Yuching Yang

Summary

Affiliation: The Hamner Institutes for Health Sciences
Country: USA

Publications

  1. doi request reprint Kinetic modeling of β-chloroprene metabolism: Probabilistic in vitro-in vivo extrapolation of metabolism in the lung, liver and kidneys of mice, rats and humans
    Yuching Yang
    Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA
    Toxicol In Vitro 26:1047-55. 2012
  2. doi request reprint Using a physiologically based pharmacokinetic model to link urinary biomarker concentrations to dietary exposure of perchlorate
    Yuching Yang
    The Hamner Institutes for Health Sciences, RTP, NC, USA
    Chemosphere 88:1019-27. 2012
  3. pmc A Bayesian population PBPK model for multiroute chloroform exposure
    Yuching Yang
    Exposure Science Division, Environmental and Occupational Health Sciences Institute, Joint Institute of UMDNJ Robert Wood Johnson Medical School and Rutgers University, Piscataway, NJ 08854, USA
    J Expo Sci Environ Epidemiol 20:326-41. 2010
  4. doi request reprint In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI
    Brett A Howell
    The Hamner UNC Institute for Drug Safety Sciences, The Hamner Institutes, Durham, NC 27709, USA
    J Pharmacokinet Pharmacodyn 39:527-41. 2012
  5. doi request reprint Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene
    Russell S Thomas
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 131:629-40. 2013
  6. doi request reprint Bayesian analysis of a rat formaldehyde DNA-protein cross-link model
    Yuching Yang
    The Hamner Institutes for Health Sciences, Center for Human Health Assessment, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 73:787-806. 2010
  7. pmc Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches
    Sudin Bhattacharya
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences Research Triangle Park, NC, USA
    Front Physiol 3:462. 2012
  8. doi request reprint An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury
    Jeffrey L Woodhead
    The Hamner University of North Carolina Institute for Drug Safety Sciences, The Hamner Institutes, Research Triangle Park, North Carolina, USA
    J Pharmacol Exp Ther 342:529-40. 2012

Detail Information

Publications8

  1. doi request reprint Kinetic modeling of β-chloroprene metabolism: Probabilistic in vitro-in vivo extrapolation of metabolism in the lung, liver and kidneys of mice, rats and humans
    Yuching Yang
    Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA
    Toxicol In Vitro 26:1047-55. 2012
    ....
  2. doi request reprint Using a physiologically based pharmacokinetic model to link urinary biomarker concentrations to dietary exposure of perchlorate
    Yuching Yang
    The Hamner Institutes for Health Sciences, RTP, NC, USA
    Chemosphere 88:1019-27. 2012
    ..The type of information needed to reduce the uncertainty in estimating intake doses, for individuals, based on biomarker measurements is discussed...
  3. pmc A Bayesian population PBPK model for multiroute chloroform exposure
    Yuching Yang
    Exposure Science Division, Environmental and Occupational Health Sciences Institute, Joint Institute of UMDNJ Robert Wood Johnson Medical School and Rutgers University, Piscataway, NJ 08854, USA
    J Expo Sci Environ Epidemiol 20:326-41. 2010
    ..This study demonstrates the use of the Bayesian approach to optimize PBPK model parameters for typical household exposure scenarios...
  4. doi request reprint In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI
    Brett A Howell
    The Hamner UNC Institute for Drug Safety Sciences, The Hamner Institutes, Durham, NC 27709, USA
    J Pharmacokinet Pharmacodyn 39:527-41. 2012
    ..Differences in model sensitivity to the parameters were related to species differences, but the severity of DILI for each drug/species combination was also an important factor...
  5. doi request reprint Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene
    Russell S Thomas
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 131:629-40. 2013
    ....
  6. doi request reprint Bayesian analysis of a rat formaldehyde DNA-protein cross-link model
    Yuching Yang
    The Hamner Institutes for Health Sciences, Center for Human Health Assessment, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 73:787-806. 2010
    ....
  7. pmc Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches
    Sudin Bhattacharya
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences Research Triangle Park, NC, USA
    Front Physiol 3:462. 2012
    ..The model initially focuses on reactive metabolite-induced DILI in response to administration of acetaminophen, and spans multiple biological scales...
  8. doi request reprint An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury
    Jeffrey L Woodhead
    The Hamner University of North Carolina Institute for Drug Safety Sciences, The Hamner Institutes, Research Triangle Park, North Carolina, USA
    J Pharmacol Exp Ther 342:529-40. 2012
    ..The modeling also suggests that modification of the current treatment nomograms should be considered...