T Wittmann

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells
    Torsten Wittmann
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 169:929-39. 2005
  2. ncbi request reprint The spindle: a dynamic assembly of microtubules and motors
    T Wittmann
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Cell Biol 3:E28-34. 2001
  3. ncbi request reprint Microtubule cytoskeleton: a new twist at the end
    Torsten Wittmann
    The Scripps Research Institute, Department of Cell Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Biol 15:R126-9. 2005
  4. ncbi request reprint Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1
    Torsten Wittmann
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 279:6196-203. 2004
  5. pmc Analysis of microtubule dynamic instability using a plus-end growth marker
    Alexandre Matov
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
    Nat Methods 7:761-8. 2010
  6. pmc Regulation of leading edge microtubule and actin dynamics downstream of Rac1
    Torsten Wittmann
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    J Cell Biol 161:845-51. 2003
  7. pmc Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks
    Violaine Delorme
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Dev Cell 13:646-62. 2007
  8. ncbi request reprint Cell motility: can Rho GTPases and microtubules point the way?
    T Wittmann
    The Scripps Research Institute, Department of Cell Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Sci 114:3795-803. 2001
  9. ncbi request reprint A high-speed multispectral spinning-disk confocal microscope system for fluorescent speckle microscopy of living cells
    Michael C Adams
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Methods 29:29-41. 2003
  10. pmc Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1
    Katsuhiro Kita
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 17:2331-45. 2006

Collaborators

Detail Information

Publications13

  1. pmc Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells
    Torsten Wittmann
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 169:929-39. 2005
    ....
  2. ncbi request reprint The spindle: a dynamic assembly of microtubules and motors
    T Wittmann
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Cell Biol 3:E28-34. 2001
    ..Here we describe the structural and dynamic properties of the spindle, and introduce the current concepts regarding how a bipolar spindle is assembled and how it functions to segregate chromosomes...
  3. ncbi request reprint Microtubule cytoskeleton: a new twist at the end
    Torsten Wittmann
    The Scripps Research Institute, Department of Cell Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Biol 15:R126-9. 2005
    ..Two recent papers on one such protein, CLIP-170, provide new insights into the cellular functions of +TIPs as well as the mechanism by which they track microtubule ends...
  4. ncbi request reprint Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1
    Torsten Wittmann
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 279:6196-203. 2004
    ..However, in vivo, Pak1 activity alone is not sufficient to phosphorylate Op18, indicating that additional pathways downstream of Rac1 are required for Op18 regulation...
  5. pmc Analysis of microtubule dynamic instability using a plus-end growth marker
    Alexandre Matov
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
    Nat Methods 7:761-8. 2010
    ..We used our method to analyze spatial variations of intracellular microtubule dynamics in migrating epithelial cells...
  6. pmc Regulation of leading edge microtubule and actin dynamics downstream of Rac1
    Torsten Wittmann
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    J Cell Biol 161:845-51. 2003
    ..In addition, Rac1(Q61L) promoted lamellipodial actin polymerization and Pak-dependent retrograde flow. Together, these results indicate coordinated regulation of the two cytoskeletal systems in the leading edge of migrating cells...
  7. pmc Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks
    Violaine Delorme
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Dev Cell 13:646-62. 2007
    ..We propose that cofilin functions as a regulator of cell protrusion by modulating the spatial interaction of the lamellipodium and lamella in response to upstream signals...
  8. ncbi request reprint Cell motility: can Rho GTPases and microtubules point the way?
    T Wittmann
    The Scripps Research Institute, Department of Cell Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Sci 114:3795-803. 2001
    ..Thus, microtubules might be part of a positive feedback mechanism that maintains the stable polarization of a directionally migrating cell...
  9. ncbi request reprint A high-speed multispectral spinning-disk confocal microscope system for fluorescent speckle microscopy of living cells
    Michael C Adams
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Methods 29:29-41. 2003
    ..We present recent applications of this system for imaging the cytoskeleton in migrating tissue cells and neurons...
  10. pmc Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1
    Katsuhiro Kita
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 17:2331-45. 2006
    ....
  11. ncbi request reprint Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked
    Mimi Shirasu-Hiza
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Curr Biol 14:1941-5. 2004
    ..These results suggest that Eg5 is responsible for flux-associated MT translocation and that dynein and Xklp2 regulate flux-associated microtubule depolymerization at spindle poles...
  12. pmc Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts
    Stephane Brunet
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Heidelberg 69 117, Germany
    Mol Biol Cell 15:5318-28. 2004
    ..These and previous results suggest that under physiological conditions, TPX2 is essential for microtubule nucleation around chromatin and functions in a network of other molecules, some of which also are regulated by RanGTP...
  13. ncbi request reprint Toward reconstitution of in vivo microtubule dynamics in vitro
    Søren S L Andersen
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Bioessays 24:305-7. 2002
    ..By mixing the microtubule stabilizer XMAP215 and the microtubule destabilizer XKCM1, reconstitution of in vivo-like microtubule dynamics has now been achieved in vitro...