Research Topics
Species | Edward T YehSummaryAffiliation: The University of Texas Country: USA Publications
Research Grants
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Detail Information
Publications
High-sensitivity C-reactive protein as a risk assessment tool for cardiovascular diseaseEdward T H Yeh
Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
Clin Cardiol 28:408-12. 2005..Statin therapy and other interventions can lower hs-CRP. Whether or not such reductions can prevent cardiovascular events is under investigation...- Cardiotoxicity induced by chemotherapy and antibody therapyEdward T H Yeh
Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Annu Rev Med 57:485-98. 2006..Strategies to monitor for and to manage these effects are discussed in this review... 
A novel approach to studying transformation of human stem cells into cardiac cells in vivoEdward T H Yeh
Department of Cardiology, The University of Texas, MD Anderson Cancer Center, Brown Foundation Institute of Moleclar Medicine for the Prevention of Human Diseases, Houston, USA
Can J Cardiol 22:66B-71B. 2006..This analytical method should provide a novel approach to identifying the mechanisms of stem cell transformation into cardiomyocytes in vivo...- The potential role of antiplatelet agents in modulating inflammatory markers in atherothrombosisE T H Yeh
Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, and Coronary Care Unit and Vascular Research, Grady Memorial Hospital, Atlanta, GA, USA
J Thromb Haemost 4:2308-16. 2006..Ongoing studies will provide further insight into routine assessment of inflammatory markers as a guide to the management of patients with atherothrombosis... - Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and managementEdward T H Yeh
Department of Cardiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Tex 77030 4095, USA
Circulation 109:3122-31. 2004..Further research will be required to more accurately predict which patients are at risk for developing cardiotoxicity. In addition, management plans, as well as strategies to reduce cardiotoxicity, need to be developed... - CRP as a mediator of diseaseEdward T H Yeh
Research Center for Cardiovascular Diseases, University of Texas Houston Health Science Center, USA
Circulation 109:II11-4. 2004..Antiatherosclerotic drugs may be exerting some of their beneficial effects by inhibiting the harmful effects of CRP... - SUMOylation and De-SUMOylation: wrestling with life's processesEdward T H Yeh
Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 284:8223-7. 2009..This review will focus on the de-SUMOylating enzymes with special attention to their biological function... 
Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and managementEdward T H Yeh
Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Am Coll Cardiol 53:2231-47. 2009....- Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivoEdward T H Yeh
Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Tex, USA
Circulation 108:2070-3. 2003..We investigated whether these cells could also transdifferentiate into human cardiomyocytes, mature endothelial cells, and smooth muscle cells in vivo... - C-reactive protein: the pawn has been promoted to queenEdward T H Yeh
Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 449, Houston, TX 77030 4095, USA
Curr Atheroscler Rep 5:101-5. 2003..Developing consensus to incorporate CRP determination into clinical practice guidelines will be the subject of intense debate and at the same time provide clinical research opportunities in the years to come... - Both cell fusion and transdifferentiation account for the transformation of human peripheral blood CD34-positive cells into cardiomyocytes in vivoSui Zhang
Department of Cardiology, University of Texas-M.D. Anderson Cancer Center, Houston, Tex 77030, USA
Circulation 110:3803-7. 2004..CONCLUSIONS: Thus, both cell fusion and transdifferentiation may account for the transformation of peripheral blood CD34+ cells into cardiomyocytes in vivo... - Human CD34+ cells in experimental myocardial infarction: long-term survival, sustained functional improvement, and mechanism of actionJingxiong Wang
University of Texas MD Anderson Cancer Center, 1400 Pressler Blvd, Box 1451, Houston, TX 77030, USA
Circ Res 106:1904-11. 2010..However, it is unknown how long the CD34(+) cells persist in hearts, whether the improvement in cardiac function is sustained, or what are the underlying mechanisms... - The diagnosis and management of cardiovascular disease in cancer patientsSyed Wamique Yusuf
University of Texas MD Anderson Cancer Center, TX, USA
Curr Probl Cardiol 33:163-96. 2008..The cardiac complications of cancer therapy will be discussed according to common syndromes: left ventricular dysfunction, myocardial ischemia, blood pressure changes, thromboembolism, bradyarrhythmias, and prolonged QT interval... - Coming of age of C-reactive protein: using inflammation markers in cardiologyEdward T H Yeh
University of Texas-Houston Health Science Center, Houston, Tex, USA
Circulation 107:370-1. 2003 - Therapy insight: Management of cardiovascular disease in patients with cancer and cardiac complications of cancer therapyAarif Y Khakoo
Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
Nat Clin Pract Oncol 5:655-67. 2008..In this Review, we discuss management strategies for cardiovascular disease in patients with cancer, focusing on the prevention and treatment of congestive heart failure and myocardial infarction... - Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cellsPaolo Calabro
Department of Cardiology, University of Texas M D Anderson Cancer Center, Houston, Tex 77030 4095, USA
Circulation 108:1930-2. 2003..Several lines of evidence have suggested that atherosclerotic arteries can also produce CRP. However, the cell types that produce CRP locally in the atherosclerotic arterial wall have not been clearly identified... - PROCLAIM: pilot study to examine the effects of clopidogrel on inflammatory markers in patients with metabolic syndrome receiving low-dose aspirinJames T Willerson
Cullen Cardiovascular Research Laboratories, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
Tex Heart Inst J 36:530-9. 2009..There were no deaths or serious adverse events in either treatment arm. Data from this study suggest that clopidogrel can decrease the expression of the CD40-ligand biomarker... - Vascular complications of selected cancer therapiesIyad N Daher
Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Nat Clin Pract Cardiovasc Med 5:797-805. 2008..This Review describes the vascular complications of treatment with 5-fluorouracil, bevacizumab, and several new tyrosine kinase inhibitors, with special emphasis on thrombotic complications and hypertension... - C-reactive protein is an essential aspect of cardiovascular risk factor stratificationEdward T H Yeh
The University of Texas MD Anderson Cancer Center, Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Houston Health Science Center, Houston, Texas 77030, USA
Can J Cardiol 20:93B-96B. 2004..The author has recently demonstrated that CRP can be produced by vascular smooth muscle cells in response to inflammatory cytokines. Thus, CRP can be produced in the vascular wall and directly exerts its proatherogenic effect locally... - Cadherin-11 promotes the metastasis of prostate cancer cells to boneKhoi Chu
Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Mol Cancer Res 6:1259-67. 2008..Cadherin-11 expression was not detected in metastatic lesions that occur in other organs. Collectively, these findings suggest that cadherin-11 is involved in the metastasis of prostate cancer cells to bone... - Fusion of human hematopoietic progenitor cells and murine cardiomyocytes is mediated by alpha 4 beta 1 integrin/vascular cell adhesion molecule-1 interactionSui Zhang
Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Circ Res 100:693-702. 2007..Thus, hematopoietic progenitor cell and cardiomyocyte fusion is mediated by alpha4beta1/VCAM-1 interaction, leading to cell cycle reentry and cellular proliferation... - Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complexHong Dou
Department of Cardiology, The University of Texas MD Anderson Cancer Center, The University of Texas Houston Health Science Center, Houston, TX 77030, USA
Mol Cell 39:333-45. 2010..These results demonstrate that SUMOylation status of RPA70 plays a critical role in the regulation of DNA repair through homologous recombination... - Multitasking of the 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor: beyond cardiovascular diseasesPaolo Calabro
Department of Cardiology, The University of Texas-MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 449, Houston, TX 77030-4095, USA
Curr Atheroscler Rep 6:36-41. 2004..However, because these studies have been only preliminary and observational in nature, large randomized, placebo-controlled studies are needed to confirm the modulatory role of statins in these important diseases... - SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1Jinke Cheng
Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cell Biol 24:6021-8. 2004..Thus, SENP1 could regulate AR-dependent transcription through desumoylation of HDAC1. These studies provide insights on the potential role of desumoylation in the regulation of nuclear receptor activity... - Differential regulation of c-Jun-dependent transcription by SUMO-specific proteasesJinke Cheng
Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 280:14492-8. 2005..Thus, two SUMO-specific proteases regulate c-Jun-dependent transcription through entirely different mechanisms... - A proatherogenic role for C-reactive protein in vivoAntoni Paul
Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Curr Opin Lipidol 16:512-7. 2005..We have selectively reviewed some of the latest papers on the mechanistic role of C-reactive protein in atherosclerotic cardiovascular disease... - SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxiaJinke Cheng
Department of Cardiology, The University of Texas MD Anderson Cancer Center, The University of Texas, Houston Health Science Center, Houston, TX 77030, USA
Cell 131:584-95. 2007..These results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation... - Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cellsTASNEEM BAWA-KHALFE
Research Center for Cardiovascular Diseases, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, TX 77030, USA
J Biol Chem 282:37341-9. 2007..Because increased SENP1 expression directly modulated androgen receptor-dependent cell proliferation and transcription, SENP1 could play an important role in prostate carcinogenesis... - Regulation of the NEDD8 conjugation system by a splicing variant, NUB1LTomoaki Tanaka
Department of Cardiology, The University of Texas M D Anderson Cancer Center and Institute of Molecular Medicine, The University of Texas Houston Health Science Center, Houston, Texas 77030, USA
J Biol Chem 278:32905-13. 2003..The NEDD8-binding ability at the UBA2 domain might be required for an unknown function of NUB1L... - A proline-90 residue unique to SUMO-4 prevents maturation and sumoylationDavid Owerbach
Molecular Diabetes and Metabolism Section and the Harry B and Aileen B Gordon Diabetes Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Biochem Biophys Res Commun 337:517-20. 2005..Native SUMO-4, thus, appears to be unable to form covalent isopeptide bonds with substrates. A biological role of SUMO-4, through non-covalent interactions is proposed... - C-reactive protein and atherothrombosis--beyond a biomarker: an actual partaker of lesion formationSubodh Verma
Division of Cardiac Surgery, Toronto General Hospital, 14EN-215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
Am J Physiol Regul Integr Comp Physiol 285:R1253-6; discussion R1257-8. 2003 - C-reactive protein: structure affects functionSubodh Verma
Division of Cardiac Surgery, University of Toronto, Toronto, Canada
Circulation 109:1914-7. 2004 - The pleiotropic effects of statinsPaolo Calabro
Division of Cardiology, University of Naples Federico II Naples, Italy
Curr Opin Cardiol 20:541-6. 2005.... - Intra-abdominal adiposity, inflammation, and cardiovascular risk: new insight into global cardiometabolic riskPaolo Calabro
Division of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples, Naples, Italy
Curr Hypertens Rep 10:32-8. 2008.... - Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathwaysPaolo Calabro
Research Center for Cardiovascular Diseases at the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, USA
Circulation 110:3335-40. 2004..Thus, the purpose of this study was to assess whether resistin could induce SMC proliferation and to study the mechanisms whereby resistin signals in SMCs... - Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammationPaolo Calabro
J Am Coll Cardiol 46:1112-3. 2005 - A new perspective on the biology of C-reactive proteinEdward T H Yeh
Circ Res 97:609-11. 2005 - Blood-derived progenitor cells after recanalization of chronic coronary artery occlusions in humansJames T Willerson
Circ Res 97:735-6. 2005
Research Grants
- PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIAEdward Yeh; Fiscal Year: 2004..These studies should provide novel insights into the mechanism and function of sentrinization and increase our understanding of the pathogenesis of acute promyelocytic leukemia. ..
- De-SUMOylation and the Hypoxic ResponseEdward T H Yeh; Fiscal Year: 2010..We will study how SENP1 is regulated by hypoxia, how HIF11 is modified by SUMO, and how SENP1 can regulate the development of normal and abnormal blood vessels. ..