Marina E Wolf

Summary

Affiliation: The Chicago Medical School
Country: USA

Publications

  1. ncbi request reprint Pharmacological reversal of behavioral and cellular indices of cocaine sensitization in the rat
    Y Li
    Department of Neuroscience, FUHS The Chicago Medical School, North Chicago, IL 60064 3095, USA
    Psychopharmacology (Berl) 151:175-83. 2000
  2. ncbi request reprint Psychomotor stimulants and neuronal plasticity
    Marina E Wolf
    Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Neuropharmacology 47:61-79. 2004
  3. ncbi request reprint LTP may trigger addiction
    Marina E Wolf
    Department of Neuroscience The Chicago Medical School, North Chicago, IL 60064 USA
    Mol Interv 3:248-52. 2003
  4. ncbi request reprint Mechanisms by which dopamine receptors may influence synaptic plasticity
    Marina E Wolf
    Department of Neuroscience, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60064 3095, USA
    Ann N Y Acad Sci 1003:241-9. 2003
  5. ncbi request reprint Addiction: making the connection between behavioral changes and neuronal plasticity in specific pathways
    Marina E Wolf
    Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Mol Interv 2:146-57. 2002
  6. ncbi request reprint Amphetamine increases glutamate efflux in the rat ventral tegmental area by a mechanism involving glutamate transporters and reactive oxygen species
    M E Wolf
    Department of Neuroscience, FUHS The Chicago Medical School, North Chicago, Illinois 60064 3095, USA
    J Neurochem 75:1634-44. 2000
  7. doi request reprint Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving
    Jessica A Loweth
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    Nat Neurosci 17:73-80. 2014
  8. pmc Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²⁺-permeable AMPA receptors during the incubation of cocaine craving
    Carrie R Ferrario
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Neuropharmacology 61:1141-51. 2011
  9. pmc Dopamine receptors regulate NMDA receptor surface expression in prefrontal cortex neurons
    Can Gao
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurochem 106:2489-501. 2008
  10. ncbi request reprint Dopamine alters AMPA receptor synaptic expression and subunit composition in dopamine neurons of the ventral tegmental area cultured with prefrontal cortex neurons
    Can Gao
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 27:14275-85. 2007

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Pharmacological reversal of behavioral and cellular indices of cocaine sensitization in the rat
    Y Li
    Department of Neuroscience, FUHS The Chicago Medical School, North Chicago, IL 60064 3095, USA
    Psychopharmacology (Berl) 151:175-83. 2000
    ..The goal of this study was to determine if established cocaine sensitization could be reversed by pharmacological manipulation of these transmitter systems...
  2. ncbi request reprint Psychomotor stimulants and neuronal plasticity
    Marina E Wolf
    Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Neuropharmacology 47:61-79. 2004
    ..When this mechanism is activated in an unregulated manner by psychostimulants, maladaptive forms of neuroplasticity may occur that contribute to the transition from casual to compulsive drug use...
  3. ncbi request reprint LTP may trigger addiction
    Marina E Wolf
    Department of Neuroscience The Chicago Medical School, North Chicago, IL 60064 USA
    Mol Interv 3:248-52. 2003
    ..These findings will increase our understanding of the intricacies of addiction and LTP, and may lead to new interventions for breaking addiction...
  4. ncbi request reprint Mechanisms by which dopamine receptors may influence synaptic plasticity
    Marina E Wolf
    Department of Neuroscience, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60064 3095, USA
    Ann N Y Acad Sci 1003:241-9. 2003
    ..Preliminary results suggest that D1 receptor stimulation or PKA activation leads to increased surface GluR1 expression in PFC neurons but not to insertion into synaptic sites...
  5. ncbi request reprint Addiction: making the connection between behavioral changes and neuronal plasticity in specific pathways
    Marina E Wolf
    Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Mol Interv 2:146-57. 2002
  6. ncbi request reprint Amphetamine increases glutamate efflux in the rat ventral tegmental area by a mechanism involving glutamate transporters and reactive oxygen species
    M E Wolf
    Department of Neuroscience, FUHS The Chicago Medical School, North Chicago, Illinois 60064 3095, USA
    J Neurochem 75:1634-44. 2000
    ..each amphetamine injection in a chronic regimen is important in triggering drug-induced adaptations in ventral tegmental area dopamine neurons, and that such adaptations may in part represent a response to metabolic and oxidative stress..
  7. doi request reprint Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving
    Jessica A Loweth
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    Nat Neurosci 17:73-80. 2014
    ..These results suggest a strategy in which recovering addicts could use a systemically active compound to protect against cue-induced relapse...
  8. pmc Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²⁺-permeable AMPA receptors during the incubation of cocaine craving
    Carrie R Ferrario
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Neuropharmacology 61:1141-51. 2011
    ..Overall, AMPAR plasticity in the incubation model shares some features with better described forms of synaptic plasticity, although the timing of the phenomenon and the persistence of related neuroadaptations are significantly different...
  9. pmc Dopamine receptors regulate NMDA receptor surface expression in prefrontal cortex neurons
    Can Gao
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurochem 106:2489-501. 2008
    ..Our results show that tyrosine phosphorylation plays an important role in the trafficking of NR2B-containing NMDA receptors in PFC neurons and the regulation of their trafficking by DA receptors...
  10. ncbi request reprint Dopamine alters AMPA receptor synaptic expression and subunit composition in dopamine neurons of the ventral tegmental area cultured with prefrontal cortex neurons
    Can Gao
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 27:14275-85. 2007
    ..These results help define the cellular basis for plasticity underlying the development of behavioral sensitization...
  11. pmc Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 31:14536-41. 2011
    ..Furthermore, they suggest that activation of mGluR1 may represent a potential strategy for reducing cue-induced cocaine craving in abstinent cocaine addicts...
  12. ncbi request reprint Dopamine receptor stimulation modulates AMPA receptor synaptic insertion in prefrontal cortex neurons
    Xiu Sun
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 25:7342-51. 2005
    ..Abnormal engagement of this mechanism during unregulated dopamine release may account for maladaptive plasticity after repeated exposure to cocaine or amphetamine...
  13. pmc Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine
    Amy C Boudreau
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurochem 110:363-77. 2009
    ....
  14. doi request reprint Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure
    Xiu Sun
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    Eur J Neurosci 30:539-50. 2009
    ....
  15. pmc Plasticity of L-type Ca2+ channels after cocaine withdrawal
    Kerstin A Ford
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    Synapse 63:690-7. 2009
    ..More generally, our results are the first to demonstrate that repeated cocaine exposure alters the membrane trafficking of a voltage-sensitive ion channel...
  16. pmc Different roles of BDNF in nucleus accumbens core versus shell during the incubation of cue-induced cocaine craving and its long-term maintenance
    Xuan Li
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 33:1130-42. 2013
    ....
  17. pmc Acute and chronic dopamine receptor stimulation modulates AMPA receptor trafficking in nucleus accumbens neurons cocultured with prefrontal cortex neurons
    Xiu Sun
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 28:4216-30. 2008
    ....
  18. pmc Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 31:5737-43. 2011
    ..In conclusion, in adult rats, accumulation of synaptic CP-AMPARs in the NAc occurs after prolonged withdrawal from extended-access cocaine self-administration but not after prolonged withdrawal from noncontingent cocaine injections...
  19. ncbi request reprint D1 dopamine receptor stimulation increases GluR1 surface expression in nucleus accumbens neurons
    Steven Z Chao
    Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    J Neurochem 83:704-12. 2002
    ..When dopamine receptors are over-stimulated during chronic drug administration, this regulation may be disrupted, leading to inappropriate plasticity in neuronal circuits governing motivation and reward...
  20. pmc Effects of acute cocaine or dopamine receptor agonists on AMPA receptor distribution in the rat nucleus accumbens
    Carrie R Ferrario
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064 3095, USA
    Synapse 65:54-63. 2011
    ..They further suggest that cocaine exerts these effects by influencing neuronal circuits rather than simply stimulating NAc DA transmission...
  21. ncbi request reprint D1 dopamine receptor stimulation increases the rate of AMPA receptor insertion onto the surface of cultured nucleus accumbens neurons through a pathway dependent on protein kinase A
    Simona Mangiavacchi
    Department of Neuroscience, The Chicago Medical School, North Chicago, Illinois 60064 3095, USA
    J Neurochem 88:1261-71. 2004
    ..Together, our findings suggest that PKA phosphorylation of GluR1 is required for GluR1 externalization in response to D1 receptor stimulation...
  22. ncbi request reprint Activation of D1 dopamine receptors increases surface expression of AMPA receptors and facilitates their synaptic incorporation in cultured hippocampal neurons
    Can Gao
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurochem 98:1664-77. 2006
    ..By increasing the size of the extrasynaptic GluR1 pool, D1 receptors may promote LTP. Psychostimulants may usurp this mechanism, leading to inappropriate plasticity that contributes to addiction-related behaviors...
  23. pmc Behavioral sensitization to amphetamine is not accompanied by changes in glutamate receptor surface expression in the rat nucleus accumbens
    Christopher L Nelson
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurochem 109:35-51. 2009
    ..Our results suggest that glutamate transmission in the NAc is dramatically different in rats sensitized to amphetamine versus cocaine...
  24. ncbi request reprint Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens
    Amy C Boudreau
    Department of Neuroscience, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurosci 25:9144-51. 2005
    ..We propose that drug-seeking responses are more effectively triggered in cocaine-sensitized rats because of increased cell surface expression of AMPA receptors...
  25. ncbi request reprint Stimulation of N-methyl-D-aspartate receptors, AMPA receptors or metabotropic glutamate receptors leads to rapid internalization of AMPA receptors in cultured nucleus accumbens neurons
    Simona Mangiavacchi
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Eur J Neurosci 20:649-57. 2004
    ..These data suggest that AMPA receptors on NAc neurons may be subject to rapid regulation of their surface expression in response to changes in the activity of glutamate inputs from cortical and limbic regions...
  26. pmc Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization
    Xiaoting Wang
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 33:11012-22. 2013
    ....
  27. pmc The role of glutamate receptor redistribution in locomotor sensitization to cocaine
    Carrie R Ferrario
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064 3095, USA
    Neuropsychopharmacology 35:818-33. 2010
    ....
  28. ncbi request reprint D(1) dopamine receptor stimulation increases GluR1 phosphorylation in postnatal nucleus accumbens cultures
    Steven Z Chao
    Department of Neuroscience, FUHS The Chicago Medical School, North Chicago, Illinois 60064 3095, USA
    J Neurochem 81:984-92. 2002
    ..Thus, the present results suggest that AMPA receptor transmission in the nucleus accumbens may be augmented by concurrent D(1) receptor stimulation...
  29. pmc Using metabotropic glutamate receptors to modulate cocaine's synaptic and behavioral effects: mGluR1 finds a niche
    Jessica A Loweth
    Department of Neuroscience, Rosalind Franklin University of Medicine, USA
    Curr Opin Neurobiol 23:500-6. 2013
    ..Therefore, activation of mGluR1 with positive allosteric modulators (PAM) may reduce cue-induced relapse in abstinent cocaine addicts. ..
  30. pmc A protein cross-linking assay for measuring cell surface expression of glutamate receptor subunits in the rodent brain after in vivo treatments
    Amy C Boudreau
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    Curr Protoc Neurosci . 2012
    ..A disadvantage is that some antibodies no longer recognize their target protein after cross-linking. We have used this method to quantify changes in receptor distribution after acute and chronic exposure to psychomotor stimulants...
  31. pmc The Bermuda Triangle of cocaine-induced neuroadaptations
    Marina E Wolf
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Trends Neurosci 33:391-8. 2010
    ..This review will consider the possibility that they are causally related and speculate about how time-dependent changes in their interactions may regulate MSN output during early and late withdrawal from repeated cocaine exposure...
  32. pmc Cell surface AMPA receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with altered activation of mitogen-activated protein kinases
    Amy C Boudreau
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurosci 27:10621-35. 2007
    ..ERK phosphorylation paralleled AMPAR surface expression. Although JNK results were complex, JNK and p38 may be involved in AMPAR internalization after cocaine or saline challenge, respectively...
  33. ncbi request reprint Extracellular glutamate levels in prefrontal cortex during the expression of associative responses to cocaine related stimuli
    Gregory Hotsenpiller
    Department of Neuroscience, FUHS The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Neuropharmacology 43:1218-29. 2002
    ....
  34. pmc Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
    KELLY L CONRAD
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Nature 454:118-21. 2008
    ....
  35. pmc AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine
    Marina E Wolf
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, United States
    Neurosci Biobehav Rev 35:185-211. 2010
    ..This may contribute to a broad range of addiction-related behavioral changes...
  36. doi request reprint Regulation of AMPA receptor trafficking in the nucleus accumbens by dopamine and cocaine
    Marina E Wolf
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Neurotox Res 18:393-409. 2010
    ....
  37. pmc Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens
    Carrie R Ferrario
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, United States
    Neurosci Lett 490:180-4. 2011
    ..These experiments provide fundamental information that will aid in the interpretation of studies on AMPAR-related plasticity in the NAc...
  38. doi request reprint Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens
    Xuan Li
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064 3095, USA
    Eur J Neurosci 34:190-8. 2011
    ....
  39. ncbi request reprint Impaired DRL 30 performance during amphetamine withdrawal
    Jayms D Peterson
    Department of Neuroscience, Finch University of Health Sciences The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Behav Brain Res 143:101-8. 2003
    ..This suggests that impulsivity is increased during amphetamine withdrawal, which we hypothesize is associated with disrupted DA function in the mPFC...
  40. pmc Different adaptations in AMPA receptor transmission in the nucleus accumbens after short vs long access cocaine self-administration regimens
    Anthony Purgianto
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL, USA
    Neuropsychopharmacology 38:1789-97. 2013
    ..Together with data on cocaine infusions in each group, our results show that CP-AMPAR accumulation and enhanced glutamate transmission is associated with longer sessions (6 h), rather than the number of sessions or cocaine infusions...
  41. pmc Visualization of virus-infected brain regions using a GFP-illuminating flashlight enables accurate and rapid dissection for biochemical analysis
    Xuan Li
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    J Neurosci Methods 201:177-9. 2011
    ..Processing of dissected tissue for EGFP immunoblotting further validated the approach...
  42. ncbi request reprint Conditioned locomotion is not correlated with behavioral sensitization to cocaine: an intra-laboratory multi-sample analysis
    Gregory Hotsenpiller
    Department of Neuroscience, FUHS The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Neuropsychopharmacology 27:924-9. 2002
    ..These results underscore the importance of focusing research on drug-free conditioned behaviors when attempting to model conditioned responses to drug related cues in human addicts...
  43. ncbi request reprint Repeated administration of amphetamine or cocaine does not alter AMPA receptor subunit expression in the rat midbrain
    Wenxiao Lu
    Department of Neuroscience, FUHS The Chicago Medical School, North Chicago, IL 60064 3095, USA
    Neuropsychopharmacology 26:1-13. 2002
    ..Our results suggest that enhanced responsiveness of VTA dopamine neurons to AMPA after withdrawal from repeated stimulant administration involves mechanisms more complex than increased expression of AMPA receptor subunits...
  44. ncbi request reprint Effects of psychomotor stimulants on glutamate receptor expression
    Marina E Wolf
    Department of Neuroscience, Chicago Medical School, North Chicago, IL, USA
    Methods Mol Med 79:13-31. 2003
  45. pmc Quantitative analysis of AMPA receptor subunit composition in addiction-related brain regions
    Jeremy M Reimers
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Brain Res 1367:223-33. 2011
    ....
  46. doi request reprint Impact of neonatal NOS-1 inhibitor exposure on neurobehavioural measures and prefrontal-temporolimbic integration in the rat nucleus accumbens
    Alexander M Dec
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL, 60064, USA
    Int J Neuropsychopharmacol 17:275-87. 2014
    ..Greater understanding of the role of NOS-1 in the development of these circuits will shed light on how developmental insults translate to pathophysiology associated with schizophrenia...
  47. pmc Adaptations in AMPA receptor transmission in the nucleus accumbens contributing to incubation of cocaine craving
    Jessica A Loweth
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Neuropharmacology 76:287-300. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  48. ncbi request reprint Dissociation of conditioned locomotion and Fos induction in response to stimuli formerly paired with cocaine
    Gregory Hotsenpiller
    Department of Neuroscience, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60064 3095, USA
    Behav Neurosci 116:634-45. 2002
    ..The possibility that expectancy and frustrative nonreward contribute to Fos expression in rats conditioned to contextual cues is discussed...
  49. doi request reprint AMPA receptor upregulation in the nucleus accumbens shell of cocaine-sensitized rats depends upon S-nitrosylation of stargazin
    Balakrishnan Selvakumar
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuropharmacology 77:28-38. 2014
    ..It is possible that AMPAR upregulation in core involves a different TARP, γ4, which also upregulates in the NAc of sensitized rats...
  50. pmc Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why?
    Marina E Wolf
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago IL, USA
    Front Mol Neurosci 5:72. 2012
    ..Loss of mGluR1 tone during cocaine withdrawal may contribute to CP-AMPAR accumulation in the NAc. Thus, results in both brain regions point to the possibility of using positive modulators of mGluR1 as treatments for cocaine addiction...
  51. ncbi request reprint Psychomotor stimulant addiction: a neural systems perspective
    Barry J Everitt
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:3312-20. 2002
  52. ncbi request reprint Repeated amphetamine administration decreases D1 dopamine receptor-mediated inhibition of voltage-gated sodium currents in the prefrontal cortex
    Jayms D Peterson
    Department of Physiology, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 26:3164-8. 2006
    ..This adaptation may contribute to perseverative behaviors in animals that self-administer psychostimulants as well as compromised PFC-dependent behaviors in human addicts...