Peter E Wright

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. Fenwick R, Oyen D, Wright P. Multi-probe relaxation dispersion measurements increase sensitivity to protein dynamics. Phys Chem Chem Phys. 2016;18:5789-98 pubmed publisher
    ..This work demonstrates the power of combined (1)H and (15)N probes for the study of backbone dynamics on the micro-millisecond timescale though the analysis of chemical shift changes. ..
  2. Liang F, Kroon G, McAvoy C, Chi C, Wright P, Shan S. Conformational dynamics of a membrane protein chaperone enables spatially regulated substrate capture and release. Proc Natl Acad Sci U S A. 2016;113:E1615-24 pubmed publisher
    ..Our work demonstrates how the intrinsic conformational dynamics of a chaperone enables spatially coordinated substrate capture and release, which may be general to other ATP-independent chaperone systems. ..
  3. Krois A, Dyson H, Wright P. Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A. 2018;115:E11302-E11310 pubmed publisher
  4. Yang K, Stanfield R, Martinez Yamout M, Dyson H, Wilson I, Wright P. Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain. Proc Natl Acad Sci U S A. 2018;115:10040-10045 pubmed publisher
  5. Arai M, Sugase K, Dyson H, Wright P. Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding. Proc Natl Acad Sci U S A. 2015;112:9614-9 pubmed publisher
    ..We propose that the intrinsic secondary structure propensities of pKID and c-Myb determine their binding mechanisms, consistent with their functions as inducible and constitutive transcriptional activators. ..
  6. Berlow R, Dyson H, Wright P. Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation. J Mol Biol. 2018;430:2309-2320 pubmed publisher
    ..Ongoing and future work in this rapidly evolving area of research will expand our appreciation of the central role of intrinsically disordered proteins in ensuring the fidelity and efficiency of cellular regulation. ..
  7. Sun X, Dyson H, Wright P. Kinetic analysis of the multistep aggregation pathway of human transthyretin. Proc Natl Acad Sci U S A. 2018;115:E6201-E6208 pubmed publisher
    ..A monomeric intermediate was observed only for V122I: aggregation of V30M and L55P proceeds without an observable monomeric intermediate, whereas the protective mutant T119M remains resistant to tetramer dissociation and aggregation. ..
  8. Wright P, Dyson H. Linking folding and binding. Curr Opin Struct Biol. 2009;19:31-8 pubmed publisher
  9. Berlow R, Dyson H, Wright P. Functional advantages of dynamic protein disorder. FEBS Lett. 2015;589:2433-40 pubmed publisher
    ..This feature also adds to the faithfulness of cellular regulation, as the availability of a given disordered domain depends on competition between various partners relevant to different cellular processes. ..

More Information

Publications13

  1. Krois A, Ferreon J, Martinez Yamout M, Dyson H, Wright P. Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc Natl Acad Sci U S A. 2016;113:E1853-62 pubmed publisher
  2. Jansma A, Martinez Yamout M, Liao R, Sun P, Dyson H, Wright P. The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb. J Mol Biol. 2014;426:4030-48 pubmed publisher
  3. Dyson H, Wright P. Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300. J Biol Chem. 2016;291:6714-22 pubmed publisher
    ..The functional diversity of the CBP/p300 interactome provides an excellent example of the power of intrinsic disorder to facilitate the complexity of living systems. ..
  4. Park S, Stanfield R, Martinez Yamout M, Dyson H, Wilson I, Wright P. Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation. Proc Natl Acad Sci U S A. 2017;114:E5335-E5342 pubmed publisher
    ..Upon autoacetylation, acetyl-K1596 (Ac-K1596) binds intramolecularly to the BRD, competing with histones for binding to the BRD and acting as a negative regulator that inhibits histone H3 acetylation. ..