 2009
    ....
  8. ncbi request reprint High-sensitivity C-reactive protein as a risk assessment tool for cardiovascular disease
    Edward T H Yeh
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Clin Cardiol 28:408-12. 2005
    ..Statin therapy and other interventions can lower hs-CRP. Whether or not such reductions can prevent cardiovascular events is under investigation...
  9. ncbi request reprint C-reactive protein: the pawn has been promoted to queen
    Edward T H Yeh
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 449, Houston, TX 77030 4095, USA
    Curr Atheroscler Rep 5:101-5. 2003
    ..Developing consensus to incorporate CRP determination into clinical practice guidelines will be the subject of intense debate and at the same time provide clinical research opportunities in the years to come...
  10. ncbi request reprint Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management
    Edward T H Yeh
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Tex 77030 4095, USA
    Circulation 109:3122-31. 2004
    ..Further research will be required to more accurately predict which patients are at risk for developing cardiotoxicity. In addition, management plans, as well as strategies to reduce cardiotoxicity, need to be developed...
  11. ncbi request reprint Both cell fusion and transdifferentiation account for the transformation of human peripheral blood CD34-positive cells into cardiomyocytes in vivo
    Sui Zhang
    Department of Cardiology, University of Texas M D Anderson Cancer Center, Houston, Tex 77030, USA
    Circulation 110:3803-7. 2004
    ..It remains unclear, however, whether the apparent transformation is the result of transdifferentiation of the donor stem cells or of fusion of the donor cell with the cardiomyocyte of the recipients...
  12. pmc Targeting constitutively activated β1 integrins inhibits prostate cancer metastasis
    Yu Chen Lee
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Res 11:405-17. 2013
    ..Thus, constitutively activated β1 integrins play a role in survival of PC3-mm2 cells in circulation and represent a potential target for metastasis prevention...
  13. doi request reprint The diagnosis and management of cardiovascular disease in cancer patients
    Syed Wamique Yusuf
    University of Texas MD Anderson Cancer Center, TX, USA
    Curr Probl Cardiol 33:163-96. 2008
    ..The cardiac complications of cancer therapy will be discussed according to common syndromes: left ventricular dysfunction, myocardial ischemia, blood pressure changes, thromboembolism, bradyarrhythmias, and prolonged QT interval...
  14. doi request reprint Therapy insight: Management of cardiovascular disease in patients with cancer and cardiac complications of cancer therapy
    Aarif Y Khakoo
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Nat Clin Pract Oncol 5:655-67. 2008
    ..In this Review, we discuss management strategies for cardiovascular disease in patients with cancer, focusing on the prevention and treatment of congestive heart failure and myocardial infarction...
  15. pmc Human CD34+ cells in experimental myocardial infarction: long-term survival, sustained functional improvement, and mechanism of action
    Jingxiong Wang
    University of Texas MD Anderson Cancer Center, 1400 Pressler Blvd, Box 1451, Houston, TX 77030, USA
    Circ Res 106:1904-11. 2010
    ..However, it is unknown how long the CD34(+) cells persist in hearts, whether the improvement in cardiac function is sustained, or what are the underlying mechanisms...
  16. ncbi request reprint Coming of age of C-reactive protein: using inflammation markers in cardiology
    Edward T H Yeh
    University of Texas Houston Health Science Center, Houston, Tex, USA
    Circulation 107:370-1. 2003
  17. ncbi request reprint Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells
    Paolo Calabro
    Department of Cardiology, University of Texas M D Anderson Cancer Center, Houston, Tex 77030 4095, USA
    Circulation 108:1930-2. 2003
    ..Several lines of evidence have suggested that atherosclerotic arteries can also produce CRP. However, the cell types that produce CRP locally in the atherosclerotic arterial wall have not been clearly identified...
  18. doi request reprint Vascular complications of selected cancer therapies
    Iyad N Daher
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Clin Pract Cardiovasc Med 5:797-805. 2008
    ..This Review describes the vascular complications of treatment with 5-fluorouracil, bevacizumab, and several new tyrosine kinase inhibitors, with special emphasis on thrombotic complications and hypertension...
  19. pmc PROCLAIM: pilot study to examine the effects of clopidogrel on inflammatory markers in patients with metabolic syndrome receiving low-dose aspirin
    James T Willerson
    Cullen Cardiovascular Research Laboratories, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Tex Heart Inst J 36:530-9. 2009
    ..There were no deaths or serious adverse events in either treatment arm. Data from this study suggest that clopidogrel can decrease the expression of the CD40-ligand biomarker...
  20. pmc Cadherin-11 promotes the metastasis of prostate cancer cells to bone
    Khoi Chu
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Res 6:1259-67. 2008
    ..Cadherin-11 expression was not detected in metastatic lesions that occur in other organs. Collectively, these findings suggest that cadherin-11 is involved in the metastasis of prostate cancer cells to bone...
  21. ncbi request reprint C-reactive protein is an essential aspect of cardiovascular risk factor stratification
    Edward T H Yeh
    The University of Texas MD Anderson Cancer Center, Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Houston Health Science Center, Houston, Texas 77030, USA
    Can J Cardiol 20:93B-96B. 2004
    ..The author has recently demonstrated that CRP can be produced by vascular smooth muscle cells in response to inflammatory cytokines. Thus, CRP can be produced in the vascular wall and directly exerts its proatherogenic effect locally...
  22. ncbi request reprint Multitasking of the 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor: beyond cardiovascular diseases
    Paolo Calabro
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 449, Houston, TX 77030 4095, USA
    Curr Atheroscler Rep 6:36-41. 2004
    ..However, because these studies have been only preliminary and observational in nature, large randomized, placebo-controlled studies are needed to confirm the modulatory role of statins in these important diseases...
  23. ncbi request reprint Fusion of human hematopoietic progenitor cells and murine cardiomyocytes is mediated by alpha 4 beta 1 integrin/vascular cell adhesion molecule-1 interaction
    Sui Zhang
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Circ Res 100:693-702. 2007
    ..Thus, hematopoietic progenitor cell and cardiomyocyte fusion is mediated by alpha4beta1/VCAM-1 interaction, leading to cell cycle reentry and cellular proliferation...
  24. pmc Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex
    Hong Dou
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, The University of Texas Houston Health Science Center, Houston, TX 77030, USA
    Mol Cell 39:333-45. 2010
    ..These results demonstrate that SUMOylation status of RPA70 plays a critical role in the regulation of DNA repair through homologous recombination...
  25. ncbi request reprint Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L
    Tomoaki Tanaka
    Department of Cardiology, The University of Texas M D Anderson Cancer Center and Institute of Molecular Medicine, The University of Texas Houston Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 278:32905-13. 2003
    ..The NEDD8-binding ability at the UBA2 domain might be required for an unknown function of NUB1L...
  26. ncbi request reprint A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation
    David Owerbach
    Molecular Diabetes and Metabolism Section and the Harry B and Aileen B Gordon Diabetes Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Biochem Biophys Res Commun 337:517-20. 2005
    ..Native SUMO-4, thus, appears to be unable to form covalent isopeptide bonds with substrates. A biological role of SUMO-4, through non-covalent interactions is proposed...
  27. ncbi request reprint A proatherogenic role for C-reactive protein in vivo
    Antoni Paul
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Lipidol 16:512-7. 2005
    ..We have selectively reviewed some of the latest papers on the mechanistic role of C-reactive protein in atherosclerotic cardiovascular disease...
  28. pmc SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
    Jinke Cheng
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, The University of Texas, Houston Health Science Center, Houston, TX 77030, USA
    Cell 131:584-95. 2007
    ..These results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation...
  29. ncbi request reprint Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells
    TASNEEM BAWA-KHALFE
    Research Center for Cardiovascular Diseases, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, TX 77030, USA
    J Biol Chem 282:37341-9. 2007
    ..Because increased SENP1 expression directly modulated androgen receptor-dependent cell proliferation and transcription, SENP1 could play an important role in prostate carcinogenesis...
  30. ncbi request reprint Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases
    Jinke Cheng
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:14492-8. 2005
    ..Thus, two SUMO-specific proteases regulate c-Jun-dependent transcription through entirely different mechanisms...
  31. pmc SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1
    Jinke Cheng
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 24:6021-8. 2004
    ..Thus, SENP1 could regulate AR-dependent transcription through desumoylation of HDAC1. These studies provide insights on the potential role of desumoylation in the regulation of nuclear receptor activity...
  32. ncbi request reprint C-reactive protein: structure affects function
    Subodh Verma
    Division of Cardiac Surgery, University of Toronto, Toronto, Canada
    Circulation 109:1914-7. 2004
  33. ncbi request reprint The pleiotropic effects of statins
    Paolo Calabro
    Division of Cardiology, University of Naples Federico II Naples, Italy
    Curr Opin Cardiol 20:541-6. 2005
    ....
  34. ncbi request reprint C-reactive protein and atherothrombosis--beyond a biomarker: an actual partaker of lesion formation
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, 14EN 215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Am J Physiol Regul Integr Comp Physiol 285:R1253-6; discussion R1257-8. 2003
  35. ncbi request reprint Intra-abdominal adiposity, inflammation, and cardiovascular risk: new insight into global cardiometabolic risk
    Paolo Calabro
    Division of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples, Naples, Italy
    Curr Hypertens Rep 10:32-8. 2008
    ....
  36. ncbi request reprint Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation
    Paolo Calabro
    J Am Coll Cardiol 46:1112-3. 2005
  37. ncbi request reprint Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways
    Paolo Calabro
    Research Center for Cardiovascular Diseases at the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, USA
    Circulation 110:3335-40. 2004
    ..Thus, the purpose of this study was to assess whether resistin could induce SMC proliferation and to study the mechanisms whereby resistin signals in SMCs...
  38. ncbi request reprint A new perspective on the biology of C-reactive protein
    Edward T H Yeh
    Circ Res 97:609-11. 2005
  39. ncbi request reprint Blood-derived progenitor cells after recanalization of chronic coronary artery occlusions in humans
    James T Willerson
    Circ Res 97:735-6. 2005

Research Grants7

  1. PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA
    Edward Yeh; Fiscal Year: 2000
    ..These studies should provide novel insights into the mechanism and function of sentrinization and increase our understanding of the pathogenesis of acute promyelocytic leukemia. ..
  2. PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA
    Edward Yeh; Fiscal Year: 2001
    ..These studies should provide novel insights into the mechanism and function of sentrinization and increase our understanding of the pathogenesis of acute promyelocytic leukemia. ..
  3. PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA
    Edward Yeh; Fiscal Year: 2002
    ..These studies should provide novel insights into the mechanism and function of sentrinization and increase our understanding of the pathogenesis of acute promyelocytic leukemia. ..
  4. PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA
    Edward Yeh; Fiscal Year: 2003
    ..These studies should provide novel insights into the mechanism and function of sentrinization and increase our understanding of the pathogenesis of acute promyelocytic leukemia. ..
  5. PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA
    Edward Yeh; Fiscal Year: 2004
    ..These studies should provide novel insights into the mechanism and function of sentrinization and increase our understanding of the pathogenesis of acute promyelocytic leukemia. ..
  6. De-SUMOylation and the Hypoxic Response
    Edward Yeh; Fiscal Year: 2009
    ..We will study how SENP1 is regulated by hypoxia, how HIF11 is modified by SUMO, and how SENP1 can regulate the development of normal and abnormal blood vessels. ..
  7. De-SUMOylation and the Hypoxic Response
    Edward T H Yeh; Fiscal Year: 2010
    ..We will study how SENP1 is regulated by hypoxia, how HIF11 is modified by SUMO, and how SENP1 can regulate the development of normal and abnormal blood vessels. ..