Kan Yang

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations
    Kan Yang
    Strang Cancer Research Laboratory at The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Carcinogenesis 24:605-11. 2003
  2. pmc Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations
    Osamu Itano
    Strang Cancer Research Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Carcinogenesis 30:1923-6. 2009
  3. doi request reprint Dietary induction of colonic tumors in a mouse model of sporadic colon cancer
    Kan Yang
    Strang Cancer Research Laboratory, Department of Medicine, Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, New York 10467, USA
    Cancer Res 68:7803-10. 2008
  4. ncbi request reprint Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice
    Kan Yang
    Strang Cancer Research Laboratory, Department of Medicine Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, NY 10065, USA
    J Nutr 138:1658-63. 2008
  5. ncbi request reprint Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland
    Sadanori Abe
    Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021, USA
    J Med Food 10:18-24. 2007
  6. doi request reprint Effect of caloric intake on Western-style diet-induced intestinal tumors in a mouse model for hereditary colon cancer
    Osamu Itano
    Department of Medicine Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY 10021, USA
    Nutr Cancer 64:401-8. 2012
  7. doi request reprint Effect of a Western-style diet fortified with increased calcium and vitamin D on mammary gland of C57BL/6 mice
    Naoto Kurihara
    Strang Cancer Research Laboratory, Department of Medicine Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Med Food 11:201-6. 2008
  8. pmc Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation
    Kan Yang
    Strang Cancer Center at New York Blood Bank, New York, USA
    Cancer Res 68:7313-22. 2008
  9. ncbi request reprint Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice
    Kunhua Fan
    Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021, USA
    J Med Food 10:11-7. 2007
  10. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice
    Kan Yang
    Strang Cancer Research Laboratory at The Rockefeller University, New York, NY, USA
    Int J Cancer 116:495-9. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations
    Kan Yang
    Strang Cancer Research Laboratory at The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Carcinogenesis 24:605-11. 2003
    ..These findings thus suggest involvement of Bax and apoptosis in tumors developing after sulindac treatment in this mouse model...
  2. pmc Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations
    Osamu Itano
    Strang Cancer Research Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Carcinogenesis 30:1923-6. 2009
    ..Findings indicate that the effects of sulindac in the intestine of these mutant mouse models are probably related to genetic background and appear to be associated with its inflammatory-inducing response...
  3. doi request reprint Dietary induction of colonic tumors in a mouse model of sporadic colon cancer
    Kan Yang
    Strang Cancer Research Laboratory, Department of Medicine, Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, New York 10467, USA
    Cancer Res 68:7803-10. 2008
    ....
  4. ncbi request reprint Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice
    Kan Yang
    Strang Cancer Research Laboratory, Department of Medicine Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, NY 10065, USA
    J Nutr 138:1658-63. 2008
    ....
  5. ncbi request reprint Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland
    Sadanori Abe
    Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021, USA
    J Med Food 10:18-24. 2007
    ..01) with no inhibition of mitosis. Thus, a standardized preparation of OPE with 30% PMFs decreased development of an atypical hyperplastic lesion and increased apoptosis in ductal epithelial cells of mouse mammary gland...
  6. doi request reprint Effect of caloric intake on Western-style diet-induced intestinal tumors in a mouse model for hereditary colon cancer
    Osamu Itano
    Department of Medicine Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY 10021, USA
    Nutr Cancer 64:401-8. 2012
    ..05). Body weights showed no association with tumor development. Findings indicated modified nutrients in NWD were mainly responsible for increased tumors in mice fed NWD vs. AIN-76A in this preclinical mouse model for human FAP...
  7. doi request reprint Effect of a Western-style diet fortified with increased calcium and vitamin D on mammary gland of C57BL/6 mice
    Naoto Kurihara
    Strang Cancer Research Laboratory, Department of Medicine Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Med Food 11:201-6. 2008
    ....
  8. pmc Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation
    Kan Yang
    Strang Cancer Center at New York Blood Bank, New York, USA
    Cancer Res 68:7313-22. 2008
    ..We hypothesize that Muc2(-/-) tumors develop through an inflammation-related pathway that is distinct from and can complement mechanisms of tumorigenesis in Apc(+/-) mice...
  9. ncbi request reprint Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice
    Kunhua Fan
    Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021, USA
    J Med Food 10:11-7. 2007
    ..5% OPE in NWD further increased apoptosis in tumors of the small and large intestine. Findings indicated that OPE inhibited tumorigenesis in this preclinical mouse model of FAP, and increased apoptosis may have contributed to this effect...
  10. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice
    Kan Yang
    Strang Cancer Research Laboratory at The Rockefeller University, New York, NY, USA
    Int J Cancer 116:495-9. 2005
    ..This observation indicates that preexisting mutational events are not necessary for induction of colonic tumors by activated PPAR-gamma in vivo...
  11. ncbi request reprint Molecular targets of calcium and vitamin D in mouse genetic models of intestinal cancer
    Kan Yang
    Strang Cancer Prevention Center, New York, New York, USA
    Nutr Rev 65:S134-7. 2007
  12. ncbi request reprint Cyclin D1 expression in the intestinal mucosa and tumors of Apc1638N mice
    Hiroharu Shinozaki
    Strang Cancer Prevention Center, New York, NY 10021, USA
    Anticancer Res 23:2217-26. 2003
    ..These altered patterns of expression of cyclin D1 may provide useful biomarkers of abnormal cell development for studies of tumorigenesis and the effects of chemopreventive agents...
  13. ncbi request reprint Calcium plus vitamin D alters preneoplastic features of colorectal adenomas and rectal mucosa
    Peter R Holt
    Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University, New York, New York, USA
    Cancer 106:287-96. 2006
    ..Biologic changes that may occur in colorectal adenomas after chemopreventive regimens have not been reported...
  14. ncbi request reprint An Msh2 point mutation uncouples DNA mismatch repair and apoptosis
    Diana P Lin
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Cancer Res 64:517-22. 2004
    ....
  15. ncbi request reprint Piroxicam increases colon tumorigenesis and promotes apoptosis in Mlh1 +/- /Apc1638(N/+) mice
    Emanuela Palmerini
    Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Res 27:3807-12. 2007
    ..The present study examines the effect of piroxicam, a non-steroidal anti-inflammatory drug, on tumor development in Mlh1+/- /Apc1638(N/+) mice, in a preclinical model of human colon cancer...
  16. ncbi request reprint Dietary components modify gene expression: implications for carcinogenesis
    Kan Yang
    Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY 10467, USA
    J Nutr 135:2710-4. 2005
    ....
  17. ncbi request reprint Application of gene expression profiling to colon cell maturation, transformation and chemoprevention
    Leonard H Augenlicht
    Albert Einstein Cancer Center, Bronx, NY, USA
    J Nutr 133:2410S-2416S. 2003
    ....
  18. ncbi request reprint Pathology of mouse models of intestinal cancer: consensus report and recommendations
    Gregory P Boivin
    Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA
    Gastroenterology 124:762-77. 2003
  19. pmc Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
    Melanie Kucherlapati
    Department of Medicine and Harvard Partners Center for Genetics and Genomics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:9924-9. 2002
    ..The tumors from these mice show microsatellite instability. Because one copy of the Fen1 gene remained intact in tumors, Fen1 haploinsufficiency appears to lead to rapid progression of cancer...