Xifeng Wu

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer
    Michelle A T Hildebrandt
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e12402. 2010
  2. pmc Genetic variations in the regulator of G-protein signaling genes are associated with survival in late-stage non-small cell lung cancer
    Jingyao Dai
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e21120. 2011
  3. pmc Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer
    J Xing
    Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Br J Cancer 98:1716-22. 2008
  4. pmc Genetic variations in the transforming growth factor beta pathway as predictors of bladder cancer risk
    Hua Wei
    Departments of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 7:e51758. 2012
  5. pmc Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Guérin
    Hua Wei
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e38533. 2012
  6. doi request reprint Mutagen sensitivity as measured by induced chromatid breakage as a marker of cancer risk
    Xifeng Wu
    Department of Epidemiology, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Box 189, Houston, TX, 77030, USA
    Methods Mol Biol 1105:183-92. 2014
  7. pmc Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers
    Xifeng Wu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 73:4028-38. 2013
  8. pmc Energy balance, polymorphisms in the mTOR pathway, and renal cell carcinoma risk
    Xiang Shu
    Department of Epidemiology, Unit 1340, University of Texas MD Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA
    J Natl Cancer Inst 105:424-32. 2013
  9. pmc Ionizing radiation-induced γ-H2AX activity in whole blood culture and the risk of lung cancer
    Yonggang He
    Corresponding Author Xifeng Wu, Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Herman Pressler, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 22:443-51. 2013
  10. pmc MicroRNA expression signatures during malignant progression from Barrett's esophagus to esophageal adenocarcinoma
    Xifeng Wu
    Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 6:196-205. 2013

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. pmc Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer
    Michelle A T Hildebrandt
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e12402. 2010
    ..These results suggest that genetic variations among inflammation pathway genes may modulate the development of radiation-induced toxicity and, ultimately, help in identifying patients who are at an increased likelihood for such events...
  2. pmc Genetic variations in the regulator of G-protein signaling genes are associated with survival in late-stage non-small cell lung cancer
    Jingyao Dai
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e21120. 2011
    ..To our knowledge, this is the first study to reveal the importance of RGS gene family in the survival of late-stage NSCLC patients...
  3. pmc Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer
    J Xing
    Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Br J Cancer 98:1716-22. 2008
    ..Our results suggest that DNMT1, DNMT3b, and MBD2 may play important roles in modulating NSCLC patient survival and thus be useful for identifying NSCLC patients who would benefit most from aggressive therapy...
  4. pmc Genetic variations in the transforming growth factor beta pathway as predictors of bladder cancer risk
    Hua Wei
    Departments of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 7:e51758. 2012
    ..Our study provides the first epidemiological evidence supporting a connection between TGF-β pathway variants and bladder cancer risk...
  5. pmc Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Guérin
    Hua Wei
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e38533. 2012
    ..1). These results support the hypothesis that genetic variations in host oxidative stress genes in NMIBC patients may affect response to therapy with BCG...
  6. doi request reprint Mutagen sensitivity as measured by induced chromatid breakage as a marker of cancer risk
    Xifeng Wu
    Department of Epidemiology, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Box 189, Houston, TX, 77030, USA
    Methods Mol Biol 1105:183-92. 2014
    ....
  7. pmc Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers
    Xifeng Wu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 73:4028-38. 2013
    ..These findings identify several novel, candidate prognostic markers for NSCLC in never smokers, with eQTL analysis suggesting a potential biologic mechanism for a subset of these observed associations...
  8. pmc Energy balance, polymorphisms in the mTOR pathway, and renal cell carcinoma risk
    Xiang Shu
    Department of Epidemiology, Unit 1340, University of Texas MD Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA
    J Natl Cancer Inst 105:424-32. 2013
    ..We examined the associations between obesity, weight gain, physical activity, and RCC risk. We also analyzed whether genetic variants in the mTOR pathway could modify the association...
  9. pmc Ionizing radiation-induced γ-H2AX activity in whole blood culture and the risk of lung cancer
    Yonggang He
    Corresponding Author Xifeng Wu, Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Herman Pressler, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 22:443-51. 2013
    ..Phenotypic biomarkers of DNA damage repair may enhance cancer risk prediction. The γ-H2AX formed at the sites of double-strand break (DSB) after ionizing radiation is a specific marker of DNA damage...
  10. pmc MicroRNA expression signatures during malignant progression from Barrett's esophagus to esophageal adenocarcinoma
    Xifeng Wu
    Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 6:196-205. 2013
    ....
  11. ncbi request reprint MicroRNA in the pathogenesis and prognosis of esophageal cancer
    Jian Gu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Pressler Blvd, Houston, TX 77030, USA
    Curr Pharm Des 19:1292-300. 2013
    ..A better understanding of roles of miRNA in EC developemnt may provide new avenues for the early detection, diagnosis, prognosis, and therapy of this deadly disease...
  12. pmc Hepatocellular carcinoma risk prediction model for the general population: the predictive power of transaminases
    Chi Pang Wen
    Institute of Population Science, National Health Research Institutes, Zhunan, Taiwan
    J Natl Cancer Inst 104:1599-611. 2012
    ..We developed five simple risk prediction models based on clinically available data from the general population...
  13. pmc A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23
    Xifeng Wu
    Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Hum Mol Genet 21:456-62. 2012
    ..18 (95% CI: 1.12-1.25) for rs1049380. It has been recently identified that rs718314 in ITPR2 is associated with waist-hip ratio (WHR) phenotype. To our knowledge, this is the first genetic locus associated with both cancer risk and WHR...
  14. pmc A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"
    Lisa H Butterfield
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15213, USA
    J Transl Med 6:81. 2008
    ..This foreword provides an overview of the task force and invites feedback from readers that might be incorporated in the discussions and in the final document...
  15. pmc Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology
    Hideaki Tahara
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Transl Med 7:45. 2009
    ..The institution of an interactive consortium for high throughput molecular monitoring of clinical trials with voluntary participation might provide cost-effective solutions...
  16. pmc Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group
    Harry H Yoon
    Mayo Clinic, Rochester, MN 55905, USA
    BMC Cancer 11:176. 2011
    ..As a secondary aim, we investigated the rate of allelic imbalance between germline and tumor DNA...
  17. pmc Risk of urinary bladder cancer: a case-control analysis of industry and occupation
    Adrian Cassidy
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 9:443. 2009
    ..Uncertainty remains about urinary bladder cancer (UBC) risk for many occupations. Here, we investigate the association between occupation, industry and UBC...
  18. ncbi request reprint Pharmacogenetics in esophageal cancer
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Semin Oncol 32:S87-9. 2005
    ..This emergent area of biomedicine could lead to substantially improved clinical outcomes for patients with adenocarcinoma or squamous cell carcinoma of the esophagus...
  19. ncbi request reprint Interplay between mutagen sensitivity and epidemiological factors in modulatinglung cancer risk
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 120:2687-95. 2007
    ..This new integrative approach should facilitate identification of high-risk subgroups and has important implications in LC prevention...
  20. ncbi request reprint Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer
    Xifeng Wu
    Department of Epidemiology, Experimental Therapeutics, GI Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 24:3789-98. 2006
    ..Understanding how specific genetic variants modify drug action pathways may provide informative blueprints for individualized chemotherapy...
  21. pmc Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Hum Genet 78:464-79. 2006
    ....
  22. ncbi request reprint Genetic polymorphism in bladder cancer
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Front Biosci 12:192-213. 2007
    ..This review presents an overview of current molecular epidemiology of bladder cancer and provides a useful resource for understanding the pathogenesis of bladder cancer...
  23. ncbi request reprint Joint effect of mutagen sensitivity and insulin-like growth factors in predicting the risk of developing secondary primary tumors and tumor recurrence in patients with head and neck cancer
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:7194-201. 2006
    ..We hypothesized that latent genetic instability and proliferation potential may be associated with elevated risks of SPT and recurrence...
  24. pmc Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Pharmacogenet Genomics 18:955-65. 2008
    ..Therefore, we applied a pathway-based approach to evaluate the cumulative effect of multiple polymorphisms on clinical outcome of patients with non-small cell lung cancer...
  25. ncbi request reprint Mutagen sensitivity has high heritability: evidence from a twin study
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:5993-6. 2006
    ..This study provides the strongest and most direct evidence that mutagen sensitivity is highly heritable, thereby validating the use of mutagen sensitivity as a cancer susceptibility factor...
  26. ncbi request reprint Projecting individualized probabilities of developing bladder cancer in white individuals
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 25:4974-81. 2007
    ..There has been no risk assessment model for bladder cancer (BC). We developed the first model incorporating mutagen sensitivity and epidemiologic factors to predict BC risk...
  27. ncbi request reprint Cell cycle checkpoints, DNA damage/repair, and lung cancer risk
    Xifeng Wu
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:349-57. 2005
    ..This study is significant because it provides the first molecular epidemiologic evidence linking defects in cell cycle checkpoints and DNA damage/repair capacity to elevated lung cancer risk...
  28. ncbi request reprint Mutagen sensitivity: a genetic predisposition factor for cancer
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Res 67:3493-5. 2007
    ..The evidence is becoming increasingly convincing that mutagen sensitivity is a risk factor for cancer development...
  29. ncbi request reprint Telomere dysfunction: a potential cancer predisposition factor
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 95:1211-8. 2003
    ..Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the association between telomere length and cancer risk in four ongoing case-control studies...
  30. ncbi request reprint Genetic susceptibility to tobacco-related cancer
    Xifeng Wu
    Department of Epidemiology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:6500-23. 2004
    ..Finally, we present a number of current concerns that need to be addressed as the exciting field of molecular cancer epidemiology advances rapidly...
  31. ncbi request reprint Serum levels of insulin growth factor (IGF-I) and IGF-binding protein predict risk of second primary tumors in patients with head and neck cancer
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:3988-95. 2004
    ..Serum levels of insulin growth factors (IGFs) and their binding proteins (IGFBPs) have been associated with subsequent development of several epithelial cancers in prospective studies...
  32. doi request reprint Genome-wide association studies of bladder cancer risk: a field synopsis of progress and potential applications
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA
    Cancer Metastasis Rev 28:269-80. 2009
    ..The ultimate goal is the development of a comprehensive risk prediction model which integrates genetic, environment, and person risk factors to benefit disease diagnosis, prevention, and treatment...
  33. pmc Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy
    Xifeng Wu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1340, Houston, TX 77030, USA
    J Natl Cancer Inst 103:817-25. 2011
    ..Interindividual variation in genetic background may influence the response to chemotherapy and overall survival for patients with advanced-stage non-small cell lung cancer (NSCLC)...
  34. pmc Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma
    Jie Lin
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:1805-12. 2010
    ..Future investigation in larger populations and functional characterizations are necessary to validate these results...
  35. pmc Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway
    Jennifer Pan
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:785-92. 2009
    ..These findings warrant further replications in different populations...
  36. ncbi request reprint Nucleotide excision repair pathway genes and oral premalignant lesions
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:3753-8. 2007
    ..Polymorphisms in NER genes may cause variations in DNA repair capacity and increase susceptibility to both premalignant lesions and cancer...
  37. ncbi request reprint Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival
    Dan Leibovici
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA
    J Clin Oncol 23:5746-56. 2005
    ..Since chronic inflammation contributes to tumorigenesis, we hypothesized that the risk and clinical outcome of bladder cancer (BC) might be modulated by genetic variations in inflammation genes...
  38. pmc Genetic variations in cell-cycle pathway and the risk of oral premalignant lesions
    Yuanqing Ye
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 113:2488-95. 2008
    ..Cell-cycle checkpoint controls regulate cell-cycle progression and proliferation. Alterations in cell-cycle control mechanisms are linked to tumorigenesis...
  39. pmc Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study
    Christopher I Amos
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 102:1199-205. 2010
    ..Thus, among African American persons, multiple loci in the region of chromosome 15q25.1 appear to be strongly associated with lung cancer risk...
  40. ncbi request reprint Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation
    Jie Lin
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2065-71. 2007
    ..As risk assessment for cancer risk is moving toward a multigenic pathway-based approach, future genotype-phenotype correlation studies should also investigate the combined effects of multiple genetic variants...
  41. ncbi request reprint Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 11:1408-15. 2005
    ..Polymorphisms in NER genes may influence DNA repair capacity and affect clinical outcome of bladder cancer treatment...
  42. ncbi request reprint Evaluation of glutathione S-transferase polymorphisms and mutagen sensitivity as risk factors for the development of second primary tumors in patients previously diagnosed with early-stage head and neck cancer
    Charles G Minard
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:2636-44. 2006
    ..Data were available for 303 patients who were enrolled in a placebo-controlled chemoprevention trial of low-dose 13-cis-retinoic acid to reduce the occurrence of SPTs...
  43. ncbi request reprint Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness
    A Karim Kader
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:2614-20. 2007
    ..MMP levels are elevated in bladder cancer patients correlating with more advanced stage. We tested whether polymorphisms in MMP genes modify the risk of bladder cancer invasiveness and whether smoke exposure modifies this risk...
  44. pmc Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma
    Jinliang Xing
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:1104-12. 2008
    ..Renal cell carcinoma accounts for 85% of all renal cancers. No studies have investigated the association between mtDNA content and the risk of renal cell carcinoma...
  45. pmc Genetic variation in MicroRNA genes and risk of oral premalignant lesions
    Jessica Clague
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Carcinog 49:183-9. 2010
    ....
  46. pmc Genetic variations of the PI3K-AKT-mTOR pathway and clinical outcome in muscle invasive and metastatic bladder cancer patients
    Meng Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Carcinogenesis 31:1387-91. 2010
    ..These findings warrant further replication in independent populations and may provide information on disease management and development of target therapies...
  47. ncbi request reprint Combined effects of the p53 and p73 polymorphisms on lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    Cancer Epidemiol Biomarkers Prev 15:158-61. 2006
    ....
  48. pmc The influence of tumor necrosis factor-alpha -308 G/A and IL-6 -174 G/C on pain and analgesia response in lung cancer patients receiving supportive care
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, 1155 Pressler Street Unit 1340, Houston, TX 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 17:3262-7. 2008
    ....
  49. pmc Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma
    Jianming Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:1755-61. 2010
    ..Our results stressed the importance of taking a polygenic approach to evaluate the cumulative and interaction effects of genetic variations in the prediction of cancer risk and prognosis...
  50. pmc PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy
    Xia Pu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Lung Cancer 71:82-8. 2011
    ..With further validation, our findings may provide additional biomarkers for customized treatment of platinum-based chemotherapy for NSCLC...
  51. ncbi request reprint High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk
    Meng Chen
    Department of Epidemiology and Urology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Carcinogenesis 28:2160-5. 2007
    ..The contributions of these polymorphisms may jointly affect bladder cancer risk through gene-gene and gene-smoking interactions...
  52. pmc An expanded risk prediction model for lung cancer
    Margaret R Spitz
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, P O Box 301439, Houston, TX 77230 1439, USA
    Cancer Prev Res (Phila) 1:250-4. 2008
    ..Addition of biomarker assays improved the sensitivity of the expanded models...
  53. doi request reprint Global assessment of genetic variation influencing response to retinoid chemoprevention in head and neck cancer patients
    J Jack Lee
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 4:185-93. 2011
    ..The lack of any alternatives for reducing risk in these patients highlights the need for future clinical trials to prospectively validate our findings...
  54. pmc Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk
    Meng Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:2047-52. 2009
    ..71) increased bladder cancer risk. This is the first study to evaluate the role of germ line genetic variations in PI3K-AKT-mTOR pathway as cancer susceptibility factors that will help us identify high-risk individuals for bladder cancer...
  55. ncbi request reprint From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    DNA Repair (Amst) 2:901-8. 2003
    ..To our knowledge, this is the largest study conducted evaluating the functional relevance of these polymorphisms...
  56. ncbi request reprint Cyclin D1 guanine/adenine 870 polymorphism with altered protein expression is associated with genomic instability and aggressive clinical biology of esophageal adenocarcinoma
    Julie G Izzo
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 25:698-707. 2007
    ..We hypothesized that CD1 A870 allele would be associated with higher CD1 protein expression, and increased genomic instability during EAC evolution, leading to more aggressive phenotype...
  57. pmc Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 2:617-24. 2009
    ..Furthermore, this study underscores the importance of incorporating germ-line genetic variation data with clinical and risk factor data in constructing prediction models for clinical outcomes...
  58. ncbi request reprint Mutagen sensitivity may predict lung protection by amifostine for patients with locally advanced non-small cell lung cancer treated by chemoradiotherapy
    Ritsuko Komaki
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 97, Houston, TX 77030, USA
    Semin Oncol 32:S92-8. 2005
    ..AMF reduced the incidence of grade 3/4 lung fibrosis among higher MS. These data suggest that MS might help identify subgroups of patients who could receive more benefit from AMF with respect to lung damage...
  59. pmc MicroRNA expression signatures in Barrett's esophagus and esophageal adenocarcinoma
    Hushan Yang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:5744-52. 2009
    ..Although microRNA (miRNA) expression signatures have been associated with the etiology and prognosis of several types of cancers, their roles in the development of esophageal adenocarcinoma have not been extensively evaluated...
  60. ncbi request reprint Polymorphisms in XPD exons 10 and 23 and bladder cancer risk
    Matthew B Schabath
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Unit 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:878-84. 2005
    ....
  61. ncbi request reprint Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251T/A
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Street, Houston, TX 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 16:2745-51. 2007
    ..We explored if polymorphisms in candidate cytokine genes could explain variability in self-reported pain in lung cancer patients of all stages...
  62. doi request reprint Genome-wide catalogue of chromosomal aberrations in barrett's esophagus and esophageal adenocarcinoma: a high-density single nucleotide polymorphism array analysis
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 3:1176-86. 2010
    ..8q24 (containing Myc) and 8p23.1 (containing CTSB) were the two most frequently amplified regions. In addition, a significant trend toward increasing amplification was associated with higher progression stage...
  63. pmc Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions
    Hushan Yang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1340, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Eur J Cancer 44:1603-11. 2008
    ..Our data also suggest that the effects of high-order interactions should be taken into consideration when evaluating OPL predisposition...
  64. ncbi request reprint Genetic variants in cell cycle control pathway confer susceptibility to lung cancer
    Wei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:5974-81. 2007
    ..To test the hypothesis that common sequence variants of cell cycle control genes may affect lung cancer predisposition...
  65. ncbi request reprint Genetic instability in bladder cancer assessed by the comet assay
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 95:540-7. 2003
    ..We used the comet assay (single-cell gel electrophoresis) to assess whether genetic instability, as reflected by susceptibility to DNA damage, was associated with the risk of bladder cancer in a case-control study...
  66. ncbi request reprint High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility
    Maosheng Huang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:84-91. 2007
    ..02%; P < 0.001). These results support the hypothesis that genetic variants in BER genes contribute to bladder cancer risk through gene-gene and gene-environmental interactions...
  67. ncbi request reprint Matrix metalloproteinase polymorphisms and bladder cancer risk
    A Karim Kader
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:11644-8. 2006
    ..Heavy carcinogen exposure may overwhelm some of the genetic effects of MMP polymorphisms. Our study confirms the importance of taking a multigenic pathway-based approach to risk assessment...
  68. pmc Genetic susceptibility to renal cell carcinoma: the role of DNA double-strand break repair pathway
    Vitaly Margulis
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 17:2366-73. 2008
    ..These findings require further validation in independent populations...
  69. pmc ATM sequence variants associate with susceptibility to non-small cell lung cancer
    Hushan Yang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX
    Int J Cancer 121:2254-9. 2007
    ....
  70. ncbi request reprint XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 24:505-9. 2003
    ..Our data suggest that the XPA 5' non-coding region polymorphism modulates NER capacity and is associated with decreased lung cancer risk, especially in the presence of exposure to tobacco carcinogens...
  71. pmc Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays
    Meng Chen
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 125:2342-8. 2009
    ..The identified regions and genes may become diagnostic and prognostic biomarkers as well as potential targets of therapy...
  72. pmc Genetic variations in interleukin-8 and interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patients
    Cielito C Reyes-Gibby
    Department of Emergency Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Pain Symptom Manage 46:161-72. 2013
    ..A report by the National Cancer Institute identified that an important gap in symptom research is the investigation of multiple symptoms of cancer that might identify common biological mechanisms among cancer-related symptoms...
  73. pmc Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma
    Yohei Horikawa
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:7956-62. 2008
    ..Compelling evidence has shown that miRNAs are involved in cancer initiation and progression. We hypothesized that genetic variations of the miRNA machinery genes could be associated with the risk of renal cell carcinoma...
  74. ncbi request reprint Dietary carotenoids and genetic instability modify bladder cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Nutr 134:3362-9. 2004
    ..18; 95% CI, 1.13-4.22). This study provides evidence of a preventive role for carotenoids in bladder cancer, and these data may have important implications for cancer prevention, especially for individuals susceptible to DNA damage...
  75. pmc Family history and risk of renal cell carcinoma: results from a case-control study and systematic meta-analysis
    Jessica Clague
    Department of Epidemiology, Box 1340, The University of Texas M D Anderson Cancer Center, 1155 Pressler Street, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 18:801-7. 2009
    ....
  76. pmc MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer
    Xiaofan Zhang
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:2118-23. 2010
    ..9 months (log rank P = 2.28 × 10(-13)). Our results suggested that miRNA-related genetic polymorphisms may be used individually and jointly to predict the risk of SPT/recurrence of early-stage head and neck cancer patients...
  77. ncbi request reprint p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Natl Cancer Inst 94:681-90. 2002
    ..We also examined the functionality of the p53 variants in apoptosis and DNA repair...
  78. ncbi request reprint Case-control analysis of dietary folate and risk of bladder cancer
    Matthew B Schabath
    The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Nutr Cancer 53:144-51. 2005
    ..These data may have important implications for cancer prevention; however, large, hypothesis-driven, population-based clinical trials will be required to confirm these findings...
  79. ncbi request reprint Moving toward individualized therapy based on NER polymorphisms that predict platinum sensitivity in ovarian cancer patients
    J Salvador Saldivar
    Department of Gynecology Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Gynecol Oncol 107:S223-9. 2007
    ..We hypothesized that genetic polymorphisms in XP genes may predict clinical response to platinum chemotherapeutic treatment and survival in women with gynecological cancers...
  80. ncbi request reprint Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk
    Hua Zhao
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Int J Cancer 120:2208-13. 2007
    ..The protective effect of ITCs against bladder cancer was not modified by GSTM1, GSTT1 or NAT2 genotypes. This is the first epidemiological report that ITCs from cruciferous vegetable consumption protect against bladder cancer...
  81. ncbi request reprint A risk model for prediction of lung cancer
    Margaret R Spitz
    Department of Epidemiology Unit 1340, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    J Natl Cancer Inst 99:715-26. 2007
    ..Reliable risk prediction tools for estimating individual probability of lung cancer have important public health implications. We constructed and validated a comprehensive clinical tool for lung cancer risk prediction by smoking status...
  82. ncbi request reprint Differential induction in telomerase activity among bladder cancer patients and controls on gamma-radiation
    Jinliang Xing
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1304, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:606-9. 2007
    ..Our findings provide the first evidence linking the mutagen-induced telomerase activity in peripheral blood lymphocytes to the risk of bladder cancer, which warrants further investigation in large-sized studies and other cancer types...
  83. ncbi request reprint Association between asbestos exposure, cigarette smoking, myeloperoxidase (MPO) genotypes, and lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Holcombe Blvd, Houston, Texas 77303, USA
    Am J Ind Med 42:29-37. 2002
    ..As observed in tobacco-associated carcinogenesis, genetic factors such as the polymorphic metabolic/oxidative enzyme myeloperoxidase (MPO) could modulate individual susceptibility to asbestos-associated carcinogenesis...
  84. ncbi request reprint A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 106:2716-24. 2006
    ..Recently, the authors reported that 3 single-nucleotide polymorphisms (SNPs) in 2 members of the RGS family were associated with significant reductions in the risk of cancer...
  85. pmc Sensitivity to NNKOAc is associated with renal cancer risk
    Jessica Clague
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, 1155 Pressler, Unit 1340, Houston, TX 77030, USA
    Carcinogenesis 30:706-10. 2009
    ..Future studies with larger sample sizes are warranted to further investigate whether repair of NNKOAc-induced damage, as quantified by the comet assay, could be used as a predictive marker for RCC risk...
  86. ncbi request reprint Assessment of insulin-like growth factors and mutagen sensitivity as predictors of lung cancer risk
    Xifeng Wu
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Methods Mol Med 75:279-87. 2003
  87. ncbi request reprint Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Lung Cancer 40:25-32. 2003
    ..53; 95% CI 0.21-1.33). These data demonstrate that the GSTP1 exon 6 polymorphism, but not the exon 5 polymorphism, is associated with lung cancer risk that is especially evident in men, younger individuals, and ever smokers...
  88. ncbi request reprint An association between NQO1 genetic polymorphism and risk of bladder cancer
    Seun Ja Park
    Department of Epidemiology, Unit 189, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mutat Res 536:131-7. 2003
    ..78; 95% CI=1.06-3.00), but not in never smokers (OR=1.19; 95% CI=0.65-2.20). These results suggest that the NQO1 genetic polymorphism modulates bladder cancer risk, especially in men and ever smokers...
  89. ncbi request reprint BPDE-induced lymphocytic 3p21.3 aberrations may predict head and neck carcinoma risk
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer 95:563-8. 2002
    ..Chromosomal aberrations in peripheral blood lymphocytes (PBLs) induced by BPDE may reflect individuals' genetic susceptibility to tobacco carcinogens...
  90. pmc Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk
    Jian Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas
    Cancer 116:3458-62. 2010
    ..However, it has not been established whether the association between genetic variants and lung cancer risk is a direct one or one mediated by nicotine dependence...
  91. ncbi request reprint An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 64:2251-7. 2004
    ..Using such a molecular evolutionary approach may hold great promise for prioritizing SNPs to be genotyped in future molecular epidemiological studies...
  92. ncbi request reprint Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Epidemiol 161:412-22. 2005
    ..19, 0.66) protective genotypes as compared with none (OR = 0.69, 95% CI: 0.30, 1.59). The biologic role of respiratory disease in lung cancer is unclear. Further study may yield new insights for identification of susceptible subgroups...
  93. ncbi request reprint Predictors of esophageal cancer risk: assessment of susceptibility to DNA damage using comet assay
    Lina Shao
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Chromosomes Cancer 44:415-22. 2005
    ..4-fold risk for EC and those sensitive to both mutagens showed an 8.7-fold risk for EC. Thus, we conclude that susceptibility to DNA damage as assessed by comet assay might help identify individuals with high EC risk...
  94. doi request reprint Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells
    Peter C Black
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:1478-86. 2008
    ..The aim of this study was to define molecular markers of response to cetuximab therapy in a panel of urothelial carcinoma cell lines...
  95. ncbi request reprint Telomere dysfunction in peripheral lymphocytes as a potential predisposition factor for renal cancer
    Lina Shao
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 178:1492-6. 2007
    ..In this study we modified the assay by incorporating 9 control cell lines to normalize telomere length...
  96. ncbi request reprint Methyl-CpG-binding domain 2: a protective role in bladder carcinoma
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:1853-8. 2004
    ..In the current case-control study, the authors investigated the association between MBD2 expression and bladder carcinoma risk...
  97. ncbi request reprint A myeloperoxidase polymorphism associated with reduced risk of lung cancer
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Lung Cancer 37:35-40. 2002
    ..This report provides further support for the hypothesis that a single nucleotide polymorphism in the MPO gene is a protective factor in lung cancer carcinogenesis...
  98. ncbi request reprint Genotypes, haplotypes and diplotypes of XPC and risk of bladder cancer
    Yimin Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 28:698-703. 2007
    ..53 (0.34-0.82) for C-A/T-A, 0.48 (0.27-0.84) for C-A/C-C, 0.18 (0.053-0.60) for C-C/C-C and 0.57 (0.36-0.90) for C+C/C+C. These results suggest that sequence variants in the XPC gene might modulate the risk of bladder cancer...
  99. ncbi request reprint Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center Houston, TX 77030, USA
    Carcinogenesis 28:350-5. 2007
    ..45% of controls) exhibited a reduced lung cancer risk (OR=0.78, 95% CI=0.63-0.97). This is the first epidemiological study to report significant associations between STK15 polymorphisms and lung cancer risk...
  100. ncbi request reprint A case-control analysis of lymphocytic chromosome 9 aberrations in lung cancer
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 102:536-40. 2002
    ..67 [0.84, 3.32]) and lung cancer (OR = 2.49 [0.81, 7.67]). Our findings suggest that chromosome 9 aberrations in PBLs might be considered a marker of lung cancer predisposition and may be associated with familial aggregation of cancer...
  101. ncbi request reprint Modification of lung cancer susceptibility by green tea extract as measured by the comet assay
    Huifeng Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center Box 189 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cancer Detect Prev 26:411-8. 2002
    ..This reports also demonstrated the chemopreventive effects of green tea extract on BPDE-induced DNA damage. These observations provide further support for the application of the comet assay in molecular epidemiologic studies...

Research Grants29

  1. GENETIC SUSCEPTIBILITY TO BLADDER CANCER
    Xifeng Wu; Fiscal Year: 1999
    ..Our long-term plan is to refine our risk assessment in patients with BC so that we can identify high-risk subgroups of candidates for primary and secondary prevention measures. ..
  2. Markers of Genetic Susceptibility to Bladder Cancer
    Xifeng Wu; Fiscal Year: 2006
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  3. Genetic Susceptibility Modifiers in Renal Cell Carcinoma
    Xifeng Wu; Fiscal Year: 2006
    ..Such individuals may then be targeted for intervention programs such as chemoprevention or dietary modification. ..
  4. Markers of Genetic Susceptibility to Bladder Cancer
    Xifeng Wu; Fiscal Year: 2007
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  5. Genetic Susceptibility Modifiers in Renal Cell Carcinoma
    Xifeng Wu; Fiscal Year: 2007
    ..Such individuals may then be targeted for intervention programs such as chemoprevention or dietary modification. ..
  6. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2007
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..
  7. Genetic Instability & Risk for Esophageal Carcinoma
    Xifeng Wu; Fiscal Year: 2009
    ..The ability to identify high-risk subgroups of individuals for EAC will provide immense public health benefit for those high-risk people who may be subjected to close surveillance and chemoprevention. ..
  8. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2009
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..
  9. Genetic Instability & Risk for Esophageal Carcinoma
    Xifeng Wu; Fiscal Year: 2010
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  10. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2006
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..
  11. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2005
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..
  12. Markers of Genetic Susceptibility to Bladder Cancer
    Xifeng Wu; Fiscal Year: 2005
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  13. GENETIC SUSCEPTIBILITY TO BLADDER CANCER
    Xifeng Wu; Fiscal Year: 2000
    ..Our long-term plan is to refine our risk assessment in patients with BC so that we can identify high-risk subgroups of candidates for primary and secondary prevention measures. ..
  14. GENETIC INFLUENCE ON MUTAGEN SENSITIVITY--A TWIN STUDY
    Xifeng Wu; Fiscal Year: 2001
    ..Additionally, these potential biomarkers may ultimately be used to identify individuals who should be targeted for more intense screening programs or behavior modification interventions. ..
  15. GENETIC SUSCEPTIBILITY TO BLADDER CANCER
    Xifeng Wu; Fiscal Year: 2001
    ..Our long-term plan is to refine our risk assessment in patients with BC so that we can identify high-risk subgroups of candidates for primary and secondary prevention measures. ..
  16. GENETIC SUSCEPTIBILITY TO BLADDER CANCER
    Xifeng Wu; Fiscal Year: 2002
    ..Our long-term plan is to refine our risk assessment in patients with BC so that we can identify high-risk subgroups of candidates for primary and secondary prevention measures. ..
  17. GENETIC INFLUENCE ON MUTAGEN SENSITIVITY--A TWIN STUDY
    Xifeng Wu; Fiscal Year: 2002
    ..Additionally, these potential biomarkers may ultimately be used to identify individuals who should be targeted for more intense screening programs or behavior modification interventions. ..
  18. GENETIC SUSCEPTIBILITY TO BLADDER CANCER
    Xifeng Wu; Fiscal Year: 2003
    ..Our long-term plan is to refine our risk assessment in patients with BC so that we can identify high-risk subgroups of candidates for primary and secondary prevention measures. ..
  19. GENETIC INFLUENCE ON MUTAGEN SENSITIVITY--A TWIN STUDY
    Xifeng Wu; Fiscal Year: 2003
    ..Additionally, these potential biomarkers may ultimately be used to identify individuals who should be targeted for more intense screening programs or behavior modification interventions. ..
  20. Genetic Susceptibility Modifiers in Renal Cell Carcinoma
    Xifeng Wu; Fiscal Year: 2003
    ..Such individuals may then be targeted for intervention programs such as chemoprevention or dietary modification. ..
  21. GENETIC INFLUENCE ON MUTAGEN SENSITIVITY--A TWIN STUDY
    Xifeng Wu; Fiscal Year: 2004
    ..Additionally, these potential biomarkers may ultimately be used to identify individuals who should be targeted for more intense screening programs or behavior modification interventions. ..
  22. Genetic Susceptibility Modifiers in Renal Cell Carcinoma
    Xifeng Wu; Fiscal Year: 2004
    ..Such individuals may then be targeted for intervention programs such as chemoprevention or dietary modification. ..
  23. Markers of Genetic Susceptibility to Bladder Cancer
    Xifeng Wu; Fiscal Year: 2004
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  24. Genetic Susceptibility Modifiers in Renal Cell Carcinoma
    Xifeng Wu; Fiscal Year: 2005
    ..Such individuals may then be targeted for intervention programs such as chemoprevention or dietary modification. ..
  25. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2009
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..