Chih Chieh Wu

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Whole-genome detection of disease-associated deletions or excess homozygosity in a case-control study of rheumatoid arthritis
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Hum Mol Genet 22:1249-61. 2013
  2. doi Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome
    Chih Chieh Wu
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Genet 129:663-73. 2011
  3. pmc Effects of measured susceptibility genes on cancer risk in family studies
    Chih Chieh Wu
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Genet 127:349-57. 2010
  4. pmc Detection of disease-associated deletions in case-control studies using SNP genotypes with application to rheumatoid arthritis
    Chih Chieh Wu
    Unit 1340, Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Genet 126:303-15. 2009
  5. ncbi Statistical methods for anomalous discrete time series based on minimum cell count
    Chih Chieh Wu
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    Biom J 50:86-96. 2008
  6. ncbi Joint effects of germ-line p53 mutation and sex on cancer risk in Li-Fraumeni syndrome
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 66:8287-92. 2006
  7. pmc Analysis of genes for alcoholism using two-disease-locus models
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    BMC Genet 6:S149. 2005
  8. ncbi Linkage analysis of affected sib pairs allowing for parent-of-origin effects
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 189, Houston, TX 77030, USA
    Ann Hum Genet 69:113-26. 2005
  9. ncbi Statistical properties of affected sib-pair linkage tests
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Hered 55:153-62. 2003
  10. ncbi Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23
    Linda L Bachinski
    Section of Cancer Genetics, Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:427-31. 2005

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc Whole-genome detection of disease-associated deletions or excess homozygosity in a case-control study of rheumatoid arthritis
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Hum Mol Genet 22:1249-61. 2013
    ..Using Fisher's exact test for comparing the numbers of cases and controls with copy number <2 per SNP, we identified 26 significant SNPs (protective; more controls than cases) aggregating on chromosome 14 with P-values <10(-8)...
  2. doi Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome
    Chih Chieh Wu
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Genet 129:663-73. 2011
    ..Our results showed that SNP309 G-alleles were associated with accelerated tumor formation in both carriers and non-carriers of germ-line TP53 mutations...
  3. pmc Effects of measured susceptibility genes on cancer risk in family studies
    Chih Chieh Wu
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Genet 127:349-57. 2010
    ....
  4. pmc Detection of disease-associated deletions in case-control studies using SNP genotypes with application to rheumatoid arthritis
    Chih Chieh Wu
    Unit 1340, Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Genet 126:303-15. 2009
    ..We detected disease-associated deletions within the region of human leukocyte antigen in which genomic deletions were previously discovered in rheumatoid arthritis patients...
  5. ncbi Statistical methods for anomalous discrete time series based on minimum cell count
    Chih Chieh Wu
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    Biom J 50:86-96. 2008
    ..Data on a temporal series of adolescent suicide from the US National Center for Health Statistics were analyzed using these methods...
  6. ncbi Joint effects of germ-line p53 mutation and sex on cancer risk in Li-Fraumeni syndrome
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 66:8287-92. 2006
    ..1-fold higher odds of having cancer than did men with mutations (95% CI, 2.5-20.3). These findings provide quantitative cancer risk assessments for LFS families...
  7. pmc Analysis of genes for alcoholism using two-disease-locus models
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    BMC Genet 6:S149. 2005
    ..We investigated the genetic linkage, pattern of disease inheritance, and pair-wise genetic epistasis of these loci using the TLINKAGE program for two-disease-locus analysis...
  8. ncbi Linkage analysis of affected sib pairs allowing for parent-of-origin effects
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 189, Houston, TX 77030, USA
    Ann Hum Genet 69:113-26. 2005
    ..We also provide useful strategies to determine the optimal tests to use while performing a genome scan...
  9. ncbi Statistical properties of affected sib-pair linkage tests
    Chih Chieh Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Hered 55:153-62. 2003
    ....
  10. ncbi Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23
    Linda L Bachinski
    Section of Cancer Genetics, Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:427-31. 2005
    ..Identification ofa third predisposing gene and its underlying mutation(s) should provide insight into other genetic events that predispose to the genesis of the diverse tumor types associated with LFS and its variants...
  11. pmc Age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis
    E Warwick Daw
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, USA
    BMC Genet 4:S80. 2003
    ..The measures selected were age-of-onset of hypertension and systolic blood pressure at first visit...
  12. pmc Joint linkage and imprinting analyses of GAW15 rheumatoid arthritis and gene expression data
    Xiaojun Zhou
    Department of Epidemiology, Unit 1340, The University of Texas M, Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX, 77030, USA
    BMC Proc 1:S53. 2007
    ..03 for imprinting, but increase in the LOD score did not meet the required threshold to reliably identify imprinting as the correct mode of inheritance in genome-wide linkage scans...
  13. ncbi Nuchal translucence incorporated into a one-stage multifactorial screening model for Down syndrome prediction at second-trimester pregnancy
    Jeng Hsiu Hung
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan
    Ultrasound Med Biol 29:1667-74. 2003
    ..The risk probability of Down syndrome could be readily calculated after inputting data for all four predictor variables...

Research Grants2

  1. Development of Statistical Approaches Allowing for Genetic Covariates
    Chih Chieh Wu; Fiscal Year: 2007
    ..The Texas Cancer Genetic Consortium, a Cancer Genetic Network regional center, will provide the breast cancer data. ..