Defne Yarar

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis
    Defne Yarar
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Dev Cell 13:43-56. 2007
  2. ncbi request reprint SNX9 activities are regulated by multiple phosphoinositides through both PX and BAR domains
    Defne Yarar
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Traffic 9:133-46. 2008
  3. pmc SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis
    Fabienne Soulet
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 16:2058-67. 2005
  4. pmc Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis
    Marcel Mettlen
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 188:919-33. 2010
  5. pmc The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways
    Neal M Alto
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 178:1265-78. 2007
  6. pmc Cargo and dynamin regulate clathrin-coated pit maturation
    Dinah Loerke
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    PLoS Biol 7:e57. 2009
  7. pmc A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis
    Defne Yarar
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 16:964-75. 2005
  8. pmc An assembly-incompetent mutant establishes a requirement for dynamin self-assembly in clathrin-mediated endocytosis in vivo
    Byeong Doo Song
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:2243-52. 2004
  9. ncbi request reprint Cortical patches on the move
    Defne Yarar
    Department of Cell Biology, The Scripps Research Institute, La Jolla, Califonia 92037, USA
    Cell 115:373-5. 2003
  10. pmc Formation of filopodia-like bundles in vitro from a dendritic network
    Danijela Vignjevic
    Northwestern University Medical School, Department of Cell and Molecular Biology, 303 E Chicago Ave, Ward 8 063, Chicago, IL 60611, USA
    J Cell Biol 160:951-62. 2003

Collaborators

Detail Information

Publications11

  1. ncbi request reprint SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis
    Defne Yarar
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Dev Cell 13:43-56. 2007
    ..These results suggest a mechanism for the spatial and temporal regulation of N-WASP-dependent actin assembly and implicate SNX9 in directly coupling actin dynamics to membrane remodeling during multiple modes of endocytosis...
  2. ncbi request reprint SNX9 activities are regulated by multiple phosphoinositides through both PX and BAR domains
    Defne Yarar
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Traffic 9:133-46. 2008
    ..In total, our results suggest that SNX9 can integrate signals from varied lipids through two domains to direct membrane remodeling events at multiple cellular locations...
  3. pmc SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis
    Fabienne Soulet
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 16:2058-67. 2005
    ..Thus, our results establish that SNX9 is required for efficient clathrin-mediated endocytosis and suggest that it functions to regulate dynamin activity...
  4. pmc Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis
    Marcel Mettlen
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 188:919-33. 2010
    ..Altogether, our results underscore the highly dynamic and cargo-responsive nature of CCP assembly and suggest that the observed heterogeneity is, in part, related to compositional differences (e.g., cargo and adaptors) between CCPs...
  5. pmc The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways
    Neal M Alto
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 178:1265-78. 2007
    ..Thus, our findings suggest that the EspF-dependent assembly of SNX9 and N-WASP represents a novel form of signaling mimicry used to promote EPEC pathogenesis and gastrointestinal disease...
  6. pmc Cargo and dynamin regulate clathrin-coated pit maturation
    Dinah Loerke
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    PLoS Biol 7:e57. 2009
    ..From these data, we infer the existence of an endocytic restriction or checkpoint, responsive to cargo and regulated by dynamin...
  7. pmc A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis
    Defne Yarar
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 16:964-75. 2005
    ..Our results demonstrate a key role for actin during clathrin-mediated endocytosis in mammalian cells...
  8. pmc An assembly-incompetent mutant establishes a requirement for dynamin self-assembly in clathrin-mediated endocytosis in vivo
    Byeong Doo Song
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:2243-52. 2004
    ..Together these results provide new structural insight into the role of GED in self-assembly and assembly-stimulated GTPase activity and establish that dynamin self-assembly is essential for clathrin-mediated endocytosis...
  9. ncbi request reprint Cortical patches on the move
    Defne Yarar
    Department of Cell Biology, The Scripps Research Institute, La Jolla, Califonia 92037, USA
    Cell 115:373-5. 2003
    ..use real-time microscopy to define the temporal assembly of components of the endocytic machinery in the yeast S. cerevisiae. They also provide new insight into how the actin cytoskeleton is coordinated with the endocytic machinery...
  10. pmc Formation of filopodia-like bundles in vitro from a dendritic network
    Danijela Vignjevic
    Northwestern University Medical School, Department of Cell and Molecular Biology, 303 E Chicago Ave, Ward 8 063, Chicago, IL 60611, USA
    J Cell Biol 160:951-62. 2003
    ..We propose a model for filopodial formation in which actin filaments of a preexisting dendritic network are elongated by inhibition of capping and subsequently cross-linked into bundles by fascin...
  11. pmc Motility determinants in WASP family proteins
    Defne Yarar
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Mol Biol Cell 13:4045-59. 2002
    ..Our results suggest that recruitment of factors, including profilin, by the proline-rich regions of WASP and Scar1 and the EVH1 domain of WASP stimulates cellular actin-based motility...