K M Wittkowski

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. doi request reprint A novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism
    K M Wittkowski
    The Rockefeller University, Center for Clinical and Translational Science, New York, NY, USA
    Transl Psychiatry 4:e354. 2014
  2. pmc From single-SNP to wide-locus: genome-wide association studies identifying functionally related genes and intragenic regions in small sample studies
    Knut M Wittkowski
    Center for Clinical and Translational Science, The Rockefeller University, 1230 York Ave Box 322, New York, NY 10021, USA
    Pharmacogenomics 14:391-401. 2013
  3. pmc Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
    Francesca Chamian
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, USA
    J Transl Med 5:27. 2007
  4. pmc An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene
    Sreeram V Ramagopalan
    1Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Med Genet 10:10. 2009
  5. pmc "Harshlighting" small blemishes on microarrays
    Mayte Suárez-Fariñas
    Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Ave, Box 212, New York, NY 10021, USA
    BMC Bioinformatics 6:65. 2005
  6. pmc Harshlight: a "corrective make-up" program for microarray chips
    Mayte Suárez-Fariñas
    Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Ave, Box 212, New York, NY 10021, USA
    BMC Bioinformatics 6:294. 2005
  7. pmc Bioinformatics tools enabling u-statistics for microarrays
    Knut M Wittkowski
    Gen Clinical Res Center, Rockefeller Univ Hosp, New York, NY 10021
    Conf Proc IEEE Eng Med Biol Soc 1:3464-9. 2006
  8. ncbi request reprint Combining several ordinal measures in clinical studies
    Knut M Wittkowski
    General Clinical Research Center, The Rockefeller University, New York, NY 10021, USA
    Stat Med 23:1579-92. 2004
  9. ncbi request reprint A statistically valid alternative to the TDT
    K M Wittkowski
    General Clinical Research Center, The Rockefeller University, New York, NY 10021, USA
    Hum Hered 54:157-64. 2002
  10. doi request reprint Phenotyping genetic diseases using an extension of mu-scores for multivariate data
    José F Morales
    The Rockefeller University
    Stat Appl Genet Mol Biol 7:Article 19. 2008

Collaborators

Detail Information

Publications24

  1. doi request reprint A novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism
    K M Wittkowski
    The Rockefeller University, Center for Clinical and Translational Science, New York, NY, USA
    Transl Psychiatry 4:e354. 2014
    ..By extension, the same computational biostatistics approach could yield profound insights into the etiology of many common diseases from the genetic data collected over the last decade. ..
  2. pmc From single-SNP to wide-locus: genome-wide association studies identifying functionally related genes and intragenic regions in small sample studies
    Knut M Wittkowski
    Center for Clinical and Translational Science, The Rockefeller University, 1230 York Ave Box 322, New York, NY 10021, USA
    Pharmacogenomics 14:391-401. 2013
    ..In the presence of epistasis, multivariate approaches based on the linear model (including stepwise logistic regression) often have low sensitivity and generate an abundance of artifacts...
  3. pmc Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
    Francesca Chamian
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, USA
    J Transl Med 5:27. 2007
    ..Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease...
  4. pmc An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene
    Sreeram V Ramagopalan
    1Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Med Genet 10:10. 2009
    ..Given the role of this locus in antigen presentation it has been suggested that variations in the peptide binding site of the allele may underlie allelic variation in disease risk...
  5. pmc "Harshlighting" small blemishes on microarrays
    Mayte Suárez-Fariñas
    Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Ave, Box 212, New York, NY 10021, USA
    BMC Bioinformatics 6:65. 2005
    ..However, most blemishes are hard to find by the unaided eye, particularly in high-density oligonucleotide arrays (HDONAs)...
  6. pmc Harshlight: a "corrective make-up" program for microarray chips
    Mayte Suárez-Fariñas
    Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Ave, Box 212, New York, NY 10021, USA
    BMC Bioinformatics 6:294. 2005
    ..Although all but the starkest blemishes are hard to find by the unaided eye, particularly in high-density oligonucleotide arrays (HDONAs), few tools are available to help with the detection of those defects...
  7. pmc Bioinformatics tools enabling u-statistics for microarrays
    Knut M Wittkowski
    Gen Clinical Res Center, Rockefeller Univ Hosp, New York, NY 10021
    Conf Proc IEEE Eng Med Biol Soc 1:3464-9. 2006
    ....
  8. ncbi request reprint Combining several ordinal measures in clinical studies
    Knut M Wittkowski
    General Clinical Research Center, The Rockefeller University, New York, NY 10021, USA
    Stat Med 23:1579-92. 2004
    ..The scoring method is demonstrated to be applicable to scoring clinical response profiles in the treatment of psoriasis and then to identifying genomic pathways that best correlate with these profiles...
  9. ncbi request reprint A statistically valid alternative to the TDT
    K M Wittkowski
    General Clinical Research Center, The Rockefeller University, New York, NY 10021, USA
    Hum Hered 54:157-64. 2002
    ..To present an alternative linkage test to the transmission/disequilibrium test (TDT) which is conservative under the null hypothesis and generally more powerful under alternatives...
  10. doi request reprint Phenotyping genetic diseases using an extension of mu-scores for multivariate data
    José F Morales
    The Rockefeller University
    Stat Appl Genet Mol Biol 7:Article 19. 2008
    ..The proposed extension increases information content of the phenotype scores obtained and, thereby, the power of genotype-phenotype relationships studies...
  11. pmc In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1
    Jasimuddin Ahamed
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY, USA
    PLoS ONE 4:e6608. 2009
    ....
  12. ncbi request reprint Inflammatory role of two venom components of yellow jackets (Vespula vulgaris): a mast cell degranulating peptide mastoparan and phospholipase A1
    Te Piao King
    The Rockefeller University, New York, NY 10021, USA
    Int Arch Allergy Immunol 131:25-32. 2003
    ..Venom sac extract of yellow jackets Vespula vulgaris was toxic in mice when injected intraperitoneally but not toxic when injected subcutaneously. Necropsy showed the toxicity to be an inflammatory response...
  13. ncbi request reprint Opiate-like effects of sugar on gene expression in reward areas of the rat brain
    Rudolph Spangler
    Laboratory of Behavioral Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res Mol Brain Res 124:134-42. 2004
    ..These findings support a major role for the nucleus accumbens in mediating the effects of naturally rewarding substances and extend an animal model for studying the common substrates of drug addiction and eating disorders...
  14. ncbi request reprint Identification of cellular pathways of "type 1," Th17 T cells, and TNF- and inducible nitric oxide synthase-producing dendritic cells in autoimmune inflammation through pharmacogenomic study of cyclosporine A in psoriasis
    Asifa S Haider
    Laboratory for Investigative Dermatology, Rockefeller University, New York, NY, 10021, USA
    J Immunol 180:1913-20. 2008
    ..In addition, these data also identify new gene targets for therapeutic modulation and may be applied to wide range of autoimmune diseases...
  15. doi request reprint Atherosclerosis in survivors of Kawasaki disease
    Monesha Gupta-Malhotra
    Division of Pediatric Cardiology, Department of Pediatrics, Komansky Center for Children s Health, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA
    J Pediatr 155:572-7. 2009
    ..To test the hypothesis that long-term survivors of low-risk Kawasaki disease (KD) have ongoing vascular inflammation and dysfunction and a higher risk of accelerated atherosclerosis than healthy control subjects...
  16. pmc Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
    Michelle A Lowes
    Laboratory for Investigative Dermatology and Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:19057-62. 2005
    ....
  17. pmc Nonparametric methods for molecular biology
    Knut M Wittkowski
    Center for Clinical and Translational Science, The Rockefeller University, New York, NY, USA
    Methods Mol Biol 620:105-53. 2010
    ....
  18. ncbi request reprint In silico quantitative trait locus map for atherosclerosis susceptibility in apolipoprotein E-deficient mice
    Jonathan D Smith
    Rockefeller University, New York, NY, USA
    Arterioscler Thromb Vasc Biol 23:117-22. 2003
    ....
  19. pmc Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris
    Francesca Chamian
    Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, New York, NY 10021
    Proc Natl Acad Sci U S A 102:2075-80. 2005
    ..Because we observed that alefacept binds primarily to T cells and not DCs, we suggest that T cells are the primary target for therapy, but that DCs and a spectrum of type 1 inflammatory genes are coordinately suppressed...
  20. pmc Interactions between estrogen effects and hunger effects in ovariectomized female mice. I. Measures of arousal
    Deborah N Shelley
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, Box 275, New York, NY 10021, USA
    Horm Behav 52:546-53. 2007
    ..E., 2006. Metabolic and hormonal control of the desire for food and sex: implications for obesity and eating disorders. Horm. Behav. 50, 562-571]...
  21. pmc A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus
    Damien Chaussabel
    Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:150-64. 2008
    ..Thus, this work describes the implementation and application of a methodology designed to support systems-scale analysis of the human immune system in translational research settings...
  22. ncbi request reprint Detecting artifacts on SNP chips
    Maurizio Pellegrino
    Conf Proc IEEE Eng Med Biol Soc 1:4100-2. 2006
    ..We demonstrate that Harshlight can be widely used for chips with different technologies thanks to its user-tunable parameters. Here we report its application to SNP microarrays...
  23. pmc Gene expression patterns in blood leukocytes discriminate patients with acute infections
    Octavio Ramilo
    Baylor National Institute of Allergy and Infections Diseases NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 109:2066-77. 2007
    ..Thus, microarray analyses of patient peripheral blood leukocytes might assist in the differential diagnosis of infectious diseases...
  24. pmc Analytical approaches to reporting long-term clinical trial data
    Kim A Papp
    Probity Medical Research, Waterloo, ON, Canada
    Curr Med Res Opin 24:2001-8. 2008
    ..Therefore, standard analytical strategies used in short-term randomized, controlled trials (intent-to-treat, per-protocol) may not always be appropriate for data generated in long-term studies...