Mark J Yeager

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Structure of gap junction intercellular channels
    M Yeager
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 6:183-92. 1996
  2. pmc Supramolecular organization of immature and mature murine leukemia virus revealed by electron cryo-microscopy: implications for retroviral assembly mechanisms
    M Yeager
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:7299-304. 1998
  3. ncbi request reprint Synthesis, assembly and structure of gap junction intercellular channels
    M Yeager
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 8:517-24. 1998
  4. pmc Gap junction channel structure in the early 21st century: facts and fantasies
    Mark Yeager
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 19:521-8. 2007
  5. ncbi request reprint Membrane topology and quaternary structure of cardiac gap junction ion channels
    M Yeager
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037
    J Mol Biol 223:929-48. 1992
  6. ncbi request reprint The structure of pariacoto virus reveals a dodecahedral cage of duplex RNA
    L Tang
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Struct Biol 8:77-83. 2001
  7. ncbi request reprint Localization of membrane permeabilization and receptor binding sites on the VP4 hemagglutinin of rotavirus: implications for cell entry
    M Tihova
    Departments of Cell and Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA
    J Mol Biol 314:985-92. 2001
  8. ncbi request reprint Structural determinants of rotavirus subgroup specificity mapped by cryo-electron microscopy
    Sarah L Greig
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Mol Biol 356:209-21. 2006

Research Grants

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Structure of gap junction intercellular channels
    M Yeager
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 6:183-92. 1996
    ....
  2. pmc Supramolecular organization of immature and mature murine leukemia virus revealed by electron cryo-microscopy: implications for retroviral assembly mechanisms
    M Yeager
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:7299-304. 1998
    ..The maturation process involves a dramatic reorganization of the packing arrangements within the ribonucleoprotein core with disordering and loosening of the individual protein components...
  3. ncbi request reprint Synthesis, assembly and structure of gap junction intercellular channels
    M Yeager
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 8:517-24. 1998
    ..The potential to correlate the structure and biochemistry of gap junction channels with recently identified human diseases involving connexin mutations makes this a particularly exciting area of research...
  4. pmc Gap junction channel structure in the early 21st century: facts and fantasies
    Mark Yeager
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 19:521-8. 2007
    ..An experimentally determined structure at atomic resolution will be essential to confirm and resolve these concepts...
  5. ncbi request reprint Membrane topology and quaternary structure of cardiac gap junction ion channels
    M Yeager
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037
    J Mol Biol 223:929-48. 1992
    ..The similar hexameric architecture of cardiac and liver gap junction connexins indicates conservation in the molecular design of the gap junction channels formed by alpha or beta connexins...
  6. ncbi request reprint The structure of pariacoto virus reveals a dodecahedral cage of duplex RNA
    L Tang
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Struct Biol 8:77-83. 2001
    ..The C-terminal segments (residues 394-401) of the A subunits lie in channels near the quasi three-fold axes. Electron cryo-microscopy and image reconstruction of PaV particles clearly show the dodecahedral RNA cage...
  7. ncbi request reprint Localization of membrane permeabilization and receptor binding sites on the VP4 hemagglutinin of rotavirus: implications for cell entry
    M Tihova
    Departments of Cell and Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA
    J Mol Biol 314:985-92. 2001
    ....
  8. ncbi request reprint Structural determinants of rotavirus subgroup specificity mapped by cryo-electron microscopy
    Sarah L Greig
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Mol Biol 356:209-21. 2006
    ..Thus, subgroup specificity of rotavirus may reflect differences in the architecture of the double-layered particle, with resultant consequences for viral mRNA synthesis...

Research Grants29

  1. Structure Analysis of Viral Assembly Mechanisms
    Mark Yeager; Fiscal Year: 2006
    ..Our results will contribute to our general understanding of the mechanistic details of virus assembly. ..
  2. Structure Analysis of Aquaporin Membrane Channels
    Mark Yeager; Fiscal Year: 2006
    ..In addition, this project will provide insight into the molecular basis for channel regulation and will contribute to the general principles that govern conformational changes of membrane proteins. ..
  3. Structure Analysis of Integrin Activation
    Mark Yeager; Fiscal Year: 2007
    ..The structural details revealed by these studies will provide insight into the molecular basis of integrin activation, relevant for the design of new therapeutic agents. ..
  4. Structure Analysis of Viral Assembly Mechanisms
    Mark Yeager; Fiscal Year: 2007
    ..These studies will provide a deeper understanding of the molecular interactions in the immature and mature lattices, which will be important for the design of new therapeutic strategies. ..
  5. Structure Analysis of Viral Assembly Mechanisms
    Mark Yeager; Fiscal Year: 2009
    ..These studies will provide a deeper understanding of the molecular interactions in the immature and mature lattices, which will be important for the design of new therapeutic strategies. ..
  6. Structure Analysis of Integrin Activation
    Mark Yeager; Fiscal Year: 2009
    ..The structural details revealed by these studies will provide insight into the molecular basis of integrin activation, relevant for the design of new therapeutic agents. ..
  7. STRUCTURE AND DYNAMICS OF CARDIAC GAP JUNCTION CHANNELS
    Mark Yeager; Fiscal Year: 2002
    ....
  8. STRUCTURE AND DYNAMICS OF CARDIAC GAP JUNCTION CHANNELS
    Mark Yeager; Fiscal Year: 2007
    ..High resolution structures in the open and closed states would provide considerable insight into the molecular basis of current flow in the heart and will be essential to guide the design of novel agents to treat arrhythmias. ..