Research Topics
Genomes and Genes
| Yu YamaguchiSummaryAffiliation: The Burnham Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Gene expression of EXT1 and EXT2 during mouse brain developmentMasaru Inatani
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Brain Res Dev Brain Res 141:129-36. 2003..Our results demonstrate that EXT1 and EXT2 are highly expressed in the developing brain, and that their expression is developmentally regulated, suggesting that HS is involved in various neurodevelopmental processes...
Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuriaShoujun Chen
1Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA
Kidney Int 74:289-99. 2008..Heparan sulfate glycosaminoglycans appear to have functions that control podocyte behavior rather than be primarily an ultrafiltration barrier...
Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfateFumitoshi Irie
Genetic Disease Program, Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 109:5052-6. 2012..Our results demonstrate that heparan sulfate is critical for normal functioning of glutamatergic synapses and that its deficiency mediates socio-communicative deficits and stereotypies characteristic for autism...- Lecticans: organizers of the brain extracellular matrixY Yamaguchi
The Burnham Institute, La Jolla, California 92037, USA
Cell Mol Life Sci 57:276-89. 2000..We propose that the hyaluronan-lectican-tenascin-R complex constitutes the core assembly of the adult brain extracellular matrix, which is found mainly in pericellular spaces of neurons as 'perineuronal nets'... - Heparan sulfate proteoglycans in the nervous system: their diverse roles in neurogenesis, axon guidance, and synaptogenesisY Yamaguchi
Neurobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Semin Cell Dev Biol 12:99-106. 2001..This article reviews our current knowledge about the functional roles of heparan sulfate proteoglycans in three critical events in mammalian neural development, namely neurogenesis, axon guidance, and synapse development... - Glycobiology of the synapse: the role of glycans in the formation, maturation, and modulation of synapsesYu Yamaguchi
Neurobiology Program, The Burnham Institute, La Jolla, CA 92037, USA
Biochim Biophys Acta 1573:369-76. 2002.... - Eph receptors in the adult brainYu Yamaguchi
Developmental Neurobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Curr Opin Neurobiol 14:288-96. 2004.... - Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defectsYoshihiro Matsumoto
Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
J Biol Chem 285:19227-34. 2010..Together, our results show that HS is essential for patterning of limb skeletal elements and that BMP signaling is one of the major targets for the regulatory role of HS in this developmental context... - NG2 proteoglycan expression in mouse skin: altered postnatal skin development in the NG2 null mouseKuniko Kadoya
Burnham Institute for Medical Research, La Jolla, California, USA
J Histochem Cytochem 56:295-303. 2008..Thickening of the subcutis is also delayed in NG2 null skin due to deficiencies in the adipocyte population... - Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limbKazu Matsumoto
Sanford Children s Health Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Development 136:2825-35. 2009..Taken together, our results demonstrate that HA has a crucial role in skeletal growth, patterning, chondrocyte maturation and synovial joint formation in the developing limb... - Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfateYoshihiro Matsumoto
Developmental Neurobiology Program, Burnham Institute for Medical Research, La Jolla, California 92037, USA
J Neurosci 27:4342-50. 2007..These results demonstrate that the expression of HS by commissural neurons is essential for these neurons to transduce netrin-1 signals, thus providing evidence for a cell-autonomous role of HS in netrin-1/DCC-mediated axon guidance... - Heparan sulfate regulates ephrin-A3/EphA receptor signalingFumitoshi Irie
Sanford Children s Health Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:12307-12. 2008..These results show that heparan sulfate modulates ephrin/Eph signaling and suggest a physiological role for heparan sulfate proteoglycans in the regulation of ephrin-A3-dependent biological processes... - Mammalian brain morphogenesis and midline axon guidance require heparan sulfateMasaru Inatani
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 302:1044-6. 2003..Furthermore, the EXT1-null brain displayed severe guidance errors in major commissural tracts, revealing a pivotal role of HS in midline axon guidance. These findings demonstrate that HS is essential for mammalian brain development... - Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signalingKeith K Murai
The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Neurosci 6:153-60. 2003..Thus, our data support a model in which transient interactions between the ephrin-A3 ligand and the EphA4 receptor regulate the structure of excitatory synaptic connections through neuroglial cross-talk... - EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1Fumitoshi Irie
Developmental Neurobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Nat Cell Biol 7:501-9. 2005..Our results indicate that ephrinB-EphB signalling regulates clathrin-mediated endocytosis in various cellular contexts by influencing protein interactions and phosphoinositide turnover through tyrosine phosphorylation of synaptojanin 1... - A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostosesKazu Matsumoto
Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 107:10932-7. 2010..Because the observed osteochondromas in our mouse model do not arise from clonal growth of chondrocytes, they cannot be considered true neoplasms... - Small changes in lymphocyte development and activation in mice through tissue-specific alteration of heparan sulphateOmai B Garner
Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA
Immunology 125:420-9. 2008..These findings demonstrate that cell surface heparan sulphate may not play a crucial role in lymphocyte development, but can modulate the sensitivity of T cells to activation... - Expression of NG2 proteoglycan during endochondral and intramembranous ossificationJun ichi Fukushi
The Burnham Institute, La Jolla, California 92037, USA
Dev Dyn 228:143-8. 2003..Our results indicate that NG2 expression is up-regulated during both endochondral and intramembranous ossification, but is down-regulated as ossification is completed... - Roles of heparan sulfate in mammalian brain development current views based on the findings from Ext1 conditional knockout studiesYu Yamaguchi
Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California, USA
Prog Mol Biol Transl Sci 93:133-52. 2010..This chapter reviews the current understanding of the in vivo function of HS deduced from the phenotypes of conditional Ext1 knockout mice... - Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodesXingfeng Bao
Glycobiology Unit, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
Immunity 33:817-29. 2010..By contrast, lymphocyte rolling was increased because of loss of electrostatic repulsion by heparan sulfate. These results demonstrate critical roles of endothelial heparan sulfate in immune surveillance and immune response generation... - Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signalingOmai B Garner
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Dev Biol 355:394-403. 2011.... - [Roles of Eph receptors and the cell surface heparan sulfate proteoglycan syndecan-2 in dendritic spine morphogenesis]Yu Yamaguchi
Neurobiology Program, Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA
Seikagaku 74:391-5. 2002 - EPHB receptor signaling in dendritic spine developmentFumitoshi Irie
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Front Biosci 9:1365-73. 2004.... - Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bonesBeverly M Zak
Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA
Bone 48:979-87. 2011..The data also indicate that the nature and organization of ectopic tissue may be influenced by site-specific anatomical cues and mechanisms... - Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene functionKay Grobe
Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
Development 132:3777-86. 2005..Most importantly, the data suggest the possibility that defects in heparan sulfate synthesis could give rise to or contribute to a number of developmental brain and facial defects in humans... - Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier functionLars Bode
Burnham Institute for Medical Research, La Jolla, California 92037, USA
J Clin Invest 118:229-38. 2008..We demonstrate here that non-anticoagulant 2,3-de-O-sulfated heparin could prevent intestinal protein leakage in syndecan-deficient mice, suggesting that this may be a safe and effective therapy for PLE patients... - EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASPFumitoshi Irie
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Neurosci 5:1117-8. 2002 - NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitorsLeonard L Jones
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 22:2792-803. 2002..Thus, NG2 is a major component of this putatively inhibitory class of ECM molecules expressed at sites of SCI and may restrict axonal regeneration... - Polysialic acid facilitates tumor invasion by glioma cellsMasami Suzuki
Glycobiology, Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
Glycobiology 15:887-94. 2005..These results combined indicate that PSA facilitates tumor invasion of glioma in the brain, and that NCAM-NCAM interaction is likely attenuated in the PSA-mediated tumor invasion... - Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injuryMaryla Krajewska
Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd La Jolla, CA 92037, USA
Brain Res 1370:227-37. 2011.... - N -Glycans on the receptor for advanced glycation end products influence amphoterin binding and neurite outgrowthGeetha Srikrishna
The Burnham Institute, La Jolla, California 92037, USA
J Neurochem 80:998-1008. 2002..These results indicate that carboxylated N -glycans on RAGE play an important functional role in amphoterin-RAGE-mediated signalling... - [Heparan sulfate, an essential of CNS development]Masaru Inatani
Tanpakushitsu Kakusan Koso 49:2369-75. 2004 - Human glioblastomas overexpress ADAMTS-5 that degrades brevicanMitsutoshi Nakada
Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
Acta Neuropathol 110:239-46. 2005..These results demonstrate for the first time that ADAMTS-5 is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 may play a role in glioma cell invasion through the cleavage of brevican... - Effect of PKC412, an inhibitor of protein kinase C, on spontaneous metastatic model miceKazuki Nakamura
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo 663 8179, Japan
Anticancer Res 23:1395-9. 2003..Thus, PKC412 exerts an anti-metastatic action through inhibition of the invasiveness of melanoma cells in the extracellular matrix... - Effect of cordycepin (3'-deoxyadenosine) on hematogenic lung metastatic model miceKazuki Nakamura
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo 663 8179, Japan
In Vivo 19:137-41. 2005..These results suggest that cordycepin exerts an anti-metastatic action, in part, by inhibiting the invasiveness of mouse melanoma cells... - Characterization of mouse melanoma cell lines by their mortal malignancy using an experimental metastatic modelKazuki Nakamura
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
Life Sci 70:791-8. 2002..These results suggest that mortal malignancy is not necessarily correlated with lung-colonizing potential and even only one-time selected B16-F0 mouse melanoma cells are useful as an experimental metastatic model in vivo... - Effect of PKC412, a selective inhibitor of protein kinase C, on lung metastasis in mice injected with B16 melanoma cellsNoriko Yoshikawa
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo 663-8179, Japan
Life Sci 72:1377-87. 2003..PKC412 is potentially a promising candidate for an anti-metastatic agent... - Relationship between plasma and hippocampal lipid peroxidation in obese and hypertensive SHR/NDmcr-cp ratsMichio Hashimoto
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Japan
Clin Exp Pharmacol Physiol 31:S62-4. 2004..5. These results indicate that, in SHR-cp, lipid peroxidation in the hippocampus would not be affected even if plasma levels of fatty acids and lipid peroxide increased markedly, when ageing is not a predicative factor... - Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycansDavid B Kantor
Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
Neuron 44:961-75. 2004..Thus, neuronal responses to Sema5A are proteoglycan dependent and interpreted according to the biological context in which this membrane bound guidance cue is presented... - Reinforcement of antitumor effect of Cordyceps sinensis by 2'-deoxycoformycin, an adenosine deaminase inhibitorNoriko Yoshikawa
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo 663 8179, Japan
In Vivo 21:291-5. 2007..These results suggest that DCF has a remarkable reinforcement effect on the antitumor activity of WECS. DCF is a potent adjuvant for WECS... - Antitumour activity of cordycepin in miceNoriko Yoshikawa
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukpgawa Women's University, Nishinomiya, Japan
Clin Exp Pharmacol Physiol 31:S51-3. 2004..4. These results indicate that orally administered cordycepin inhibits melanoma cell growth in mice with no adverse effects...
Research Grants
- Neuronal heparan sulfate deficiency and autismYu Yamaguchi; Fiscal Year: 2007..If our hypothesis proves correct, this project will pave a way toward a new direction of autism research. ..
- Heparan Sulfate in Skeletal Development and DiseasesYu Yamaguchi; Fiscal Year: 2010..The proposed studies will generate new insights into the pathogenesis of hereditary multiple exostosis, and may help define new drug targets for osteoporosis. ..
- Role of hyaluronan in developing and adult CNSYu Yamaguchi; Fiscal Year: 2005..The insight derived from these studies could lead to the development of hyaluronan based therapeutic approaches for neurodegenerative and demyelinating diseases. ..
- Neuron-Glia Communication in DevelopmentYu Yamaguchi; Fiscal Year: 2007....
- Heparan sulfate in neural developmentYu Yamaguchi; Fiscal Year: 2007..We will perform histological, cell biological, and physiological analyses to determine the physiological role of HS in CNS synapses. ..
- BRAIN EXTRACELLULAR MATRIX--ROLES IN NEURAL FUNCTION ANDYu Yamaguchi; Fiscal Year: 2002....
- MOLECULAR ANALYSIS OF NOVEL BRAIN PROTEOGLYCANSYu Yamaguchi; Fiscal Year: 1999....
- FUNCTIONAL ANALYSIS OF GLYPICANS IN BRAIN DEVELOPMENTYu Yamaguchi; Fiscal Year: 2001..These studies not only provide new insight into the mechanism of neurogenesis but may shed light on the pathogenesis of congenital brain malformations that may derive from defective proliferation of neural precursor cells. ..
- Heparan Sulfate in Skeletal Development and DiseasesYu Yamaguchi; Fiscal Year: 2009..The proposed studies will establish a novel mouse model for HME and generate new insights into the pathogenic mechanism of this human disorder. ..