Xifeng Wu

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 24:505-9. 2003
  2. ncbi request reprint p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Natl Cancer Inst 94:681-90. 2002
  3. ncbi request reprint Chromosome instability in lymphocytes: a potential indicator of predisposition to oral premalignant lesions
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 62:2813-8. 2002
  4. pmc Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma
    Jie Lin
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:1805-12. 2010
  5. pmc Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Pharmacogenet Genomics 18:955-65. 2008
  6. pmc Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway
    Jennifer Pan
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:785-92. 2009
  7. pmc Genetic variations in cell-cycle pathway and the risk of oral premalignant lesions
    Yuanqing Ye
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 113:2488-95. 2008
  8. ncbi request reprint Nucleotide excision repair pathway genes and oral premalignant lesions
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:3753-8. 2007
  9. pmc Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study
    Christopher I Amos
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 102:1199-205. 2010
  10. ncbi request reprint Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation
    Jie Lin
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2065-71. 2007

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 24:505-9. 2003
    ..Our data suggest that the XPA 5' non-coding region polymorphism modulates NER capacity and is associated with decreased lung cancer risk, especially in the presence of exposure to tobacco carcinogens...
  2. ncbi request reprint p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Natl Cancer Inst 94:681-90. 2002
    ..We also examined the functionality of the p53 variants in apoptosis and DNA repair...
  3. ncbi request reprint Chromosome instability in lymphocytes: a potential indicator of predisposition to oral premalignant lesions
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 62:2813-8. 2002
    ..This is the first study to examine mutagen sensitivity in a premalignant condition. The next step is to correlate these findings in surrogate (lymphocyte) tissue with molecular events in the target tissue...
  4. pmc Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma
    Jie Lin
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:1805-12. 2010
    ..Future investigation in larger populations and functional characterizations are necessary to validate these results...
  5. pmc Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Pharmacogenet Genomics 18:955-65. 2008
    ..Therefore, we applied a pathway-based approach to evaluate the cumulative effect of multiple polymorphisms on clinical outcome of patients with non-small cell lung cancer...
  6. pmc Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway
    Jennifer Pan
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:785-92. 2009
    ..These findings warrant further replications in different populations...
  7. pmc Genetic variations in cell-cycle pathway and the risk of oral premalignant lesions
    Yuanqing Ye
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 113:2488-95. 2008
    ..Cell-cycle checkpoint controls regulate cell-cycle progression and proliferation. Alterations in cell-cycle control mechanisms are linked to tumorigenesis...
  8. ncbi request reprint Nucleotide excision repair pathway genes and oral premalignant lesions
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:3753-8. 2007
    ..Polymorphisms in NER genes may cause variations in DNA repair capacity and increase susceptibility to both premalignant lesions and cancer...
  9. pmc Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study
    Christopher I Amos
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 102:1199-205. 2010
    ..Thus, among African American persons, multiple loci in the region of chromosome 15q25.1 appear to be strongly associated with lung cancer risk...
  10. ncbi request reprint Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation
    Jie Lin
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2065-71. 2007
    ..As risk assessment for cancer risk is moving toward a multigenic pathway-based approach, future genotype-phenotype correlation studies should also investigate the combined effects of multiple genetic variants...
  11. ncbi request reprint Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer
    Xifeng Wu
    Department of Epidemiology, Experimental Therapeutics, GI Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 24:3789-98. 2006
    ..Understanding how specific genetic variants modify drug action pathways may provide informative blueprints for individualized chemotherapy...
  12. ncbi request reprint Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival
    Dan Leibovici
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA
    J Clin Oncol 23:5746-56. 2005
    ..Since chronic inflammation contributes to tumorigenesis, we hypothesized that the risk and clinical outcome of bladder cancer (BC) might be modulated by genetic variations in inflammation genes...
  13. pmc Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer
    Michelle A T Hildebrandt
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e12402. 2010
    ..These results suggest that genetic variations among inflammation pathway genes may modulate the development of radiation-induced toxicity and, ultimately, help in identifying patients who are at an increased likelihood for such events...
  14. pmc Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma
    Jinliang Xing
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:1104-12. 2008
    ..Renal cell carcinoma accounts for 85% of all renal cancers. No studies have investigated the association between mtDNA content and the risk of renal cell carcinoma...
  15. pmc Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy
    Xifeng Wu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1340, Houston, TX 77030, USA
    J Natl Cancer Inst 103:817-25. 2011
    ..Interindividual variation in genetic background may influence the response to chemotherapy and overall survival for patients with advanced-stage non-small cell lung cancer (NSCLC)...
  16. ncbi request reprint Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness
    A Karim Kader
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:2614-20. 2007
    ..MMP levels are elevated in bladder cancer patients correlating with more advanced stage. We tested whether polymorphisms in MMP genes modify the risk of bladder cancer invasiveness and whether smoke exposure modifies this risk...
  17. pmc Genetic variation in MicroRNA genes and risk of oral premalignant lesions
    Jessica Clague
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Carcinog 49:183-9. 2010
    ....
  18. ncbi request reprint Joint effect of mutagen sensitivity and insulin-like growth factors in predicting the risk of developing secondary primary tumors and tumor recurrence in patients with head and neck cancer
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:7194-201. 2006
    ..We hypothesized that latent genetic instability and proliferation potential may be associated with elevated risks of SPT and recurrence...
  19. ncbi request reprint Interplay between mutagen sensitivity and epidemiological factors in modulatinglung cancer risk
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 120:2687-95. 2007
    ..This new integrative approach should facilitate identification of high-risk subgroups and has important implications in LC prevention...
  20. pmc The influence of tumor necrosis factor-alpha -308 G/A and IL-6 -174 G/C on pain and analgesia response in lung cancer patients receiving supportive care
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, 1155 Pressler Street Unit 1340, Houston, TX 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 17:3262-7. 2008
    ....
  21. pmc Genetic variations of the PI3K-AKT-mTOR pathway and clinical outcome in muscle invasive and metastatic bladder cancer patients
    Meng Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Carcinogenesis 31:1387-91. 2010
    ..These findings warrant further replication in independent populations and may provide information on disease management and development of target therapies...
  22. ncbi request reprint Combined effects of the p53 and p73 polymorphisms on lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    Cancer Epidemiol Biomarkers Prev 15:158-61. 2006
    ....
  23. ncbi request reprint Evaluation of glutathione S-transferase polymorphisms and mutagen sensitivity as risk factors for the development of second primary tumors in patients previously diagnosed with early-stage head and neck cancer
    Charles G Minard
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:2636-44. 2006
    ..Data were available for 303 patients who were enrolled in a placebo-controlled chemoprevention trial of low-dose 13-cis-retinoic acid to reduce the occurrence of SPTs...
  24. pmc PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy
    Xia Pu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Lung Cancer 71:82-8. 2011
    ..With further validation, our findings may provide additional biomarkers for customized treatment of platinum-based chemotherapy for NSCLC...
  25. ncbi request reprint Cyclin D1 guanine/adenine 870 polymorphism with altered protein expression is associated with genomic instability and aggressive clinical biology of esophageal adenocarcinoma
    Julie G Izzo
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 25:698-707. 2007
    ..We hypothesized that CD1 A870 allele would be associated with higher CD1 protein expression, and increased genomic instability during EAC evolution, leading to more aggressive phenotype...
  26. pmc Global assessment of genetic variation influencing response to retinoid chemoprevention in head and neck cancer patients
    J Jack Lee
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 4:185-93. 2011
    ..The lack of any alternatives for reducing risk in these patients highlights the need for future clinical trials to prospectively validate our findings...
  27. pmc Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk
    Meng Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:2047-52. 2009
    ..71) increased bladder cancer risk. This is the first study to evaluate the role of germ line genetic variations in PI3K-AKT-mTOR pathway as cancer susceptibility factors that will help us identify high-risk individuals for bladder cancer...
  28. pmc Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 2:617-24. 2009
    ..Furthermore, this study underscores the importance of incorporating germ-line genetic variation data with clinical and risk factor data in constructing prediction models for clinical outcomes...
  29. ncbi request reprint Telomere dysfunction: a potential cancer predisposition factor
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 95:1211-8. 2003
    ..Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the association between telomere length and cancer risk in four ongoing case-control studies...
  30. pmc Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma
    Jianming Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:1755-61. 2010
    ..Our results stressed the importance of taking a polygenic approach to evaluate the cumulative and interaction effects of genetic variations in the prediction of cancer risk and prognosis...
  31. pmc Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays
    Meng Chen
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 125:2342-8. 2009
    ..The identified regions and genes may become diagnostic and prognostic biomarkers as well as potential targets of therapy...
  32. ncbi request reprint High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility
    Maosheng Huang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:84-91. 2007
    ..02%; P < 0.001). These results support the hypothesis that genetic variants in BER genes contribute to bladder cancer risk through gene-gene and gene-environmental interactions...
  33. ncbi request reprint Matrix metalloproteinase polymorphisms and bladder cancer risk
    A Karim Kader
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:11644-8. 2006
    ..Heavy carcinogen exposure may overwhelm some of the genetic effects of MMP polymorphisms. Our study confirms the importance of taking a multigenic pathway-based approach to risk assessment...
  34. pmc Genetic susceptibility to renal cell carcinoma: the role of DNA double-strand break repair pathway
    Vitaly Margulis
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 17:2366-73. 2008
    ..These findings require further validation in independent populations...
  35. pmc Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Hum Genet 78:464-79. 2006
    ....
  36. ncbi request reprint Polymorphisms in XPD exons 10 and 23 and bladder cancer risk
    Matthew B Schabath
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Unit 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:878-84. 2005
    ....
  37. pmc An expanded risk prediction model for lung cancer
    Margaret R Spitz
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, P O Box 301439, Houston, TX 77230 1439, USA
    Cancer Prev Res (Phila) 1:250-4. 2008
    ..Addition of biomarker assays improved the sensitivity of the expanded models...
  38. ncbi request reprint High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk
    Meng Chen
    Department of Epidemiology and Urology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Carcinogenesis 28:2160-5. 2007
    ..The contributions of these polymorphisms may jointly affect bladder cancer risk through gene-gene and gene-smoking interactions...
  39. ncbi request reprint Genetic variants in cell cycle control pathway confer susceptibility to lung cancer
    Wei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:5974-81. 2007
    ..To test the hypothesis that common sequence variants of cell cycle control genes may affect lung cancer predisposition...
  40. ncbi request reprint Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251T/A
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Street, Houston, TX 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 16:2745-51. 2007
    ..We explored if polymorphisms in candidate cytokine genes could explain variability in self-reported pain in lung cancer patients of all stages...
  41. pmc Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions
    Hushan Yang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1340, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Eur J Cancer 44:1603-11. 2008
    ..Our data also suggest that the effects of high-order interactions should be taken into consideration when evaluating OPL predisposition...
  42. pmc Genetic variations in interleukin-8 and interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patients
    Cielito C Reyes-Gibby
    Department of Emergency Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Pain Symptom Manage 46:161-72. 2013
    ..A report by the National Cancer Institute identified that an important gap in symptom research is the investigation of multiple symptoms of cancer that might identify common biological mechanisms among cancer-related symptoms...
  43. pmc MicroRNA expression signatures during malignant progression from Barrett's esophagus to esophageal adenocarcinoma
    Xifeng Wu
    Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 6:196-205. 2013
    ....
  44. ncbi request reprint Case-control analysis of dietary folate and risk of bladder cancer
    Matthew B Schabath
    The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Nutr Cancer 53:144-51. 2005
    ..These data may have important implications for cancer prevention; however, large, hypothesis-driven, population-based clinical trials will be required to confirm these findings...
  45. pmc Family history and risk of renal cell carcinoma: results from a case-control study and systematic meta-analysis
    Jessica Clague
    Department of Epidemiology, Box 1340, The University of Texas M D Anderson Cancer Center, 1155 Pressler Street, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 18:801-7. 2009
    ....
  46. pmc Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma
    Yohei Horikawa
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:7956-62. 2008
    ..Compelling evidence has shown that miRNAs are involved in cancer initiation and progression. We hypothesized that genetic variations of the miRNA machinery genes could be associated with the risk of renal cell carcinoma...
  47. pmc ATM sequence variants associate with susceptibility to non-small cell lung cancer
    Hushan Yang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX
    Int J Cancer 121:2254-9. 2007
    ....
  48. ncbi request reprint Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk
    Hua Zhao
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Int J Cancer 120:2208-13. 2007
    ..The protective effect of ITCs against bladder cancer was not modified by GSTM1, GSTT1 or NAT2 genotypes. This is the first epidemiological report that ITCs from cruciferous vegetable consumption protect against bladder cancer...
  49. pmc MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer
    Xiaofan Zhang
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:2118-23. 2010
    ..9 months (log rank P = 2.28 × 10(-13)). Our results suggested that miRNA-related genetic polymorphisms may be used individually and jointly to predict the risk of SPT/recurrence of early-stage head and neck cancer patients...
  50. ncbi request reprint Dietary carotenoids and genetic instability modify bladder cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Nutr 134:3362-9. 2004
    ..18; 95% CI, 1.13-4.22). This study provides evidence of a preventive role for carotenoids in bladder cancer, and these data may have important implications for cancer prevention, especially for individuals susceptible to DNA damage...
  51. pmc Genetic variants in the PI3K/PTEN/AKT/mTOR pathway predict head and neck cancer patient second primary tumor/recurrence risk and response to retinoid chemoprevention
    Michelle A T Hildebrandt
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 18:3705-13. 2012
    ..Therefore, we investigated whether genetic variants in the PI3K/PTEN/AKT/mTOR pathway could serve as biomarkers to identify which patients are at high risk of an SPT/recurrence, while also predicting response to 13-cRA chemoprevention...
  52. ncbi request reprint Moving toward individualized therapy based on NER polymorphisms that predict platinum sensitivity in ovarian cancer patients
    J Salvador Saldivar
    Department of Gynecology Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Gynecol Oncol 107:S223-9. 2007
    ..We hypothesized that genetic polymorphisms in XP genes may predict clinical response to platinum chemotherapeutic treatment and survival in women with gynecological cancers...
  53. pmc Sensitivity to NNKOAc is associated with renal cancer risk
    Jessica Clague
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, 1155 Pressler, Unit 1340, Houston, TX 77030, USA
    Carcinogenesis 30:706-10. 2009
    ..Future studies with larger sample sizes are warranted to further investigate whether repair of NNKOAc-induced damage, as quantified by the comet assay, could be used as a predictive marker for RCC risk...
  54. ncbi request reprint Projecting individualized probabilities of developing bladder cancer in white individuals
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 25:4974-81. 2007
    ..There has been no risk assessment model for bladder cancer (BC). We developed the first model incorporating mutagen sensitivity and epidemiologic factors to predict BC risk...
  55. ncbi request reprint Genetic instability in bladder cancer assessed by the comet assay
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 95:540-7. 2003
    ..We used the comet assay (single-cell gel electrophoresis) to assess whether genetic instability, as reflected by susceptibility to DNA damage, was associated with the risk of bladder cancer in a case-control study...
  56. pmc Role of inflammation gene polymorphisms on pain severity in lung cancer patients
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Street, Houston, TX 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 18:2636-42. 2009
    ..This study suggests the importance of inflammation gene polymorphisms in modulating pain severity. Additional studies are needed to validate our findings...
  57. pmc MicroRNA expression signatures in Barrett's esophagus and esophageal adenocarcinoma
    Hushan Yang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:5744-52. 2009
    ..Although microRNA (miRNA) expression signatures have been associated with the etiology and prognosis of several types of cancers, their roles in the development of esophageal adenocarcinoma have not been extensively evaluated...
  58. ncbi request reprint A risk model for prediction of lung cancer
    Margaret R Spitz
    Department of Epidemiology Unit 1340, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    J Natl Cancer Inst 99:715-26. 2007
    ..Reliable risk prediction tools for estimating individual probability of lung cancer have important public health implications. We constructed and validated a comprehensive clinical tool for lung cancer risk prediction by smoking status...
  59. ncbi request reprint Differential induction in telomerase activity among bladder cancer patients and controls on gamma-radiation
    Jinliang Xing
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1304, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:606-9. 2007
    ..Our findings provide the first evidence linking the mutagen-induced telomerase activity in peripheral blood lymphocytes to the risk of bladder cancer, which warrants further investigation in large-sized studies and other cancer types...
  60. pmc Modulation of DNA damage/DNA repair capacity by XPC polymorphisms
    Yimin Zhu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    DNA Repair (Amst) 7:141-8. 2008
    ..16, P=0.0009). The haplotypes "T-A" (in the order of Ala499Val-PAT-Lys939Gln) was associated with the lowest DNA damages. Our results suggested that the DRC of host cells might be modulated by specific XPC polymorphisms...
  61. ncbi request reprint Association between glutathione S-transferase pi polymorphisms and survival in patients with advanced nonsmall cell lung carcinoma
    Charles Lu
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 106:441-7. 2006
    ....
  62. pmc Genome-wide catalogue of chromosomal aberrations in barrett's esophagus and esophageal adenocarcinoma: a high-density single nucleotide polymorphism array analysis
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 3:1176-86. 2010
    ..8q24 (containing Myc) and 8p23.1 (containing CTSB) were the two most frequently amplified regions. In addition, a significant trend toward increasing amplification was associated with higher progression stage...
  63. pmc A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer
    Jian Gu
    Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 4:514-21. 2011
    ..In conclusion, we found that the SNP rs398652 on 14q21 was associated with longer telomere length and a reduced risk of bladder cancer and that a portion of the effect of this SNP on bladder cancer risk was mediated by telomere length...
  64. ncbi request reprint Serum levels of insulin growth factor (IGF-I) and IGF-binding protein predict risk of second primary tumors in patients with head and neck cancer
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:3988-95. 2004
    ..Serum levels of insulin growth factors (IGFs) and their binding proteins (IGFBPs) have been associated with subsequent development of several epithelial cancers in prospective studies...
  65. ncbi request reprint Association between asbestos exposure, cigarette smoking, myeloperoxidase (MPO) genotypes, and lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Holcombe Blvd, Houston, Texas 77303, USA
    Am J Ind Med 42:29-37. 2002
    ..As observed in tobacco-associated carcinogenesis, genetic factors such as the polymorphic metabolic/oxidative enzyme myeloperoxidase (MPO) could modulate individual susceptibility to asbestos-associated carcinogenesis...
  66. ncbi request reprint Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 11:1408-15. 2005
    ..Polymorphisms in NER genes may influence DNA repair capacity and affect clinical outcome of bladder cancer treatment...
  67. ncbi request reprint From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    DNA Repair (Amst) 2:901-8. 2003
    ..To our knowledge, this is the largest study conducted evaluating the functional relevance of these polymorphisms...
  68. ncbi request reprint Assessment of insulin-like growth factors and mutagen sensitivity as predictors of lung cancer risk
    Xifeng Wu
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Methods Mol Med 75:279-87. 2003
  69. ncbi request reprint A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 106:2716-24. 2006
    ..Recently, the authors reported that 3 single-nucleotide polymorphisms (SNPs) in 2 members of the RGS family were associated with significant reductions in the risk of cancer...
  70. ncbi request reprint Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Lung Cancer 40:25-32. 2003
    ..53; 95% CI 0.21-1.33). These data demonstrate that the GSTP1 exon 6 polymorphism, but not the exon 5 polymorphism, is associated with lung cancer risk that is especially evident in men, younger individuals, and ever smokers...
  71. ncbi request reprint An association between NQO1 genetic polymorphism and risk of bladder cancer
    Seun Ja Park
    Department of Epidemiology, Unit 189, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mutat Res 536:131-7. 2003
    ..78; 95% CI=1.06-3.00), but not in never smokers (OR=1.19; 95% CI=0.65-2.20). These results suggest that the NQO1 genetic polymorphism modulates bladder cancer risk, especially in men and ever smokers...
  72. ncbi request reprint Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Epidemiol 161:412-22. 2005
    ..19, 0.66) protective genotypes as compared with none (OR = 0.69, 95% CI: 0.30, 1.59). The biologic role of respiratory disease in lung cancer is unclear. Further study may yield new insights for identification of susceptible subgroups...
  73. ncbi request reprint An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 64:2251-7. 2004
    ..Using such a molecular evolutionary approach may hold great promise for prioritizing SNPs to be genotyped in future molecular epidemiological studies...
  74. ncbi request reprint BPDE-induced lymphocytic 3p21.3 aberrations may predict head and neck carcinoma risk
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer 95:563-8. 2002
    ..Chromosomal aberrations in peripheral blood lymphocytes (PBLs) induced by BPDE may reflect individuals' genetic susceptibility to tobacco carcinogens...
  75. ncbi request reprint Predictors of esophageal cancer risk: assessment of susceptibility to DNA damage using comet assay
    Lina Shao
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Chromosomes Cancer 44:415-22. 2005
    ..4-fold risk for EC and those sensitive to both mutagens showed an 8.7-fold risk for EC. Thus, we conclude that susceptibility to DNA damage as assessed by comet assay might help identify individuals with high EC risk...
  76. doi request reprint Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells
    Peter C Black
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:1478-86. 2008
    ..The aim of this study was to define molecular markers of response to cetuximab therapy in a panel of urothelial carcinoma cell lines...
  77. ncbi request reprint Telomere dysfunction in peripheral lymphocytes as a potential predisposition factor for renal cancer
    Lina Shao
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 178:1492-6. 2007
    ..In this study we modified the assay by incorporating 9 control cell lines to normalize telomere length...
  78. ncbi request reprint A case-control analysis of lymphocytic chromosome 9 aberrations in lung cancer
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 102:536-40. 2002
    ..67 [0.84, 3.32]) and lung cancer (OR = 2.49 [0.81, 7.67]). Our findings suggest that chromosome 9 aberrations in PBLs might be considered a marker of lung cancer predisposition and may be associated with familial aggregation of cancer...
  79. ncbi request reprint Hormone replacement therapy and lung cancer risk: a case-control analysis
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:113-23. 2004
    ..Experimental Design: In a secondary analysis, we compared self-reported HRT use among 499 women with lung cancer and 519 healthy age-matched controls...
  80. ncbi request reprint A myeloperoxidase polymorphism associated with reduced risk of lung cancer
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Lung Cancer 37:35-40. 2002
    ..This report provides further support for the hypothesis that a single nucleotide polymorphism in the MPO gene is a protective factor in lung cancer carcinogenesis...
  81. ncbi request reprint Methyl-CpG-binding domain 2: a protective role in bladder carcinoma
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:1853-8. 2004
    ..In the current case-control study, the authors investigated the association between MBD2 expression and bladder carcinoma risk...
  82. ncbi request reprint Modification of lung cancer susceptibility by green tea extract as measured by the comet assay
    Huifeng Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center Box 189 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cancer Detect Prev 26:411-8. 2002
    ..This reports also demonstrated the chemopreventive effects of green tea extract on BPDE-induced DNA damage. These observations provide further support for the application of the comet assay in molecular epidemiologic studies...
  83. ncbi request reprint Genotypes, haplotypes and diplotypes of XPC and risk of bladder cancer
    Yimin Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 28:698-703. 2007
    ..53 (0.34-0.82) for C-A/T-A, 0.48 (0.27-0.84) for C-A/C-C, 0.18 (0.053-0.60) for C-C/C-C and 0.57 (0.36-0.90) for C+C/C+C. These results suggest that sequence variants in the XPC gene might modulate the risk of bladder cancer...
  84. ncbi request reprint Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center Houston, TX 77030, USA
    Carcinogenesis 28:350-5. 2007
    ..45% of controls) exhibited a reduced lung cancer risk (OR=0.78, 95% CI=0.63-0.97). This is the first epidemiological study to report significant associations between STK15 polymorphisms and lung cancer risk...
  85. doi request reprint Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer
    Yuanqing Ye
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 112:2467-74. 2008
    ..Cell cycle checkpoint regulation is crucial for the prevention of carcinogenesis in mammalian cells...
  86. pmc Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk
    Yuanqing Ye
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Prev Res (Phila) 1:460-9. 2008
    ..The present study provides the first evidence that miRNAs may affect esophageal cancer risk in general and that specific genetic variants in miRNA-related genes may affect esophageal cancer risk individually and jointly...
  87. ncbi request reprint Death receptor 4 and bladder cancer risk
    Aditi Hazra
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:1157-9. 2003
    ....
  88. ncbi request reprint Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis
    Yunfei Wang
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, Box 189, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Lung Cancer 35:137-42. 2002
    ..74, 95% CI: 1.08-2.29) and heavy smokers (OR=1.45, 95% CI: 1.05-2.00). Our results support the hypothesis that a genetic polymorphism in the SULT1A1 gene may be associated with increased lung cancer risk...
  89. pmc The D2 dopamine receptor gene and nicotine dependence among bladder cancer patients and controls
    Jessica Clague
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Pressler Blvd Unit 1340, Houston, TX 77030, USA
    Behav Genet 40:49-58. 2010
    ..01). The present study suggests that the DRD2 alleles A1 and B1 confer greater vulnerability to tobacco use...
  90. ncbi request reprint Mutagen-induced chromatid breakage as a marker of cancer risk
    Xifeng Wu
    Department of Epidemiology, M D Anderson Cancer Center, Houston, TX, USA
    Methods Mol Biol 291:59-67. 2005
    ....
  91. pmc Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk
    Jian Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas
    Cancer 116:3458-62. 2010
    ..However, it has not been established whether the association between genetic variants and lung cancer risk is a direct one or one mediated by nicotine dependence...
  92. pmc Case-control analysis of nucleotide excision repair pathway and the risk of renal cell carcinoma
    Jie Lin
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 29:2112-9. 2008
    ..These results need to be replicated in larger studies...
  93. ncbi request reprint A modified host cell reactivation assay to measure DNA repair capacity for removing 4-aminobiphenyl adducts: a pilot study of bladder cancer
    Jie Lin
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1832-6. 2005
    ..Our assay provides a new tool to specifically quantify DNA repair capacity in bladder cancer studies and, therefore, contributes to our goal of further elucidating bladder carcinogenesis...
  94. ncbi request reprint Cyclin D1 gene polymorphism as a risk factor for oral premalignant lesions
    Maosheng Huang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 27:2034-7. 2006
    ..Deregulation of cell cycle plays an important role in tumorigenesis. Cyclin D1 gene (CCND1) is a key regulator of the G(1) phase of the cell cycle...
  95. ncbi request reprint Deficiency of cell cycle checkpoints and DNA repair system predispose individuals to esophageal cancer
    Lina Shao
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mutat Res 602:143-50. 2006
    ..However, such association was not seen in esophageal cancer patients. This study provides the first molecular epidemiologic evidence linking increased esophageal cancer risk with defects in cell-cycle checkpoints and DNA repair capacity...
  96. pmc Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk
    Yanhong Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:1762-9. 2010
    ..However, polymorphisms in DNA strand break repair genes that may determine mutagen sensitivity are not well studied in cancer risk, especially in gliomas...
  97. ncbi request reprint Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study
    Jie Lin
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Carcinogenesis 25:1639-47. 2004
    ..These results have important implications for cancer prevention in susceptible populations...
  98. ncbi request reprint Serum levels of insulin-like growth factor I and risk of squamous intraepithelial lesions of the cervix
    Xifeng Wu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:3356-61. 2003
    ..However, after adjustment for IGF-I, no relationship was evident between IGFBP-3 level and risk of SILs. Serum levels of IGF-I may be a useful biomarker for assessing risk of SIL development...
  99. ncbi request reprint Systematic evaluation of genetic variants in the inflammation pathway and risk of lung cancer
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Cancer Res 67:6520-7. 2007
    ..IL1A and IL1B are critical signals in initiating inflammation. Our results suggest that a dysregulated inflammatory response to tobacco-induced lung damage promotes carcinogenesis...
  100. ncbi request reprint Assessing the function of genetic variants in candidate gene association studies
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, and Abramson Cancer Center, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Genet 5:589-97. 2004
  101. ncbi request reprint Expression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer
    Xin Lin
    Departments of Epidemiology and Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 12:5720-5. 2006
    ..We hypothesized that the expression of these genes would have significant predictive value for cancer development and prognosis...